Details for: NT5E
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 82.6126
Cell Significance Index: -12.8500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 13.2287
Cell Significance Index: -12.6300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 10.4302
Cell Significance Index: -12.8600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.6853
Cell Significance Index: -15.2300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.2590
Cell Significance Index: -12.8600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.6029
Cell Significance Index: 164.0500 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.4974
Cell Significance Index: 29.7700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.1540
Cell Significance Index: 409.9300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 2.0298
Cell Significance Index: 59.7900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.8702
Cell Significance Index: 304.1700 - Cell Name: endocardial cell (CL0002350)
Fold Change: 1.3296
Cell Significance Index: 7.8500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.2458
Cell Significance Index: 26.6300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.8987
Cell Significance Index: 17.5400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8922
Cell Significance Index: 97.0400 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.8137
Cell Significance Index: 12.9100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7792
Cell Significance Index: 425.5500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7766
Cell Significance Index: 701.2400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5899
Cell Significance Index: 12.7800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.5003
Cell Significance Index: 25.2900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4870
Cell Significance Index: 33.6800 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.3951
Cell Significance Index: 5.9200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3529
Cell Significance Index: 48.4600 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.3305
Cell Significance Index: 3.7600 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.2188
Cell Significance Index: 3.6800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2022
Cell Significance Index: 40.1300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1741
Cell Significance Index: 120.4400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1650
Cell Significance Index: 4.7600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1569
Cell Significance Index: 19.2900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1496
Cell Significance Index: 14.8000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1255
Cell Significance Index: 5.6900 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1227
Cell Significance Index: 15.7300 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1225
Cell Significance Index: 0.7400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1134
Cell Significance Index: 13.2200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0999
Cell Significance Index: 35.8300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0819
Cell Significance Index: 16.4200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0637
Cell Significance Index: 40.4400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0514
Cell Significance Index: 9.2700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0343
Cell Significance Index: 3.9100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.0276
Cell Significance Index: 0.7900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0040
Cell Significance Index: 0.1000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0014
Cell Significance Index: -2.6100 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0019
Cell Significance Index: -0.0300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0028
Cell Significance Index: -5.0900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0035
Cell Significance Index: -5.4400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0058
Cell Significance Index: -4.3200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0058
Cell Significance Index: -3.6200 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.0079
Cell Significance Index: -0.1300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0114
Cell Significance Index: -15.4400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0120
Cell Significance Index: -6.7800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0142
Cell Significance Index: -10.7300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0183
Cell Significance Index: -13.4200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0201
Cell Significance Index: -8.8900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0239
Cell Significance Index: -0.8400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0254
Cell Significance Index: -7.3000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0280
Cell Significance Index: -12.7200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0292
Cell Significance Index: -1.7900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0309
Cell Significance Index: -0.6400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0415
Cell Significance Index: -8.7500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0444
Cell Significance Index: -7.5900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0613
Cell Significance Index: -3.1900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0731
Cell Significance Index: -2.3400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0764
Cell Significance Index: -7.8000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0789
Cell Significance Index: -1.6800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0793
Cell Significance Index: -9.0800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0840
Cell Significance Index: -5.4200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0895
Cell Significance Index: -13.0100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1012
Cell Significance Index: -13.0700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1128
Cell Significance Index: -13.3000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1225
Cell Significance Index: -12.7600 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.1411
Cell Significance Index: -2.4400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1472
Cell Significance Index: -11.3000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1519
Cell Significance Index: -4.0600 - Cell Name: endothelial stalk cell (CL0002671)
Fold Change: -0.1633
Cell Significance Index: -1.8300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1698
Cell Significance Index: -13.4500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1715
Cell Significance Index: -8.0600 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.1742
Cell Significance Index: -1.1800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1915
Cell Significance Index: -14.2700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1921
Cell Significance Index: -12.9200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2019
Cell Significance Index: -12.4100 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.2081
Cell Significance Index: -2.9100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2122
Cell Significance Index: -5.9300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2190
Cell Significance Index: -5.6300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2198
Cell Significance Index: -11.4500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2255
Cell Significance Index: -4.7200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2351
Cell Significance Index: -3.9600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2408
Cell Significance Index: -13.5200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2604
Cell Significance Index: -10.6700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2668
Cell Significance Index: -14.0100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2828
Cell Significance Index: -12.5100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2917
Cell Significance Index: -13.6000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3170
Cell Significance Index: -4.5400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3351
Cell Significance Index: -12.3000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3362
Cell Significance Index: -12.7300 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.3421
Cell Significance Index: -2.6200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3540
Cell Significance Index: -12.4000 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3556
Cell Significance Index: -2.9000 - Cell Name: precursor cell (CL0011115)
Fold Change: -0.3574
Cell Significance Index: -2.7100 - Cell Name: fibroblast of the aortic adventitia (CL0002547)
Fold Change: -0.3587
Cell Significance Index: -3.6200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3596
Cell Significance Index: -9.6200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3762
Cell Significance Index: -10.0800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 213973406
Symbol: 5NTD_HUMAN
Name: 5'-nucleotidase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2129526
Title: Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form.
PubMed ID: 2129526
PubMed ID: 16303743
Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
PubMed ID: 16303743
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 8566797
Title: Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene.
PubMed ID: 8566797
PubMed ID: 2173922
Title: Characterization of soluble vs membrane-bound human placental 5'-nucleotidase.
PubMed ID: 2173922
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 21933152
Title: The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism.
PubMed ID: 21933152
DOI: 10.1042/bj20111263
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 22997138
Title: Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity.
PubMed ID: 22997138
PubMed ID: 23142347
Title: Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling.
PubMed ID: 23142347
PubMed ID: 34403084
Title: Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives.
PubMed ID: 34403084
PubMed ID: 21288095
PubMed ID: 24887587
Title: NT5E mutations that cause human disease are associated with intracellular mistrafficking of NT5E protein.
PubMed ID: 24887587
Sequence Information:
- Length: 574
- Mass: 63368
- Checksum: A99AF170AB7EAECE
- Sequence:
MCPRAARAPA TLLLALGAVL WPAAGAWELT ILHTNDVHSR LEQTSEDSSK CVNASRCMGG VARLFTKVQQ IRRAEPNVLL LDAGDQYQGT IWFTVYKGAE VAHFMNALRY DAMALGNHEF DNGVEGLIEP LLKEAKFPIL SANIKAKGPL ASQISGLYLP YKVLPVGDEV VGIVGYTSKE TPFLSNPGTN LVFEDEITAL QPEVDKLKTL NVNKIIALGH SGFEMDKLIA QKVRGVDVVV GGHSNTFLYT GNPPSKEVPA GKYPFIVTSD DGRKVPVVQA YAFGKYLGYL KIEFDERGNV ISSHGNPILL NSSIPEDPSI KADINKWRIK LDNYSTQELG KTIVYLDGSS QSCRFRECNM GNLICDAMIN NNLRHTDEMF WNHVSMCILN GGGIRSPIDE RNNGTITWEN LAAVLPFGGT FDLVQLKGST LKKAFEHSVH RYGQSTGEFL QVGGIHVVYD LSRKPGDRVV KLDVLCTKCR VPSYDPLKMD EVYKVILPNF LANGGDGFQM IKDELLRHDS GDQDINVVST YISKMKVIYP AVEGRIKFST GSHCHGSFSL IFLSLWAVIF VLYQ
Genular Protein ID: 3526796529
Symbol: Q6NZX3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 574
- Mass: 63308
- Checksum: F64C54E50056B196
- Sequence:
MCPRAARAPA TLLLALGAVL WPAAGAWELT ILHTNDVHSR LEQTSEDSSK CVNASRCMGG VARLFTKVQQ IRRAEPNVLL LDAGDQYQGT IWFTVYKGAE VAHFMNALRY DAMALGNHEF DNGVEGLIEP LLKEAKFPIL SANIKAKGPL ASQISGLYLP YKVLPVGDEV VGIVGYTSKE TPFLSNPGTN LVFEDEITAL QPEVDKLKTL NVNKIIALGH SGFEMDKLIA QKVRGVDVVV GGHSNTFLYT GNPPSKEVPA GKYPFIVTSD DGRKVPVVQA YAFGKYLGYL KIEFDERGNV ISSHGNPILL NSSIPEDPSI KADINKWRIK LDNYSTQELG KTIVYLDGSS QSCRFRECNM GNLICDAMIN NNLRHADETF WNHVSMCILN GGGIRSPIDE RNNGTITWEN LAAVLPFGGT FDLVQLKGST LKKAFEHSVH RYGQSTGEFL QVGGIHVVYD LSRKPGDRVV KLDVLCTKCR VPSYDPLKMD EVYKVILPNF LANGGDGFQM IKDELLRHDS GDQDINVVST YISKMKVIYP AVEGRIKFST GSHCHGSFSL IFLSLWAVIF VLYQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.