Details for: SLC45A1

Gene ID: 50651

Symbol: SLC45A1

Ensembl ID: ENSG00000162426

Description: solute carrier family 45 member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.5672
    Cell Significance Index: -3.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1055
    Cell Significance Index: 50.1100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.0453
    Cell Significance Index: 16.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7899
    Cell Significance Index: 150.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5502
    Cell Significance Index: 54.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4934
    Cell Significance Index: 445.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4042
    Cell Significance Index: 279.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3389
    Cell Significance Index: 7.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3196
    Cell Significance Index: 64.1100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2924
    Cell Significance Index: 3.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2760
    Cell Significance Index: 44.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2620
    Cell Significance Index: 16.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2503
    Cell Significance Index: 13.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2218
    Cell Significance Index: 24.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1985
    Cell Significance Index: 8.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1868
    Cell Significance Index: 67.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1826
    Cell Significance Index: 5.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1713
    Cell Significance Index: 6.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1555
    Cell Significance Index: 4.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1155
    Cell Significance Index: 7.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0551
    Cell Significance Index: 3.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0543
    Cell Significance Index: 0.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0524
    Cell Significance Index: 1.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0497
    Cell Significance Index: 6.8300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0439
    Cell Significance Index: 0.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0420
    Cell Significance Index: 2.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0079
    Cell Significance Index: 10.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0076
    Cell Significance Index: 1.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0058
    Cell Significance Index: 8.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0056
    Cell Significance Index: 10.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0049
    Cell Significance Index: 0.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0038
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0037
    Cell Significance Index: 6.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0008
    Cell Significance Index: 0.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0010
    Cell Significance Index: -0.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0011
    Cell Significance Index: -0.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0027
    Cell Significance Index: -1.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0028
    Cell Significance Index: -0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0029
    Cell Significance Index: -1.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0034
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0083
    Cell Significance Index: -6.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0096
    Cell Significance Index: -1.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0097
    Cell Significance Index: -7.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0105
    Cell Significance Index: -5.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0118
    Cell Significance Index: -8.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0144
    Cell Significance Index: -8.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0184
    Cell Significance Index: -1.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0188
    Cell Significance Index: -2.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0194
    Cell Significance Index: -0.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0228
    Cell Significance Index: -6.5500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0252
    Cell Significance Index: -0.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0292
    Cell Significance Index: -0.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0364
    Cell Significance Index: -4.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0383
    Cell Significance Index: -8.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0397
    Cell Significance Index: -6.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0412
    Cell Significance Index: -0.5900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0480
    Cell Significance Index: -1.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0492
    Cell Significance Index: -5.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0520
    Cell Significance Index: -6.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0550
    Cell Significance Index: -6.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0589
    Cell Significance Index: -7.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0609
    Cell Significance Index: -6.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0609
    Cell Significance Index: -1.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0655
    Cell Significance Index: -4.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0694
    Cell Significance Index: -8.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0704
    Cell Significance Index: -5.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0833
    Cell Significance Index: -6.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0848
    Cell Significance Index: -2.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0901
    Cell Significance Index: -2.9500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0914
    Cell Significance Index: -1.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0932
    Cell Significance Index: -5.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0938
    Cell Significance Index: -1.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0949
    Cell Significance Index: -1.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0971
    Cell Significance Index: -1.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0984
    Cell Significance Index: -7.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1055
    Cell Significance Index: -3.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1156
    Cell Significance Index: -5.3900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1260
    Cell Significance Index: -1.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1264
    Cell Significance Index: -3.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1286
    Cell Significance Index: -6.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1286
    Cell Significance Index: -6.6800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1287
    Cell Significance Index: -4.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1300
    Cell Significance Index: -2.5700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1331
    Cell Significance Index: -1.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1356
    Cell Significance Index: -6.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1370
    Cell Significance Index: -3.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1409
    Cell Significance Index: -1.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1421
    Cell Significance Index: -3.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1422
    Cell Significance Index: -4.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1588
    Cell Significance Index: -3.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1634
    Cell Significance Index: -3.1900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1697
    Cell Significance Index: -1.1500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1736
    Cell Significance Index: -2.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1741
    Cell Significance Index: -4.9900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1782
    Cell Significance Index: -3.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1917
    Cell Significance Index: -6.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1925
    Cell Significance Index: -4.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1997
    Cell Significance Index: -5.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2030
    Cell Significance Index: -5.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2040
    Cell Significance Index: -7.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Solute Carrier Function**: The SLC45A1 gene encodes a protein that functions as a solute carrier, responsible for transporting sugars and protons across cellular membranes. 2. **Sugar Transport**: The gene is involved in the transport of glucose, galactose, sucrose, and protons, which are essential for maintaining cellular homeostasis. 3. **Cellular Expression**: The SLC45A1 gene is significantly expressed in various cell types, including epidermal Langerhans cells, enterocytes, decidual cells, and neurons. 4. **Protein Structure**: The protein encoded by the SLC45A1 gene, S45A1_HUMAN, is a transmembrane protein with multiple membrane-spanning domains. **Pathways and Functions:** 1. **D-Glucose:Proton Symporter Activity**: The SLC45A1 gene is involved in the transport of glucose and protons across cellular membranes, regulating glucose homeostasis. 2. **D-Glucose Transmembrane Transport**: The gene is responsible for the transport of glucose across cellular membranes, essential for maintaining cellular energy metabolism. 3. **Galactose:Proton Symporter Activity**: The SLC45A1 gene is involved in the transport of galactose and protons across cellular membranes, regulating galactose homeostasis. 4. **Galactose Transmembrane Transport**: The gene is responsible for the transport of galactose across cellular membranes, essential for maintaining cellular energy metabolism. 5. **Sucrose:Proton Symporter Activity**: The SLC45A1 gene is involved in the transport of sucrose and protons across cellular membranes, regulating sucrose homeostasis. 6. **Sucrose Transport**: The gene is responsible for the transport of sucrose across cellular membranes, essential for maintaining cellular energy metabolism. **Clinical Significance:** 1. **Neurological Disorders**: The SLC45A1 gene has been implicated in various neurological disorders, including neuroblastoma, Alzheimer's disease, and Parkinson's disease. 2. **Diabetes**: The gene is involved in glucose homeostasis, and alterations in SLC45A1 expression have been linked to diabetes. 3. **Cancer**: The SLC45A1 gene has been implicated in cancer development and progression, particularly in neuroblastoma and other sugar transport-related cancers. 4. **Neurodevelopmental Disorders**: The gene is expressed in neurons and has been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, the SLC45A1 gene plays a crucial role in maintaining cellular homeostasis through its involvement in sugar transport and proton symporter activities. Further research is necessary to fully understand the clinical significance of this gene and its implications in various diseases.

Genular Protein ID: 1895788613

Symbol: S45A1_HUMAN

Name: Deleted in neuroblastoma 5 protein

UniProtKB Accession Codes:

Q9Y2W3 A0A0A0MT80 A0A2H2EQP0 Q5VY46 Q5VY49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 2 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 10729226

Title: Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP.

PubMed ID: 10729226

DOI: 10.1006/geno.1999.6097

PubMed ID: 28434495

Title: Dysfunction of the cerebral glucose transporter SLC45A1 in individuals with intellectual disability and epilepsy.

PubMed ID: 28434495

DOI: 10.1016/j.ajhg.2017.03.009

PubMed ID: 27431290

Title: Clinical genomics expands the morbid genome of intellectual disability and offers a high diagnostic yield.

PubMed ID: 27431290

DOI: 10.1038/mp.2016.113

Sequence Information:

  • Length: 748
  • Mass: 80843
  • Checksum: 159F779C9EEF5A74
  • Sequence:
    • MIPAASSTPP GDALFPSVAP QDFWRSQVTG YSGSVTRHLS HRANNFKRHP KRRKCIRPSP 
PPPPNTPCPL ELVDFGDLHP QRSFRELLFN GCILFGIEFS YAMETAYVTP VLLQMGLPDQ 
LYSLVWFISP ILGFLLQPLL GAWSDRCTSR FGRRRPFILV LAIGALLGLS LLLNGRDIGI 
ALADVTGNHK WGLLLTVCGV VLMDFSADSA DNPSHAYMMD VCSPADQDRG LNIHALLAGL 
GGGFGYVVGG IHWDKTGFGR ALGGQLRVIY LFTAVTLSVT TVLTLVSIPE RPLRPPSEKR 
AAMKSPSLPL PPSPPVLPEE GPGDSLPSHT ATNFSSPISP PSPLTPKYGS FISRDSSLTG 
ISEFASSFGT ANIDSVLIDC FTGGHDSYLA IPGSVPRPPI SVSFPRAPDG FYRQDRGLLE 
GREGALTSGC DGDILRVGSL DTSKPRSSGI LKRPQTLAIP DAAGGGGPET SRRRNVTFSQ 
QVANILLNGV KYESELTGSS ERAEQPLSVG RLCSTICNMP KALRTLCVNH FLGWLSFEGM 
LLFYTDFMGE VVFQGDPKAP HTSEAYQKYN SGVTMGCWGM CIYAFSAAFY SAILEKLEEF 
LSVRTLYFIA YLAFGLGTGL ATLSRNLYVV LSLCITYGIL FSTLCTLPYS LLCDYYQSKK 
FAGSSADGTR RGMGVDISLL SCQYFLAQIL VSLVLGPLTS AVGSANGVMY FSSLVSFLGC 
LYSSLFVIYE IPPSDAADEE HRPLLLNV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.