Details for: FURIN

Gene ID: 5045

Symbol: FURIN

Ensembl ID: ENSG00000140564

Description: furin, paired basic amino acid cleaving enzyme

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 115.9791
    Cell Significance Index: -18.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.4639
    Cell Significance Index: -18.3800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.0269
    Cell Significance Index: -17.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.3868
    Cell Significance Index: -20.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.6542
    Cell Significance Index: -17.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.1587
    Cell Significance Index: -18.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.0422
    Cell Significance Index: -18.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9847
    Cell Significance Index: -19.6700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.6461
    Cell Significance Index: 34.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4694
    Cell Significance Index: 159.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4662
    Cell Significance Index: 238.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1788
    Cell Significance Index: 34.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0740
    Cell Significance Index: 64.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7183
    Cell Significance Index: 19.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6722
    Cell Significance Index: 46.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6720
    Cell Significance Index: 31.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6374
    Cell Significance Index: 33.2000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.5234
    Cell Significance Index: 1.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4414
    Cell Significance Index: 195.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4237
    Cell Significance Index: 80.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4160
    Cell Significance Index: 82.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4094
    Cell Significance Index: 69.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3791
    Cell Significance Index: 10.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3562
    Cell Significance Index: 8.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3442
    Cell Significance Index: 187.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3406
    Cell Significance Index: 21.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3236
    Cell Significance Index: 9.2800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3224
    Cell Significance Index: 4.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3194
    Cell Significance Index: 16.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3185
    Cell Significance Index: 6.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3163
    Cell Significance Index: 38.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3013
    Cell Significance Index: 60.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3008
    Cell Significance Index: 5.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2940
    Cell Significance Index: 53.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2681
    Cell Significance Index: 7.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2399
    Cell Significance Index: 16.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2152
    Cell Significance Index: 21.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2005
    Cell Significance Index: 9.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1924
    Cell Significance Index: 5.1600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1725
    Cell Significance Index: 1.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1339
    Cell Significance Index: 92.6000
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.1312
    Cell Significance Index: 0.7300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1300
    Cell Significance Index: 1.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1142
    Cell Significance Index: 7.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1111
    Cell Significance Index: 15.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1050
    Cell Significance Index: 3.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0712
    Cell Significance Index: 25.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0460
    Cell Significance Index: 1.2300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0397
    Cell Significance Index: 0.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0217
    Cell Significance Index: 2.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0091
    Cell Significance Index: 6.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0016
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0071
    Cell Significance Index: -5.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0111
    Cell Significance Index: -20.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0114
    Cell Significance Index: -7.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0143
    Cell Significance Index: -22.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0162
    Cell Significance Index: -0.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0171
    Cell Significance Index: -23.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0176
    Cell Significance Index: -11.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0232
    Cell Significance Index: -3.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0247
    Cell Significance Index: -13.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0338
    Cell Significance Index: -3.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0342
    Cell Significance Index: -15.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0384
    Cell Significance Index: -4.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0391
    Cell Significance Index: -8.2400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0516
    Cell Significance Index: -0.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0547
    Cell Significance Index: -15.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0600
    Cell Significance Index: -6.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0766
    Cell Significance Index: -0.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0776
    Cell Significance Index: -9.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0784
    Cell Significance Index: -5.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0815
    Cell Significance Index: -11.8500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0905
    Cell Significance Index: -0.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0991
    Cell Significance Index: -2.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1169
    Cell Significance Index: -2.4900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1233
    Cell Significance Index: -1.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1408
    Cell Significance Index: -3.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1576
    Cell Significance Index: -12.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1686
    Cell Significance Index: -2.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1688
    Cell Significance Index: -11.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1808
    Cell Significance Index: -1.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1812
    Cell Significance Index: -2.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1842
    Cell Significance Index: -19.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2318
    Cell Significance Index: -18.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2423
    Cell Significance Index: -4.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2468
    Cell Significance Index: -15.1700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2575
    Cell Significance Index: -4.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2606
    Cell Significance Index: -13.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2926
    Cell Significance Index: -16.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2968
    Cell Significance Index: -12.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2972
    Cell Significance Index: -9.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3022
    Cell Significance Index: -15.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3050
    Cell Significance Index: -7.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3314
    Cell Significance Index: -20.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3476
    Cell Significance Index: -12.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3872
    Cell Significance Index: -17.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4032
    Cell Significance Index: -8.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4098
    Cell Significance Index: -10.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** Furin is a serine-type endopeptidase that cleaves dibasic amino acid sequences, resulting in the activation of precursor proteins. 2. **Cellular Expression:** Furin is expressed in various tissues, including the salivary gland, pancreas, and prostate, as well as in immune cells, such as T cells and macrophages. 3. **Substrate Specificity:** Furin cleaves a wide range of substrates, including growth factors, hormones, and viral proteins. 4. **Regulatory Mechanisms:** Furin is regulated by various mechanisms, including feedback inhibition, allosteric modulation, and proteolytic processing. **Pathways and Functions:** 1. **Immune Regulation:** Furin plays a crucial role in regulating immune responses, including the processing and activation of cytokines, chemokines, and growth factors. 2. **Viral Replication:** Furin is involved in the processing and activation of viral proteins, including HIV, SARS-CoV-2, and Leishmania parasites. 3. **Cellular Signaling:** Furin regulates various cellular signaling pathways, including the Notch, Wnt, and TGF-β signaling pathways. 4. **Protein Processing:** Furin is involved in the processing and activation of precursor proteins, including growth factors, hormones, and viral proteins. **Clinical Significance:** 1. **HIV Infection:** Furin is involved in the processing and activation of HIV proteins, making it a potential target for therapeutic interventions. 2. **SARS-CoV-2 Infection:** Furin is involved in the processing and activation of SARS-CoV-2 proteins, making it a potential target for therapeutic interventions. 3. **Leishmania Infection:** Furin is involved in the processing and activation of Leishmania proteins, making it a potential target for therapeutic interventions. 4. **Cancer:** Furin is involved in the processing and activation of growth factors and hormones, making it a potential target for therapeutic interventions in cancer. **Conclusion:** Furin is a multifaceted enzyme that plays a crucial role in various biological processes, including immune regulation, viral replication, and cellular signaling. Its clinical significance in various diseases, including HIV, SARS-CoV-2, and Leishmania infections, highlights the potential for furin as a therapeutic target. Further research is needed to fully elucidate the mechanisms of furin and its role in disease. **Recommendations:** 1. **Further Research:** Conduct further research to elucidate the mechanisms of furin and its role in disease. 2. **Therapeutic Interventions:** Develop therapeutic interventions targeting furin to treat diseases such as HIV, SARS-CoV-2, and Leishmania infections. 3. **Immunotherapy:** Explore the use of furin as an immunotherapeutic agent to regulate immune responses and prevent disease. **Limitations:** 1. **Limited Understanding:** The mechanisms of furin are not fully understood, and further research is needed to elucidate its role in disease. 2. **Lack of Therapeutic Interventions:** There is a lack of therapeutic interventions targeting furin, and further research is needed to develop effective treatments. 3. **Complexity of Furin:** Furin is a complex enzyme with multiple substrates and regulatory mechanisms, making it challenging to develop effective therapeutic interventions.

Genular Protein ID: 1934831896

Symbol: FURIN_HUMAN

Name: Dibasic-processing enzyme

UniProtKB Accession Codes:

P09958 Q14336 Q6LBS3 Q9UCZ5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 ELM 1 EMBL 4 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 52 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 40 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 21 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2408021

Title: Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2.

PubMed ID: 2408021

DOI: 10.1093/nar/18.3.664

PubMed ID: 2251280

Title: Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.

PubMed ID: 2251280

DOI: 10.1073/pnas.87.23.9378

PubMed ID: 1713771

Title: cDNA and gene structure for a human subtilisin-like protease with cleavage specificity for paired basic amino acid residues.

PubMed ID: 1713771

DOI: 10.1089/dna.1991.10.319

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2674906

Title: Nucleotide sequence analysis of the human fur gene.

PubMed ID: 2674906

DOI: 10.1093/nar/17.17.7101

PubMed ID: 3023061

Title: Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.

PubMed ID: 3023061

DOI: 10.1002/j.1460-2075.1986.tb04484.x

PubMed ID: 7690548

Title: A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells.

PubMed ID: 7690548

DOI: 10.1006/bbrc.1993.2146

PubMed ID: 7592877

Title: A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation.

PubMed ID: 7592877

DOI: 10.1074/jbc.270.44.26565

PubMed ID: 1629222

Title: Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage.

PubMed ID: 1629222

DOI: 10.1016/s0021-9258(19)49712-3

PubMed ID: 1644824

Title: Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

PubMed ID: 1644824

DOI: 10.1016/s0021-9258(18)42016-9

PubMed ID: 1438214

Title: Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.

PubMed ID: 1438214

DOI: 10.1073/pnas.89.21.10277

PubMed ID: 8253774

Title: Evidence for involvement of furin in cleavage and activation of diphtheria toxin.

PubMed ID: 8253774

DOI: 10.1016/s0021-9258(19)74337-3

PubMed ID: 7737999

Title: Processing of transforming growth factor beta 1 precursor by human furin convertase.

PubMed ID: 7737999

DOI: 10.1074/jbc.270.18.10618

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31091448

Title: Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting furin-mediated processing of viral envelope proteins.

PubMed ID: 31091448

DOI: 10.1016/j.celrep.2019.04.063

PubMed ID: 8020465

Title: Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases.

PubMed ID: 8020465

DOI: 10.1111/j.1432-1033.1994.tb18864.x

PubMed ID: 8846780

Title: Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail.

PubMed ID: 8846780

DOI: 10.1002/j.1460-2075.1995.tb00275.x

PubMed ID: 9130696

Title: Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage.

PubMed ID: 9130696

DOI: 10.1093/emboj/16.7.1508

PubMed ID: 9412467

Title: Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway.

PubMed ID: 9412467

DOI: 10.1083/jcb.139.7.1719

PubMed ID: 11331585

Title: PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.

PubMed ID: 11331585

DOI: 10.1093/emboj/20.9.2191

PubMed ID: 11799113

Title: The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation.

PubMed ID: 11799113

DOI: 10.1074/jbc.m108740200

PubMed ID: 20489134

Title: Processing of pro-B-type natriuretic peptide: furin and corin as candidate convertases.

PubMed ID: 20489134

DOI: 10.1373/clinchem.2010.143883

PubMed ID: 21763278

Title: Glycosylation and processing of pro-B-type natriuretic peptide in cardiomyocytes.

PubMed ID: 21763278

DOI: 10.1016/j.bbrc.2011.06.192

PubMed ID: 27582320

Title: The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation.

PubMed ID: 27582320

DOI: 10.1038/srep32371

PubMed ID: 32703818

Title: TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells.

PubMed ID: 32703818

DOI: 10.26508/lsa.202000786

PubMed ID: 32362314

Title: A multibasic cleavage site in the Spike protein of SARS-CoV-2 is essential for infection of human lung cells.

PubMed ID: 32362314

DOI: 10.1016/j.molcel.2020.04.022

PubMed ID: 32295904

Title: Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein.

PubMed ID: 32295904

DOI: 10.1128/jvi.00050-20

PubMed ID: 34699015

Title: Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin.

PubMed ID: 34699015

DOI: 10.1007/s10719-021-10018-8

PubMed ID: 24666235

Title: X-ray structures of human furin in complex with competitive inhibitors.

PubMed ID: 24666235

DOI: 10.1021/cb500087x

PubMed ID: 25974265

Title: Novel Furin inhibitors with potent anti-infectious activity.

PubMed ID: 25974265

DOI: 10.1002/cmdc.201500103

PubMed ID: 32867305

Title: COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells.

PubMed ID: 32867305

DOI: 10.3390/genes11091010

Sequence Information:

  • Length: 794
  • Mass: 86678
  • Checksum: 10C44DD5892EF85D
  • Sequence:
    • MELRPWLLWV VAATGTLVLL AADAQGQKVF TNTWAVRIPG GPAVANSVAR KHGFLNLGQI 
FGDYYHFWHR GVTKRSLSPH RPRHSRLQRE PQVQWLEQQV AKRRTKRDVY QEPTDPKFPQ 
QWYLSGVTQR DLNVKAAWAQ GYTGHGIVVS ILDDGIEKNH PDLAGNYDPG ASFDVNDQDP 
DPQPRYTQMN DNRHGTRCAG EVAAVANNGV CGVGVAYNAR IGGVRMLDGE VTDAVEARSL 
GLNPNHIHIY SASWGPEDDG KTVDGPARLA EEAFFRGVSQ GRGGLGSIFV WASGNGGREH 
DSCNCDGYTN SIYTLSISSA TQFGNVPWYS EACSSTLATT YSSGNQNEKQ IVTTDLRQKC 
TESHTGTSAS APLAAGIIAL TLEANKNLTW RDMQHLVVQT SKPAHLNAND WATNGVGRKV 
SHSYGYGLLD AGAMVALAQN WTTVAPQRKC IIDILTEPKD IGKRLEVRKT VTACLGEPNH 
ITRLEHAQAR LTLSYNRRGD LAIHLVSPMG TRSTLLAARP HDYSADGFND WAFMTTHSWD 
EDPSGEWVLE IENTSEANNY GTLTKFTLVL YGTAPEGLPV PPESSGCKTL TSSQACVVCE 
EGFSLHQKSC VQHCPPGFAP QVLDTHYSTE NDVETIRASV CAPCHASCAT CQGPALTDCL 
SCPSHASLDP VEQTCSRQSQ SSRESPPQQQ PPRLPPEVEA GQRLRAGLLP SHLPEVVAGL 
SCAFIVLVFV TVFLVLQLRS GFSFRGVKVY TMDRGLISYK GLPPEAWQEE CPSDSEEDEG 
RGERTAFIKD QSAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.