Details for: NFKB1

Gene ID: 4790

Symbol: NFKB1

Ensembl ID: ENSG00000109320

Description: nuclear factor kappa B subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 338.6796
    Cell Significance Index: -52.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 201.3851
    Cell Significance Index: -51.0800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 143.1007
    Cell Significance Index: -58.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 110.0904
    Cell Significance Index: -44.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 101.0138
    Cell Significance Index: -51.9600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 81.5472
    Cell Significance Index: -54.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.1386
    Cell Significance Index: -45.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.0591
    Cell Significance Index: -53.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.6427
    Cell Significance Index: -52.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.5148
    Cell Significance Index: -53.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.3282
    Cell Significance Index: -29.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.9352
    Cell Significance Index: -39.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.4390
    Cell Significance Index: 69.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7181
    Cell Significance Index: 344.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3726
    Cell Significance Index: 272.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.3352
    Cell Significance Index: 26.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.2857
    Cell Significance Index: 32.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2045
    Cell Significance Index: 62.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0634
    Cell Significance Index: 115.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0300
    Cell Significance Index: 369.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9634
    Cell Significance Index: 156.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9602
    Cell Significance Index: 57.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8945
    Cell Significance Index: 807.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8266
    Cell Significance Index: 23.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7565
    Cell Significance Index: 58.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7504
    Cell Significance Index: 19.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6468
    Cell Significance Index: 30.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6455
    Cell Significance Index: 79.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6369
    Cell Significance Index: 440.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5396
    Cell Significance Index: 97.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5248
    Cell Significance Index: 14.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4861
    Cell Significance Index: 25.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4411
    Cell Significance Index: 19.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4197
    Cell Significance Index: 23.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4050
    Cell Significance Index: 179.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3828
    Cell Significance Index: 19.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3815
    Cell Significance Index: 44.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3706
    Cell Significance Index: 47.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3473
    Cell Significance Index: 13.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3418
    Cell Significance Index: 186.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3408
    Cell Significance Index: 46.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3136
    Cell Significance Index: 9.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2488
    Cell Significance Index: 158.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2417
    Cell Significance Index: 23.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1939
    Cell Significance Index: 13.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1406
    Cell Significance Index: 264.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0734
    Cell Significance Index: 12.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0511
    Cell Significance Index: 23.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0474
    Cell Significance Index: 3.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0434
    Cell Significance Index: 3.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0271
    Cell Significance Index: 5.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0094
    Cell Significance Index: 17.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0054
    Cell Significance Index: 8.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0033
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0154
    Cell Significance Index: -20.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0203
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0243
    Cell Significance Index: -18.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0255
    Cell Significance Index: -0.6800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0331
    Cell Significance Index: -0.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0386
    Cell Significance Index: -29.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0487
    Cell Significance Index: -30.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0491
    Cell Significance Index: -36.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0592
    Cell Significance Index: -33.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1015
    Cell Significance Index: -7.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1501
    Cell Significance Index: -19.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1555
    Cell Significance Index: -9.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1575
    Cell Significance Index: -45.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1666
    Cell Significance Index: -24.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1712
    Cell Significance Index: -36.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1750
    Cell Significance Index: -17.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1972
    Cell Significance Index: -22.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2074
    Cell Significance Index: -24.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2154
    Cell Significance Index: -7.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2543
    Cell Significance Index: -29.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2556
    Cell Significance Index: -4.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2656
    Cell Significance Index: -12.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2811
    Cell Significance Index: -6.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3003
    Cell Significance Index: -5.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3489
    Cell Significance Index: -4.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3536
    Cell Significance Index: -7.5300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3928
    Cell Significance Index: -5.6500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4359
    Cell Significance Index: -6.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4396
    Cell Significance Index: -45.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4669
    Cell Significance Index: -14.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5810
    Cell Significance Index: -16.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5980
    Cell Significance Index: -47.3600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6533
    Cell Significance Index: -13.9700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6533
    Cell Significance Index: -11.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6756
    Cell Significance Index: -41.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6757
    Cell Significance Index: -18.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7056
    Cell Significance Index: -18.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7645
    Cell Significance Index: -7.0400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7879
    Cell Significance Index: -11.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7962
    Cell Significance Index: -50.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8797
    Cell Significance Index: -18.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9192
    Cell Significance Index: -48.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.9655
    Cell Significance Index: -14.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0267
    Cell Significance Index: -22.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0581
    Cell Significance Index: -33.7000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.0801
    Cell Significance Index: -15.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NFKB1 is a member of the NF-κB family of transcription factors, which are heterotrimeric complexes composed of a p50/p65 subunit (p105/p110) and one of three other subunits (p52, RelB, or c-Rel). The p105/p110 subunit is the precursor to the p50/p65 subunit, which is generated through proteolytic cleavage. NFKB1 is highly expressed in various cell types, including myeloid leukocytes, innate lymphoid cells, and epithelial cells, and is involved in the regulation of immune responses to infections, inflammation, and cellular stress. **Pathways and Functions** NFKB1 is involved in various signaling pathways, including: 1. **Activation of NF-κB in B cells**: NFKB1 is essential for the activation of NF-κB in B cells, which is critical for the regulation of immune responses to infections and inflammation. 2. **Adaptive immune system**: NFKB1 is involved in the regulation of immune responses to infections and inflammation, and plays a critical role in the development and function of immune cells, including T cells and B cells. 3. **C-type lectin receptors (CLRs)**: NFKB1 is involved in the regulation of immune responses to pathogens through the activation of CLR signaling pathways. 4. **Cell recruitment**: NFKB1 is involved in the recruitment of immune cells to sites of inflammation, and plays a critical role in the regulation of immune responses to infections and inflammation. 5. **Cellular responses to stimuli**: NFKB1 is involved in the regulation of cellular responses to stimuli, including stress, DNA damage, and viral infections. **Clinical Significance** NFKB1 is involved in various diseases, including: 1. **Autoimmune disorders**: NFKB1 is involved in the regulation of immune responses to self-antigens, and dysregulation of NF-κB signaling pathways has been implicated in the development of autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Inflammatory diseases**: NFKB1 is involved in the regulation of immune responses to inflammation, and dysregulation of NF-κB signaling pathways has been implicated in the development of inflammatory diseases, such as atherosclerosis and inflammatory bowel disease. 3. **Cancer**: NFKB1 is involved in the regulation of cellular responses to stress and damage, and dysregulation of NF-κB signaling pathways has been implicated in the development of various cancers, including lung cancer and breast cancer. 4. **Infectious diseases**: NFKB1 is involved in the regulation of immune responses to infections, and dysregulation of NF-κB signaling pathways has been implicated in the development of infectious diseases, such as tuberculosis and HIV. In conclusion, NFKB1 is a crucial component of the NF-κB signaling pathway, which plays a pivotal role in the regulation of immune responses, inflammation, and cellular survival. Dysregulation of NF-κB signaling pathways has been implicated in the development of various diseases, including autoimmune disorders, inflammatory diseases, cancer, and infectious diseases.

Genular Protein ID: 5695990

Symbol: NFKB1_HUMAN

Name: Nuclear factor NF-kappa-B p105 subunit

UniProtKB Accession Codes:

P19838 A8K5Y5 B3KVE8 Q68D84 Q86V43 Q8N4X7 Q9NZC0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 2 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 16 DrugCentral 1 ELM 1 EMBL 28 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 63 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 26 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2203531

Title: The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product.

PubMed ID: 2203531

DOI: 10.1016/0092-8674(90)90275-j

PubMed ID: 2234062

Title: Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs.

PubMed ID: 2234062

DOI: 10.1038/348076a0

PubMed ID: 1992489

Title: Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha.

PubMed ID: 1992489

DOI: 10.1073/pnas.88.3.966

PubMed ID: 8825636

Title: The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-kappa B and I kappa B-gamma: implications for NF-kappa B-mediated signal transduction.

PubMed ID: 8825636

DOI: 10.1006/geno.1995.1270

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1423592

Title: The precursor of NF-kappa B p50 has I kappa B-like functions.

PubMed ID: 1423592

DOI: 10.1016/0092-8674(92)90353-e

PubMed ID: 1740106

Title: A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.

PubMed ID: 1740106

DOI: 10.1002/j.1460-2075.1992.tb05043.x

PubMed ID: 8087845

Title: The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B.

PubMed ID: 8087845

DOI: 10.1016/s0092-8674(94)90482-0

PubMed ID: 8152812

Title: Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.

PubMed ID: 8152812

PubMed ID: 8626394

Title: Phosphorylation of p105 PEST sequence via a redox-insensitive pathway up-regulates processing of p50 NF-kappaB.

PubMed ID: 8626394

DOI: 10.1074/jbc.271.11.6084

PubMed ID: 8628291

Title: A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit.

PubMed ID: 8628291

DOI: 10.1128/mcb.16.5.2248

PubMed ID: 8710491

Title: Inhibition of NF-kappaB DNA binding by nitric oxide.

PubMed ID: 8710491

DOI: 10.1093/nar/24.12.2236

PubMed ID: 9315679

Title: A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription.

PubMed ID: 9315679

DOI: 10.1128/mcb.17.10.6184

PubMed ID: 9529257

Title: Cotranslational biogenesis of NF-kappaB p50 by the 26S proteasome.

PubMed ID: 9529257

DOI: 10.1016/s0092-8674(00)81409-9

PubMed ID: 10469655

Title: NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes.

PubMed ID: 10469655

DOI: 10.1093/emboj/18.17.4766

PubMed ID: 9950430

Title: TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105.

PubMed ID: 9950430

DOI: 10.1038/16946

PubMed ID: 10835356

Title: SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase.

PubMed ID: 10835356

DOI: 10.1093/emboj/19.11.2580

PubMed ID: 10970863

Title: Cotranslational dimerization of the Rel homology domain of NF-kappaB1 generates p50-p105 heterodimers and is required for effective p50 production.

PubMed ID: 10970863

DOI: 10.1093/emboj/19.17.4712

PubMed ID: 11094166

Title: RAC-3 is a NF-kappa B coactivator.

PubMed ID: 11094166

DOI: 10.1016/s0014-5793(00)02223-7

PubMed ID: 11327828

Title: Inhibition of NF-kappaB by S-nitrosylation.

PubMed ID: 11327828

DOI: 10.1021/bi002239y

PubMed ID: 11468175

Title: Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappa B.

PubMed ID: 11468175

DOI: 10.1182/blood.v98.3.743

PubMed ID: 11466314

Title: 15-Deoxy-Delta 12,14-prostaglandin J2 inhibition of NF-kappaB-DNA binding through covalent modification of the p50 subunit.

PubMed ID: 11466314

DOI: 10.1074/jbc.m104518200

PubMed ID: 11297557

Title: Direct phosphorylation of NF-kappa B1 p105 by the Ikappa B kinase complex on serine 927 is essential for signal-induced p105 proteolysis.

PubMed ID: 11297557

DOI: 10.1074/jbc.m101754200

PubMed ID: 11158290

Title: Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.

PubMed ID: 11158290

DOI: 10.1128/mcb.21.4.1024-1035.2001

PubMed ID: 11526476

Title: The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.

PubMed ID: 11526476

DOI: 10.1038/sj.onc.1204529

PubMed ID: 13679070

Title: Casper/c-FLIP is physically and functionally associated with NF-kappaB1 p105.

PubMed ID: 13679070

DOI: 10.1016/j.bbrc.2003.08.104

PubMed ID: 11739381

Title: Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins.

PubMed ID: 11739381

DOI: 10.1074/jbc.m107848200

PubMed ID: 12393603

Title: Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10.

PubMed ID: 12393603

DOI: 10.1182/blood-2002-02-0538

PubMed ID: 12471036

Title: Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation.

PubMed ID: 12471036

DOI: 10.1074/jbc.m209286200

PubMed ID: 12871932

Title: Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability.

PubMed ID: 12871932

DOI: 10.1074/jbc.m305676200

PubMed ID: 12482991

Title: betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.

PubMed ID: 12482991

DOI: 10.1128/mcb.23.1.402-413.2003

PubMed ID: 14769797

Title: Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB.

PubMed ID: 14769797

DOI: 10.1074/jbc.m310737200

PubMed ID: 14673179

Title: Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing.

PubMed ID: 14673179

DOI: 10.1128/mcb.24.1.475-486.2004

PubMed ID: 15169888

Title: ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.

PubMed ID: 15169888

DOI: 10.1128/mcb.24.12.5235-5248.2004

PubMed ID: 15102766

Title: Leishmania major amastigotes induce p50/c-Rel NF-kappa B transcription factor in human macrophages: involvement in cytokine synthesis.

PubMed ID: 15102766

DOI: 10.1128/iai.72.5.2582-2589.2004

PubMed ID: 15485931

Title: Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.

PubMed ID: 15485931

DOI: 10.1128/mcb.24.21.9658-9667.2004

PubMed ID: 14743216

Title: A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.

PubMed ID: 14743216

DOI: 10.1038/ncb1086

PubMed ID: 17003112

Title: Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).

PubMed ID: 17003112

DOI: 10.1073/pnas.0606877103

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26279205

Title: Haploinsufficiency of the NF-kappaB1 Subunit p50 in Common Variable Immunodeficiency.

PubMed ID: 26279205

DOI: 10.1016/j.ajhg.2015.07.008

PubMed ID: 25860612

Title: KPC1-mediated ubiquitination and proteasomal processing of NF-kappaB1 p105 to p50 restricts tumor growth.

PubMed ID: 25860612

DOI: 10.1016/j.cell.2015.03.001

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 7830764

Title: Structure of the NF-kappa B p50 homodimer bound to DNA.

PubMed ID: 7830764

DOI: 10.1038/373311a0

PubMed ID: 9865693

Title: Structure of an IkappaBalpha/NF-kappaB complex.

PubMed ID: 9865693

DOI: 10.1016/s0092-8674(00)81698-0

Sequence Information:

  • Length: 968
  • Mass: 105356
  • Checksum: 2A7C8FF86A10D1A8
  • Sequence:
    • MAEDDPYLGR PEQMFHLDPS LTHTIFNPEV FQPQMALPTD GPYLQILEQP KQRGFRFRYV 
CEGPSHGGLP GASSEKNKKS YPQVKICNYV GPAKVIVQLV TNGKNIHLHA HSLVGKHCED 
GICTVTAGPK DMVVGFANLG ILHVTKKKVF ETLEARMTEA CIRGYNPGLL VHPDLAYLQA 
EGGGDRQLGD REKELIRQAA LQQTKEMDLS VVRLMFTAFL PDSTGSFTRR LEPVVSDAIY 
DSKAPNASNL KIVRMDRTAG CVTGGEEIYL LCDKVQKDDI QIRFYEEEEN GGVWEGFGDF 
SPTDVHRQFA IVFKTPKYKD INITKPASVF VQLRRKSDLE TSEPKPFLYY PEIKDKEEVQ 
RKRQKLMPNF SDSFGGGSGA GAGGGGMFGS GGGGGGTGST GPGYSFPHYG FPTYGGITFH 
PGTTKSNAGM KHGTMDTESK KDPEGCDKSD DKNTVNLFGK VIETTEQDQE PSEATVGNGE 
VTLTYATGTK EESAGVQDNL FLEKAMQLAK RHANALFDYA VTGDVKMLLA VQRHLTAVQD 
ENGDSVLHLA IIHLHSQLVR DLLEVTSGLI SDDIINMRND LYQTPLHLAV ITKQEDVVED 
LLRAGADLSL LDRLGNSVLH LAAKEGHDKV LSILLKHKKA ALLLDHPNGD GLNAIHLAMM 
SNSLPCLLLL VAAGADVNAQ EQKSGRTALH LAVEHDNISL AGCLLLEGDA HVDSTTYDGT 
TPLHIAAGRG STRLAALLKA AGADPLVENF EPLYDLDDSW ENAGEDEGVV PGTTPLDMAT 
SWQVFDILNG KPYEPEFTSD DLLAQGDMKQ LAEDVKLQLY KLLEIPDPDK NWATLAQKLG 
LGILNNAFRL SPAPSKTLMD NYEVSGGTVR ELVEALRQMG YTEAIEVIQA ASSPVKTTSQ 
AHSLPLSPAS TRQQIDELRD SDSVCDSGVE TSFRKLSFTE SLTSGASLLT LNKMPHDYGQ 
EGPLEGKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.