NRAS | ENSG00000213281 | NCBI 4893

Details for: NRAS

Gene ID: 4893

Symbol: NRAS

Ensembl ID: ENSG00000213281

Description: NRAS proto-oncogene, GTPase

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cd209 (dc-sign) signaling
(R-HSA-5621575)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Constitutive signaling by overexpressed erbb2
(R-HSA-9634285)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream signal transduction
(R-HSA-186763)
Erythropoietin activates ras
(R-HSA-9027284)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated mapk activation
(R-HSA-2871796)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling in disease
(R-HSA-9682385)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Hemostasis
(R-HSA-109582)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Met activates ras signaling
(R-HSA-8851805)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Neutrophil degranulation
(R-HSA-6798695)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Ptk6 regulates rho gtpases, ras gtpase and map kinases
(R-HSA-8849471)
Raf/map kinase cascade
(R-HSA-5673001)
Ras signaling downstream of nf1 loss-of-function variants
(R-HSA-6802953)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 ecd mutants
(R-HSA-9665348)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr4 in disease
(R-HSA-5655291)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by flt3 fusion proteins
(R-HSA-9703465)
Signaling by flt3 itd and tkd mutants
(R-HSA-9703648)
Signaling by gpcr
(R-HSA-372790)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by met
(R-HSA-6806834)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrk3 (trkc)
(R-HSA-9034015)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by pdgf
(R-HSA-186797)
Signaling by pdgfra extracellular domain mutants
(R-HSA-9673770)
Signaling by pdgfra transmembrane, juxtamembrane and kinase domain mutants
(R-HSA-9673767)
Signaling by pdgfr in disease
(R-HSA-9671555)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain kit mutants
(R-HSA-9670439)
Signaling by ptk6
(R-HSA-8848021)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Tie2 signaling
(R-HSA-210993)
Transmission across chemical synapses
(R-HSA-112315)
Vegfa-vegfr2 pathway
(R-HSA-4420097)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 105.7570
Cell Significance Index: -16.4500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 69.6253
Cell Significance Index: -17.6600
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 53.9874
Cell Significance Index: -22.2400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 43.8638
Cell Significance Index: -17.8200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 39.1438
Cell Significance Index: -20.1400
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 18.9475
Cell Significance Index: -18.0900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 15.4628
Cell Significance Index: -19.0700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.8537
Cell Significance Index: -18.3600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.0633
Cell Significance Index: -19.9800
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.8831
Cell Significance Index: -6.3100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.9956
Cell Significance Index: 232.5600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.0582
Cell Significance Index: 55.1200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9972
Cell Significance Index: 162.1800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.8274
Cell Significance Index: 22.5200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4481
Cell Significance Index: 20.3100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4466
Cell Significance Index: 23.2000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3960
Cell Significance Index: 25.5500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3935
Cell Significance Index: 74.8900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3845
Cell Significance Index: 8.3300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3820
Cell Significance Index: 10.2400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3658
Cell Significance Index: 199.7600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3575
Cell Significance Index: 10.3000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3390
Cell Significance Index: 33.5400
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.3297
Cell Significance Index: 8.6700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.3187
Cell Significance Index: 6.6700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3165
Cell Significance Index: 37.3200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.3134
Cell Significance Index: 35.9000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3086
Cell Significance Index: 136.4300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3032
Cell Significance Index: 60.1800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2858
Cell Significance Index: 9.9300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.2774
Cell Significance Index: 7.1300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2692
Cell Significance Index: 33.1100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2456
Cell Significance Index: 44.2800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.2341
Cell Significance Index: 6.2500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2333
Cell Significance Index: 6.2400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2236
Cell Significance Index: 44.8600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1969
Cell Significance Index: 2.9500
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.1954
Cell Significance Index: 5.7400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1786
Cell Significance Index: 161.3100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1610
Cell Significance Index: 12.0000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1554
Cell Significance Index: 2.6000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.1501
Cell Significance Index: 2.7800
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.1491
Cell Significance Index: 0.9900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1400
Cell Significance Index: 6.5800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1319
Cell Significance Index: 6.1500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1267
Cell Significance Index: 17.4000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1071
Cell Significance Index: 3.0700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1039
Cell Significance Index: 1.1800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0953
Cell Significance Index: 34.1800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0632
Cell Significance Index: 4.4700
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0614
Cell Significance Index: 7.9300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0511
Cell Significance Index: 8.7200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0316
Cell Significance Index: 4.0500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0154
Cell Significance Index: 1.7600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0131
Cell Significance Index: 0.4600
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0043
Cell Significance Index: -0.0700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0056
Cell Significance Index: -4.2600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0063
Cell Significance Index: -11.8400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0082
Cell Significance Index: -6.0800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0119
Cell Significance Index: -7.4600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0131
Cell Significance Index: -24.1700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0158
Cell Significance Index: -24.3100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0163
Cell Significance Index: -11.9200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0181
Cell Significance Index: -24.6000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0218
Cell Significance Index: -13.8300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0232
Cell Significance Index: -0.1400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0263
Cell Significance Index: -14.8100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0314
Cell Significance Index: -3.2100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0378
Cell Significance Index: -17.1400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0494
Cell Significance Index: -10.4100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0533
Cell Significance Index: -15.3400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0706
Cell Significance Index: -2.2600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0830
Cell Significance Index: -2.3200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0908
Cell Significance Index: -5.5800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0971
Cell Significance Index: -14.1200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1080
Cell Significance Index: -2.7000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1185
Cell Significance Index: -6.6500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1239
Cell Significance Index: -1.6900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1321
Cell Significance Index: -10.1400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1602
Cell Significance Index: -10.1000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1642
Cell Significance Index: -4.2000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1891
Cell Significance Index: -19.6900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2000
Cell Significance Index: -13.4500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2211
Cell Significance Index: -17.5200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2402
Cell Significance Index: -14.7300
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.2438
Cell Significance Index: -2.6500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2620
Cell Significance Index: -5.5800
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.2735
Cell Significance Index: -4.6000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.3302
Cell Significance Index: -5.8400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3328
Cell Significance Index: -3.4500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3668
Cell Significance Index: -19.2600
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.3782
Cell Significance Index: -2.3500
Cell Name: kidney cell (CL1000497)
Fold Change: -0.3807
Cell Significance Index: -3.0400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3877
Cell Significance Index: -17.1500
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.4448
Cell Significance Index: -9.7400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4457
Cell Significance Index: -16.3600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4537
Cell Significance Index: -17.1800
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.4565
Cell Significance Index: -3.8800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4710
Cell Significance Index: -15.4200
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4719
Cell Significance Index: -16.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** NRAS is a small GTPase that belongs to the Ras superfamily of GTP-binding proteins. It is composed of three conserved domains: the Ras box, the GTP-binding domain, and the effector domain. NRAS is activated by guanine nucleotide exchange factors (GEFs) and inactivates through guanine nucleotide dissociation inhibitors (GDIs). The activated NRAS protein binds to downstream effectors, such as RAF and MEK, to regulate signaling pathways. **Pathways and Functions** NRAS is involved in various signaling pathways, including: 1. **MAPK/ERK pathway**: NRAS activates the MAPK/ERK pathway, which regulates cell growth, differentiation, and survival. 2. **PI3K/AKT pathway**: NRAS also activates the PI3K/AKT pathway, which regulates cell survival and proliferation. 3. **Raf/MEK/ERK pathway**: NRAS activates the Raf/MEK/ERK pathway, which regulates cell growth and differentiation. 4. **Cytokine signaling**: NRAS is involved in cytokine signaling pathways, including those mediated by IL-2, IL-4, and IL-13. 5. **Adhesion and migration**: NRAS regulates cell adhesion and migration through the activation of the focal adhesion kinase (FAK) pathway. **Clinical Significance** Mutations in the NRAS gene have been associated with various cancers, including: 1. **Melanoma**: NRAS mutations are common in melanoma, particularly in the NRAS Q61E and NRAS G12D mutations. 2. **Colorectal cancer**: NRAS mutations are also found in colorectal cancer, particularly in the NRAS G12D and NRAS Q61E mutations. 3. **Breast cancer**: NRAS mutations have been identified in breast cancer, particularly in the NRAS G12D and NRAS Q61E mutations. 4. **Leukemia**: NRAS mutations have been associated with certain types of leukemia, including acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). In addition to its role in cancer, NRAS has also been implicated in various other diseases, including: 1. **Atherosclerosis**: NRAS is involved in the development of atherosclerosis, particularly through its regulation of the PI3K/AKT pathway. 2. **Neurodegenerative diseases**: NRAS has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Inflammatory disorders**: NRAS is involved in the regulation of inflammatory responses, particularly through its activation of the MAPK/ERK pathway. In summary, NRAS is a critical regulator of cellular signaling pathways, and its dysregulation has been implicated in various diseases, including cancer, atherosclerosis, and neurodegenerative disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

GTPase NRas

Genular Protein ID: 1403879024

Symbol: RASN_HUMAN

Name: GTPase NRas

UniProtKB Accession Codes:

P01111 Q14971 Q15104 Q15282

Database IDs:

Citations:

PubMed ID: 6616621

Title: Structure and activation of the human N-ras gene.

PubMed ID: 6616621

DOI: 10.1016/0092-8674(83)90390-2

PubMed ID: 2991860

Title: Human N-ras: cDNA cloning and gene structure.

PubMed ID: 2991860

DOI: 10.1093/nar/13.14.5255

PubMed ID: 6086315

Title: Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080.

PubMed ID: 6086315

DOI: 10.1002/j.1460-2075.1984.tb01970.x

PubMed ID: 6587382

Title: Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells.

PubMed ID: 6587382

DOI: 10.1073/pnas.81.12.3670

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2998510

Title: Transforming genes in human leukemia cells.

PubMed ID: 2998510

PubMed ID: 1970154

Title: Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay.

PubMed ID: 1970154

PubMed ID: 3856237

Title: Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon.

PubMed ID: 3856237

DOI: 10.1073/pnas.82.3.879

PubMed ID: 3295562

Title: A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome.

PubMed ID: 3295562

DOI: 10.1038/327430a0

PubMed ID: 3276402

Title: Detection of a low frequency of activated ras genes in human melanomas using a tumorigenicity assay.

PubMed ID: 3276402

PubMed ID: 2661017

Title: All ras proteins are polyisoprenylated but only some are palmitoylated.

PubMed ID: 2661017

DOI: 10.1016/0092-8674(89)90054-8

PubMed ID: 12727991

Title: RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.

PubMed ID: 12727991

DOI: 10.1210/jc.2002-021907

PubMed ID: 16000296

Title: DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.

PubMed ID: 16000296

DOI: 10.1074/jbc.m504113200

PubMed ID: 15705808

Title: An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.

PubMed ID: 15705808

DOI: 10.1126/science.1105654

PubMed ID: 19744486

Title: Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin.

PubMed ID: 19744486

DOI: 10.1016/j.febslet.2009.09.006

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21278800

Title: RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7.

PubMed ID: 21278800

DOI: 10.1038/cdd.2010.137

PubMed ID: 26701913

Title: ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization.

PubMed ID: 26701913

DOI: 10.7554/elife.11306

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29239724

Title: SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a.

PubMed ID: 29239724

DOI: 10.7554/elife.32436

PubMed ID: 30442762

Title: Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination.

PubMed ID: 30442762

DOI: 10.1126/science.aap7607

PubMed ID: 30712867

Title: Pharmacological targeting of STK19 inhibits oncogenic NRAS-driven melanomagenesis.

PubMed ID: 30712867

DOI: 10.1016/j.cell.2019.01.002

PubMed ID: 3102434

Title: Amino-acid substitution at codon 13 of the N-ras oncogene in rectal cancer in a Japanese patient.

PubMed ID: 3102434

PubMed ID: 17332249

Title: Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.

PubMed ID: 17332249

DOI: 10.1182/blood-2006-09-046649

PubMed ID: 17517660

Title: NRAS mutation causes a human autoimmune lymphoproliferative syndrome.

PubMed ID: 17517660

DOI: 10.1073/pnas.0702975104

PubMed ID: 18633438

Title: Genotypic and gene expression studies in congenital melanocytic nevi: insight into initial steps of melanotumorigenesis.

PubMed ID: 18633438

DOI: 10.1038/jid.2008.203

PubMed ID: 19966803

Title: A restricted spectrum of NRAS mutations causes Noonan syndrome.

PubMed ID: 19966803

DOI: 10.1038/ng.497

PubMed ID: 22499344

Title: Keratinocytic epidermal nevi are associated with mosaic RAS mutations.

PubMed ID: 22499344

DOI: 10.1136/jmedgenet-2011-100637

PubMed ID: 23392294

Title: Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS.

PubMed ID: 23392294

DOI: 10.1038/jid.2013.70

Sequence Information:

Length: 189
Mass: 21229
Checksum: 6898D3F6815B1EC7
Sequence:

MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 
QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI KRVKDSDDVP MVLVGNKCDL 
PTRTVDTKQA HELAKSYGIP FIETSAKTRQ GVEDAFYTLV REIRQYRMKK LNSSDDGTQG 
CMGLPCVVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NRAS

Associated with

Cells (max top 100)

Other Information

Structure and activation of the human N-ras gene. PubMed ID: 6616621

Human N-ras: cDNA cloning and gene structure. PubMed ID: 2991860

Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. PubMed ID: 6086315

Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells. PubMed ID: 6587382

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Transforming genes in human leukemia cells. PubMed ID: 2998510

Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay. PubMed ID: 1970154

Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon. PubMed ID: 3856237

A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome. PubMed ID: 3295562

Detection of a low frequency of activated ras genes in human melanomas using a tumorigenicity assay. PubMed ID: 3276402

All ras proteins are polyisoprenylated but only some are palmitoylated. PubMed ID: 2661017

RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma. PubMed ID: 12727991

DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. PubMed ID: 16000296

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. PubMed ID: 15705808

Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin. PubMed ID: 19744486

Initial characterization of the human central proteome. PubMed ID: 21269460

RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7. PubMed ID: 21278800

ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization. PubMed ID: 26701913

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. PubMed ID: 29239724

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. PubMed ID: 30442762

Pharmacological targeting of STK19 inhibits oncogenic NRAS-driven melanomagenesis. PubMed ID: 30712867

Amino-acid substitution at codon 13 of the N-ras oncogene in rectal cancer in a Japanese patient. PubMed ID: 3102434

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. PubMed ID: 17332249

NRAS mutation causes a human autoimmune lymphoproliferative syndrome. PubMed ID: 17517660

Genotypic and gene expression studies in congenital melanocytic nevi: insight into initial steps of melanotumorigenesis. PubMed ID: 18633438

A restricted spectrum of NRAS mutations causes Noonan syndrome. PubMed ID: 19966803

Keratinocytic epidermal nevi are associated with mosaic RAS mutations. PubMed ID: 22499344

Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS. PubMed ID: 23392294