Details for: NFRKB
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 109.9359
Cell Significance Index: -17.1000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 61.0700
Cell Significance Index: -15.4900 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 42.9181
Cell Significance Index: -17.6800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 39.7039
Cell Significance Index: -16.1300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 16.9993
Cell Significance Index: -16.2300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 14.5098
Cell Significance Index: -17.8900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.5625
Cell Significance Index: -17.5800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.6071
Cell Significance Index: -18.1800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.0193
Cell Significance Index: 27.5500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.5822
Cell Significance Index: 301.1100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.3225
Cell Significance Index: 154.1200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9714
Cell Significance Index: 96.0900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9431
Cell Significance Index: 153.3900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7434
Cell Significance Index: 147.5400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6552
Cell Significance Index: 18.3100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6007
Cell Significance Index: 16.3500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4865
Cell Significance Index: 59.8200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.4608
Cell Significance Index: 17.4500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4450
Cell Significance Index: 80.2200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4425
Cell Significance Index: 88.7700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.4167
Cell Significance Index: 11.1700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4038
Cell Significance Index: 17.8600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4033
Cell Significance Index: 10.7700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3942
Cell Significance Index: 17.8700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3627
Cell Significance Index: 10.4500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3542
Cell Significance Index: 18.4000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3327
Cell Significance Index: 18.6700 - Cell Name: decidual cell (CL2000002)
Fold Change: 0.3163
Cell Significance Index: 5.0800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3102
Cell Significance Index: 6.7200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2861
Cell Significance Index: 19.7900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2797
Cell Significance Index: 9.7200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2265
Cell Significance Index: 31.1100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2081
Cell Significance Index: 113.6700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2025
Cell Significance Index: 140.0500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.1934
Cell Significance Index: 4.1400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1805
Cell Significance Index: 64.7500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1758
Cell Significance Index: 77.7400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1126
Cell Significance Index: 5.2500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1011
Cell Significance Index: 7.1500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0839
Cell Significance Index: 10.7500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0669
Cell Significance Index: 5.1300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0576
Cell Significance Index: 3.0000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0574
Cell Significance Index: 3.5300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0513
Cell Significance Index: 2.4100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0455
Cell Significance Index: 2.9400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0361
Cell Significance Index: 1.2700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0306
Cell Significance Index: 2.2800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0281
Cell Significance Index: 25.3500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0197
Cell Significance Index: 37.0100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0193
Cell Significance Index: 29.6400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0184
Cell Significance Index: 33.8800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0115
Cell Significance Index: 1.9700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0094
Cell Significance Index: 5.9500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0026
Cell Significance Index: 3.5300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0027
Cell Significance Index: -0.3400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0067
Cell Significance Index: -0.4200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0108
Cell Significance Index: -1.2700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0113
Cell Significance Index: -5.1300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0121
Cell Significance Index: -0.3100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0131
Cell Significance Index: -9.6300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0156
Cell Significance Index: -11.8200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0205
Cell Significance Index: -15.1700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0217
Cell Significance Index: -3.1500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0232
Cell Significance Index: -0.5000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0233
Cell Significance Index: -0.2200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0318
Cell Significance Index: -17.9500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0342
Cell Significance Index: -21.3400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0463
Cell Significance Index: -4.7300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0501
Cell Significance Index: -14.4100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0638
Cell Significance Index: -1.2500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0802
Cell Significance Index: -1.7600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0805
Cell Significance Index: -5.4100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0884
Cell Significance Index: -10.1300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0938
Cell Significance Index: -1.5700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0975
Cell Significance Index: -20.5400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1090
Cell Significance Index: -2.8700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1108
Cell Significance Index: -2.7700 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1458
Cell Significance Index: -2.0900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1500
Cell Significance Index: -15.6200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1526
Cell Significance Index: -8.0100 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1532
Cell Significance Index: -2.1500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1538
Cell Significance Index: -3.2200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1636
Cell Significance Index: -5.2400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1689
Cell Significance Index: -4.9600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1990
Cell Significance Index: -3.4100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2010
Cell Significance Index: -15.9200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2181
Cell Significance Index: -13.3700 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.2386
Cell Significance Index: -2.9600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2451
Cell Significance Index: -6.2600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2535
Cell Significance Index: -6.7800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2856
Cell Significance Index: -6.8500 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2930
Cell Significance Index: -1.7700 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2954
Cell Significance Index: -8.4300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2986
Cell Significance Index: -3.5600 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3051
Cell Significance Index: -7.0500 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3101
Cell Significance Index: -3.2100 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.3330
Cell Significance Index: -4.7400 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3397
Cell Significance Index: -2.7700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3473
Cell Significance Index: -11.0600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3580
Cell Significance Index: -11.7200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1075524967
Symbol: NFRKB_HUMAN
Name: Nuclear factor related to kappa-B-binding protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1777480
Title: Cloning of R kappa B, a novel DNA-binding protein that recognizes the interleukin-2 receptor alpha chain kappa B site.
PubMed ID: 1777480
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16230350
Title: A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex.
PubMed ID: 16230350
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18922472
Title: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex.
PubMed ID: 18922472
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21303910
Title: Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.
PubMed ID: 21303910
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 22984442
Title: Structure of a novel winged-helix like domain from human NFRKB protein.
PubMed ID: 22984442
Sequence Information:
- Length: 1299
- Mass: 139001
- Checksum: 087B212E283C3820
- Sequence:
MDSLDHMLTD PLELGPCGDG HGTRIMEDCL LGGTRVSLPE DLLEDPEIFF DVVSLSTWQE VLSDSQREHL QQFLPQFPED SAEQQNELIL ALFSGENFRF GNPLHIAQKL FRDGHFNPEV VKYRQLCFKS QYKRYLNSQQ QYFHRLLKQI LASRSDLLEM ARRSGPALPF RQKRPSPSRT PEEREWRTQQ RYLKVLREVK EECGDTALSS DEEDLSSWLP SSPARSPSPA VPLRVVPTLS TTDMKTADKV ELGDSDLKIM LKKHHEKRKH QPDHPDLLTG DLTLNDIMTR VNAGRKGSLA ALYDLAVLKK KVKEKEEKKK KKIKTIKSEA EDLAEPLSST EGVAPLSQAP SPLAIPAIKE EPLEDLKPCL GINEISSSFF SLLLEILLLE SQASLPMLEE RVLDWQSSPA SSLNSWFSAA PNWAELVLPA LQYLAGESRA VPSSFSPFVE FKEKTQQWKL LGQSQDNEKE LAALFQLWLE TKDQAFCKQE NEDSSDATTP VPRVRTDYVV RPSTGEEKRV FQEQERYRYS QPHKAFTFRM HGFESVVGPV KGVFDKETSL NKAREHSLLR SDRPAYVTIL SLVRDAAARL PNGEGTRAEI CELLKDSQFL APDVTSTQVN TVVSGALDRL HYEKDPCVKY DIGRKLWIYL HRDRSEEEFE RIHQAQAAAA KARKALQQKP KPPSKVKSSS KESSIKVLSS GPSEQSQMSL SDSSMPPTPV TPVTPTTPAL PAIPISPPPV SAVNKSGPST VSEPAKSSSG VLLVSSPTMP HLGTMLSPAS SQTAPSSQAA ARVVSHSGSA GLSQVRVVAQ PSLPAVPQQS GGPAQTLPQM PAGPQIRVPA TATQTKVVPQ TVMATVPVKA QTTAATVQRP GPGQTGLTVT SLPATASPVS KPATSSPGTS APSASTAAVI QNVTGQNIIK QVAITGQLGV KPQTGNSIPL TATNFRIQGK DVLRLPPSSI TTDAKGQTVL RITPDMMATL AKSQVTTVKL TQDLFGTGGN TTGKGISATL HVTSNPVHAA DSPAKASSAS APSSTPTGTT VVKVTPDLKP TEASSSAFRL MPALGVSVAD QKGKSTVASS EAKPAATIRI VQGLGVMPPK AGQTITVATH AKQGASVASG SGTVHTSAVS LPSMNAAVSK TVAVASGAAS TPISISTGAP TVRQVPVSTT VVSTSQAGKL PTRITVPLSV ISQPMKGKSV VTAPIIKGNL GANLSGLGRN IILTTMPAGT KLIAGNKPVS FLTAQQLQQL QQQGQATQVR IQTVPASHLQ QGTASGSSKA VSTVVVTTAP SPKQAPEQQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.