Details for: NFKBIB

Gene ID: 4793

Symbol: NFKBIB

Ensembl ID: ENSG00000104825

Description: NFKB inhibitor beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 115.7220
    Cell Significance Index: -18.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.2668
    Cell Significance Index: -18.3300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 51.9241
    Cell Significance Index: -21.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.9504
    Cell Significance Index: -20.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 40.6310
    Cell Significance Index: -20.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.8968
    Cell Significance Index: -19.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.9321
    Cell Significance Index: -18.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1038
    Cell Significance Index: -20.1400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2891
    Cell Significance Index: -5.0100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.3398
    Cell Significance Index: 21.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1833
    Cell Significance Index: 33.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1727
    Cell Significance Index: 16.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0899
    Cell Significance Index: 107.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0897
    Cell Significance Index: 29.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8805
    Cell Significance Index: 52.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7948
    Cell Significance Index: 41.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7550
    Cell Significance Index: 82.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6608
    Cell Significance Index: 14.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5051
    Cell Significance Index: 82.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4633
    Cell Significance Index: 21.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4237
    Cell Significance Index: 11.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4191
    Cell Significance Index: 19.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3949
    Cell Significance Index: 27.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3660
    Cell Significance Index: 10.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3493
    Cell Significance Index: 22.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3412
    Cell Significance Index: 9.8300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3260
    Cell Significance Index: 5.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3219
    Cell Significance Index: 23.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2895
    Cell Significance Index: 34.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2797
    Cell Significance Index: 50.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2604
    Cell Significance Index: 32.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2595
    Cell Significance Index: 29.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2511
    Cell Significance Index: 34.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2474
    Cell Significance Index: 31.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2462
    Cell Significance Index: 11.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2398
    Cell Significance Index: 45.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2231
    Cell Significance Index: 98.6200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2216
    Cell Significance Index: 1.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1964
    Cell Significance Index: 4.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1891
    Cell Significance Index: 170.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1830
    Cell Significance Index: 99.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1783
    Cell Significance Index: 4.7600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1765
    Cell Significance Index: 20.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1531
    Cell Significance Index: 2.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1470
    Cell Significance Index: 29.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1241
    Cell Significance Index: 3.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0846
    Cell Significance Index: 10.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0705
    Cell Significance Index: 3.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0671
    Cell Significance Index: 13.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0649
    Cell Significance Index: 4.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0634
    Cell Significance Index: 0.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0584
    Cell Significance Index: 9.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0441
    Cell Significance Index: 15.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0414
    Cell Significance Index: 2.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0198
    Cell Significance Index: 0.5200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0184
    Cell Significance Index: 0.2800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0184
    Cell Significance Index: 0.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0065
    Cell Significance Index: 0.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0020
    Cell Significance Index: 0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0009
    Cell Significance Index: 0.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0045
    Cell Significance Index: -2.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0056
    Cell Significance Index: -10.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0074
    Cell Significance Index: -4.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0079
    Cell Significance Index: -0.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0084
    Cell Significance Index: -12.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0113
    Cell Significance Index: -7.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0133
    Cell Significance Index: -18.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0155
    Cell Significance Index: -11.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0203
    Cell Significance Index: -2.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0304
    Cell Significance Index: -13.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0462
    Cell Significance Index: -9.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0493
    Cell Significance Index: -7.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0541
    Cell Significance Index: -15.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0550
    Cell Significance Index: -6.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0741
    Cell Significance Index: -1.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0912
    Cell Significance Index: -7.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1015
    Cell Significance Index: -4.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1016
    Cell Significance Index: -1.7000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1308
    Cell Significance Index: -0.7900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1379
    Cell Significance Index: -1.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1682
    Cell Significance Index: -2.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1856
    Cell Significance Index: -19.3300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1874
    Cell Significance Index: -1.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2184
    Cell Significance Index: -12.2600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2284
    Cell Significance Index: -1.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2324
    Cell Significance Index: -18.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2657
    Cell Significance Index: -16.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2822
    Cell Significance Index: -6.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2940
    Cell Significance Index: -7.5100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3101
    Cell Significance Index: -4.4200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3389
    Cell Significance Index: -4.7500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3403
    Cell Significance Index: -3.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3479
    Cell Significance Index: -12.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3595
    Cell Significance Index: -15.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3754
    Cell Significance Index: -9.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4005
    Cell Significance Index: -14.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4057
    Cell Significance Index: -13.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4127
    Cell Significance Index: -15.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NFKBIB is a 65-kDa protein that belongs to the inhibitor of κB (IκB) family. It is a critical regulator of the NF-κB signaling pathway, which is a transcription factor that controls the expression of genes involved in inflammation, immune response, and cell survival. NFKBIB is specifically designed to inhibit the NF-κB signaling cascade by binding to the NF-κB subunit p65 and preventing its interaction with DNA, thereby terminating the signaling process. **Pathways and Functions:** NFKBIB is involved in various signaling pathways, including: 1. **Activation of NF-κB in B cells:** NFKBIB inhibits the NF-κB signaling cascade in B cells, thereby regulating the expression of genes involved in immune response and inflammation. 2. **Adaptive immune system:** NFKBIB plays a crucial role in regulating the adaptive immune response by modulating the expression of genes involved in T cell activation and proliferation. 3. **Cellular response to lipopolysaccharide (LPS):** NFKBIB inhibits the NF-κB signaling cascade in response to LPS, thereby regulating the expression of genes involved in inflammation and immune response. 4. **Cytokine signaling in the immune system:** NFKBIB regulates the expression of genes involved in cytokine signaling, including the production of pro-inflammatory cytokines. 5. **Ddx58/ifih1-mediated induction of interferon-alpha/beta:** NFKBIB inhibits the NF-κB signaling cascade in response to Ddx58/ifih1-mediated induction of interferon-alpha/beta. **Clinical Significance:** NFKBIB has been implicated in various diseases, including: 1. **Inflammatory disorders:** NFKBIB has been shown to play a crucial role in regulating the expression of genes involved in inflammatory disorders, such as rheumatoid arthritis and inflammatory bowel disease. 2. **Cancer:** NFKBIB has been implicated in the development and progression of various cancers, including lung cancer and colon cancer. 3. **Neurodegenerative diseases:** NFKBIB has been shown to play a role in regulating the expression of genes involved in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Autoimmune diseases:** NFKBIB has been implicated in the development of autoimmune diseases, including multiple sclerosis and type 1 diabetes. In conclusion, NFKBIB is a critical regulator of the NF-κB signaling pathway, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of NFKBIB in immune cells and its potential as a therapeutic target for the treatment of inflammatory and autoimmune disorders.

Genular Protein ID: 4053860773

Symbol: IKBB_HUMAN

Name: NF-kappa-B inhibitor beta

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7776974

Title: Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

PubMed ID: 7776974

DOI: 10.1210/mend.9.2.7776974

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8816457

Title: Role of unphosphorylated, newly synthesized IkappaB beta in persistent activation of NF-kappaB.

PubMed ID: 8816457

DOI: 10.1128/mcb.16.10.5444

PubMed ID: 10657303

Title: A subclass of Ras proteins that regulate the degradation of IkappaB.

PubMed ID: 10657303

DOI: 10.1126/science.287.5454.869

PubMed ID: 8657102

Title: Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.

PubMed ID: 8657102

DOI: 10.1128/mcb.16.4.1295

PubMed ID: 8887627

Title: Basal phosphorylation of the PEST domain in the I(kappa)B(beta) regulates its functional interaction with the c-rel proto-oncogene product.

PubMed ID: 8887627

DOI: 10.1128/mcb.16.11.5974

PubMed ID: 12672800

Title: KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta.NF-kappaB complexes.

PubMed ID: 12672800

DOI: 10.1074/jbc.m301021200

PubMed ID: 15024091

Title: Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras.

PubMed ID: 15024091

DOI: 10.1128/mcb.24.7.3048-3056.2004

PubMed ID: 16573520

Title: Characterization of COMMD protein-protein interactions in NF-kappaB signalling.

PubMed ID: 16573520

DOI: 10.1042/bj20051664

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 356
  • Mass: 37771
  • Checksum: E84575971B6F81CC
  • Sequence:
  • MAGVACLGKA ADADEWCDSG LGSLGPDAAA PGGPGLGAEL GPGLSWAPLV FGYVTEDGDT 
    ALHLAVIHQH EPFLDFLLGF SAGTEYMDLQ NDLGQTALHL AAILGETSTV EKLYAAGAGL 
    CVAERRGHTA LHLACRVGAH ACARALLQPR PRRPREAPDT YLAQGPDRTP DTNHTPVALY 
    PDSDLEKEEE ESEEDWKLQL EAENYEGHTP LHVAVIHKDV EMVRLLRDAG ADLDKPEPTC 
    GRSPLHLAVE AQAADVLELL LRAGANPAAR MYGGRTPLGS AMLRPNPILA RLLRAHGAPE 
    PEGEDEKSGP CSSSSDSDSG DEGDEYDDIV VHSSRSQTRL PPTPASKPLP DDPRPV

Genular Protein ID: 2939654193

Symbol: G5E9C2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 270
  • Mass: 29145
  • Checksum: AB74380323EA4CC8
  • Sequence:
  • MDLQNDLGQT ALHLAAILGE TSTVEKLYAA GAGLCVAERR GHTALHLACR VGAHACARAL 
    LQPRPRRPRE APDTYLAQGP DRTPDTNHTP VALYPDSDLE KEEEESEEDW KLQLEAENYE 
    GHTPLHVAVI HKDVEMVRLL RDAGADLDKP EPTCGRSPLH LAVEAQAADV LELLLRAGAN 
    PAARMYGGRT PLGSAMLRPN PILARLLRAH GAPEPEGEDE KSGPCSSSSD SDSGDEGDEY 
    DDIVVHSSRS QTRLPPTPAS KPLPDDPRPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.