Details for: SCAPER

Gene ID: 49855

Symbol: SCAPER

Ensembl ID: ENSG00000140386

Description: S-phase cyclin A associated protein in the ER

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 463.5308
    Cell Significance Index: -72.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 274.5193
    Cell Significance Index: -69.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 153.1594
    Cell Significance Index: -72.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 141.3637
    Cell Significance Index: -57.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 60.3723
    Cell Significance Index: -57.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 58.5260
    Cell Significance Index: -72.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.5724
    Cell Significance Index: -68.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.2891
    Cell Significance Index: -68.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.3230
    Cell Significance Index: -42.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.3500
    Cell Significance Index: -72.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 13.1235
    Cell Significance Index: 156.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.3437
    Cell Significance Index: 273.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.4500
    Cell Significance Index: 1237.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.4483
    Cell Significance Index: 264.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.0890
    Cell Significance Index: 173.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.7511
    Cell Significance Index: 58.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6743
    Cell Significance Index: 536.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4801
    Cell Significance Index: 492.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.2890
    Cell Significance Index: 63.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.1883
    Cell Significance Index: 56.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.0565
    Cell Significance Index: 1422.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.9821
    Cell Significance Index: 133.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.6755
    Cell Significance Index: 32.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4892
    Cell Significance Index: 65.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.4623
    Cell Significance Index: 41.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4023
    Cell Significance Index: 53.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.1996
    Cell Significance Index: 29.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.1851
    Cell Significance Index: 20.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0338
    Cell Significance Index: 27.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0173
    Cell Significance Index: 100.6300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.9869
    Cell Significance Index: 8.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.9721
    Cell Significance Index: 24.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.7469
    Cell Significance Index: 1406.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5798
    Cell Significance Index: 368.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5473
    Cell Significance Index: 89.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5289
    Cell Significance Index: 11.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4827
    Cell Significance Index: 743.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4816
    Cell Significance Index: 13.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4205
    Cell Significance Index: 775.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3827
    Cell Significance Index: 47.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3762
    Cell Significance Index: 40.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3491
    Cell Significance Index: 62.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2739
    Cell Significance Index: 124.3100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2253
    Cell Significance Index: 3.2400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.2189
    Cell Significance Index: 2.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2104
    Cell Significance Index: 286.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1622
    Cell Significance Index: 7.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1336
    Cell Significance Index: 8.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1065
    Cell Significance Index: 58.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0812
    Cell Significance Index: 1.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0754
    Cell Significance Index: 33.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0056
    Cell Significance Index: 0.1500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0237
    Cell Significance Index: -4.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0320
    Cell Significance Index: -23.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0453
    Cell Significance Index: -2.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0496
    Cell Significance Index: -36.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0504
    Cell Significance Index: -6.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0581
    Cell Significance Index: -36.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0783
    Cell Significance Index: -44.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0819
    Cell Significance Index: -1.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0849
    Cell Significance Index: -4.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0852
    Cell Significance Index: -64.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0895
    Cell Significance Index: -4.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0922
    Cell Significance Index: -6.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1139
    Cell Significance Index: -19.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1410
    Cell Significance Index: -6.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1910
    Cell Significance Index: -6.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2005
    Cell Significance Index: -25.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2010
    Cell Significance Index: -29.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2059
    Cell Significance Index: -3.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2084
    Cell Significance Index: -43.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2175
    Cell Significance Index: -62.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2240
    Cell Significance Index: -23.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2764
    Cell Significance Index: -28.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3452
    Cell Significance Index: -21.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3529
    Cell Significance Index: -45.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3599
    Cell Significance Index: -18.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3805
    Cell Significance Index: -44.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3926
    Cell Significance Index: -45.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4060
    Cell Significance Index: -5.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4164
    Cell Significance Index: -47.7000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4805
    Cell Significance Index: -6.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5229
    Cell Significance Index: -59.6900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5321
    Cell Significance Index: -6.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6129
    Cell Significance Index: -39.5400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6295
    Cell Significance Index: -7.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6822
    Cell Significance Index: -48.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6970
    Cell Significance Index: -51.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7773
    Cell Significance Index: -61.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8486
    Cell Significance Index: -52.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8770
    Cell Significance Index: -28.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8883
    Cell Significance Index: -17.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9438
    Cell Significance Index: -30.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9468
    Cell Significance Index: -30.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9519
    Cell Significance Index: -14.0500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9742
    Cell Significance Index: -12.3000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.1270
    Cell Significance Index: -9.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1387
    Cell Significance Index: -22.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.1391
    Cell Significance Index: -10.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Location**: SCAPER is primarily localized in the ER, where it interacts with S-phase cyclin A to regulate cell cycle progression. 2. **Expression**: SCAPER is expressed in a wide range of cell types, including hematopoietic cells, smooth muscle cells, mast cells, and T cells. 3. **Function**: SCAPER regulates S-phase cyclin A, which is involved in cell cycle progression and DNA replication. **Pathways and Functions** SCAPER is involved in various cellular pathways, including: 1. **Cell cycle regulation**: SCAPER regulates S-phase cyclin A, which is essential for cell cycle progression and DNA replication. 2. **Hematopoiesis**: SCAPER is expressed in hematopoietic cells and plays a crucial role in regulating cell cycle progression and differentiation. 3. **Immune cell development**: SCAPER is expressed in immune cells such as mast cells and T cells, where it regulates cell cycle progression and differentiation. 4. **Neurodevelopment**: SCAPER is involved in the development of the retina and camera-type eye. **Clinical Significance** 1. **Cancer research**: SCAPER has been implicated in various types of cancer, including leukemia and lymphoma, where it is involved in regulating cell cycle progression and differentiation. 2. **Immune system disorders**: SCAPER has been linked to immune system disorders such as autoimmune diseases and immunodeficiency syndromes. 3. **Neurological disorders**: SCAPER has been implicated in neurological disorders such as retinitis pigmentosa and other eye diseases. 4. **Hematological disorders**: SCAPER has been linked to hematological disorders such as anemia and leukemia. In conclusion, SCAPER is a multifunctional protein that plays a crucial role in regulating cell cycle progression, hematopoiesis, immune cell development, and neurodevelopment. Further research is necessary to fully understand the clinical significance of SCAPER and its potential applications in cancer research, immune system disorders, neurological disorders, and hematological disorders.

Genular Protein ID: 176502670

Symbol: SCAPE_HUMAN

Name: Zinc finger protein 291

UniProtKB Accession Codes:

Q9BY12 F5H7X8 H3BNR7 Q3B7X7 Q96BS9 Q9H3D8 Q9NT03 Q9P274

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 EMDB 1 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17698606

Title: SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression.

PubMed ID: 17698606

DOI: 10.1083/jcb.200701166

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28794130

Title: Mutations in SCAPER cause autosomal recessive retinitis pigmentosa with intellectual disability.

PubMed ID: 28794130

DOI: 10.1136/jmedgenet-2017-104632

Sequence Information:

  • Length: 1400
  • Mass: 158287
  • Checksum: 9DBAF02F75CB1AA7
  • Sequence:
    • MMASFQRSNS HDKVRRIVAE EGRTARNLIA WSVPLESKDD DGKPKCQTGG KSKRTIQGTH 
KTTKQSTAVD CKITSSTTGD KHFDKSPTKT RHPRKIDLRA RYWAFLFDNL RRAVDEIYVT 
CESDQSVVEC KEVLMMLDNY VRDFKALIDW IQLQEKLEKT DAQSRPTSLA WEVKKMSPGR 
HVIPSPSTDR INVTSNARRS LNFGGSTGTV PAPRLAPTGV SWADKVKAHH TGSTASSEIT 
PAQSCPPMTV QKASRKNERK DAEGWETVQR GRPIRSRSTA VMPKVSLATE ATRSKDDSDK 
ENVCLLPDES IQKGQFVGDG TSNTIESHPK DSLHSCDHPL AEKTQFTVST LDDVKNSGSI 
RDNYVRTSEI SAVHIDTECV SVMLQAGTPP LQVNEEKFPA EKARIENEMD PSDISNSMAE 
VLAKKEELAD RLEKANEEAI ASAIAEEEQL TREIEAEENN DINIETDNDS DFSASMGSGS 
VSFCGMSMDW NDVLADYEAR ESWRQNTSWG DIVEEEPARP PGHGIHMHEK LSSPSRKRTI 
AESKKKHEEK QMKAQQLREK LREEKTLKLQ KLLEREKDVR KWKEELLDQR RRMMEEKLLH 
AEFKREVQLQ AIVKKAQEEE AKVNEIAFIN TLEAQNKRHD VLSKLKEYEQ RLNELQEERQ 
RRQEEKQARD EAVQERKRAL EAERQARVEE LLMKRKEQEA RIEQQRQEKE KAREDAARER 
ARDREERLAA LTAAQQEAME ELQKKIQLKH DESIRRHMEQ IEQRKEKAAE LSSGRHANTD 
YAPKLTPYER KKQCSLCNVL ISSEVYLFSH VKGRKHQQAV RENTSIQGRE LSDEEVEHLS 
LKKYIIDIVV ESTAPAEALK DGEERQKNKK KAKKIKARMN FRAKEYESLM ETKNSGSDSP 
YKAKLQRLAK DLLKQVQVQD SGSWANNKVS ALDRTLGEIT RILEKENVAD QIAFQAAGGL 
TALEHILQAV VPATNVNTVL RIPPKSLCNA INVYNLTCNN CSENCSDVLF SNKITFLMDL 
LIHQLTVYVP DENNTILGRN TNKQVFEGLT TGLLKVSAVV LGCLIANRPD GNCQPATPKI 
PTQEMKNKPS QGDPFNNRVQ DLISYVVNMG LIDKLCACFL SVQGPVDENP KMAIFLQHAA 
GLLHAMCTLC FAVTGRSYSI FDNNRQDPTG LTAALQATDL AGVLHMLYCV LFHGTILDPS 
TASPKENYTQ NTIQVAIQSL RFFNSFAALH LPAFQSIVGA EGLSLAFRHM ASSLLGHCSQ 
VSCESLLHEV IVCVGYFTVN HPDNQVIVQS GRHPTVLQKL CQLPFQYFSD PRLIKVLFPS 
LIAACYNNHQ NKIILEQEMS CVLLATFIQD LAQTPGQAEN QPYQPKGKCL GSQDYLELAN 
RFPQQAWEEA RQFFLKKEKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.