Details for: NKX6 1

Gene ID: 4825

Symbol: NKX6 1

Ensembl ID: ENSG00000163623

Description: NK6 homeobox 1

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Regulation of beta-cell development
    (R-HSA-186712)
  • Regulation of gene expression in beta cells
    (R-HSA-210745)
  • Regulation of gene expression in early pancreatic precursor cells
    (R-HSA-210747)
  • Animal organ morphogenesis
    (GO:0009887)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to cytokine stimulus
    (GO:0071345)
  • Cellular response to peptide hormone stimulus
    (GO:0071375)
  • Central nervous system neuron differentiation
    (GO:0021953)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Extracellular exosome
    (GO:0070062)
  • Glucose mediated signaling pathway
    (GO:0010255)
  • Negative regulation of oligodendrocyte differentiation
    (GO:0048715)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Pancreas development
    (GO:0031016)
  • Pancreatic a cell differentiation
    (GO:0003310)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of oligodendrocyte differentiation
    (GO:0048714)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of type b pancreatic cell development
    (GO:2000078)
  • Regulation of axon extension
    (GO:0030516)
  • Regulation of neuron migration
    (GO:2001222)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to nicotine
    (GO:0035094)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Smoothened signaling pathway
    (GO:0007224)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Type b pancreatic cell maturation
    (GO:0072560)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.5119
    Cell Significance Index: -5.7100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 9.6537
    Cell Significance Index: 116.6800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.8547
    Cell Significance Index: 8.2400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.5261
    Cell Significance Index: 5.5900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.2416
    Cell Significance Index: 2.3900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2175
    Cell Significance Index: 3.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2060
    Cell Significance Index: 2.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1669
    Cell Significance Index: 19.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1646
    Cell Significance Index: 18.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1092
    Cell Significance Index: 1.4900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0966
    Cell Significance Index: 1.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0070
    Cell Significance Index: 5.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0012
    Cell Significance Index: 0.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0008
    Cell Significance Index: 0.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0003
    Cell Significance Index: -0.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0036
    Cell Significance Index: -0.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0062
    Cell Significance Index: -1.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0077
    Cell Significance Index: -5.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0088
    Cell Significance Index: -4.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0093
    Cell Significance Index: -5.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0100
    Cell Significance Index: -1.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0103
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0119
    Cell Significance Index: -2.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0121
    Cell Significance Index: -5.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0150
    Cell Significance Index: -2.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0290
    Cell Significance Index: -5.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0435
    Cell Significance Index: -2.0300
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0507
    Cell Significance Index: -0.6900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0525
    Cell Significance Index: -0.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0590
    Cell Significance Index: -7.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0702
    Cell Significance Index: -1.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0726
    Cell Significance Index: -1.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0732
    Cell Significance Index: -4.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0763
    Cell Significance Index: -5.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0796
    Cell Significance Index: -4.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0913
    Cell Significance Index: -4.1400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.0968
    Cell Significance Index: -0.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1046
    Cell Significance Index: -2.9200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1109
    Cell Significance Index: -4.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1158
    Cell Significance Index: -1.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1163
    Cell Significance Index: -5.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1236
    Cell Significance Index: -6.4900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1279
    Cell Significance Index: -1.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1289
    Cell Significance Index: -4.4800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1299
    Cell Significance Index: -2.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1332
    Cell Significance Index: -2.6000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1409
    Cell Significance Index: -1.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1414
    Cell Significance Index: -4.5300
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1441
    Cell Significance Index: -1.4100
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1457
    Cell Significance Index: -1.6700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1489
    Cell Significance Index: -2.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1502
    Cell Significance Index: -4.4300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1537
    Cell Significance Index: -1.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1640
    Cell Significance Index: -5.7500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1683
    Cell Significance Index: -2.2700
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1683
    Cell Significance Index: -1.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1687
    Cell Significance Index: -6.3900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1720
    Cell Significance Index: -2.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1742
    Cell Significance Index: -4.6600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1744
    Cell Significance Index: -2.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1747
    Cell Significance Index: -5.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1754
    Cell Significance Index: -4.7000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1770
    Cell Significance Index: -4.5100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1800
    Cell Significance Index: -2.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1815
    Cell Significance Index: -5.1800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1825
    Cell Significance Index: -3.1200
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1863
    Cell Significance Index: -1.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1880
    Cell Significance Index: -6.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1882
    Cell Significance Index: -3.1500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1882
    Cell Significance Index: -2.2700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1888
    Cell Significance Index: -2.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1943
    Cell Significance Index: -5.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1981
    Cell Significance Index: -5.0600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1983
    Cell Significance Index: -2.0900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2008
    Cell Significance Index: -2.9200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2042
    Cell Significance Index: -2.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2048
    Cell Significance Index: -5.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2128
    Cell Significance Index: -4.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2129
    Cell Significance Index: -5.1100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2161
    Cell Significance Index: -3.6700
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.2163
    Cell Significance Index: -2.4200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.2171
    Cell Significance Index: -2.3200
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.2200
    Cell Significance Index: -2.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2202
    Cell Significance Index: -5.5000
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.2204
    Cell Significance Index: -2.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2262
    Cell Significance Index: -5.4800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2274
    Cell Significance Index: -2.6800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2321
    Cell Significance Index: -3.2600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2359
    Cell Significance Index: -3.0300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2368
    Cell Significance Index: -2.8800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2392
    Cell Significance Index: -3.2800
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2402
    Cell Significance Index: -1.4100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2416
    Cell Significance Index: -1.4800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.2440
    Cell Significance Index: -3.0900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2461
    Cell Significance Index: -5.2600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2470
    Cell Significance Index: -2.0000
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.2509
    Cell Significance Index: -1.3600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2598
    Cell Significance Index: -3.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2610
    Cell Significance Index: -6.9700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2674
    Cell Significance Index: -4.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NKX6.1 is a homeobox gene that encodes a transcription factor protein, which regulates gene expression by binding to specific DNA sequences. It is characterized by its unique structure, which includes a homeodomain and a non-homeodomain region. The homeodomain is responsible for DNA binding, while the non-homeodomain region is involved in dimerization and transcriptional regulation. NKX6.1 is highly conserved across species, suggesting its essential role in evolution. **Pathways and Functions** NKX6.1 is involved in multiple signaling pathways, including: 1. **Cell differentiation**: NKX6.1 regulates the differentiation of neurons, oligodendrocytes, and pancreatic cells by binding to specific transcription factors and co-factors. 2. **Central nervous system (CNS) development**: NKX6.1 is essential for the development and patterning of the CNS, including the formation of neurons, glial cells, and the blood-brain barrier. 3. **Pancreatic development**: NKX6.1 regulates the development and function of pancreatic cells, including insulin-producing beta cells and pancreatic exocrine cells. 4. **Glucose metabolism**: NKX6.1 is involved in glucose-mediated signaling pathways, which regulate glucose uptake and insulin secretion in pancreatic beta cells. 5. **Neuron migration and axon extension**: NKX6.1 regulates the migration and extension of axons, which is essential for neural circuit formation and function. **Clinical Significance** Dysregulation of NKX6.1 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: NKX6.1 has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Diabetes**: NKX6.1 regulates pancreatic beta-cell function and glucose metabolism, making it a potential target for diabetes treatment. 3. **Cardiovascular diseases**: NKX6.1 has been implicated in the development of cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. 4. **Cancer**: NKX6.1 has been shown to regulate the development and progression of certain cancers, including pancreatic cancer and glioblastoma. In summary, NKX6.1 is a critical transcription factor that regulates various cellular processes, including cell differentiation, development, and function. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention. Further research is needed to fully understand the role of NKX6.1 in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 3627409208

Symbol: NKX61_HUMAN

Name: Homeobox protein Nkx-6.1

UniProtKB Accession Codes:

P78426

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9119408

Title: Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene.

PubMed ID: 9119408

DOI: 10.1006/geno.1996.4568

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 367
  • Mass: 37849
  • Checksum: 5C78F06C3CAE6486
  • Sequence:
    • MLAVGAMEGT RQSAFLLSSP PLAALHSMAE MKTPLYPAAY PPLPAGPPSS SSSSSSSSSP 
SPPLGTHNPG GLKPPATGGL SSLGSPPQQL SAATPHGIND ILSRPSMPVA SGAALPSASP 
SGSSSSSSSS ASASSASAAA AAAAAAAAAA SSPAGLLAGL PRFSSLSPPP PPPGLYFSPS 
AAAVAAVGRY PKPLAELPGR TPIFWPGVMQ SPPWRDARLA CTPHQGSILL DKDGKRKHTR 
PTFSGQQIFA LEKTFEQTKY LAGPERARLA YSLGMTESQV KVWFQNRRTK WRKKHAAEMA 
TAKKKQDSET ERLKGASENE EEDDDYNKPL DPNSDDEKIT QLLKKHKSSS GGGGGLLLHA 
SEPESSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.