Details for: NPAT

Gene ID: 4863

Symbol: NPAT

Ensembl ID: ENSG00000149308

Description: nuclear protein, coactivator of histone transcription

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 152.5923
    Cell Significance Index: -23.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.4346
    Cell Significance Index: -24.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 53.5454
    Cell Significance Index: -25.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.0945
    Cell Significance Index: -21.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 37.6888
    Cell Significance Index: -25.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.8020
    Cell Significance Index: -21.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.8037
    Cell Significance Index: -25.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9329
    Cell Significance Index: -23.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6015
    Cell Significance Index: -26.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5424
    Cell Significance Index: -12.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7305
    Cell Significance Index: 171.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.6497
    Cell Significance Index: 114.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2234
    Cell Significance Index: 1104.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1428
    Cell Significance Index: 229.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9648
    Cell Significance Index: 104.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9477
    Cell Significance Index: 12.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8807
    Cell Significance Index: 143.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7651
    Cell Significance Index: 274.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7070
    Cell Significance Index: 140.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5893
    Cell Significance Index: 33.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5713
    Cell Significance Index: 25.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5018
    Cell Significance Index: 19.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4614
    Cell Significance Index: 28.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4397
    Cell Significance Index: 11.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4207
    Cell Significance Index: 51.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3433
    Cell Significance Index: 61.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2737
    Cell Significance Index: 5.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2624
    Cell Significance Index: 20.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2617
    Cell Significance Index: 13.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2489
    Cell Significance Index: 29.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2423
    Cell Significance Index: 5.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2241
    Cell Significance Index: 6.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2081
    Cell Significance Index: 28.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1826
    Cell Significance Index: 5.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1750
    Cell Significance Index: 77.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1621
    Cell Significance Index: 30.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1533
    Cell Significance Index: 10.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1425
    Cell Significance Index: 3.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1404
    Cell Significance Index: 3.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1303
    Cell Significance Index: 16.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1255
    Cell Significance Index: 68.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1206
    Cell Significance Index: 226.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1131
    Cell Significance Index: 7.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1006
    Cell Significance Index: 4.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0811
    Cell Significance Index: 2.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0654
    Cell Significance Index: 1.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0448
    Cell Significance Index: 2.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0445
    Cell Significance Index: 28.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0445
    Cell Significance Index: 68.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0423
    Cell Significance Index: 19.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0390
    Cell Significance Index: 72.0100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0239
    Cell Significance Index: 0.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0093
    Cell Significance Index: 12.6000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0064
    Cell Significance Index: -0.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0155
    Cell Significance Index: -11.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0174
    Cell Significance Index: -2.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0253
    Cell Significance Index: -19.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0272
    Cell Significance Index: -20.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0335
    Cell Significance Index: -0.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0420
    Cell Significance Index: -23.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0446
    Cell Significance Index: -27.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0453
    Cell Significance Index: -2.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0460
    Cell Significance Index: -3.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0502
    Cell Significance Index: -0.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0520
    Cell Significance Index: -0.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0627
    Cell Significance Index: -6.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0730
    Cell Significance Index: -2.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0733
    Cell Significance Index: -21.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0749
    Cell Significance Index: -4.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0843
    Cell Significance Index: -14.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0984
    Cell Significance Index: -11.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1048
    Cell Significance Index: -12.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1241
    Cell Significance Index: -16.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1284
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1310
    Cell Significance Index: -27.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1573
    Cell Significance Index: -8.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1681
    Cell Significance Index: -4.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1710
    Cell Significance Index: -17.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1838
    Cell Significance Index: -3.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1848
    Cell Significance Index: -13.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1904
    Cell Significance Index: -3.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2242
    Cell Significance Index: -5.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2293
    Cell Significance Index: -5.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2306
    Cell Significance Index: -6.5800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2503
    Cell Significance Index: -3.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2682
    Cell Significance Index: -21.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2738
    Cell Significance Index: -8.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3605
    Cell Significance Index: -22.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3962
    Cell Significance Index: -12.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4008
    Cell Significance Index: -10.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4081
    Cell Significance Index: -14.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4192
    Cell Significance Index: -13.3500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4206
    Cell Significance Index: -3.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4359
    Cell Significance Index: -7.3000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4415
    Cell Significance Index: -8.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4441
    Cell Significance Index: -14.5400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4647
    Cell Significance Index: -6.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4752
    Cell Significance Index: -9.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5159
    Cell Significance Index: -11.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NPAT is a nuclear protein that belongs to the CRTC (CREB-regulated transcription coactivator) family of coactivators. It is characterized by its ability to interact with histone-modifying enzymes, such as histone acetyltransferases (HATs), to regulate chromatin structure and transcription. NPAT is specifically expressed in neurons, particularly in GABAergic cortical interneurons and glutamatergic neurons, suggesting its involvement in the development and function of neural circuits. **Pathways and Functions:** NPAT is implicated in various cellular pathways, including: 1. **Cell cycle regulation:** NPAT is involved in the G1/S phase transition, regulating the expression of genes involved in cell cycle progression. 2. **Transcriptional regulation:** NPAT acts as a coactivator of histone transcription, enhancing the recruitment of RNA polymerase II to gene promoters and promoting the transcription of target genes. 3. **Cajal body formation:** NPAT is required for the formation of Cajal bodies, small nuclear structures involved in the regulation of RNA metabolism and transcription. 4. **In utero embryonic development:** NPAT plays a role in the development of neural tissues during embryonic development. **Clinical Significance:** Dysregulation of NPAT has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders:** Mutations in NPAT have been associated with neurodevelopmental disorders, such as autism spectrum disorder (ASD) and schizophrenia. 2. **Neurodegenerative diseases:** NPAT has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Neuropsychiatric disorders:** NPAT has been linked to neuropsychiatric disorders, including bipolar disorder and major depressive disorder. In conclusion, NPAT is a crucial transcriptional coactivator that plays a significant role in the regulation of histone transcription in neurons. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of NPAT in maintaining neural circuit function and development. Further research is necessary to fully elucidate the mechanisms by which NPAT regulates transcription and to explore its therapeutic potential in neurological disorders.

Genular Protein ID: 4122077796

Symbol: NPAT_HUMAN

Name: Protein NPAT

UniProtKB Accession Codes:

Q14207 A8K1V5 A8K6M2 Q13632 Q14967 Q16580 Q86W55 Q8IWE9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8743993

Title: Identification and characterization of a new gene physically linked to the ATM gene.

PubMed ID: 8743993

DOI: 10.1101/gr.6.5.439

PubMed ID: 8923007

Title: A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies.

PubMed ID: 8923007

DOI: 10.1093/hmg/5.11.1785

PubMed ID: 9205109

Title: The structure and organization of the human NPAT gene.

PubMed ID: 9205109

DOI: 10.1006/geno.1997.4769

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9060412

Title: CAND3: a ubiquitously expressed gene immediately adjacent and in opposite transcriptional orientation to the ATM gene at 11q23.1.

PubMed ID: 9060412

DOI: 10.1007/s003359900371

PubMed ID: 9472014

Title: Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry.

PubMed ID: 9472014

DOI: 10.1101/gad.12.4.456

PubMed ID: 10995386

Title: NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.

PubMed ID: 10995386

DOI: 10.1101/gad.827700

PubMed ID: 10995387

Title: Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.

PubMed ID: 10995387

DOI: 10.1101/gad.829500

PubMed ID: 12032824

Title: Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line.

PubMed ID: 12032824

DOI: 10.1038/sj.onc.1205485

PubMed ID: 12887926

Title: S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component.

PubMed ID: 12887926

DOI: 10.1016/s0092-8674(03)00552-x

PubMed ID: 12665581

Title: NPAT expression is regulated by E2F and is essential for cell cycle progression.

PubMed ID: 12665581

DOI: 10.1128/mcb.23.8.2821-2833.2003

PubMed ID: 12724424

Title: The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain.

PubMed ID: 12724424

DOI: 10.1128/mcb.23.10.3669-3680.2003

PubMed ID: 14585971

Title: Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase.

PubMed ID: 14585971

DOI: 10.1128/mcb.23.22.8110-8123.2003

PubMed ID: 14612403

Title: The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells.

PubMed ID: 14612403

DOI: 10.1128/mcb.23.23.8586-8600.2003

PubMed ID: 15555599

Title: Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry.

PubMed ID: 15555599

DOI: 10.1016/j.bbrc.2004.10.198

PubMed ID: 14976556

Title: DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway.

PubMed ID: 14976556

DOI: 10.1038/sj.emboj.7600120

PubMed ID: 16131487

Title: Coordinate control and selective expression of the full complement of replication-dependent histone H4 genes in normal and cancer cells.

PubMed ID: 16131487

DOI: 10.1074/jbc.m506995200

PubMed ID: 15988025

Title: HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.

PubMed ID: 15988025

DOI: 10.1128/mcb.25.14.6140-6153.2005

PubMed ID: 17068332

Title: Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression.

PubMed ID: 17068332

DOI: 10.1074/jbc.m608165200

PubMed ID: 16972248

Title: Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase.

PubMed ID: 16972248

DOI: 10.1002/jcp.20776

PubMed ID: 17003125

Title: FLASH is required for histone transcription and S-phase progression.

PubMed ID: 17003125

DOI: 10.1073/pnas.0604227103

PubMed ID: 17974976

Title: The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes.

PubMed ID: 17974976

DOI: 10.1158/0008-5472.can-07-1560

PubMed ID: 17826007

Title: Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition.

PubMed ID: 17826007

DOI: 10.1016/j.gene.2007.07.027

PubMed ID: 17163457

Title: HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription.

PubMed ID: 17163457

DOI: 10.1002/jcb.21157

PubMed ID: 17096384

Title: Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells.

PubMed ID: 17096384

DOI: 10.1002/jcp.20903

PubMed ID: 17520687

Title: Cell cycle dependent phosphorylation and subnuclear organization of the histone gene regulator p220(NPAT) in human embryonic stem cells.

PubMed ID: 17520687

DOI: 10.1002/jcp.21119

PubMed ID: 17967892

Title: Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.

PubMed ID: 17967892

DOI: 10.1128/mcb.00607-07

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 1427
  • Mass: 154290
  • Checksum: D5C5E630A56227F9
  • Sequence:
    • MLLPSDVARL VLGYLQQENL ISTCQTFILE SSDLKEYAEH CTDEGFIPAC LLSLFGKNLT 
TILNEYVAMK TKETSNNVPA IMSSLWKKLD HTLSQIRSMQ SSPRFAGSQR ARTRTGIAEI 
KRQRKLASQT APASAELLTL PYLSGQFTTP PSTGTQVTRP SGQISDPSRS YFVVVNHSQS 
QDTVTTGEAL NVIPGAQEKK AHASLMSPGR RKSESQRKST TLSGPHSTIR NFQDPNAFAV 
EKQMVIENAR EKILSNKSLQ EKLAENINKF LTSDNNIAQV PKQTDNNPTE PETSIDEFLG 
LPSEIHMSEE AIQDILEQTE SDPAFQALFD LFDYGKTKNN KNISQSISSQ PMESNPSIVL 
ADETNLAVKG SFETEESDGQ SGQPAFCTSY QNDDPLNALK NSNNHDVLRQ EDQENFSQIS 
TSIQKKAFKT AVPTEQKCDI DITFESVPNL NDFNQRGNSN AECNPHCAEL YTNQMSTETE 
MAIGIEKNSL SSNVPSESQL QPDQPDIPIT SFVSLGCEAN NENLILSGKS SQLLSQDTSL 
TGKPSKKSQF CENSNDTVKL KINFHGSKSS DSSEVHKSKI EINVLEPVMS QLSNCQDNSC 
LQSEILPVSV ESSHLNVSGQ VEIHLGDSLS STKQPSNDSA SVELNHTENE AQASKSENSQ 
EPSSSVKEEN TIFLSLGGNA NCEKVALTPP EGTPVENSHS LPPESVCSSV GDSHPESQNT 
DDKPSSNNSA EIDASNIVSL KVIISDDPFV SSDTELTSAV SSINGENLPT IILSSPTKSP 
TKNAELVKCL SSEETVGAVV YAEVGDSASM EQSLLTFKSE DSAVNNTQNE DGIAFSANVT 
PCVSKDGGYI QLMPATSTAF GNSNNILIAT CVTDPTALGT SVSQSNVVVL PGNSAPMTAQ 
PLPPQLQTPP RSNSVFAVNQ AVSPNFSQGS AIIIASPVQP VLQGMVGMIP VSVVGQNGNN 
FSTPPRQVLH MPLTAPVCNR SIPQFPVPPK SQKAQGLRNK PCIGKQVNNL VDSSGHSVGC 
HAQKTEVSDK SIATDLGKKS EETTVPFPEE SIVPAAKPCH RRVLCFDSTT APVANTQGPN 
HKMVSQNKER NAVSFPNLDS PNVSSTLKPP SNNAIKREKE KPPLPKILSK SESAISRHTT 
IRETQSEKKV SPTEIVLESF HKATANKENE LCSDVERQKN PENSKLSIGQ QNGGLRSEKS 
IASLQEMTKK QGTSSNNKNV LSVGTAVKDL KQEQTKSASS LITTEMLQDI QRHSSVSRLA 
DSSDLPVPRT PGSGAGEKHK EEPIDIIKAP SSRRFSEDSS TSKVMVPPVT PDLPACSPAS 
ETGSENSVNM AAHTLMILSR AAISRTTSAT PLKDNTQQFR ASSRSTTKKR KIEELDERER 
NSRPSSKNLT NSSIPMKKKK IKKKKLPSSF PAGMDVDKFL LSLHYDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.