Details for: PARN

Gene ID: 5073

Symbol: PARN

Ensembl ID: ENSG00000140694

Description: poly(A)-specific ribonuclease

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 227.8437
    Cell Significance Index: -35.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 135.9389
    Cell Significance Index: -34.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.8460
    Cell Significance Index: -37.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.6418
    Cell Significance Index: -30.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.8091
    Cell Significance Index: -34.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.3333
    Cell Significance Index: -30.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.7496
    Cell Significance Index: -36.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.8002
    Cell Significance Index: -34.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.6004
    Cell Significance Index: -35.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.4040
    Cell Significance Index: -22.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.3891
    Cell Significance Index: -37.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7532
    Cell Significance Index: 121.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6622
    Cell Significance Index: 333.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5510
    Cell Significance Index: 307.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3499
    Cell Significance Index: 34.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2780
    Cell Significance Index: 1153.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2653
    Cell Significance Index: 35.3600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.2615
    Cell Significance Index: 18.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2037
    Cell Significance Index: 25.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0378
    Cell Significance Index: 14.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9863
    Cell Significance Index: 75.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9724
    Cell Significance Index: 26.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9179
    Cell Significance Index: 99.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9090
    Cell Significance Index: 326.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8633
    Cell Significance Index: 51.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7717
    Cell Significance Index: 19.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7672
    Cell Significance Index: 530.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7466
    Cell Significance Index: 28.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7463
    Cell Significance Index: 33.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7103
    Cell Significance Index: 39.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6433
    Cell Significance Index: 18.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5803
    Cell Significance Index: 11.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5645
    Cell Significance Index: 66.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5105
    Cell Significance Index: 11.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4817
    Cell Significance Index: 56.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4660
    Cell Significance Index: 84.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3951
    Cell Significance Index: 48.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3367
    Cell Significance Index: 15.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2394
    Cell Significance Index: 32.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2090
    Cell Significance Index: 393.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1929
    Cell Significance Index: 85.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1884
    Cell Significance Index: 6.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1683
    Cell Significance Index: 8.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1644
    Cell Significance Index: 2.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1521
    Cell Significance Index: 83.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1406
    Cell Significance Index: 63.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1401
    Cell Significance Index: 7.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1397
    Cell Significance Index: 257.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1303
    Cell Significance Index: 200.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1132
    Cell Significance Index: 71.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0799
    Cell Significance Index: 108.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0720
    Cell Significance Index: 13.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0607
    Cell Significance Index: 1.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0455
    Cell Significance Index: 4.5000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0324
    Cell Significance Index: 0.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0152
    Cell Significance Index: -0.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0166
    Cell Significance Index: -2.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0324
    Cell Significance Index: -23.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0334
    Cell Significance Index: -25.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0336
    Cell Significance Index: -24.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0560
    Cell Significance Index: -31.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0665
    Cell Significance Index: -8.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0668
    Cell Significance Index: -41.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0686
    Cell Significance Index: -11.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0806
    Cell Significance Index: -1.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0873
    Cell Significance Index: -8.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1083
    Cell Significance Index: -5.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1106
    Cell Significance Index: -31.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1135
    Cell Significance Index: -7.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1807
    Cell Significance Index: -38.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2001
    Cell Significance Index: -25.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2049
    Cell Significance Index: -14.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2052
    Cell Significance Index: -21.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2285
    Cell Significance Index: -11.9000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2389
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2464
    Cell Significance Index: -28.2300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2512
    Cell Significance Index: -2.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2957
    Cell Significance Index: -18.6400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2990
    Cell Significance Index: -4.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3318
    Cell Significance Index: -24.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3446
    Cell Significance Index: -7.3400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3635
    Cell Significance Index: -8.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4047
    Cell Significance Index: -32.0500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4188
    Cell Significance Index: -5.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4403
    Cell Significance Index: -6.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4828
    Cell Significance Index: -10.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5055
    Cell Significance Index: -14.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5062
    Cell Significance Index: -26.5800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.5075
    Cell Significance Index: -6.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5190
    Cell Significance Index: -16.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5192
    Cell Significance Index: -11.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5654
    Cell Significance Index: -18.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5700
    Cell Significance Index: -12.4800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5722
    Cell Significance Index: -7.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5739
    Cell Significance Index: -18.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5879
    Cell Significance Index: -8.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5890
    Cell Significance Index: -36.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6216
    Cell Significance Index: -16.9200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6287
    Cell Significance Index: -10.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PARN is a member of the RNase A family and is characterized by its ability to degrade poly(A) tails, which are essential for mRNA stability and translation. PARN is a 3' to 5' exonuclease, meaning it reads the RNA strand from the 3' end to the 5' end, allowing it to target and degrade specific mRNA molecules. The enzyme is highly specific, with a preference for degrading poly(A) tails that are longer than 50 nucleotides. PARN is also known to interact with various proteins, including KSRP, which binds and destabilizes mRNA, and PKC, which regulates PARN activity. **Pathways and Functions** PARN is involved in several key RNA decay pathways, including: 1. **Deadenylation-dependent mRNA decay**: PARN is responsible for degrading poly(A) tails, which are essential for mRNA stability. By removing these tails, PARN regulates the half-life of mRNAs and prevents excessive expression of genes. 2. **Nonsense-mediated decay (NMD)**: PARN interacts with the NMD pathway, which is responsible for degrading mRNAs containing premature stop codons. PARN's activity is required for the efficient removal of these mRNAs from the cell. 3. **Telomerase RNA stabilization**: PARN interacts with telomerase RNA, which is essential for maintaining telomere length. By stabilizing telomerase RNA, PARN ensures that telomerase can efficiently carry out its function. 4. **Unfolded protein response (UPR)**: PARN is involved in the UPR, which is a cellular response to endoplasmic reticulum (ER) stress. PARN's activity is required for the efficient removal of mRNAs that are misfolded or aberrant, which helps to prevent ER stress. **Clinical Significance** Dysregulation of PARN has been implicated in various diseases, including: 1. **Cancer**: PARN's role in regulating mRNA stability and deadenylation makes it a potential target for cancer therapy. Cancer cells often exhibit altered PARN expression, which can contribute to their growth and survival. 2. **Neurodegenerative diseases**: PARN's interaction with telomerase RNA suggests that it may play a role in maintaining telomere length and preventing neurodegenerative diseases such as Alzheimer's and Parkinson's. 3. **Genetic disorders**: PARN's involvement in the NMD pathway makes it a potential target for treating genetic disorders caused by premature stop codons. In conclusion, PARN is a critical enzyme involved in the regulation of mRNA stability and deadenylation. Its widespread expression in various cell types and its involvement in multiple RNA decay pathways make it an important target for understanding the regulation of gene expression and the development of novel therapeutic strategies.

Genular Protein ID: 3116453332

Symbol: PARN_HUMAN

Name: Poly(A)-specific ribonuclease PARN

UniProtKB Accession Codes:

O95453 B2RCB3 B4DDG8 B4DSB0 B4DWR4 B4E1H6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 2 DisGeNET 1 EC 2 EMBL 10 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9736620

Title: The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes.

PubMed ID: 9736620

DOI: 10.1093/emboj/17.18.5427

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10640832

Title: The human gene for the poly(A)-specific ribonuclease (PARN) maps to 16p13 and has a truncated copy in the Prader-Willi/Angelman syndrome region on 15q11-->q13.

PubMed ID: 10640832

DOI: 10.1159/000015378

PubMed ID: 10801819

Title: A 54-kDa fragment of the Poly(A)-specific ribonuclease is an oligomeric, processive, and cap-interacting Poly(A)-specific 3' exonuclease.

PubMed ID: 10801819

DOI: 10.1074/jbc.m001705200

PubMed ID: 10882133

Title: Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro.

PubMed ID: 10882133

DOI: 10.1016/s1097-2765(00)80442-6

PubMed ID: 11359775

Title: The mRNA cap structure stimulates rate of poly(A) removal and amplifies processivity of degradation.

PubMed ID: 11359775

DOI: 10.1074/jbc.m102270200

PubMed ID: 11742007

Title: Identification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe(2+)-mediated cleavage.

PubMed ID: 11742007

DOI: 10.1074/jbc.m111515200

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 14527413

Title: Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.

PubMed ID: 14527413

DOI: 10.1016/s1097-2765(03)00349-6

PubMed ID: 12748283

Title: Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease.

PubMed ID: 12748283

DOI: 10.1128/mcb.23.11.3798-3812.2003

PubMed ID: 14731398

Title: Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU.

PubMed ID: 14731398

DOI: 10.1016/s1097-2765(03)00481-7

PubMed ID: 15175153

Title: A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.

PubMed ID: 15175153

DOI: 10.1016/j.molcel.2004.05.002

PubMed ID: 15358788

Title: Coordination of divalent metal ions in the active site of poly(A)-specific ribonuclease.

PubMed ID: 15358788

DOI: 10.1074/jbc.m403858200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16601207

Title: CUG-BP binds to RNA substrates and recruits PARN deadenylase.

PubMed ID: 16601207

DOI: 10.1261/rna.59606

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20932473

Title: DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.

PubMed ID: 20932473

DOI: 10.1016/j.molcel.2010.09.018

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21876179

Title: Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation.

PubMed ID: 21876179

DOI: 10.1073/pnas.1101676108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22442037

Title: Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming.

PubMed ID: 22442037

DOI: 10.1261/rna.032292.112

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25049417

Title: PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease.

PubMed ID: 25049417

DOI: 10.1073/pnas.1317751111

PubMed ID: 25893599

Title: Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.

PubMed ID: 25893599

DOI: 10.1172/jci78963

PubMed ID: 25848748

Title: Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening.

PubMed ID: 25848748

DOI: 10.1038/ng.3278

PubMed ID: 16281054

Title: Structural insight into poly(A) binding and catalytic mechanism of human PARN.

PubMed ID: 16281054

DOI: 10.1038/sj.emboj.7600869

Sequence Information:

  • Length: 639
  • Mass: 73451
  • Checksum: 6994BE39384DF7AC
  • Sequence:
    • MEIIRSNFKS NLHKVYQAIE EADFFAIDGE FSGISDGPSV SALTNGFDTP EERYQKLKKH 
SMDFLLFQFG LCTFKYDYTD SKYITKSFNF YVFPKPFNRS SPDVKFVCQS SSIDFLASQG 
FDFNKVFRNG IPYLNQEEER QLREQYDEKR SQANGAGALS YVSPNTSKCP VTIPEDQKKF 
IDQVVEKIED LLQSEENKNL DLEPCTGFQR KLIYQTLSWK YPKGIHVETL ETEKKERYIV 
ISKVDEEERK RREQQKHAKE QEELNDAVGF SRVIHAIANS GKLVIGHNML LDVMHTVHQF 
YCPLPADLSE FKEMTTCVFP RLLDTKLMAS TQPFKDIINN TSLAELEKRL KETPFNPPKV 
ESAEGFPSYD TASEQLHEAG YDAYITGLCF ISMANYLGSF LSPPKIHVSA RSKLIEPFFN 
KLFLMRVMDI PYLNLEGPDL QPKRDHVLHV TFPKEWKTSD LYQLFSAFGN IQISWIDDTS 
AFVSLSQPEQ VKIAVNTSKY AESYRIQTYA EYMGRKQEEK QIKRKWTEDS WKEADSKRLN 
PQCIPYTLQN HYYRNNSFTA PSTVGKRNLS PSQEEAGLED GVSGEISDTE LEQTDSCAEP 
LSEGRKKAKK LKRMKKELSP AGSISKNSPA TLFEVPDTW

Genular Protein ID: 1606683551

Symbol: B3KN69_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KN69

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 3 RefSeq 3 SAM 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 351
  • Mass: 40070
  • Checksum: 5F43352B6A8F8AA9
  • Sequence:
    • MLLDVMHTVH QFYCPLPADL SEFKEMTTCV FPRLLDTKLM ASTQPFKDII NNTSLAELEK 
RLKETPFNPP KVESAEGFPS YDTASEQLHE AGYDAYITGL CFISMANYLG SFLSPPKIHV 
SARSKLIEPF FNKLFLMRVM DIPYLNLEGP DLQPKRDHVL HVTFPKEWKT SDLYQLFSAF 
GNIQISWIDD TSAFVSLSQP EQVKIAVNTS KYAESYRIQT YAEYMGRKQE EKQIKRKWTE 
DSWKEADSKR LNPQCIPYTL QNHYYRNNSF TAPSTVGKRN LSPSQEEAGL EDGVSGEISD 
TELEQTDSCA EPLSEGRKKA KKLKRMKKEL SPAGSISKNS PATLFEVPDT W

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.