Details for: OAS1

Gene ID: 4938

Symbol: OAS1

Ensembl ID: ENSG00000089127

Description: 2'-5'-oligoadenylate synthetase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 89.7488
    Cell Significance Index: -13.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.5220
    Cell Significance Index: -11.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.9040
    Cell Significance Index: -14.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.9690
    Cell Significance Index: -15.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 21.2959
    Cell Significance Index: -14.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.9517
    Cell Significance Index: -14.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.3954
    Cell Significance Index: -14.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 7.9226
    Cell Significance Index: 1507.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.1039
    Cell Significance Index: 265.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.8218
    Cell Significance Index: -14.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6550
    Cell Significance Index: -12.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5555
    Cell Significance Index: -14.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.9424
    Cell Significance Index: 35.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7701
    Cell Significance Index: 16.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3289
    Cell Significance Index: 79.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2769
    Cell Significance Index: 138.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1420
    Cell Significance Index: 1031.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1199
    Cell Significance Index: 15.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1024
    Cell Significance Index: 198.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0543
    Cell Significance Index: 171.4700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.8286
    Cell Significance Index: 7.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7223
    Cell Significance Index: 88.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7196
    Cell Significance Index: 49.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6200
    Cell Significance Index: 18.2100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.6132
    Cell Significance Index: 5.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5486
    Cell Significance Index: 8.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5385
    Cell Significance Index: 28.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5221
    Cell Significance Index: 51.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5022
    Cell Significance Index: 64.3800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4355
    Cell Significance Index: 6.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2384
    Cell Significance Index: 15.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2373
    Cell Significance Index: 27.0900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1823
    Cell Significance Index: 2.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1642
    Cell Significance Index: 5.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1612
    Cell Significance Index: 4.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1021
    Cell Significance Index: 4.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0798
    Cell Significance Index: 2.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0784
    Cell Significance Index: 10.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0644
    Cell Significance Index: 12.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0640
    Cell Significance Index: 2.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0569
    Cell Significance Index: 6.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0531
    Cell Significance Index: 1.1300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0509
    Cell Significance Index: 0.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0460
    Cell Significance Index: 1.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0298
    Cell Significance Index: 1.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0257
    Cell Significance Index: 11.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0110
    Cell Significance Index: 6.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0043
    Cell Significance Index: 0.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0050
    Cell Significance Index: -3.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0070
    Cell Significance Index: -13.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0081
    Cell Significance Index: -14.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0109
    Cell Significance Index: -16.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0112
    Cell Significance Index: -6.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0129
    Cell Significance Index: -4.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0132
    Cell Significance Index: -17.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0150
    Cell Significance Index: -11.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0183
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0203
    Cell Significance Index: -2.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0208
    Cell Significance Index: -15.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0222
    Cell Significance Index: -14.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0268
    Cell Significance Index: -4.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0318
    Cell Significance Index: -9.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0355
    Cell Significance Index: -16.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0429
    Cell Significance Index: -8.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0437
    Cell Significance Index: -9.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0450
    Cell Significance Index: -5.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0462
    Cell Significance Index: -5.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0572
    Cell Significance Index: -1.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0694
    Cell Significance Index: -1.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0957
    Cell Significance Index: -2.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0973
    Cell Significance Index: -14.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1013
    Cell Significance Index: -4.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1022
    Cell Significance Index: -7.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1024
    Cell Significance Index: -3.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1195
    Cell Significance Index: -2.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1358
    Cell Significance Index: -14.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1410
    Cell Significance Index: -9.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1451
    Cell Significance Index: -3.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1570
    Cell Significance Index: -3.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1686
    Cell Significance Index: -2.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1822
    Cell Significance Index: -4.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1927
    Cell Significance Index: -15.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1968
    Cell Significance Index: -15.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2046
    Cell Significance Index: -13.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2058
    Cell Significance Index: -12.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2259
    Cell Significance Index: -14.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2491
    Cell Significance Index: -15.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2614
    Cell Significance Index: -6.7200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2773
    Cell Significance Index: -11.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2821
    Cell Significance Index: -7.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3033
    Cell Significance Index: -17.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3043
    Cell Significance Index: -15.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3066
    Cell Significance Index: -13.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3303
    Cell Significance Index: -11.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3445
    Cell Significance Index: -11.2800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3615
    Cell Significance Index: -13.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3657
    Cell Significance Index: -10.7700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3741
    Cell Significance Index: -2.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3745
    Cell Significance Index: -14.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Antiviral Activity:** OAS1 is a potent antiviral enzyme that inhibits viral replication by inducing the production of 2'-5'-oligoadenylates, which activate PKR and lead to the degradation of viral RNA. 2. **Interferon-Stimulated Gene (ISG):** OAS1 is a key component of the ISG pathway, which is activated in response to interferon-alpha/beta signaling. ISGs, including OAS1, play a crucial role in defending against viral infections by regulating the production of antiviral molecules. 3. **Tissue Distribution:** OAS1 is highly expressed in immune cells, including monocytes, epithelial cells, and Hofbauer cells, as well as in tissues such as the bladder urothelium, nasal mucosa, and esophageal epithelium. 4. **Regulation of Antiviral Response:** OAS1 is negatively regulated by chemokines, such as C-X-C motif chemokine ligand 2 (CXCL2), and positively regulated by interferon-beta and tumor necrosis factor-alpha (TNF-alpha). **Pathways and Functions:** OAS1 is involved in several key pathways, including: 1. **Antiviral Innate Immune Response:** OAS1 plays a crucial role in defending against viral infections by regulating the production of antiviral molecules, such as 2'-5'-oligoadenylates and PKR. 2. **Interferon Signaling:** OAS1 is activated in response to interferon-alpha/beta signaling, leading to the induction of ISGs and the production of antiviral molecules. 3. **Cytokine Signaling:** OAS1 is negatively regulated by chemokines, such as CXCL2, and positively regulated by interferon-beta and TNF-alpha. 4. **Ribonuclease Activity:** OAS1 activates the ribonuclease activity of PKR, leading to the degradation of viral RNA and the inhibition of viral replication. **Clinical Significance:** OAS1 plays a critical role in defending against viral infections, and its dysregulation has been implicated in various diseases, including: 1. **Viral Infections:** OAS1's antiviral activity makes it an important target for the treatment of viral infections, such as influenza and HIV. 2. **Autoimmune Diseases:** OAS1's dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** OAS1's antiviral activity has been shown to have anti-tumor effects, making it a potential target for cancer therapy. In conclusion, OAS1 is a crucial component of the antiviral innate immune response, and its dysregulation has significant implications for human health. Further research is needed to fully understand the mechanisms of OAS1 and its role in disease.

Genular Protein ID: 3714632712

Symbol: OAS1_HUMAN

Name: 2'-5'-oligoadenylate synthase 1

UniProtKB Accession Codes:

P00973 A8K4N8 F8VXY3 P04820 P29080 P29081 P78485 P78486 Q16700 Q16701 Q1PG42 Q3ZM01 Q53GC5 Q53YA4 Q6A1Z3 Q6IPC6 Q6P7N9 Q96J61

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 26 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 4 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2416561

Title: Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences.

PubMed ID: 2416561

DOI: 10.1002/j.1460-2075.1985.tb03922.x

PubMed ID: 3753689

Title: Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon.

PubMed ID: 3753689

DOI: 10.1016/0014-5793(86)80224-1

PubMed ID: 3754863

Title: Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase.

PubMed ID: 3754863

DOI: 10.1093/oxfordjournals.jbchem.a135615

PubMed ID: 1651324

Title: Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships.

PubMed ID: 1651324

DOI: 10.1016/s0021-9258(18)98615-1

PubMed ID: 17024523

Title: The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla.

PubMed ID: 17024523

DOI: 10.1007/s00239-006-0073-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3121313

Title: New inducers revealed by the promoter sequence analysis of two interferon-activated human genes.

PubMed ID: 3121313

DOI: 10.1111/j.1432-1033.1987.tb13614.x

PubMed ID: 2830497

Title: Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene.

PubMed ID: 2830497

DOI: 10.1128/mcb.7.12.4498-4504.1987

PubMed ID: 2456211

Title: Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene.

PubMed ID: 2456211

DOI: 10.1002/j.1460-2075.1988.tb02872.x

PubMed ID: 2411547

Title: Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure.

PubMed ID: 2411547

DOI: 10.1002/j.1460-2075.1985.tb03848.x

PubMed ID: 6348777

Title: Molecular cloning and sequence of partial cDNA for interferon-induced (2'-5')oligo(A) synthetase mRNA from human cells.

PubMed ID: 6348777

DOI: 10.1073/pnas.80.16.4904

PubMed ID: 9407111

Title: Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein.

PubMed ID: 9407111

DOI: 10.1074/jbc.272.52.33220

PubMed ID: 10464285

Title: The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases.

PubMed ID: 10464285

DOI: 10.1074/jbc.274.36.25535

PubMed ID: 12799444

Title: Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family.

PubMed ID: 12799444

DOI: 10.1093/nar/gkg427

PubMed ID: 17408844

Title: The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.

PubMed ID: 17408844

DOI: 10.1016/j.biochi.2007.02.003

PubMed ID: 18931074

Title: The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain.

PubMed ID: 18931074

DOI: 10.1099/vir.0.2008/003558-0

PubMed ID: 19923450

Title: Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection.

PubMed ID: 19923450

DOI: 10.4049/jimmunol.0902728

PubMed ID: 19203244

Title: Differential regulation of the OASL and OAS1 genes in response to viral infections.

PubMed ID: 19203244

DOI: 10.1089/jir.2008.0050

PubMed ID: 19904482

Title: Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria.

PubMed ID: 19904482

DOI: 10.1007/s00239-009-9299-1

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21142819

Title: The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities.

PubMed ID: 21142819

DOI: 10.1089/jir.2010.0107

PubMed ID: 25775560

Title: Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3.

PubMed ID: 25775560

DOI: 10.1073/pnas.1419409112

PubMed ID: 33633408

Title: A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.

PubMed ID: 33633408

DOI: 10.1038/s41591-021-01281-1

PubMed ID: 34581622

Title: A prenylated dsRNA sensor protects against severe COVID-19.

PubMed ID: 34581622

DOI: 10.1126/science.abj3624

PubMed ID: 23319625

Title: Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1.

PubMed ID: 23319625

DOI: 10.1073/pnas.1218528110

PubMed ID: 29455859

Title: Heterozygous Mutations in OAS1 Cause Infantile-Onset Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia.

PubMed ID: 29455859

DOI: 10.1016/j.ajhg.2018.01.019

PubMed ID: 34145065

Title: Heterozygous OAS1 gain-of-function variants cause an autoinflammatory immunodeficiency.

PubMed ID: 34145065

DOI: 10.1126/sciimmunol.abf9564

Sequence Information:

  • Length: 400
  • Mass: 46029
  • Checksum: 03F0A3AA17DAD4E4
  • Sequence:
    • MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS YPVCVSKVVK 
GGSSGKGTTL RGRSDADLVV FLSPLTTFQD QLNRRGEFIQ EIRRQLEACQ RERAFSVKFE 
VQAPRWGNPR ALSFVLSSLQ LGEGVEFDVL PAFDALGQLT GGYKPNPQIY VKLIEECTDL 
QKEGEFSTCF TELQRDFLKQ RPTKLKSLIR LVKHWYQNCK KKLGKLPPQY ALELLTVYAW 
ERGSMKTHFN TAQGFRTVLE LVINYQQLCI YWTKYYDFKN PIIEKYLRRQ LTKPRPVILD 
PADPTGNLGG GDPKGWRQLA QEAEAWLNYP CFKNWDGSPV SSWILLAESN SADDETDDPR 
RYQKYGYIGT HEYPHFSHRP STLQAASTPQ AEEDWTCTIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.