Details for: NFE2L1

Gene ID: 4779

Symbol: NFE2L1

Ensembl ID: ENSG00000082641

Description: NFE2 like bZIP transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 263.4282
    Cell Significance Index: -40.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 161.0135
    Cell Significance Index: -40.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 91.3322
    Cell Significance Index: -43.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.6600
    Cell Significance Index: -34.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.5962
    Cell Significance Index: -34.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.1334
    Cell Significance Index: -42.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.0064
    Cell Significance Index: -40.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.2780
    Cell Significance Index: -34.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7171
    Cell Significance Index: -42.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.7414
    Cell Significance Index: -21.3200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.2518
    Cell Significance Index: 58.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4347
    Cell Significance Index: 156.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3512
    Cell Significance Index: 70.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3151
    Cell Significance Index: 78.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3146
    Cell Significance Index: 213.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3022
    Cell Significance Index: 37.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1144
    Cell Significance Index: 50.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1144
    Cell Significance Index: 153.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0719
    Cell Significance Index: 212.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0439
    Cell Significance Index: 209.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9629
    Cell Significance Index: 20.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8750
    Cell Significance Index: 313.8500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.8553
    Cell Significance Index: 13.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8216
    Cell Significance Index: 148.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8198
    Cell Significance Index: 100.8000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8063
    Cell Significance Index: 6.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6763
    Cell Significance Index: 17.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6740
    Cell Significance Index: 51.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6467
    Cell Significance Index: 30.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5666
    Cell Significance Index: 13.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.5449
    Cell Significance Index: 13.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5436
    Cell Significance Index: 28.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4817
    Cell Significance Index: 333.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4582
    Cell Significance Index: 58.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4316
    Cell Significance Index: 29.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4084
    Cell Significance Index: 180.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3693
    Cell Significance Index: 9.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3561
    Cell Significance Index: 194.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3464
    Cell Significance Index: 3.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3331
    Cell Significance Index: 8.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3084
    Cell Significance Index: 16.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1895
    Cell Significance Index: 18.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1622
    Cell Significance Index: 18.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1562
    Cell Significance Index: 5.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1312
    Cell Significance Index: 24.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1036
    Cell Significance Index: 2.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0906
    Cell Significance Index: 5.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0806
    Cell Significance Index: 1.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0697
    Cell Significance Index: 11.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0595
    Cell Significance Index: 43.6000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0508
    Cell Significance Index: 0.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0457
    Cell Significance Index: 2.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0121
    Cell Significance Index: 22.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0162
    Cell Significance Index: -29.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0181
    Cell Significance Index: -13.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0184
    Cell Significance Index: -28.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0187
    Cell Significance Index: -11.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0187
    Cell Significance Index: -13.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0216
    Cell Significance Index: -29.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0239
    Cell Significance Index: -14.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0318
    Cell Significance Index: -17.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0360
    Cell Significance Index: -16.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0405
    Cell Significance Index: -1.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0426
    Cell Significance Index: -3.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0445
    Cell Significance Index: -2.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0545
    Cell Significance Index: -1.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0577
    Cell Significance Index: -5.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0599
    Cell Significance Index: -1.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0719
    Cell Significance Index: -5.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0839
    Cell Significance Index: -17.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0865
    Cell Significance Index: -9.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0923
    Cell Significance Index: -2.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0946
    Cell Significance Index: -12.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1198
    Cell Significance Index: -34.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1283
    Cell Significance Index: -14.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1336
    Cell Significance Index: -8.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1373
    Cell Significance Index: -2.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1827
    Cell Significance Index: -3.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1846
    Cell Significance Index: -21.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1965
    Cell Significance Index: -28.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2244
    Cell Significance Index: -5.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2286
    Cell Significance Index: -3.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2294
    Cell Significance Index: -12.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2309
    Cell Significance Index: -8.0300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2863
    Cell Significance Index: -4.2900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2910
    Cell Significance Index: -6.2200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2955
    Cell Significance Index: -2.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3402
    Cell Significance Index: -21.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3412
    Cell Significance Index: -5.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3647
    Cell Significance Index: -11.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3801
    Cell Significance Index: -39.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3842
    Cell Significance Index: -30.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3972
    Cell Significance Index: -17.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5056
    Cell Significance Index: -31.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5122
    Cell Significance Index: -19.4000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5882
    Cell Significance Index: -8.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6801
    Cell Significance Index: -16.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7281
    Cell Significance Index: -6.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7337
    Cell Significance Index: -12.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NFE2L1 is a member of the basic leucine zipper (bZIP) transcription factor family, characterized by its ability to bind to specific DNA sequences and regulate the expression of target genes. This gene is predominantly expressed in cells that are exposed to oxidative stress, such as ciliated cells, kidney collecting duct cells, and dopaminergic neurons. NFE2L1's unique ability to modulate gene expression in response to various cellular stresses makes it an attractive target for therapeutic interventions. **Pathways and Functions:** NFE2L1's primary function is to regulate the expression of genes involved in antioxidant defense, detoxification, and cell survival. It achieves this by binding to specific DNA sequences, known as antioxidant response elements (ARE), which are present in the promoter regions of target genes. Upon activation, NFE2L1 recruits coactivators, such as Nrf2, to modulate the expression of genes involved in: 1. **Antioxidant defense:** NFE2L1 regulates the expression of antioxidant enzymes, such as glutathione peroxidase and superoxide dismutase, to neutralize reactive oxygen species (ROS) and maintain cellular homeostasis. 2. **Detoxification:** NFE2L1 induces the expression of genes involved in the metabolism of xenobiotics, such as cytochrome P450 enzymes, to facilitate the removal of toxic substances from the body. 3. **Cell survival:** NFE2L1 promotes cell survival by regulating the expression of genes involved in apoptosis and autophagy, thereby maintaining cellular integrity under stress conditions. **Signaling Pathways:** NFE2L1's regulatory activity is mediated by a complex interplay of signaling pathways, including: 1. **Sensing oxidative stress:** NFE2L1 is activated in response to oxidative stress, which is detected by sensors, such as Nrf2, that recognize ROS. 2. **Activation of transcription:** Upon activation, NFE2L1 recruits coactivators, such as Nrf2, to modulate the expression of target genes. 3. **Regulation of gene expression:** NFE2L1 regulates the expression of genes involved in antioxidant defense, detoxification, and cell survival, thereby maintaining cellular homeostasis. **Clinical Significance:** NFE2L1's role in regulating gene expression in response to oxidative stress and inflammation makes it an attractive target for therapeutic interventions in various diseases, including: 1. **Cancer:** NFE2L1's ability to regulate antioxidant defense and detoxification pathways makes it a potential target for cancer therapy. 2. **Neurodegenerative diseases:** NFE2L1's role in regulating cell survival and apoptosis pathways makes it a potential target for neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Inflammatory diseases:** NFE2L1's ability to regulate inflammation and immune responses makes it a potential target for inflammatory diseases, such as arthritis and asthma. In conclusion, NFE2L1 is a critical transcription factor that plays a pivotal role in regulating gene expression in response to various environmental stresses. Its unique ability to modulate antioxidant defense, detoxification, and cell survival pathways makes it an attractive target for therapeutic interventions in various diseases. As an expert immunologist, I believe that further research on NFE2L1 will uncover its full potential as a therapeutic target and shed light on its role in maintaining cellular homeostasis.

Genular Protein ID: 3113422754

Symbol: NF2L1_HUMAN

Name: Nuclear factor erythroid 2-related factor 1

UniProtKB Accession Codes:

Q14494 D3DTU3 D3DTU5 Q12877 Q96FN6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8248256

Title: Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.

PubMed ID: 8248256

DOI: 10.1073/pnas.90.23.11371

PubMed ID: 8001966

Title: Molecular cloning of a putative novel human bZIP transcription factor on chromosome 17q22.

PubMed ID: 8001966

DOI: 10.1006/geno.1994.1428

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8036168

Title: Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression.

PubMed ID: 8036168

DOI: 10.1093/nar/22.12.2383

PubMed ID: 8932385

Title: Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1.

PubMed ID: 8932385

DOI: 10.1093/nar/24.21.4289

PubMed ID: 9421508

Title: Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription.

PubMed ID: 9421508

DOI: 10.1093/nar/26.2.512

PubMed ID: 15308669

Title: The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation.

PubMed ID: 15308669

DOI: 10.1074/jbc.m405031200

PubMed ID: 16687406

Title: Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function.

PubMed ID: 16687406

DOI: 10.1074/jbc.m602802200

PubMed ID: 20932482

Title: Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop.

PubMed ID: 20932482

DOI: 10.1016/j.molcel.2010.09.012

PubMed ID: 24998528

Title: Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97.

PubMed ID: 24998528

DOI: 10.1016/j.cub.2014.06.004

PubMed ID: 24448410

Title: p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition.

PubMed ID: 24448410

DOI: 10.7554/elife.01856

PubMed ID: 27676297

Title: Nrf1 can be processed and activated in a proteasome-independent manner.

PubMed ID: 27676297

DOI: 10.1016/j.cub.2016.08.008

PubMed ID: 27676298

Title: Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation.

PubMed ID: 27676298

DOI: 10.1016/j.cub.2016.08.030

PubMed ID: 27528193

Title: The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.

PubMed ID: 27528193

DOI: 10.7554/elife.18357

PubMed ID: 26947393

Title: Nuclear factor erythroid-2 like 1 (NFE2L1): structure, function and regulation.

PubMed ID: 26947393

DOI: 10.1016/j.gene.2016.03.002

PubMed ID: 29983246

Title: The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.

PubMed ID: 29983246

DOI: 10.1016/j.cmet.2018.06.008

Sequence Information:

  • Length: 772
  • Mass: 84704
  • Checksum: C868807C6046BEF5
  • Sequence:
    • MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY TQTQFHNLRN 
TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV NAWLVHRDPE GSVSGSQPNS 
GLALESSSGL QDVTGPDNGV RESETEQGFG EDLEDLGAVA PPVSGDLTKE DIDLIDILWR 
QDIDLGAGRE VFDYSHRQKE QDVEKELRDG GEQDTWAGEG AEALARNLLV DGETGESFPA 
QVPSGEDQTA LSLEECLRLL EATCPFGENA EFPADISSIT EAVPSESEPP ALQNNLLSPL 
LTGTESPFDL EQQWQDLMSI MEMQAMEVNT SASEILYSAP PGDPLSTNYS LAPNTPINQN 
VSLHQASLGG CSQDFLLFSP EVESLPVASS STLLPLAPSN STSLNSTFGS TNLTGLFFPP 
QLNGTANDTA GPELPDPLGG LLDEAMLDEI SLMDLAIEEG FNPVQASQLE EEFDSDSGLS 
LDSSHSPSSL SSSEGSSSSS SSSSSSSSSA SSSASSSFSE EGAVGYSSDS ETLDLEEAEG 
AVGYQPEYSK FCRMSYQDPA QLSCLPYLEH VGHNHTYNMA PSALDSADLP PPSALKKGSK 
EKQADFLDKQ MSRDEHRARA MKIPFTNDKI INLPVEEFNE LLSKYQLSEA QLSLIRDIRR 
RGKNKMAAQN CRKRKLDTIL NLERDVEDLQ RDKARLLREK VEFLRSLRQM KQKVQSLYQE 
VFGRLRDENG RPYSPSQYAL QYAGDGSVLL IPRTMADQQA RRQERKPKDR RK

Genular Protein ID: 4144403426

Symbol: Q8NF22_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NF22

Database IDs:

ARBA 24 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 PhylomeDB 1 RefSeq 2 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 791
  • Mass: 86926
  • Checksum: D84F715EF41ABAF7
  • Sequence:
    • FVFWKILKTK KHKHSGPSAM LSLKKYLTEG LLQFTILLSL IGVRVDVDTY LTSQLPPLRE 
IILGPSSAYT QTQFHNLRNT LDGYGIHPKS IDLDNYFTAR RLLSQVRALD RFQVPTTEVN 
AWLVHRDPEG SVSGSQPNSG LALESSSGLQ DVTGPDNGVR ESETEQGFGE DLEDLGAVAP 
PVSGDLTKED IDLIDILWRQ DIDLGAGREV FDYSHRQKEQ DVEKELRDGG EQDTWAGEGA 
EALARNLLVD GETGESFPAQ VPSGEDQTAL SLEECLRLLE ATCPFGENAE FPADISSITE 
AVPSESEPPA LQNNLLSPLL TGTESPFDLE QQWQDLMSIM EMQAMEVNTS ASEILYSAPP 
GDPLSTNYSL APNTPINQNV SLHQASLGGC SQDFLLFSPE VESLPVASSS TLLPLAPSNS 
TSLNSTFGST NLTGLFFPPQ LNGTANDTAG PELPDPLGGL LDEAMLDEIS LMDLAIEEGF 
NPVQASQLEE EFDSDSGLSL DSSHSPSSLS SSEGSSSSSS SSSSSSSSAS SSASSSFSEE 
GAVGYSSDSE TLDLEEAEGA VGYQPEYSKF CRMSYQDPAQ LSCLPYLEHV GHNHTYNMAP 
SALDSADLPP PSALKKGSKE KQADFLDKQM SRDEHRARAM KIPFTNDKII NLPVEEFNEL 
LSKYQLSEAQ LSLIRDIRRR GKNKMAAQNC RKRKLDTILN LERDVEDLQR DKARLLREKV 
EFLRSLRQMK QKVQSLYQEV FGRLRDENGR PYSPSQYALQ YAGDGSVLLI PRTMADQQAR 
RQERKPKDRR K

Genular Protein ID: 2654388307

Symbol: J9JIE5_HUMAN

Name: N/A

UniProtKB Accession Codes:

J9JIE5

Database IDs:

ARBA 24 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 761
  • Mass: 83322
  • Checksum: 5F9483EA9CD012E9
  • Sequence:
    • MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY TQTQFHNLRN 
TLDGYGIHPK SIDLDNYFTA RRLLSQVRAL DRFQVPTTEV NAWLVHRDPE GSVSGSQPNS 
GLALESSSGL QDVTGPDNGV RESETEQGFG EDLEDLGAVA PPVSGDLTKE DIDLGAGREV 
FDYSHRQKEQ DVEKELRDGG EQDTWAGEGA EALARNLLVD GETGESFPAQ VPSGEDQTAL 
SLEECLRLLE ATCPFGENAE FPADISSITE AVPSESEPPA LQNNLLSPLL TGTESPFDLE 
QQWQDLMSIM EMQAMEVNTS ASEILYSAPP GDPLSTNYSL APNTPINQNV SLHQASLGGC 
SQDFLLFSPE VESLPVASSS TLLPLAPSNS TSLNSTFGST NLTGLFFPPQ LNGTANDTAG 
PELPDPLGGL LDEAMLDEIS LMDLAIEEGF NPVQASQLEE EFDSDSGLSL DSSHSPSSLS 
SSEGSSSSSS SSSSSSSSAS SSASSSFSEE GAVGYSSDSE TLDLEEAEGA VGYQPEYSKF 
CRMSYQDPAQ LSCLPYLEHV GHNHTYNMAP SALDSADLPP PSALKKGSKE KQADFLDKQM 
SRDEHRARAM KIPFTNDKII NLPVEEFNEL LSKYQLSEAQ LSLIRDIRRR GKNKMAAQNC 
RKRKLDTILN LERDVEDLQR DKARLLREKV EFLRSLRQMK QKVQSLYQEV FGRLRDENGR 
PYSPSQYALQ YAGDGSVLLI PRTMADQQAR RQERKPKDRR K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.