Details for: P2RX4

Gene ID: 5025

Symbol: P2RX4

Ensembl ID: ENSG00000135124

Description: purinergic receptor P2X 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 121.8295
    Cell Significance Index: -18.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 64.6971
    Cell Significance Index: -16.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.6946
    Cell Significance Index: -18.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 45.1366
    Cell Significance Index: -21.3100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 40.5921
    Cell Significance Index: -20.8800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 31.7724
    Cell Significance Index: -21.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6372
    Cell Significance Index: -19.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.6862
    Cell Significance Index: -17.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9188
    Cell Significance Index: -19.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4047
    Cell Significance Index: -9.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6807
    Cell Significance Index: -9.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.3531
    Cell Significance Index: 162.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8153
    Cell Significance Index: 48.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0726
    Cell Significance Index: 106.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9071
    Cell Significance Index: 26.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8369
    Cell Significance Index: 166.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7705
    Cell Significance Index: 14.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7644
    Cell Significance Index: 35.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6614
    Cell Significance Index: 29.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6567
    Cell Significance Index: 9.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4857
    Cell Significance Index: 14.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4520
    Cell Significance Index: 90.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2912
    Cell Significance Index: 7.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2734
    Cell Significance Index: 37.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2683
    Cell Significance Index: 96.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2442
    Cell Significance Index: 18.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2325
    Cell Significance Index: 8.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2026
    Cell Significance Index: 36.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1953
    Cell Significance Index: 106.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1835
    Cell Significance Index: 126.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1627
    Cell Significance Index: 10.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1408
    Cell Significance Index: 24.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1404
    Cell Significance Index: 6.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1373
    Cell Significance Index: 3.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1334
    Cell Significance Index: 6.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1167
    Cell Significance Index: 105.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0889
    Cell Significance Index: 11.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0765
    Cell Significance Index: 1.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0735
    Cell Significance Index: 9.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0700
    Cell Significance Index: 9.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0357
    Cell Significance Index: 0.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0313
    Cell Significance Index: 13.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0216
    Cell Significance Index: 0.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0182
    Cell Significance Index: 0.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0175
    Cell Significance Index: 32.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0071
    Cell Significance Index: 5.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0011
    Cell Significance Index: 1.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -8.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0110
    Cell Significance Index: -7.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0191
    Cell Significance Index: -3.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0213
    Cell Significance Index: -15.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0227
    Cell Significance Index: -16.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0243
    Cell Significance Index: -11.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0260
    Cell Significance Index: -2.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0269
    Cell Significance Index: -3.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0283
    Cell Significance Index: -2.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0331
    Cell Significance Index: -18.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0352
    Cell Significance Index: -21.9700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0357
    Cell Significance Index: -0.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0447
    Cell Significance Index: -6.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0559
    Cell Significance Index: -6.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0603
    Cell Significance Index: -17.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0708
    Cell Significance Index: -8.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0797
    Cell Significance Index: -2.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0983
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1045
    Cell Significance Index: -22.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1059
    Cell Significance Index: -5.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1154
    Cell Significance Index: -3.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1163
    Cell Significance Index: -3.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1179
    Cell Significance Index: -8.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1443
    Cell Significance Index: -9.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1637
    Cell Significance Index: -17.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1741
    Cell Significance Index: -8.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1784
    Cell Significance Index: -4.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1811
    Cell Significance Index: -9.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2079
    Cell Significance Index: -12.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2207
    Cell Significance Index: -13.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2381
    Cell Significance Index: -2.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2456
    Cell Significance Index: -19.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2458
    Cell Significance Index: -6.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2491
    Cell Significance Index: -11.0200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2559
    Cell Significance Index: -1.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2566
    Cell Significance Index: -15.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2746
    Cell Significance Index: -14.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3013
    Cell Significance Index: -11.4100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3327
    Cell Significance Index: -3.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4294
    Cell Significance Index: -9.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4336
    Cell Significance Index: -12.4300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4476
    Cell Significance Index: -3.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4481
    Cell Significance Index: -14.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4512
    Cell Significance Index: -15.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4533
    Cell Significance Index: -14.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4772
    Cell Significance Index: -9.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4814
    Cell Significance Index: -10.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5139
    Cell Significance Index: -7.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5173
    Cell Significance Index: -18.9900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.5373
    Cell Significance Index: -7.7000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5460
    Cell Significance Index: -15.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** P2X4 is a tetrameric receptor composed of four subunits, each consisting of three transmembrane domains and an intracellular domain. This receptor is characterized by its high affinity for ATP and its ability to regulate calcium (Ca2+) influx into cells. P2X4 is primarily expressed on the surface of various immune cells, including macrophages, monocytes, and dendritic cells, as well as on neurons and other cells involved in pain sensation. **Pathways and Functions:** P2X4 is involved in multiple signaling pathways, including: 1. **Apoptotic signaling pathway:** P2X4 can modulate apoptosis (programmed cell death) by regulating Ca2+ influx and subsequent activation of pro-apoptotic and anti-apoptotic pathways. 2. **Calcium-mediated signaling:** P2X4 is a key regulator of Ca2+ influx, which is essential for various cellular processes, including muscle contraction, neurotransmitter release, and immune response. 3. **Inflammatory response:** P2X4 is activated by ATP released from damaged cells, leading to the recruitment of immune cells and the promotion of inflammation. 4. **Pain sensation:** P2X4 is involved in the transmission of pain signals, particularly in the context of inflammatory pain. 5. **Neurological processes:** P2X4 is expressed on neurons and is involved in the regulation of synaptic transmission, neuronal survival, and neuroinflammation. **Clinical Significance:** The P2RX4 gene has significant implications in various diseases and conditions, including: 1. **Inflammatory disorders:** P2X4 is overexpressed in inflammatory conditions, such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. 2. **Pain disorders:** P2X4 is involved in the pathophysiology of chronic pain, including neuropathic pain and inflammatory pain. 3. **Neurological disorders:** P2X4 is implicated in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 4. **Cancer:** P2X4 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is involved in the regulation of tumor growth and metastasis. In conclusion, the P2RX4 gene plays a critical role in regulating various physiological and pathological processes, including inflammation, pain sensation, and immune response. Further research into the P2RX4 gene is necessary to elucidate its mechanisms of action and to explore its potential as a therapeutic target in various diseases and conditions.

Genular Protein ID: 1499303272

Symbol: P2RX4_HUMAN

Name: P2X purinoceptor 4

UniProtKB Accession Codes:

Q99571 E7EPF7 F6RU17 O00450 O14722 Q5U089 Q5U090 Q8N4N1 Q9UBG9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 15 Ensembl 3 ExpressionAtlas 1 GO 53 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 3 Rhea 3 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9016352

Title: Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue.

PubMed ID: 9016352

DOI: 10.1124/mol.51.1.109

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10515189

Title: Site-specific splice variation of the human P2X4 receptor.

PubMed ID: 10515189

DOI: 10.1016/s0304-3940(99)00653-9

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24817123

Title: P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH.

PubMed ID: 24817123

DOI: 10.1074/jbc.m114.552158

PubMed ID: 26456657

Title: The P2X7/P2X4 interaction shapes the purinergic response in murine macrophages.

PubMed ID: 26456657

DOI: 10.1016/j.bbrc.2015.10.025

PubMed ID: 35165166

Title: The Purinergic Receptor P2X4 Promotes Th17 Activation and the Development of Arthritis.

PubMed ID: 35165166

DOI: 10.4049/jimmunol.2100550

PubMed ID: 22068874

Title: A loss-of-function polymorphism in the human P2X4 receptor is associated with increased pulse pressure.

PubMed ID: 22068874

DOI: 10.1161/hypertensionaha.111.176180

PubMed ID: 23303206

Title: A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration.

PubMed ID: 23303206

DOI: 10.1096/fj.12-215368

PubMed ID: 28326637

Title: Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis.

PubMed ID: 28326637

DOI: 10.1002/humu.23218

Sequence Information:

  • Length: 388
  • Mass: 43369
  • Checksum: BA3BE7F30114C2A5
  • Sequence:
    • MAGCCAALAA FLFEYDTPRI VLIRSRKVGL MNRAVQLLIL AYVIGWVFVW EKGYQETDSV 
VSSVTTKVKG VAVTNTSKLG FRIWDVADYV IPAQEENSLF VMTNVILTMN QTQGLCPEIP 
DATTVCKSDA SCTAGSAGTH SNGVSTGRCV AFNGSVKTCE VAAWCPVEDD THVPQPAFLK 
AAENFTLLVK NNIWYPKFNF SKRNILPNIT TTYLKSCIYD AKTDPFCPIF RLGKIVENAG 
HSFQDMAVEG GIMGIQVNWD CNLDRAASLC LPRYSFRRLD TRDVEHNVSP GYNFRFAKYY 
RDLAGNEQRT LIKAYGIRFD IIVFGKAGKF DIIPTMINIG SGLALLGMAT VLCDIIVLYC 
MKKRLYYREK KYKYVEDYEQ GLASELDQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.