Details for: PAFAH2

Gene ID: 5051

Symbol: PAFAH2

Ensembl ID: ENSG00000158006

Description: platelet activating factor acetylhydrolase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 67.8259
    Cell Significance Index: -10.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.1745
    Cell Significance Index: -10.1900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.5319
    Cell Significance Index: -9.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.6102
    Cell Significance Index: -10.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6297
    Cell Significance Index: -10.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0689
    Cell Significance Index: -10.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7116
    Cell Significance Index: -10.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.1429
    Cell Significance Index: -4.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9547
    Cell Significance Index: 135.1800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.6100
    Cell Significance Index: 26.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.5475
    Cell Significance Index: 41.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1254
    Cell Significance Index: 67.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8948
    Cell Significance Index: 88.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8803
    Cell Significance Index: 12.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8447
    Cell Significance Index: 98.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8351
    Cell Significance Index: 753.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8241
    Cell Significance Index: 89.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6490
    Cell Significance Index: 14.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5336
    Cell Significance Index: 86.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5302
    Cell Significance Index: 27.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4350
    Cell Significance Index: 6.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3297
    Cell Significance Index: 20.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3144
    Cell Significance Index: 2.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2998
    Cell Significance Index: 59.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2963
    Cell Significance Index: 4.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2879
    Cell Significance Index: 13.0500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2595
    Cell Significance Index: 2.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2591
    Cell Significance Index: 19.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2497
    Cell Significance Index: 155.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2007
    Cell Significance Index: 4.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1986
    Cell Significance Index: 37.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1860
    Cell Significance Index: 4.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1779
    Cell Significance Index: 32.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1503
    Cell Significance Index: 7.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1421
    Cell Significance Index: 4.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1353
    Cell Significance Index: 3.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1273
    Cell Significance Index: 88.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1203
    Cell Significance Index: 14.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1199
    Cell Significance Index: 24.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1160
    Cell Significance Index: 63.3700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1160
    Cell Significance Index: 2.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1092
    Cell Significance Index: 2.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0823
    Cell Significance Index: 14.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0680
    Cell Significance Index: 24.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0553
    Cell Significance Index: 3.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0552
    Cell Significance Index: 1.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0333
    Cell Significance Index: 4.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0330
    Cell Significance Index: 14.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0325
    Cell Significance Index: 1.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0300
    Cell Significance Index: 3.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0227
    Cell Significance Index: 42.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0100
    Cell Significance Index: 18.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0095
    Cell Significance Index: 14.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0086
    Cell Significance Index: 5.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0038
    Cell Significance Index: 5.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0005
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0038
    Cell Significance Index: -0.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0046
    Cell Significance Index: -2.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0048
    Cell Significance Index: -2.6800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0067
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0070
    Cell Significance Index: -5.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0148
    Cell Significance Index: -2.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0159
    Cell Significance Index: -0.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0191
    Cell Significance Index: -1.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0191
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0250
    Cell Significance Index: -5.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0259
    Cell Significance Index: -7.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0282
    Cell Significance Index: -2.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0297
    Cell Significance Index: -3.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0347
    Cell Significance Index: -3.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0358
    Cell Significance Index: -0.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0478
    Cell Significance Index: -6.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0718
    Cell Significance Index: -5.0800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0731
    Cell Significance Index: -3.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0731
    Cell Significance Index: -3.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0733
    Cell Significance Index: -8.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0828
    Cell Significance Index: -5.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0836
    Cell Significance Index: -3.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0866
    Cell Significance Index: -3.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0939
    Cell Significance Index: -9.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0995
    Cell Significance Index: -7.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1042
    Cell Significance Index: -6.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1140
    Cell Significance Index: -7.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1161
    Cell Significance Index: -1.9900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1202
    Cell Significance Index: -0.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1203
    Cell Significance Index: -3.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1231
    Cell Significance Index: -4.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1300
    Cell Significance Index: -7.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1538
    Cell Significance Index: -2.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1593
    Cell Significance Index: -3.6800
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1626
    Cell Significance Index: -1.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1692
    Cell Significance Index: -8.5500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1712
    Cell Significance Index: -2.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1785
    Cell Significance Index: -4.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1943
    Cell Significance Index: -5.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2149
    Cell Significance Index: -4.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2173
    Cell Significance Index: -6.9200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2213
    Cell Significance Index: -3.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2254
    Cell Significance Index: -6.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PAFAH2 is a member of the acetylhydrolase family of enzymes, which catalyze the hydrolysis of acetyl groups from phospholipids. The PAFAH2 enzyme specifically hydrolyzes the ester bond between the acetyl group and the phospholipid, resulting in the degradation of PAF. This enzyme has been shown to have a high substrate specificity, with a preference for the 1-alkyl-2-acetylglycerophosphocholine ester. **Pathways and Functions:** PAFAH2 is involved in several key pathways, including: 1. **Lipid Catabolic Process**: PAFAH2 plays a critical role in the degradation of PAF, a potent lipid mediator involved in inflammation, platelet activation, and hemostasis. 2. **Blood Coagulation**: By regulating PAF levels, PAFAH2 contributes to the maintenance of hemostasis and the prevention of excessive bleeding. 3. **Endoplasmic Reticulum Membrane**: PAFAH2 has been localized to the endoplasmic reticulum membrane, where it is thought to regulate PAF signaling. 4. **Cytoplasm**: PAFAH2 has been found in the cytoplasm of various cells, where it is involved in the degradation of PAF and the regulation of lipid metabolism. **Clinical Significance:** Dysregulation of PAFAH2 has been implicated in various diseases, including: 1. **Atherosclerosis**: Elevated PAF levels have been linked to the development of atherosclerosis, a condition characterized by the buildup of fatty deposits in the arteries. 2. **Inflammatory Disorders**: PAFAH2 has been shown to play a role in the regulation of inflammatory responses, making it a potential target for the treatment of inflammatory disorders such as arthritis and asthma. 3. **Cardiovascular Disease**: PAFAH2 has been implicated in the pathogenesis of cardiovascular disease, including myocardial infarction and stroke. In conclusion, PAFAH2 is a crucial enzyme involved in lipid metabolism and hemostasis. Its dysregulation has been linked to various diseases, highlighting the potential importance of this gene in the development of novel therapeutic strategies. Further research is needed to fully elucidate the mechanisms of PAFAH2 and its role in human disease.

Genular Protein ID: 3703851198

Symbol: PAFA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99487 D3DPK1 O15458 Q5SY02

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 43 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 ESTHER 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 18 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8955149

Title: cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase.

PubMed ID: 8955149

DOI: 10.1074/jbc.271.51.33032

PubMed ID: 9494101

Title: Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor.

PubMed ID: 9494101

DOI: 10.1042/bj3301309

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9218411

Title: Platelet-activating factor acetylhydrolases.

PubMed ID: 9218411

DOI: 10.1074/jbc.272.29.17895

Sequence Information:

  • Length: 392
  • Mass: 44036
  • Checksum: 690FB7E6F5B68317
  • Sequence:
    • MGVNQSVGFP PVTGPHLVGC GDVMEGQNLQ GSFFRLFYPC QKAEETMEQP LWIPRYEYCT 
GLAEYLQFNK RCGGLLFNLA VGSCRLPVSW NGPFKTKDSG YPLIIFSHGL GAFRTLYSAF 
CMELASRGFV VAVPEHRDRS AATTYFCKQA PEENQPTNES LQEEWIPFRR VEEGEKEFHV 
RNPQVHQRVS ECLRVLKILQ EVTAGQTVFN ILPGGLDLMT LKGNIDMSRV AVMGHSFGGA 
TAILALAKET QFRCAVALDA WMFPLERDFY PKARGPVFFI NTEKFQTMES VNLMKKICAQ 
HEQSRIITVL GSVHRSQTDF AFVTGNLIGK FFSTETRGSL DPYEGQEVMV RAMLAFLQKH 
LDLKEDYNQW NNLIEGIGPS LTPGAPHHLS SL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.