Details for: MBL3P

Gene ID: 50639

Symbol: MBL3P

Ensembl ID: ENSG00000219430

Description: mannose-binding lectin family member 3, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2075
    Cell Significance Index: 2.1200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0241
    Cell Significance Index: 0.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0231
    Cell Significance Index: 0.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0048
    Cell Significance Index: 0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0038
    Cell Significance Index: 0.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0011
    Cell Significance Index: -0.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0039
    Cell Significance Index: -0.5700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0092
    Cell Significance Index: -0.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0162
    Cell Significance Index: -0.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0165
    Cell Significance Index: -0.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0175
    Cell Significance Index: -0.5600
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0200
    Cell Significance Index: -0.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0222
    Cell Significance Index: -0.4700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0231
    Cell Significance Index: -0.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0240
    Cell Significance Index: -0.5200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0249
    Cell Significance Index: -0.5000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0269
    Cell Significance Index: -0.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0278
    Cell Significance Index: -0.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0281
    Cell Significance Index: -0.5600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0299
    Cell Significance Index: -0.5200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0301
    Cell Significance Index: -0.5900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0314
    Cell Significance Index: -0.3900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0318
    Cell Significance Index: -0.3700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0347
    Cell Significance Index: -0.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0352
    Cell Significance Index: -0.4800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0361
    Cell Significance Index: -0.4500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0362
    Cell Significance Index: -0.4800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0366
    Cell Significance Index: -0.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0374
    Cell Significance Index: -0.4500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0377
    Cell Significance Index: -0.4600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0380
    Cell Significance Index: -0.4600
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0384
    Cell Significance Index: -0.3600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0414
    Cell Significance Index: -0.4600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0415
    Cell Significance Index: -0.4500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0449
    Cell Significance Index: -0.3700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0452
    Cell Significance Index: -0.5900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0459
    Cell Significance Index: -0.6300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0471
    Cell Significance Index: -0.4200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0472
    Cell Significance Index: -0.6200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0491
    Cell Significance Index: -0.6200
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0511
    Cell Significance Index: -0.5800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0518
    Cell Significance Index: -0.5900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0533
    Cell Significance Index: -0.6100
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0546
    Cell Significance Index: -0.6600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0549
    Cell Significance Index: -0.6100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0560
    Cell Significance Index: -0.6000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0565
    Cell Significance Index: -0.5300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0584
    Cell Significance Index: -0.4500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0585
    Cell Significance Index: -0.7000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0617
    Cell Significance Index: -0.6300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0883
    Cell Significance Index: -0.8000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0924
    Cell Significance Index: -0.5800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0932
    Cell Significance Index: -1.1000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0953
    Cell Significance Index: -0.6200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1045
    Cell Significance Index: -0.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The MBL3P gene is a pseudogene, meaning that it lacks a functional coding sequence and is unable to produce a protein. Despite this, it is expressed in numerous cell types, suggesting that it may play a regulatory role in gene expression or cellular processes. The pseudogene is also characterized by its high degree of conservation across species, indicating that it may have evolved from a functional ancestor. **Pathways and Functions** While the MBL3P gene is a pseudogene, its expression in various cell types suggests that it may be involved in regulating cellular processes such as cell signaling, immune response, and tissue development. Studies have shown that MBL3P is co-expressed with other genes involved in these pathways, such as the mannose-binding lectin gene (MBL), which plays a critical role in the innate immune response. This suggests that MBL3P may act as a regulator or modulator of MBL expression, influencing the immune response and cellular signaling pathways. **Clinical Significance** Despite its pseudogenic status, the MBL3P gene has been implicated in various diseases and disorders. For example, studies have shown that MBL3P is overexpressed in patients with certain types of cancer, such as breast and lung cancer. This suggests that MBL3P may play a role in tumorigenesis and cancer progression. Additionally, MBL3P has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's, where it may contribute to the development of these diseases. In conclusion, the MBL3P gene is a complex and enigmatic pseudogene that has been implicated in various cellular processes and diseases. Further research is needed to fully understand the functional significance of this gene and its potential role in regulating the immune response, tissue development, and disease progression. **Future Directions** Future studies should aim to elucidate the functional significance of the MBL3P gene and its potential role in regulating cellular processes. This may involve: 1. Investigating the role of MBL3P in immune response and tumorigenesis. 2. Examining the expression patterns of MBL3P in different cell types and tissues. 3. Analyzing the regulatory mechanisms that control MBL3P expression. 4. Exploring the potential therapeutic applications of MBL3P in the treatment of diseases. By addressing these questions, we can gain a deeper understanding of the MBL3P gene and its potential role in regulating cellular processes and disease progression.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.