Details for: NOX4

Gene ID: 50507

Symbol: NOX4

Ensembl ID: ENSG00000086991

Description: NADPH oxidase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 28.2803
    Cell Significance Index: -11.6500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.6904
    Cell Significance Index: 31.7800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 3.8951
    Cell Significance Index: 55.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.8505
    Cell Significance Index: 116.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.6001
    Cell Significance Index: 80.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0729
    Cell Significance Index: 20.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.9434
    Cell Significance Index: 5.7000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4576
    Cell Significance Index: 7.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2796
    Cell Significance Index: 15.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1930
    Cell Significance Index: 38.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0550
    Cell Significance Index: 103.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0234
    Cell Significance Index: 1.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0078
    Cell Significance Index: 5.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0030
    Cell Significance Index: 4.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0012
    Cell Significance Index: 0.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0050
    Cell Significance Index: -0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0088
    Cell Significance Index: -16.2400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0118
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0119
    Cell Significance Index: -8.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0122
    Cell Significance Index: -8.9600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0157
    Cell Significance Index: -0.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0176
    Cell Significance Index: -6.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0177
    Cell Significance Index: -13.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0242
    Cell Significance Index: -13.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0249
    Cell Significance Index: -4.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0249
    Cell Significance Index: -13.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0258
    Cell Significance Index: -11.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0317
    Cell Significance Index: -9.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0415
    Cell Significance Index: -4.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0434
    Cell Significance Index: -5.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0476
    Cell Significance Index: -8.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0486
    Cell Significance Index: -7.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0595
    Cell Significance Index: -12.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0664
    Cell Significance Index: -11.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0692
    Cell Significance Index: -1.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0722
    Cell Significance Index: -9.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0854
    Cell Significance Index: -10.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0870
    Cell Significance Index: -11.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0955
    Cell Significance Index: -7.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1013
    Cell Significance Index: -11.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1129
    Cell Significance Index: -12.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1235
    Cell Significance Index: -9.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1239
    Cell Significance Index: -12.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1276
    Cell Significance Index: -2.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1550
    Cell Significance Index: -11.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1639
    Cell Significance Index: -11.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1651
    Cell Significance Index: -7.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1716
    Cell Significance Index: -4.4100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1788
    Cell Significance Index: -1.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1985
    Cell Significance Index: -10.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2015
    Cell Significance Index: -3.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2088
    Cell Significance Index: -2.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2094
    Cell Significance Index: -9.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2115
    Cell Significance Index: -8.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2170
    Cell Significance Index: -7.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2211
    Cell Significance Index: -3.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2308
    Cell Significance Index: -10.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2416
    Cell Significance Index: -5.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2446
    Cell Significance Index: -4.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2486
    Cell Significance Index: -8.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2527
    Cell Significance Index: -6.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2564
    Cell Significance Index: -13.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2570
    Cell Significance Index: -11.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2636
    Cell Significance Index: -13.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2640
    Cell Significance Index: -12.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2783
    Cell Significance Index: -4.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2791
    Cell Significance Index: -8.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2808
    Cell Significance Index: -9.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2809
    Cell Significance Index: -7.5000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2863
    Cell Significance Index: -2.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2961
    Cell Significance Index: -4.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3138
    Cell Significance Index: -8.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3154
    Cell Significance Index: -9.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3209
    Cell Significance Index: -10.2200
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3453
    Cell Significance Index: -4.0100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.3498
    Cell Significance Index: -3.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3543
    Cell Significance Index: -7.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3594
    Cell Significance Index: -7.8700
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.3676
    Cell Significance Index: -3.7100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.3736
    Cell Significance Index: -4.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3778
    Cell Significance Index: -10.7800
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.3891
    Cell Significance Index: -4.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4040
    Cell Significance Index: -14.8300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4221
    Cell Significance Index: -10.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4227
    Cell Significance Index: -13.3700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4247
    Cell Significance Index: -3.6100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4295
    Cell Significance Index: -8.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4363
    Cell Significance Index: -11.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4602
    Cell Significance Index: -12.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4605
    Cell Significance Index: -12.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4723
    Cell Significance Index: -11.7800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4743
    Cell Significance Index: -9.9000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4747
    Cell Significance Index: -3.7900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4770
    Cell Significance Index: -6.8600
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.4810
    Cell Significance Index: -5.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4842
    Cell Significance Index: -12.3700
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.4914
    Cell Significance Index: -6.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4930
    Cell Significance Index: -13.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5126
    Cell Significance Index: -14.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NOX4 exhibits several distinct characteristics that set it apart from other NADPH oxidases: 1. **Non-phagocytic expression**: NOX4 is primarily expressed in non-phagocytic cells, which suggests that its ROS-generating activity may be involved in signaling and cellular differentiation processes. 2. **Low activity**: NOX4 has a lower activity compared to other NADPH oxidases, which may contribute to its specific role in regulating cellular responses to stimuli. 3. **Unique subcellular localization**: NOX4 is localized to the plasma membrane and endoplasmic reticulum, which may allow for the regulation of ROS production and signaling pathways. **Pathways and Functions** NOX4 is involved in various cellular processes, including: 1. **Cellular responses to stimuli**: NOX4 is activated in response to various stimuli, such as growth factors, cytokines, and mechanical stress, which can lead to the production of ROS and subsequent signaling cascades. 2. **Cell differentiation and development**: NOX4 plays a role in the differentiation of certain cell types, including skeletal muscle fibroblasts and retinal progenitor cells. 3. **Inflammation and immune response**: NOX4 can contribute to the production of ROS in inflammatory cells, which can modulate the immune response and tissue damage. 4. **Cardiac function and disease**: NOX4 is expressed in cardiac tissue and has been implicated in cardiac function and disease, including hypertension and heart failure. **Clinical Significance** Dysregulation of NOX4 has been implicated in various diseases, including: 1. **Cardiovascular disease**: Increased NOX4 activity has been linked to hypertension, cardiac hypertrophy, and heart failure. 2. **Cancer**: NOX4 has been shown to promote cancer progression and metastasis in certain types of cancer, including breast and lung cancer. 3. **Neurological disorders**: NOX4 dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Inflammatory disorders**: NOX4 can contribute to the production of ROS in inflammatory cells, which can exacerbate conditions such as asthma and rheumatoid arthritis. In conclusion, NOX4 is a complex enzyme that plays a multifaceted role in various cellular processes, including cell differentiation, inflammation, and disease. Further research is needed to fully understand the mechanisms of NOX4 regulation and its clinical significance in various diseases.

Genular Protein ID: 878156691

Symbol: NOX4_HUMAN

Name: NADPH oxidase 4

UniProtKB Accession Codes:

Q9NPH5 A8K715 B7Z520 E7EMD7 Q5K3R4 Q5K3R5 Q5K3R6 Q5K3R8 Q7Z7G3 Q86V92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 16 Ensembl 10 ExpressionAtlas 1 GO 39 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 3 RefSeq 7 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10869423

Title: Identification of renox, an NAD(P)H oxidase in kidney.

PubMed ID: 10869423

DOI: 10.1073/pnas.130135897

PubMed ID: 11376945

Title: Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.

PubMed ID: 11376945

DOI: 10.1016/s0378-1119(01)00449-8

PubMed ID: 11032835

Title: A novel superoxide-producing NAD(P)H oxidase in kidney.

PubMed ID: 11032835

DOI: 10.1074/jbc.m007597200

PubMed ID: 15210697

Title: NADPH oxidase-dependent acid production in airway epithelial cells.

PubMed ID: 15210697

DOI: 10.1074/jbc.m404983200

PubMed ID: 15721269

Title: Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells.

PubMed ID: 15721269

DOI: 10.1016/j.bbrc.2005.01.089

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15155719

Title: Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells.

PubMed ID: 15155719

DOI: 10.1074/jbc.m400078200

PubMed ID: 15356101

Title: Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B.

PubMed ID: 15356101

DOI: 10.4049/jimmunol.173.6.3589

PubMed ID: 14966267

Title: The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction.

PubMed ID: 14966267

DOI: 10.1128/mcb.24.5.1844-1854.2004

PubMed ID: 15572675

Title: NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells.

PubMed ID: 15572675

DOI: 10.1128/mcb.24.24.10703-10717.2004

PubMed ID: 16230378

Title: Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma.

PubMed ID: 16230378

DOI: 10.1158/0008-5472.can-05-2105

PubMed ID: 16179589

Title: NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts.

PubMed ID: 16179589

DOI: 10.1161/01.res.0000187457.24338.3d

PubMed ID: 16324151

Title: The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells.

PubMed ID: 16324151

DOI: 10.1111/j.1365-2443.2005.00907.x

PubMed ID: 15927447

Title: Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases.

PubMed ID: 15927447

DOI: 10.1016/j.cellsig.2005.03.023

PubMed ID: 16019190

Title: NOX4 as an oxygen sensor to regulate TASK-1 activity.

PubMed ID: 16019190

DOI: 10.1016/j.cellsig.2005.05.025

PubMed ID: 21343298

Title: The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4.

PubMed ID: 21343298

DOI: 10.1074/jbc.m110.192138

PubMed ID: 23393389

Title: A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells.

PubMed ID: 23393389

DOI: 10.1161/atvbaha.112.300956

PubMed ID: 25062272

Title: Nox4: a hydrogen peroxide-generating oxygen sensor.

PubMed ID: 25062272

DOI: 10.1021/bi500331y

PubMed ID: 26742780

Title: Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2alpha-mediated stress signaling.

PubMed ID: 26742780

DOI: 10.15252/embj.201592394

Sequence Information:

  • Length: 578
  • Mass: 66932
  • Checksum: D150A92CC71DD40D
  • Sequence:
    • MAVSWRSWLA NEGVKHLCLF IWLSMNVLLF WKTFLLYNQG PEYHYLHQML GLGLCLSRAS 
ASVLNLNCSL ILLPMCRTLL AYLRGSQKVP SRRTRRLLDK SRTFHITCGV TICIFSGVHV 
AAHLVNALNF SVNYSEDFVE LNAARYRDED PRKLLFTTVP GLTGVCMVVV LFLMITASTY 
AIRVSNYDIF WYTHNLFFVF YMLLTLHVSG GLLKYQTNLD THPPGCISLN RTSSQNISLP 
EYFSEHFHEP FPEGFSKPAE FTQHKFVKIC MEEPRFQANF PQTWLWISGP LCLYCAERLY 
RYIRSNKPVT IISVMSHPSD VMEIRMVKEN FKARPGQYIT LHCPSVSALE NHPFTLTMCP 
TETKATFGVH LKIVGDWTER FRDLLLPPSS QDSEILPFIQ SRNYPKLYID GPFGSPFEES 
LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFR WFADLLCMLH 
NKFWQENRPD YVNIQLYLSQ TDGIQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK 
TVGVFCCGPN SLSKTLHKLS NQNNSYGTRF EYNKESFS

Genular Protein ID: 229424761

Symbol: B3KQ17_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KQ17

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 SAM 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 554
  • Mass: 64054
  • Checksum: B2D1C4CFF26147BD
  • Sequence:
    • MNVLLFWKTF LLYNQGPEYH YLHQMLGLGL CLSRASASVL NLNCSLILLP MCRTLLAYLR 
GSQKVPSRRT RRLLDKSRTF HITCGVAICI FSGVHVAAHL VNALNFSVNY SEDFVELNAA 
RYRDEDPRKL LFTTVPGLTG VCMVVVLFLM ITASTYAIRV SNYDIFWYTH NLFFVFYMLL 
TLHVSGGLLK YQTNLDTHPP GCISLNRTSS QNISLPEYFS EHFHEPFPEG FSKPAEFTQH 
KFVKICMEEP RFQANFPQTW LWISGPLCLY CAERLYRYIR SNKPVTIISV ISHPSDVMEI 
RMVKENFKAR PGQYITLHCP SVSALENHPF TLTMCPTETK ATFGVHLKIV GDWTERFRDL 
LLPPSSQDSE ILPFIQSRNY PKLYIDGPFG SPFEESLNYE VSLCVAGGIG VTPFASILNT 
LLDDWKPYKL RRLYFIWVCR DIQSFRWFAD LLCMLHNKFW QENRPDYVNI QLYLSQTDGI 
QKIIGEKYHA LNSRLFIGRP RWKLLFDEIA KYNRGKTVGV FCCGPNSLSK TLHKLSNQNN 
SYGTRFEYNK ESFS

Genular Protein ID: 406772558

Symbol: B7Z523_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z523

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SUPFAM 2

Sequence Information:

  • Length: 599
  • Mass: 69703
  • Checksum: FCC0112BA547B08A
  • Sequence:
    • MGEMWRKREE VIFREYSFSF YPLNIFALFI LFPDYFCLLG FIWLSMNVLL FWKTFLLYNQ 
GPEYHYLHQM LGLGLCLSRA SASVLNLNCS LILLPMCRTL LAYLRGSQKV PSRRTRRLLD 
KSRTFHITCG VTICIFSGVH VAAHLVNALN FSVNYSEDFV ELNAARYRDE DPRKLLFTTV 
PGLTGVCMVV VLFLMITAST YAIRVSNYDI FWYTHNLFFV FYMLLTLHVS GGLLKYQTNL 
DTHPPGCISL NRTSSQNISL PEYFSEHFHE PFPEGFSKPA EFTQHKFVKI CMEEPRFQAN 
FPQTWLWISG PLCLYCAERL YRYIRSNKPV TIISVISHPS DVMEIRMVKE NFKARPGQYI 
TLHCPSVSAL ENHPFTLTMC PTETKATFGV HLKIVGDWTE RFRDLLLPPS SQDSEILPFI 
QSRNYPKLYI DGPFGSPFEE SLNYEVSLCV AGGIGVTPFA SILNTLLDDW KPYKLRRLYF 
IWVCRDIQSF RWFADLLCML HNKFWQENRP DYVNIQLYLS QTDGIQKIIG EKYHALNSRL 
FIGRPRWKLL FDEIAKYNRG KTVGVFCCGP NSLSKTLHKL SNQNNSYGTR FEYNKESFS

Genular Protein ID: 3007500146

Symbol: B7Z529_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z529

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SUPFAM 2

Sequence Information:

  • Length: 553
  • Mass: 63453
  • Checksum: 6F424572B5053904
  • Sequence:
    • MLSAVTDLGS IESTVSKNLP VVSIHQLGLC LSRASASVLN LNCSLILLPM CRTLLAYLRG 
SQKVPSRRTR RLLDKSRTFH ITCGVTICIF SGVHVAAHLV NALNFSVNYS EDFVELNAAR 
YRDEDPRKLL FTTVPGLTGV CMVVVLFLMI TASTYAIRVS NYDIFWYTHN LFFVFYMLLT 
LHVSGGLLKY QTNLDTHPPG CISLNRTSSQ NISLPEYFSE HFHEPFPEGF SKPAEFTQHK 
FVKICMEEPR FQANFPQTWL WISGPLCLYC AERLYRYIRS NKPVTIISVI SHPSDVMEIR 
MVKENFKARP GQYITLHCPS VSALENHPFT LTMCPTETKA TFGVHLKIVG DWTERFRDLL 
LPPSSQDSEI LPFIQSRNYP KLYIDGPFGS PFEESLNYEV SLCVAGGIGV TPFASILNTL 
LDDWKPYKLR RLYFIWVCRD IQSFRWFADL LCMLHNKFWQ ENRPDYVNIQ LYLSQTDGIQ 
KIIGEKYHAL NSRLFIGRPR WKLLFDEIAK YNRGKTVGVF CCGPNSLSKT LHKLSNQNNS 
YGTRFEYNKE SFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.