NUP88 | ENSG00000108559 | NCBI 4927

Details for: NUP88

Gene ID: 4927

Symbol: NUP88

Ensembl ID: ENSG00000108559

Description: nucleoporin 88

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective tpr may confer susceptibility towards thyroid papillary carcinoma (tpc)
(R-HSA-5619107)
Disease
(R-HSA-1643685)
Disorders of transmembrane transporters
(R-HSA-5619115)
Export of viral ribonucleoproteins from nucleus
(R-HSA-168274)
Gene expression (transcription)
(R-HSA-74160)
Gene silencing by rna
(R-HSA-211000)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Interactions of rev with host cellular proteins
(R-HSA-177243)
Interactions of vpr with host cellular proteins
(R-HSA-176033)
Interferon signaling
(R-HSA-913531)
Isg15 antiviral mechanism
(R-HSA-1169408)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of non-coding rna
(R-HSA-194441)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Nep/ns2 interacts with the cellular export machinery
(R-HSA-168333)
Ns1 mediated effects on host pathways
(R-HSA-168276)
Nuclear envelope breakdown
(R-HSA-2980766)
Nuclear import of rev protein
(R-HSA-180746)
Nuclear pore complex (npc) disassembly
(R-HSA-3301854)
Post-translational protein modification
(R-HSA-597592)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Regulation of glucokinase by glucokinase regulatory protein
(R-HSA-170822)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Rev-mediated nuclear export of hiv rna
(R-HSA-165054)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Slc transporter disorders
(R-HSA-5619102)
Snrnp assembly
(R-HSA-191859)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of chromatin organization proteins
(R-HSA-4551638)
Sumoylation of dna damage response and repair proteins
(R-HSA-3108214)
Sumoylation of dna replication proteins
(R-HSA-4615885)
Sumoylation of rna binding proteins
(R-HSA-4570464)
Sumoylation of sumoylation proteins
(R-HSA-4085377)
Sumoylation of ubiquitinylation proteins
(R-HSA-3232142)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transport of mature mrna derived from an intron-containing transcript
(R-HSA-159236)
Transport of mature mrna derived from an intronless transcript
(R-HSA-159231)
Transport of mature mrnas derived from intronless transcripts
(R-HSA-159234)
Transport of mature transcript to cytoplasm
(R-HSA-72202)
Transport of ribonucleoproteins into the host nucleus
(R-HSA-168271)
Transport of the slbp dependant mature mrna
(R-HSA-159230)
Transport of the slbp independent mature mrna
(R-HSA-159227)
Trna processing
(R-HSA-72306)
Trna processing in the nucleus
(R-HSA-6784531)
Viral infection pathways
(R-HSA-9824446)
Viral messenger rna synthesis
(R-HSA-168325)
Vpr-mediated nuclear import of pics
(R-HSA-180910)
Cytosol
(GO:0005829)
Mrna export from nucleus
(GO:0006406)
Nuclear envelope
(GO:0005635)
Nuclear pore
(GO:0005643)
Nucleocytoplasmic transport
(GO:0006913)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Ribosomal large subunit export from nucleus
(GO:0000055)
Ribosomal small subunit export from nucleus
(GO:0000056)
Structural constituent of nuclear pore
(GO:0017056)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 156.2247
Cell Significance Index: -24.3000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 98.8001
Cell Significance Index: -25.0600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 60.1589
Cell Significance Index: -24.4400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 53.8312
Cell Significance Index: -27.6900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 42.6663
Cell Significance Index: -28.6300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 25.7137
Cell Significance Index: -24.5500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 21.8986
Cell Significance Index: -27.0000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.7299
Cell Significance Index: -26.0700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.3288
Cell Significance Index: -22.5100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.2389
Cell Significance Index: -28.5700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.3694
Cell Significance Index: -13.9400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3089
Cell Significance Index: 259.7600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.2785
Cell Significance Index: 149.0000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.2118
Cell Significance Index: 119.8800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0957
Cell Significance Index: 219.7900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.9921
Cell Significance Index: 59.5600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.9697
Cell Significance Index: 13.2300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.8603
Cell Significance Index: 22.9700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8285
Cell Significance Index: 90.1200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7238
Cell Significance Index: 259.6100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6957
Cell Significance Index: 36.1400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6785
Cell Significance Index: 43.7800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6738
Cell Significance Index: 18.8300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.6653
Cell Significance Index: 16.6300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6483
Cell Significance Index: 17.6500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.6464
Cell Significance Index: 36.2800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6322
Cell Significance Index: 102.8200
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.6254
Cell Significance Index: 15.2600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.5960
Cell Significance Index: 45.7400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.5914
Cell Significance Index: 26.1600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5849
Cell Significance Index: 26.5100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.5469
Cell Significance Index: 20.7100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5441
Cell Significance Index: 64.1700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5159
Cell Significance Index: 14.8700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4768
Cell Significance Index: 10.3300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.4341
Cell Significance Index: 29.1900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4086
Cell Significance Index: 282.6200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3573
Cell Significance Index: 24.7100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3546
Cell Significance Index: 63.9200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3075
Cell Significance Index: 277.6200
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.2685
Cell Significance Index: 5.2400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2565
Cell Significance Index: 31.5400
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.2335
Cell Significance Index: 5.9700
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.2090
Cell Significance Index: 3.5200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2044
Cell Significance Index: 9.6100
Cell Name: lactocyte (CL0002325)
Fold Change: 0.2015
Cell Significance Index: 26.0400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1979
Cell Significance Index: 108.0700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.1766
Cell Significance Index: 4.5400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1731
Cell Significance Index: 76.5300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1641
Cell Significance Index: 31.2200
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1091
Cell Significance Index: 1.8700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0882
Cell Significance Index: 4.1100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0843
Cell Significance Index: 129.7300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0842
Cell Significance Index: 158.5600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0776
Cell Significance Index: 10.6600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0703
Cell Significance Index: 129.6200
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0694
Cell Significance Index: 1.5200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0674
Cell Significance Index: 4.1500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0667
Cell Significance Index: 1.4200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0595
Cell Significance Index: 37.8000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0511
Cell Significance Index: 69.4200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0481
Cell Significance Index: 1.2900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0438
Cell Significance Index: 1.5400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0310
Cell Significance Index: 2.1900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0245
Cell Significance Index: 11.1400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0151
Cell Significance Index: -11.0900
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0204
Cell Significance Index: -0.4300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0238
Cell Significance Index: -4.0600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0267
Cell Significance Index: -1.9900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0291
Cell Significance Index: -22.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0293
Cell Significance Index: -21.7000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0395
Cell Significance Index: -5.0600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0457
Cell Significance Index: -25.7800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0511
Cell Significance Index: -31.9200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0550
Cell Significance Index: -1.1400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0821
Cell Significance Index: -23.6200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0946
Cell Significance Index: -13.7500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1186
Cell Significance Index: -12.1100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1199
Cell Significance Index: -7.5600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1486
Cell Significance Index: -31.2900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1636
Cell Significance Index: -18.7400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1680
Cell Significance Index: -5.3800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1701
Cell Significance Index: -5.9100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1718
Cell Significance Index: -8.9500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1822
Cell Significance Index: -2.7300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1928
Cell Significance Index: -1.7800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2057
Cell Significance Index: -5.8700
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.2082
Cell Significance Index: -2.9900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2098
Cell Significance Index: -21.8400
Cell Name: peg cell (CL4033014)
Fold Change: -0.2242
Cell Significance Index: -5.1800
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2682
Cell Significance Index: -3.9600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2707
Cell Significance Index: -7.2400
Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.2724
Cell Significance Index: -3.4300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2832
Cell Significance Index: -4.7400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2948
Cell Significance Index: -23.3500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3059
Cell Significance Index: -16.0600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3411
Cell Significance Index: -20.9100
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3550
Cell Significance Index: -5.2400
Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.3607
Cell Significance Index: -5.8200
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.4405
Cell Significance Index: -3.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** NUP88 is a conserved protein that belongs to the nucleoporin family, which plays a pivotal role in the NPC's structure and function. The protein is composed of 10 transmembrane domains and 5 nucleoporin domains, allowing it to interact with various molecules, including viral ribonucleoproteins, RNA, and proteins. NUP88's unique structure enables it to regulate the transport of molecules through the NPC, influencing various cellular processes, including cell cycle progression, gene expression, and immune response. **Pathways and Functions:** NUP88's involvement in multiple pathways and functions is a testament to its multifaceted role in cellular biology. Some of the key pathways and functions associated with NUP88 include: 1. **Antiviral Mechanism by IFN-Stimulated Genes**: NUP88 interacts with viral ribonucleoproteins, regulating their transport into the nucleus, thereby modulating the antiviral response. 2. **Cell Cycle Regulation**: NUP88 regulates the transport of molecules involved in cell cycle progression, ensuring proper cell division and proliferation. 3. **Gene Expression**: NUP88's role in regulating the transport of RNA and proteins influences gene expression, affecting cellular processes such as metabolism, protein synthesis, and immune response. 4. **Cytokine Signaling**: NUP88 interacts with cytokines, modulating their signaling pathways and influencing immune response. 5. **Viral Infection Pathways**: NUP88's involvement in viral infection pathways highlights its critical role in regulating the transport of viral ribonucleoproteins and other viral components. **Clinical Significance:** NUP88's involvement in various diseases and disorders underscores its clinical significance. Some of the key clinical implications of NUP88 include: 1. **Thyroid Papillary Carcinoma (TPC)**: Defects in NUP88 have been associated with susceptibility to TPC, highlighting its potential as a biomarker for this disease. 2. **Immunodeficiency Disorders**: NUP88's role in regulating cytokine signaling and immune response makes it a potential target for immunodeficiency disorders. 3. **Neurological Disorders**: NUP88's involvement in neuronal function and development suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer**: NUP88's role in regulating cell cycle progression and gene expression makes it a potential target for cancer therapy. In conclusion, NUP88 is a multifaceted protein that plays a critical role in various cellular processes, including immune response, cell cycle regulation, and gene expression. Its involvement in various diseases and disorders highlights its clinical significance, making it an important area of research for understanding the complex relationships between cellular biology and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 895153408

Symbol: NUP88_HUMAN

Name: Nuclear pore complex protein Nup88

UniProtKB Accession Codes:

Q99567 D3DTM2 Q9BWE5

Database IDs:

Citations:

PubMed ID: 9049309

Title: The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88.

PubMed ID: 9049309

DOI: 10.1093/emboj/16.4.807

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30543681

Title: Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.

PubMed ID: 30543681

DOI: 10.1371/journal.pgen.1007845

Sequence Information:

Length: 741
Mass: 83542
Checksum: 954A8E2E203BC20B
Sequence:

MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS PPPQLLTRNV 
VFGLGGELFL WDGEDSSFLV VRLRGPSGGG EEPALSQYQR LLCINPPLFE IYQVLLSPTQ 
HHVALIGIKG LMVLELPKRW GKNSEFEGGK STVNCSTTPV AERFFTSSTS LTLKHAAWYP 
SEILDPHVVL LTSDNVIRIY SLREPQTPTN VIILSEAEEE SLVLNKGRAY TASLGETAVA 
FDFGPLAAVP KTLFGQNGKD EVVAYPLYIL YENGETFLTY ISLLHSPGNI GKLLGPLPMH 
PAAEDNYGYD ACAVLCLPCV PNILVIATES GMLYHCVVLE GEEEDDHTSE KSWDSRIDLI 
PSLYVFECVE LELALKLASG EDDPFDSDFS CPVKLHRDPK CPSRYHCTHE AGVHSVGLTW 
IHKLHKFLGS DEEDKDSLQE LSTEQKCFVE HILCTKPLPC RQPAPIRGFW IVPDILGPTM 
ICITSTYECL IWPLLSTVHP ASPPLLCTRE DVEVAESPLR VLAETPDSFE KHIRSILQRS 
VANPAFLKAS EKDIAPPPEE CLQLLSRATQ VFREQYILKQ DLAKEEIQRR VKLLCDQKKK 
QLEDLSYCRE ERKSLREMAE RLADKYEEAK EKQEDIMNRM KKLLHSFHSE LPVLSDSERD 
MKKELQLIPD QLRHLGNAIK QVTMKKDYQQ QKMEKVLSLP KPTIILSAYQ RKCIQSILKE 
EGEHIREMVK QINDIRNHVN F

Genular Protein ID: 812795240

Symbol: J3KMX1_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KMX1

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 757
Mass: 85505
Checksum: 77442D04E1607D37
Sequence:

MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS PPPQLLTRNV 
VFGLGGELFL WDGEDSSFLV VRLRGPSGGG EEPALSQYQR LLCINPPLFE IYQVLLSPTQ 
HHVALIGIKG LMVLELPKRW GKNSEFEGGK STVNCSTTPV AERFFTSSTS LTLKHAAWYP 
SEILDPHVVL LTSDNVIRIY SLREPQTPTN VIILSEAEEE SLVLNKGRAY TASLGETAVA 
FDFGPLAAVP KTLFGQNGKD EVVAYPLYIL YENGETFLTY ISLLHSPGNI GKLLGPLPMH 
PAAEDNYGYD ACAVLCLPCV PNILVIATES GMLYHCVVLE GEEEDDHTSE KSWDSRIDLI 
PSLYVFECVE LELALKLASG EDDPFDSDFS CPVKLHRDPK CPSRYHCTHE AGVHSVGLTW 
IHKLHKFLGS DEEDKDSLQE LSTEQKCFVE HILCTKPLPC RQPAPIRGFW IVPDILGPTM 
ICITSTYECL IWPLLSTVHP ASPPLLCTRE DVEVAESPLR VLAETPDSFE KHIRSILQRS 
VANPAFLNCF TQLRKIKVET LFLRASEKDI APPPEECLQL LSRATQVFRE QYILKQDLAK 
EEIQRRVKLL CDQKKKQLED LSYCREERKS LREMAERLAD KYEEAKEKQE DIMNRMKKLL 
HSFHSELPVL SDSERDMKKE LQLIPDQLRH LGNAIKQVTM KKDYQQQKME KVLSLPKPTI 
ILSAYQRKCI QSILKEEGEH IREMVKQIND IRNHVNF

Genular Protein ID: 3536843089

Symbol: B4DP20_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DP20

Database IDs:

Sequence Information:

Length: 626
Mass: 71285
Checksum: BD8D4EBF6BDCB1E7
Sequence:

MVLELPKRWG KNSEFEGGKS TVNCSTTPVA ERFFTSSTSL TLKHAAWYPS EILDPHVVLL 
TSDNVIRIYS LREPQTPTNV IILSEAEEES LVLNKGRAYT ASLGETAVAF DFGPLAAVPK 
TLFGQNGKDE VVAYPLYILY ENGETFLTYI SLLHSPGNIG KLLGPLPMHP AAEDNYGYDA 
CAVLCLPCVP NILVIATESG MLYHCVVLEG EEEDDHTSEK SWDSRIDLIP SLYVFECVEL 
ELALKLASGE DDPFDSDFSC PVKLHRDPKC PSRYHCTHEA GVHSVGLTWI HKLHKFLGSD 
EEDKDSLQEL STEQKCFVEH ILCTKPLPCR QPAPIRGFWI VPDILGPTMI CITSTYECLI 
WPLLSTVHPA SPPLLCTRED VEVAESPLRV LAETPDSFEK HIRSILQRSV ANPAFLNCFT 
QLRKIKVETL FLRASEKDIA PPPEECLQLL SRATQVFREQ YILKQDLAKE EIQRRVKLLC 
DQKKKQLEDL SYCREERKSL REMAERLADK YEEAKEKQED IMNRMKKLLH SFHSELPVLS 
DSERDMKKEL QLIPDQLRHL GNAIKQVTMK KDYQQQKMEK VLSLPKPTII LSAYQRKCIQ 
SILKEEGEHI REMVKQINDI RNHVNF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NUP88

Associated with

Cells (max top 100)

Other Information

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88. PubMed ID: 9049309

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence. PubMed ID: 30543681

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Database document:

PubMed ID: 9049309

PubMed ID: 15489334

PubMed ID: 17081983

PubMed ID: 16964243

PubMed ID: 18691976

PubMed ID: 18669648

PubMed ID: 19413330

PubMed ID: 19690332

PubMed ID: 20068231

PubMed ID: 21269460

PubMed ID: 21406692

PubMed ID: 22223895

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 30543681

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 17081983

PubMed ID: 16964243

PubMed ID: 16625196

PubMed ID: 18691976

PubMed ID: 18669648

PubMed ID: 19413330

PubMed ID: 19690332

PubMed ID: 20068231

PubMed ID: 21269460

PubMed ID: 21406692

PubMed ID: 23186163

PubMed ID: 24275569