Details for: DDR2

Gene ID: 4921

Symbol: DDR2

Ensembl ID: ENSG00000162733

Description: discoidin domain receptor tyrosine kinase 2

Associated with

  • Extracellular matrix organization
    (R-HSA-1474244)
  • Non-integrin membrane-ecm interactions
    (R-HSA-3000171)
  • Actin cytoskeleton
    (GO:0015629)
  • Apical plasma membrane
    (GO:0016324)
  • Atp binding
    (GO:0005524)
  • Biomineral tissue development
    (GO:0031214)
  • Cell adhesion
    (GO:0007155)
  • Cell surface receptor protein tyrosine kinase signaling pathway
    (GO:0007169)
  • Cellular response to angiotensin
    (GO:1904385)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to transforming growth factor beta stimulus
    (GO:0071560)
  • Chondrocyte proliferation
    (GO:0035988)
  • Collagen-activated tyrosine kinase receptor signaling pathway
    (GO:0038063)
  • Collagen binding
    (GO:0005518)
  • Collagen fibril organization
    (GO:0030199)
  • Endochondral bone growth
    (GO:0003416)
  • Focal adhesion
    (GO:0005925)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of hydrogen peroxide-mediated programmed cell death
    (GO:1901299)
  • Ossification
    (GO:0001503)
  • Peptidyl-tyrosine phosphorylation
    (GO:0018108)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of extracellular matrix disassembly
    (GO:0090091)
  • Positive regulation of fibroblast migration
    (GO:0010763)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of g1/s transition of mitotic cell cycle
    (GO:1900087)
  • Positive regulation of hepatic stellate cell activation
    (GO:2000491)
  • Positive regulation of hepatic stellate cell proliferation
    (GO:1904899)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein kinase activity
    (GO:0045860)
  • Positive regulation of vascular associated smooth muscle cell migration
    (GO:1904754)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Positive regulation of wound healing
    (GO:0090303)
  • Protein autophosphorylation
    (GO:0046777)
  • Protein binding
    (GO:0005515)
  • Protein tyrosine kinase collagen receptor activity
    (GO:0038062)
  • Receptor complex
    (GO:0043235)
  • Regulation of bone mineralization
    (GO:0030500)
  • Regulation of extracellular matrix disassembly
    (GO:0010715)
  • Regulation of tissue remodeling
    (GO:0034103)
  • Response to muscle stretch
    (GO:0035994)
  • Signal transduction
    (GO:0007165)
  • Transmembrane receptor protein tyrosine kinase activity
    (GO:0004714)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 175.5438
    Cell Significance Index: -27.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 108.7748
    Cell Significance Index: -27.5900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.9503
    Cell Significance Index: -27.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.8575
    Cell Significance Index: -21.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.2322
    Cell Significance Index: -24.6600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 7.6830
    Cell Significance Index: 149.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8195
    Cell Significance Index: -26.9100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.5614
    Cell Significance Index: 24.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.9524
    Cell Significance Index: 1058.9700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.7284
    Cell Significance Index: 39.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 2.5538
    Cell Significance Index: 129.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.2459
    Cell Significance Index: 60.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6477
    Cell Significance Index: 34.4900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.6153
    Cell Significance Index: 20.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4969
    Cell Significance Index: 205.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3368
    Cell Significance Index: 38.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2844
    Cell Significance Index: 27.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.9096
    Cell Significance Index: 55.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8653
    Cell Significance Index: 110.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8329
    Cell Significance Index: 1568.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6588
    Cell Significance Index: 50.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6324
    Cell Significance Index: 401.6100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6286
    Cell Significance Index: 8.0500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.4870
    Cell Significance Index: 6.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4480
    Cell Significance Index: 4.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4075
    Cell Significance Index: 184.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3888
    Cell Significance Index: 73.9900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.3630
    Cell Significance Index: 1.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2437
    Cell Significance Index: 3.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1727
    Cell Significance Index: 34.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1487
    Cell Significance Index: 134.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1193
    Cell Significance Index: 183.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1091
    Cell Significance Index: 11.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1060
    Cell Significance Index: 46.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1034
    Cell Significance Index: 20.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0970
    Cell Significance Index: 178.9300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0843
    Cell Significance Index: 0.5000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.0693
    Cell Significance Index: 0.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0048
    Cell Significance Index: -0.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0161
    Cell Significance Index: -1.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0197
    Cell Significance Index: -13.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0254
    Cell Significance Index: -0.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0267
    Cell Significance Index: -4.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0279
    Cell Significance Index: -0.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0320
    Cell Significance Index: -23.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0348
    Cell Significance Index: -25.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0352
    Cell Significance Index: -26.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0412
    Cell Significance Index: -22.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0445
    Cell Significance Index: -27.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0460
    Cell Significance Index: -25.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0472
    Cell Significance Index: -6.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0563
    Cell Significance Index: -6.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0601
    Cell Significance Index: -17.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0663
    Cell Significance Index: -1.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0880
    Cell Significance Index: -9.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0928
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1059
    Cell Significance Index: -18.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1215
    Cell Significance Index: -3.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1223
    Cell Significance Index: -8.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1328
    Cell Significance Index: -27.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1444
    Cell Significance Index: -18.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1472
    Cell Significance Index: -17.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1539
    Cell Significance Index: -7.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1553
    Cell Significance Index: -7.0400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1557
    Cell Significance Index: -2.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1739
    Cell Significance Index: -17.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1906
    Cell Significance Index: -11.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2355
    Cell Significance Index: -27.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2434
    Cell Significance Index: -27.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2453
    Cell Significance Index: -6.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2525
    Cell Significance Index: -17.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2594
    Cell Significance Index: -5.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2759
    Cell Significance Index: -18.5500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2845
    Cell Significance Index: -2.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3035
    Cell Significance Index: -22.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3052
    Cell Significance Index: -18.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3088
    Cell Significance Index: -24.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3208
    Cell Significance Index: -6.9300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3337
    Cell Significance Index: -5.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3393
    Cell Significance Index: -5.0100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3619
    Cell Significance Index: -3.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3723
    Cell Significance Index: -19.3900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.3991
    Cell Significance Index: -2.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4082
    Cell Significance Index: -25.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4123
    Cell Significance Index: -26.6000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4167
    Cell Significance Index: -6.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4339
    Cell Significance Index: -24.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4382
    Cell Significance Index: -9.0900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4400
    Cell Significance Index: -6.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4631
    Cell Significance Index: -10.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4686
    Cell Significance Index: -21.8500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.4760
    Cell Significance Index: -2.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4770
    Cell Significance Index: -21.1000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.4782
    Cell Significance Index: -4.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4876
    Cell Significance Index: -25.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4990
    Cell Significance Index: -25.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5327
    Cell Significance Index: -18.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5375
    Cell Significance Index: -17.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5658
    Cell Significance Index: -7.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DDR2 is a type I transmembrane receptor tyrosine kinase that contains a discoidin domain, which is responsible for binding to collagen and other extracellular matrix (ECM) components. The receptor is activated by collagen binding, which triggers a series of downstream signaling events that regulate cellular processes. DDR2 has a high degree of specificity for collagen types I, II, and III, and its activation can modulate various cellular responses, including adhesion, migration, proliferation, and differentiation. **Pathways and Functions:** DDR2 signaling pathways are complex and multifaceted, involving the activation of various downstream kinases and transcription factors. Some of the key signaling pathways regulated by DDR2 include: 1. **Collagen-activated tyrosine kinase receptor signaling pathway:** This pathway involves the activation of DDR2 by collagen binding, which triggers the phosphorylation of tyrosine residues on the receptor and downstream kinases, such as ERK1/2 and AKT. 2. **ERK1/2 cascade:** The ERK1/2 cascade is a key downstream effector of DDR2 signaling, regulating cellular processes such as proliferation, migration, and differentiation. 3. **PI3K/AKT pathway:** The PI3K/AKT pathway is another downstream effector of DDR2 signaling, regulating cellular processes such as survival, migration, and differentiation. 4. **Wnt/β-catenin pathway:** The Wnt/β-catenin pathway is also regulated by DDR2 signaling, influencing cellular processes such as proliferation and differentiation. DDR2 has been implicated in various physiological and pathological processes, including: 1. **Cell adhesion and migration:** DDR2 plays a key role in regulating cell adhesion and migration, particularly in the context of tissue repair and remodeling. 2. **Proliferation and differentiation:** DDR2 regulates cellular proliferation and differentiation, particularly in the context of tissue development and repair. 3. **Inflammation and immune response:** DDR2 has been implicated in the regulation of inflammatory responses and immune cell function. 4. **Cancer:** DDR2 has been implicated in the development and progression of various types of cancer, including breast, lung, and colon cancer. **Clinical Significance:** DDR2 has been implicated in various diseases, including: 1. **Fibrosis:** DDR2 has been implicated in the development of fibrosis in various tissues, including the lungs, liver, and kidneys. 2. **Cancer:** DDR2 has been implicated in the development and progression of various types of cancer, including breast, lung, and colon cancer. 3. **Cardiovascular disease:** DDR2 has been implicated in the development of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 4. **Neurological disorders:** DDR2 has been implicated in the development of various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, DDR2 is a multifaceted receptor tyrosine kinase that plays a key role in various cellular processes, including cell adhesion, proliferation, migration, and differentiation. Its clinical significance is evident in various diseases, including fibrosis, cancer, cardiovascular disease, and neurological disorders. Further research is needed to fully elucidate the mechanisms of DDR2 signaling and its role in disease pathogenesis.

Genular Protein ID: 1300368684

Symbol: DDR2_HUMAN

Name: Discoidin domain-containing receptor 2

UniProtKB Accession Codes:

Q16832 Q7Z730

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8247548

Title: Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain.

PubMed ID: 8247548

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9659899

Title: The discoidin domain receptor tyrosine kinases are activated by collagen.

PubMed ID: 9659899

DOI: 10.1016/s1097-2765(00)80003-9

PubMed ID: 16186108

Title: Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation.

PubMed ID: 16186108

DOI: 10.1074/jbc.m506921200

PubMed ID: 16186104

Title: Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen.

PubMed ID: 16186104

DOI: 10.1074/jbc.m508226200

PubMed ID: 17665456

Title: Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritis.

PubMed ID: 17665456

DOI: 10.1002/art.22761

PubMed ID: 18201965

Title: Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen.

PubMed ID: 18201965

DOI: 10.1074/jbc.m709290200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20564243

Title: Transcriptional upregulation of DDR2 by ATF4 facilitates osteoblastic differentiation through p38 MAPK-mediated Runx2 activation.

PubMed ID: 20564243

DOI: 10.1002/jbmr.159

PubMed ID: 20734453

Title: An essential role of discoidin domain receptor 2 (DDR2) in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation.

PubMed ID: 20734453

DOI: 10.1002/jbmr.225

PubMed ID: 16626936

Title: Sensing extracellular matrix: an update on discoidin domain receptor function.

PubMed ID: 16626936

DOI: 10.1016/j.cellsig.2006.02.012

PubMed ID: 21568710

Title: Transmembrane collagen receptors.

PubMed ID: 21568710

DOI: 10.1146/annurev-cellbio-092910-154013

PubMed ID: 17703188

Title: Structural basis of the collagen-binding mode of discoidin domain receptor 2.

PubMed ID: 17703188

DOI: 10.1038/sj.emboj.7601833

PubMed ID: 20004161

Title: Crystallographic insight into collagen recognition by discoidin domain receptor 2.

PubMed ID: 20004161

DOI: 10.1016/j.str.2009.10.012

PubMed ID: 16140923

Title: Somatic mutations of the protein kinase gene family in human lung cancer.

PubMed ID: 16140923

DOI: 10.1158/0008-5472.can-05-1855

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19110212

Title: Mutations in DDR2 gene cause SMED with short limbs and abnormal calcifications.

PubMed ID: 19110212

DOI: 10.1016/j.ajhg.2008.12.004

PubMed ID: 20223752

Title: Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients.

PubMed ID: 20223752

DOI: 10.1093/hmg/ddq103

PubMed ID: 26463668

Title: Novel DDR2 mutation identified by whole exome sequencing in a Moroccan patient with spondylo-meta-epiphyseal dysplasia, short limb-abnormal calcification type.

PubMed ID: 26463668

DOI: 10.1002/ajmg.a.37426

PubMed ID: 30449416

Title: Recurrent, activating variants in the receptor tyrosine kinase DDR2 cause Warburg-Cinotti syndrome.

PubMed ID: 30449416

DOI: 10.1016/j.ajhg.2018.10.013

Sequence Information:

  • Length: 855
  • Mass: 96736
  • Checksum: 78662021BC53E1A0
  • Sequence:
    • MILIPRMLLV LFLLLPILSS AKAQVNPAIC RYPLGMSGGQ IPDEDITASS QWSESTAAKY 
GRLDSEEGDG AWCPEIPVEP DDLKEFLQID LHTLHFITLV GTQGRHAGGH GIEFAPMYKI 
NYSRDGTRWI SWRNRHGKQV LDGNSNPYDI FLKDLEPPIV ARFVRFIPVT DHSMNVCMRV 
ELYGCVWLDG LVSYNAPAGQ QFVLPGGSII YLNDSVYDGA VGYSMTEGLG QLTDGVSGLD 
DFTQTHEYHV WPGYDYVGWR NESATNGYIE IMFEFDRIRN FTTMKVHCNN MFAKGVKIFK 
EVQCYFRSEA SEWEPNAISF PLVLDDVNPS ARFVTVPLHH RMASAIKCQY HFADTWMMFS 
EITFQSDAAM YNNSEALPTS PMAPTTYDPM LKVDDSNTRI LIGCLVAIIF ILLAIIVIIL 
WRQFWQKMLE KASRRMLDDE MTVSLSLPSD SSMFNNNRSS SPSEQGSNST YDRIFPLRPD 
YQEPSRLIRK LPEFAPGEEE SGCSGVVKPV QPSGPEGVPH YAEADIVNLQ GVTGGNTYSV 
PAVTMDLLSG KDVAVEEFPR KLLTFKEKLG EGQFGEVHLC EVEGMEKFKD KDFALDVSAN 
QPVLVAVKML RADANKNARN DFLKEIKIMS RLKDPNIIHL LAVCITDDPL CMITEYMENG 
DLNQFLSRHE PPNSSSSDVR TVSYTNLKFM ATQIASGMKY LSSLNFVHRD LATRNCLVGK 
NYTIKIADFG MSRNLYSGDY YRIQGRAVLP IRWMSWESIL LGKFTTASDV WAFGVTLWET 
FTFCQEQPYS QLSDEQVIEN TGEFFRDQGR QTYLPQPAIC PDSVYKLMLS CWRRDTKNRP 
SFQEIHLLLL QQGDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.