Details for: NT5E

Gene ID: 4907

Symbol: NT5E

Ensembl ID: ENSG00000135318

Description: 5'-nucleotidase ecto

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.6126
    Cell Significance Index: -12.8500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.2287
    Cell Significance Index: -12.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.4302
    Cell Significance Index: -12.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6853
    Cell Significance Index: -15.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2590
    Cell Significance Index: -12.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.6029
    Cell Significance Index: 164.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.4974
    Cell Significance Index: 29.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1540
    Cell Significance Index: 409.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.0298
    Cell Significance Index: 59.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8702
    Cell Significance Index: 304.1700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.3296
    Cell Significance Index: 7.8500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2458
    Cell Significance Index: 26.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8987
    Cell Significance Index: 17.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8922
    Cell Significance Index: 97.0400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8137
    Cell Significance Index: 12.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7792
    Cell Significance Index: 425.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7766
    Cell Significance Index: 701.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5899
    Cell Significance Index: 12.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5003
    Cell Significance Index: 25.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4870
    Cell Significance Index: 33.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3951
    Cell Significance Index: 5.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3529
    Cell Significance Index: 48.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3305
    Cell Significance Index: 3.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2188
    Cell Significance Index: 3.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2022
    Cell Significance Index: 40.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1741
    Cell Significance Index: 120.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1650
    Cell Significance Index: 4.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1569
    Cell Significance Index: 19.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1496
    Cell Significance Index: 14.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1255
    Cell Significance Index: 5.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1227
    Cell Significance Index: 15.7300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1225
    Cell Significance Index: 0.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1134
    Cell Significance Index: 13.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0999
    Cell Significance Index: 35.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0819
    Cell Significance Index: 16.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0637
    Cell Significance Index: 40.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0514
    Cell Significance Index: 9.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0343
    Cell Significance Index: 3.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0276
    Cell Significance Index: 0.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0040
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0035
    Cell Significance Index: -5.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0058
    Cell Significance Index: -3.6200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0079
    Cell Significance Index: -0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0114
    Cell Significance Index: -15.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0120
    Cell Significance Index: -6.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0142
    Cell Significance Index: -10.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0183
    Cell Significance Index: -13.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0201
    Cell Significance Index: -8.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0239
    Cell Significance Index: -0.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0254
    Cell Significance Index: -7.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0280
    Cell Significance Index: -12.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0292
    Cell Significance Index: -1.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0309
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0415
    Cell Significance Index: -8.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0444
    Cell Significance Index: -7.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0613
    Cell Significance Index: -3.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0731
    Cell Significance Index: -2.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0764
    Cell Significance Index: -7.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0789
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0793
    Cell Significance Index: -9.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0840
    Cell Significance Index: -5.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0895
    Cell Significance Index: -13.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1012
    Cell Significance Index: -13.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1128
    Cell Significance Index: -13.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1225
    Cell Significance Index: -12.7600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1411
    Cell Significance Index: -2.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1472
    Cell Significance Index: -11.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1519
    Cell Significance Index: -4.0600
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.1633
    Cell Significance Index: -1.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1698
    Cell Significance Index: -13.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1715
    Cell Significance Index: -8.0600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1742
    Cell Significance Index: -1.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1915
    Cell Significance Index: -14.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1921
    Cell Significance Index: -12.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2019
    Cell Significance Index: -12.4100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2081
    Cell Significance Index: -2.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2122
    Cell Significance Index: -5.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2190
    Cell Significance Index: -5.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2198
    Cell Significance Index: -11.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2255
    Cell Significance Index: -4.7200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2351
    Cell Significance Index: -3.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2408
    Cell Significance Index: -13.5200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2604
    Cell Significance Index: -10.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2668
    Cell Significance Index: -14.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2828
    Cell Significance Index: -12.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2917
    Cell Significance Index: -13.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3170
    Cell Significance Index: -4.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3351
    Cell Significance Index: -12.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3362
    Cell Significance Index: -12.7300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.3421
    Cell Significance Index: -2.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3540
    Cell Significance Index: -12.4000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3556
    Cell Significance Index: -2.9000
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.3574
    Cell Significance Index: -2.7100
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.3587
    Cell Significance Index: -3.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3596
    Cell Significance Index: -9.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3762
    Cell Significance Index: -10.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NT5E is a member of the 5'-nucleotidase family, enzymes responsible for converting nucleotides into nucleosides. The ecto form of NT5E, specifically, is localized to the cell surface, where it participates in the regulation of various cellular processes. This gene is expressed in a wide range of cell types, including glandular epithelial cells, eye photoreceptor cells, and endothelial cells, highlighting its diverse functional roles. **Pathways and Functions:** NT5E's involvement in multiple pathways underscores its importance in maintaining cellular homeostasis. Some of the key pathways and functions associated with NT5E include: 1. **Adenosine biosynthetic process**: NT5E catalyzes the conversion of adenosine to adenosine monophosphate (AMP), a crucial step in adenosine biosynthesis. 2. **Cell recruitment and inflammatory response**: NT5E's ecto form interacts with various receptors and ligands, modulating the recruitment of immune cells to sites of inflammation. 3. **Purinergic signaling**: NT5E participates in purinergic signaling pathways, influencing the release of neurotransmitters and cytokines. 4. **Calcium ion homeostasis**: NT5E helps regulate calcium ion concentrations, which is essential for various cellular processes, including muscle contraction and neuronal signaling. **Clinical Significance:** NT5E's involvement in various diseases highlights its potential as a therapeutic target. Some of the clinical significance of NT5E includes: 1. **Leishmaniasis**: NT5E's role in purinergic signaling pathways makes it a potential target for the treatment of Leishmaniasis, a parasitic disease characterized by inflammation and tissue damage. 2. **Inflammatory disorders**: NT5E's involvement in the recruitment of immune cells and the regulation of inflammatory responses positions it as a potential therapeutic target for inflammatory disorders, such as rheumatoid arthritis and asthma. 3. **Neurological disorders**: NT5E's role in purinergic signaling pathways and calcium ion homeostasis makes it a potential target for the treatment of neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, NT5E's multifaceted role in various cellular processes underscores its importance in maintaining cellular homeostasis. Its involvement in multiple diseases highlights its potential as a therapeutic target, and further research is needed to fully elucidate its functions and clinical significance.

Genular Protein ID: 213973406

Symbol: 5NTD_HUMAN

Name: 5'-nucleotidase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2129526

Title: Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form.

PubMed ID: 2129526

DOI: 10.1111/j.1432-1033.1990.tb19158.x

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 8566797

Title: Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene.

PubMed ID: 8566797

DOI: 10.1016/0378-1119(95)00574-9

PubMed ID: 2173922

Title: Characterization of soluble vs membrane-bound human placental 5'-nucleotidase.

PubMed ID: 2173922

DOI: 10.1016/0006-291x(90)91601-n

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21933152

Title: The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism.

PubMed ID: 21933152

DOI: 10.1042/bj20111263

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 22997138

Title: Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity.

PubMed ID: 22997138

DOI: 10.1002/cbic.201200426

PubMed ID: 23142347

Title: Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling.

PubMed ID: 23142347

DOI: 10.1016/j.str.2012.10.001

PubMed ID: 34403084

Title: Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives.

PubMed ID: 34403084

DOI: 10.1007/s11302-021-09802-w

PubMed ID: 21288095

Title: NT5E mutations and arterial calcifications.

PubMed ID: 21288095

DOI: 10.1056/nejmoa0912923

PubMed ID: 24887587

Title: NT5E mutations that cause human disease are associated with intracellular mistrafficking of NT5E protein.

PubMed ID: 24887587

DOI: 10.1371/journal.pone.0098568

Sequence Information:

  • Length: 574
  • Mass: 63368
  • Checksum: A99AF170AB7EAECE
  • Sequence:
  • MCPRAARAPA TLLLALGAVL WPAAGAWELT ILHTNDVHSR LEQTSEDSSK CVNASRCMGG 
    VARLFTKVQQ IRRAEPNVLL LDAGDQYQGT IWFTVYKGAE VAHFMNALRY DAMALGNHEF 
    DNGVEGLIEP LLKEAKFPIL SANIKAKGPL ASQISGLYLP YKVLPVGDEV VGIVGYTSKE 
    TPFLSNPGTN LVFEDEITAL QPEVDKLKTL NVNKIIALGH SGFEMDKLIA QKVRGVDVVV 
    GGHSNTFLYT GNPPSKEVPA GKYPFIVTSD DGRKVPVVQA YAFGKYLGYL KIEFDERGNV 
    ISSHGNPILL NSSIPEDPSI KADINKWRIK LDNYSTQELG KTIVYLDGSS QSCRFRECNM 
    GNLICDAMIN NNLRHTDEMF WNHVSMCILN GGGIRSPIDE RNNGTITWEN LAAVLPFGGT 
    FDLVQLKGST LKKAFEHSVH RYGQSTGEFL QVGGIHVVYD LSRKPGDRVV KLDVLCTKCR 
    VPSYDPLKMD EVYKVILPNF LANGGDGFQM IKDELLRHDS GDQDINVVST YISKMKVIYP 
    AVEGRIKFST GSHCHGSFSL IFLSLWAVIF VLYQ

Genular Protein ID: 3526796529

Symbol: Q6NZX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 574
  • Mass: 63308
  • Checksum: F64C54E50056B196
  • Sequence:
  • MCPRAARAPA TLLLALGAVL WPAAGAWELT ILHTNDVHSR LEQTSEDSSK CVNASRCMGG 
    VARLFTKVQQ IRRAEPNVLL LDAGDQYQGT IWFTVYKGAE VAHFMNALRY DAMALGNHEF 
    DNGVEGLIEP LLKEAKFPIL SANIKAKGPL ASQISGLYLP YKVLPVGDEV VGIVGYTSKE 
    TPFLSNPGTN LVFEDEITAL QPEVDKLKTL NVNKIIALGH SGFEMDKLIA QKVRGVDVVV 
    GGHSNTFLYT GNPPSKEVPA GKYPFIVTSD DGRKVPVVQA YAFGKYLGYL KIEFDERGNV 
    ISSHGNPILL NSSIPEDPSI KADINKWRIK LDNYSTQELG KTIVYLDGSS QSCRFRECNM 
    GNLICDAMIN NNLRHADETF WNHVSMCILN GGGIRSPIDE RNNGTITWEN LAAVLPFGGT 
    FDLVQLKGST LKKAFEHSVH RYGQSTGEFL QVGGIHVVYD LSRKPGDRVV KLDVLCTKCR 
    VPSYDPLKMD EVYKVILPNF LANGGDGFQM IKDELLRHDS GDQDINVVST YISKMKVIYP 
    AVEGRIKFST GSHCHGSFSL IFLSLWAVIF VLYQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.