Details for: CLDN20

Gene ID: 49861

Symbol: CLDN20

Ensembl ID: ENSG00000171217

Description: claudin 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 3.4576
    Cell Significance Index: 47.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3845
    Cell Significance Index: -3.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.2907
    Cell Significance Index: 19.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4291
    Cell Significance Index: 11.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4063
    Cell Significance Index: 80.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2632
    Cell Significance Index: 5.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1949
    Cell Significance Index: 3.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1215
    Cell Significance Index: 3.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1193
    Cell Significance Index: 9.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1123
    Cell Significance Index: 3.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0841
    Cell Significance Index: 16.8700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0734
    Cell Significance Index: 2.3200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0728
    Cell Significance Index: 1.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0623
    Cell Significance Index: 3.8300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0556
    Cell Significance Index: 0.7900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0415
    Cell Significance Index: 0.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0409
    Cell Significance Index: 55.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0355
    Cell Significance Index: 1.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0328
    Cell Significance Index: 14.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0319
    Cell Significance Index: 9.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0285
    Cell Significance Index: 10.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0283
    Cell Significance Index: 43.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0267
    Cell Significance Index: 3.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0239
    Cell Significance Index: 44.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0200
    Cell Significance Index: 0.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0096
    Cell Significance Index: 0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0076
    Cell Significance Index: 14.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0046
    Cell Significance Index: 0.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0006
    Cell Significance Index: 0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0018
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -4.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0077
    Cell Significance Index: -0.9400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0078
    Cell Significance Index: -0.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0079
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0094
    Cell Significance Index: -5.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0099
    Cell Significance Index: -5.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0132
    Cell Significance Index: -1.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0179
    Cell Significance Index: -0.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0262
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0266
    Cell Significance Index: -5.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0267
    Cell Significance Index: -1.8900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0326
    Cell Significance Index: -0.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0342
    Cell Significance Index: -2.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0352
    Cell Significance Index: -0.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0396
    Cell Significance Index: -5.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0402
    Cell Significance Index: -2.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0429
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0463
    Cell Significance Index: -5.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0478
    Cell Significance Index: -5.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0478
    Cell Significance Index: -2.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0481
    Cell Significance Index: -1.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0487
    Cell Significance Index: -5.0700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0621
    Cell Significance Index: -0.8000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0635
    Cell Significance Index: -0.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0717
    Cell Significance Index: -3.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0738
    Cell Significance Index: -0.9200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0763
    Cell Significance Index: -0.7900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0879
    Cell Significance Index: -0.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0889
    Cell Significance Index: -4.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0918
    Cell Significance Index: -2.0100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0920
    Cell Significance Index: -1.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1014
    Cell Significance Index: -2.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1030
    Cell Significance Index: -5.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1046
    Cell Significance Index: -2.1900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1078
    Cell Significance Index: -1.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1084
    Cell Significance Index: -3.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1202
    Cell Significance Index: -4.2100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1247
    Cell Significance Index: -2.0000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1250
    Cell Significance Index: -1.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1286
    Cell Significance Index: -6.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1288
    Cell Significance Index: -3.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1300
    Cell Significance Index: -4.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1310
    Cell Significance Index: -4.2900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1352
    Cell Significance Index: -2.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1395
    Cell Significance Index: -2.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1437
    Cell Significance Index: -4.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1463
    Cell Significance Index: -2.1000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1476
    Cell Significance Index: -1.3100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1554
    Cell Significance Index: -2.2100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1623
    Cell Significance Index: -3.9600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1632
    Cell Significance Index: -2.6900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1707
    Cell Significance Index: -2.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1717
    Cell Significance Index: -2.9600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1824
    Cell Significance Index: -3.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1838
    Cell Significance Index: -3.6900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1866
    Cell Significance Index: -2.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1884
    Cell Significance Index: -5.4000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1888
    Cell Significance Index: -4.7100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1911
    Cell Significance Index: -4.8700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1917
    Cell Significance Index: -4.7800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1964
    Cell Significance Index: -2.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1975
    Cell Significance Index: -2.4500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1998
    Cell Significance Index: -3.9500
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.2011
    Cell Significance Index: -2.0800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2041
    Cell Significance Index: -4.2600
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.2042
    Cell Significance Index: -2.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2092
    Cell Significance Index: -5.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2104
    Cell Significance Index: -2.8700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2143
    Cell Significance Index: -4.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Claudin 20 is a transmembrane protein belonging to the claudin family, characterized by its unique structure and function. It is a member of the claudin-1 to claudin-16 subfamily and is specifically expressed in various cell types, including megakaryocyte-erythroid progenitor cells, epidermal Langerhans cells, and hepatocytes. Claudin 20 exhibits a high degree of sequence homology with other claudins, but its expression pattern and functional characteristics are distinct. Notably, claudin 20 is not involved in calcium-dependent cell-cell adhesion, unlike other claudins, which highlights its unique role in maintaining cellular homeostasis. **Pathways and Functions:** Claudin 20 plays a critical role in the formation and maintenance of tight junctions, which are essential for regulating the permeability of epithelial and endothelial barriers. Tight junctions are composed of claudins, occludins, and junctional adhesion molecules, and their dysregulation can lead to various diseases. Claudin 20 is involved in the following pathways: 1. **Bicellular tight junction assembly:** Claudin 20 interacts with occludin and junctional adhesion molecules to form functional tight junctions. 2. **Calcium-independent cell-cell adhesion:** Claudin 20 is a calcium-independent claudin, which means it does not require calcium ions to facilitate cell-cell adhesion. 3. **Cell-cell communication:** Claudin 20 is involved in the regulation of cell-cell communication, including the transmission of signals between adjacent cells. 4. **Cell adhesion:** Claudin 20 regulates cell adhesion by interacting with other proteins, such as integrins and cadherins. **Clinical Significance:** Dysregulation of claudin 20 has been implicated in various diseases, including: 1. **Cancer:** Claudin 20 is often downregulated in various types of cancer, including breast, lung, and colon cancer, which can lead to increased cell motility and invasion. 2. **Inflammatory disorders:** Claudin 20 is involved in the regulation of inflammatory responses, and its dysregulation can contribute to inflammatory disorders, such as arthritis and asthma. 3. **Neurological disorders:** Claudin 20 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular disease:** Claudin 20 is involved in the regulation of blood pressure and cardiovascular function, and its dysregulation can contribute to cardiovascular disease. In conclusion, claudin 20 plays a critical role in maintaining cellular homeostasis and regulating cell-cell interactions. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the function and regulation of claudin 20 in maintaining human health.

Genular Protein ID: 2433116030

Symbol: CLD20_HUMAN

Name: Claudin-20

UniProtKB Accession Codes:

P56880

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 219
  • Mass: 23515
  • Checksum: D2F5FAD2AAB66306
  • Sequence:
    • MASAGLQLLA FILALSGVSG VLTATLLPNW KVNVDVDSNI ITAIVQLHGL WMDCTWYSTG 
MFSCALKHSI LSLPIHVQAA RATMVLACVL SALGICTSTV GMKCTRLGGD RETKSHASFA 
GGVCFMSAGI SSLISTVWYT KEIIANFLDL TVPESNKHEP GGAIYIGFIS AMLLFISGMI 
FCTSCIKRNP EARLDPPTQQ PISNTQLENN STHNLKDYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.