Details for: SYCP3

Gene ID: 50511

Symbol: SYCP3

Ensembl ID: ENSG00000139351

Description: synaptonemal complex protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 34.8452
    Cell Significance Index: -5.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.0532
    Cell Significance Index: -5.3400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 8.2311
    Cell Significance Index: 62.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.4284
    Cell Significance Index: -5.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.8963
    Cell Significance Index: -5.0800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.9342
    Cell Significance Index: 6.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7734
    Cell Significance Index: 11.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.7166
    Cell Significance Index: 12.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6707
    Cell Significance Index: 51.4700
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.6062
    Cell Significance Index: 3.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5606
    Cell Significance Index: 11.9400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.5527
    Cell Significance Index: 6.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4591
    Cell Significance Index: 8.9600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.4337
    Cell Significance Index: 3.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4182
    Cell Significance Index: 41.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4092
    Cell Significance Index: 81.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3587
    Cell Significance Index: 323.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3551
    Cell Significance Index: 7.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3451
    Cell Significance Index: 37.5400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2434
    Cell Significance Index: 4.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2327
    Cell Significance Index: 37.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2077
    Cell Significance Index: 41.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1734
    Cell Significance Index: 11.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1674
    Cell Significance Index: 10.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1666
    Cell Significance Index: 2.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1602
    Cell Significance Index: 23.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1536
    Cell Significance Index: 4.1200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.1144
    Cell Significance Index: 1.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1064
    Cell Significance Index: 38.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0984
    Cell Significance Index: 2.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0945
    Cell Significance Index: 3.3200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0933
    Cell Significance Index: 1.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0927
    Cell Significance Index: 4.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0889
    Cell Significance Index: 16.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0859
    Cell Significance Index: 2.0600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0787
    Cell Significance Index: 1.0500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0641
    Cell Significance Index: 0.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0613
    Cell Significance Index: 2.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0570
    Cell Significance Index: 2.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0534
    Cell Significance Index: 3.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0412
    Cell Significance Index: 77.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0388
    Cell Significance Index: 1.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0374
    Cell Significance Index: 0.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0310
    Cell Significance Index: 5.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0230
    Cell Significance Index: 0.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0156
    Cell Significance Index: 0.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0143
    Cell Significance Index: 9.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0142
    Cell Significance Index: 21.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0126
    Cell Significance Index: 17.1400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0114
    Cell Significance Index: 0.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0111
    Cell Significance Index: 0.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0105
    Cell Significance Index: 0.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0090
    Cell Significance Index: 0.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0052
    Cell Significance Index: 9.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0025
    Cell Significance Index: 1.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0012
    Cell Significance Index: 0.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0014
    Cell Significance Index: -0.6400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0016
    Cell Significance Index: -0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0057
    Cell Significance Index: -4.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0059
    Cell Significance Index: -3.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0064
    Cell Significance Index: -4.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0074
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0085
    Cell Significance Index: -4.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0088
    Cell Significance Index: -5.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0095
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0129
    Cell Significance Index: -2.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0144
    Cell Significance Index: -4.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0206
    Cell Significance Index: -2.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0242
    Cell Significance Index: -5.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0258
    Cell Significance Index: -0.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0263
    Cell Significance Index: -3.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0293
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0293
    Cell Significance Index: -3.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0296
    Cell Significance Index: -1.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0333
    Cell Significance Index: -4.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0366
    Cell Significance Index: -0.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0370
    Cell Significance Index: -2.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0400
    Cell Significance Index: -1.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0401
    Cell Significance Index: -4.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0406
    Cell Significance Index: -4.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0435
    Cell Significance Index: -5.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0468
    Cell Significance Index: -1.4900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0497
    Cell Significance Index: -0.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0497
    Cell Significance Index: -1.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0498
    Cell Significance Index: -1.6300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0528
    Cell Significance Index: -1.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0532
    Cell Significance Index: -3.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0551
    Cell Significance Index: -4.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0599
    Cell Significance Index: -3.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0614
    Cell Significance Index: -3.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0634
    Cell Significance Index: -1.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0652
    Cell Significance Index: -1.8600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0698
    Cell Significance Index: -1.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0751
    Cell Significance Index: -2.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0842
    Cell Significance Index: -1.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0911
    Cell Significance Index: -3.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0986
    Cell Significance Index: -2.1300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1043
    Cell Significance Index: -1.3000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1045
    Cell Significance Index: -1.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** SYCP3 is primarily expressed in germ cells, hematopoietic stem cells, and certain epithelial cells. Its expression is also observed in other cell types, including skeletal muscle and cardiac muscle cells. 2. **Function:** SYCP3 is a crucial component of the synaptonemal complex, facilitating chromosomal pairing and synapsis during meiosis. This process is essential for the accurate segregation of genetic material during gamete formation. 3. **Cellular Localization:** SYCP3 is localized to the lateral elements of the synaptonemal complex, where it interacts with other proteins to regulate chromosomal pairing and recombination. 4. **Regulation:** SYCP3 is subject to post-translational modifications, including phosphorylation and ubiquitination, which regulate its activity and localization. **Pathways and Functions:** 1. **Meiotic Synapsis:** SYCP3 plays a central role in the formation of the synaptonemal complex, which is essential for chromosomal pairing and synapsis during meiosis. 2. **Cell Cycle Regulation:** SYCP3 is involved in the regulation of the cell cycle, particularly during the G2/M phase, where it interacts with other proteins to ensure proper chromosomal segregation. 3. **DNA Binding:** SYCP3 has been shown to bind to DNA, regulating chromosomal recombination and the formation of meiotic crossovers. 4. **Protein Interaction:** SYCP3 interacts with other proteins, including synaptonemal complex proteins and histone modifications, to regulate chromosomal pairing and recombination. **Clinical Significance:** 1. **Immune Function:** SYCP3 has been implicated in the regulation of immune cell development and function, particularly in the context of hematopoietic stem cells. 2. **Reproductive Disorders:** Dysregulation of SYCP3 has been linked to reproductive disorders, including infertility and meiotic failure. 3. **Cancer:** Alterations in SYCP3 expression and function have been observed in certain types of cancer, including leukemia and lymphoma. 4. **Therapeutic Target:** SYCP3 has emerged as a potential therapeutic target for the treatment of reproductive disorders and immune-related diseases. In conclusion, SYCP3 is a critical component of the synaptonemal complex, playing a pivotal role in meiotic chromosomal pairing and synapsis. Its implications in immune function and disease highlight the need for further research into the regulation and function of SYCP3. As a potential therapeutic target, SYCP3 offers new avenues for the treatment of reproductive disorders and immune-related diseases.

Genular Protein ID: 1537565707

Symbol: SYCP3_HUMAN

Name: Synaptonemal complex protein 3

UniProtKB Accession Codes:

Q8IZU3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12213195

Title: A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region.

PubMed ID: 12213195

DOI: 10.1006/geno.2002.6834

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14643120

Title: Azoospermia in patients heterozygous for a mutation in SYCP3.

PubMed ID: 14643120

DOI: 10.1016/s0140-6736(03)14845-3

PubMed ID: 19110213

Title: Mutations of the SYCP3 gene in women with recurrent pregnancy loss.

PubMed ID: 19110213

DOI: 10.1016/j.ajhg.2008.12.002

PubMed ID: 24950965

Title: A molecular model for the role of SYCP3 in meiotic chromosome organisation.

PubMed ID: 24950965

DOI: 10.7554/elife.02963

Sequence Information:

  • Length: 236
  • Mass: 27729
  • Checksum: D871B6AEA279ABDD
  • Sequence:
    • MVSSGKKYSR KSGKPSVEDQ FTRAYDFETE DKKDLSGSEE DVIEGKTAVI EKRRKKRSSA 
GVVEDMGGEV QNMLEGVGVD INKALLAKRK RLEMYTKASL KTSNQKIEHV WKTQQDQRQK 
LNQEYSQQFL TLFQQWDLDM QKAEEQEEKI LNMFRQQQKI LQQSRIVQSQ RLKTIKQLYE 
QFIKSMEELE KNHDNLLTGA QNEFKKEMAM LQKKIMMETQ QQEIASVRKS LQSMLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.