Details for: NVL
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 178.4690
Cell Significance Index: -27.7600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 109.5633
Cell Significance Index: -27.7900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 63.5428
Cell Significance Index: -30.0000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 59.2605
Cell Significance Index: -24.0800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 25.4152
Cell Significance Index: -24.2700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 23.7721
Cell Significance Index: -29.3100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.1386
Cell Significance Index: -27.1600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.8883
Cell Significance Index: -27.3000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.5189
Cell Significance Index: -29.6700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.0319
Cell Significance Index: -15.3900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.6347
Cell Significance Index: 324.4200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4451
Cell Significance Index: 289.8800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0923
Cell Significance Index: 986.3100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.9996
Cell Significance Index: 45.3100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.9868
Cell Significance Index: 26.3500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.9840
Cell Significance Index: 27.5000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.8627
Cell Significance Index: 48.4100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8491
Cell Significance Index: 304.5500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7698
Cell Significance Index: 83.7300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7603
Cell Significance Index: 123.6500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6925
Cell Significance Index: 53.1500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.5279
Cell Significance Index: 11.2900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.5233
Cell Significance Index: 13.0800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5104
Cell Significance Index: 353.0200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4668
Cell Significance Index: 13.4500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4593
Cell Significance Index: 9.9500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.4462
Cell Significance Index: 9.7700 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.4324
Cell Significance Index: 8.4400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.4202
Cell Significance Index: 10.8000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4092
Cell Significance Index: 18.1000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.3599
Cell Significance Index: 13.6300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3592
Cell Significance Index: 22.0800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3462
Cell Significance Index: 23.9400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3165
Cell Significance Index: 8.4800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2672
Cell Significance Index: 48.1800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.2207
Cell Significance Index: 14.8400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1793
Cell Significance Index: 22.0500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1725
Cell Significance Index: 32.8300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1712
Cell Significance Index: 16.9400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1444
Cell Significance Index: 9.1000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1391
Cell Significance Index: 61.5200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1362
Cell Significance Index: 7.1000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1228
Cell Significance Index: 16.8600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1132
Cell Significance Index: 213.1000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1084
Cell Significance Index: 3.8100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0934
Cell Significance Index: 51.0200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0726
Cell Significance Index: 8.4600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0613
Cell Significance Index: 113.0700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0549
Cell Significance Index: 84.4400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0545
Cell Significance Index: 24.7500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0516
Cell Significance Index: 32.7900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0250
Cell Significance Index: 0.6000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0146
Cell Significance Index: 19.8800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0123
Cell Significance Index: 0.2100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0112
Cell Significance Index: 1.4400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0029
Cell Significance Index: -0.1500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0075
Cell Significance Index: -0.3500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0084
Cell Significance Index: -0.9800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0289
Cell Significance Index: -21.2000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0294
Cell Significance Index: -22.2600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0308
Cell Significance Index: -22.7900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0390
Cell Significance Index: -6.6700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0444
Cell Significance Index: -0.6600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0474
Cell Significance Index: -26.7200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0501
Cell Significance Index: -1.4300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0537
Cell Significance Index: -33.5500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0592
Cell Significance Index: -1.2600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0768
Cell Significance Index: -3.6100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0855
Cell Significance Index: -24.6200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0880
Cell Significance Index: -2.8200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0989
Cell Significance Index: -14.3700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1173
Cell Significance Index: -11.9800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1213
Cell Significance Index: -7.8300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1273
Cell Significance Index: -16.4500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1284
Cell Significance Index: -9.5700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1441
Cell Significance Index: -16.5100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1543
Cell Significance Index: -32.5000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1838
Cell Significance Index: -13.0000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1907
Cell Significance Index: -19.8600 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2248
Cell Significance Index: -2.6800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2433
Cell Significance Index: -1.4700 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.2451
Cell Significance Index: -3.0400 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.2721
Cell Significance Index: -3.6300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2851
Cell Significance Index: -3.8900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3297
Cell Significance Index: -26.1100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3314
Cell Significance Index: -11.5200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.3400
Cell Significance Index: -5.0200 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.3412
Cell Significance Index: -4.9000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3500
Cell Significance Index: -18.3800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3782
Cell Significance Index: -23.1900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4132
Cell Significance Index: -6.9200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4264
Cell Significance Index: -9.0500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4433
Cell Significance Index: -14.1200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4542
Cell Significance Index: -14.8700 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.5006
Cell Significance Index: -10.0500 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.5107
Cell Significance Index: -12.4600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5271
Cell Significance Index: -15.5300 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.5312
Cell Significance Index: -7.6400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5322
Cell Significance Index: -14.0000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.5679
Cell Significance Index: -11.2300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3744035119
Symbol: NVL_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9286697
Title: NVL: a new member of the AAA family of ATPases localized to the nucleus.
PubMed ID: 9286697
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12429849
Title: Functional proteomic analysis of human nucleolus.
PubMed ID: 12429849
PubMed ID: 15469983
Title: NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal protein L5 through its nucleolar localization sequence.
PubMed ID: 15469983
PubMed ID: 16782053
Title: The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1.
PubMed ID: 16782053
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21474449
Title: Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal.
PubMed ID: 21474449
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22226966
Title: The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly.
PubMed ID: 22226966
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 26166824
Title: NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing.
PubMed ID: 26166824
PubMed ID: 26456651
Title: AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74.
PubMed ID: 26456651
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 28416111
Title: Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2.
PubMed ID: 28416111
PubMed ID: 29107693
Title: WDR74 participates in an early cleavage of the pre-rRNA processing pathway in cooperation with the nucleolar AAA-ATPase NVL2.
PubMed ID: 29107693
PubMed ID: 31358741
Title: The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
PubMed ID: 31358741
Sequence Information:
- Length: 856
- Mass: 95051
- Checksum: 7A8B373FCAFB99B7
- Sequence:
MKPRPAGFVD NKLKQRVIQY LTSNKCGKYV DIGVLASDLQ RVYSIDYGRR KRNAFRIQVE KVFSIISSEK ELKNLTELED EHLAKRARQG EEDNEYTESY SDDDSSMEDY PDPQSANHMN SSLLSLYRKG NPDSVSNTPE MEQRETTSST PRISSKTGSI PLKTPAKDSE GGWFIDKTPS VKKDSFFLDL SCEKSNPKKP ITEIQDSKDS SLLESDMKRK GKLKNKGSKR KKEDLQEVDG EIEAVLQKKA KARGLEFQIS NVKFEDVGGN DMTLKEVCKM LIHMRHPEVY HHLGVVPPRG VLLHGPPGCG KTLLAHAIAG ELDLPILKVA APEIVSGVSG ESEQKLRELF EQAVSNAPCI IFIDEIDAIT PKREVASKDM ERRIVAQLLT CMDDLNNVAA TARVLVIGAT NRPDSLDPAL RRAGRFDREI CLGIPDEASR ERILQTLCRK LRLPQAFDFC HLAHLTPGFV GADLMALCRE AAMCAVNRVL MKLQEQQKKN PEMEDLPSKG VQEERLGTEP TSETQDELQR LLGLLRDQDP LSEEQMQGLC IELNDFIVAL SSVQPSAKRE GFVTVPNVTW ADIGALEDIR EELTMAILAP VRNPDQFKAL GLVTPAGVLL AGPPGCGKTL LAKAVANESG LNFISVKGPE LLNMYVGESE RAVRQVFQRA KNSAPCVIFF DEVDALCPRR SDRETGASVR VVNQLLTEMD GLEARQQVFI MAATNRPDII DPAILRPGRL DKTLFVGLPP PADRLAILKT ITKNGTKPPL DADVNLEAIA GDLRCDCYTG ADLSALVREA SICALRQEMA RQKSGNEKGE LKVSHKHFEE AFKKVRSSIS KKDQIMYERL QESLSR
Genular Protein ID: 2085860593
Symbol: B4DF43_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 145
- Mass: 16293
- Checksum: 0246130BF977E62D
- Sequence:
MKPRPAGFVD NKLKQRVIQY LTSNKCGKYV DIGVLASDLQ RVYSIDYGRR KRNAFRIQVE KVFSIISSEK ELKNLTELED EHLAKRARQG EEDNEQRLAL SPRLQCTGTI MAYRSLDVPG PSDPPTAASQ VAGITGVCQH AQLIF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.