Details for: TAS2R10

Gene ID: 50839

Symbol: TAS2R10

Ensembl ID: ENSG00000121318

Description: taste 2 receptor member 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.5517
    Cell Significance Index: -2.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.2875
    Cell Significance Index: 140.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0628
    Cell Significance Index: 23.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8902
    Cell Significance Index: 40.3500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.8548
    Cell Significance Index: 12.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6296
    Cell Significance Index: 119.8300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5654
    Cell Significance Index: 8.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4846
    Cell Significance Index: 47.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4338
    Cell Significance Index: 13.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3821
    Cell Significance Index: 344.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2712
    Cell Significance Index: 5.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2450
    Cell Significance Index: 39.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2239
    Cell Significance Index: 24.3600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1656
    Cell Significance Index: 2.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1197
    Cell Significance Index: 8.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1151
    Cell Significance Index: 6.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0441
    Cell Significance Index: 1.2700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0189
    Cell Significance Index: 0.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0188
    Cell Significance Index: 3.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0066
    Cell Significance Index: 2.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0042
    Cell Significance Index: 0.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0041
    Cell Significance Index: 0.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0040
    Cell Significance Index: 0.0800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0028
    Cell Significance Index: 0.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0024
    Cell Significance Index: 0.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0015
    Cell Significance Index: 0.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0015
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0030
    Cell Significance Index: -1.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0031
    Cell Significance Index: -0.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0033
    Cell Significance Index: -1.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0046
    Cell Significance Index: -3.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0047
    Cell Significance Index: -0.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0082
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0085
    Cell Significance Index: -0.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0088
    Cell Significance Index: -0.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0092
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0104
    Cell Significance Index: -2.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0110
    Cell Significance Index: -1.9800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0117
    Cell Significance Index: -0.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0122
    Cell Significance Index: -0.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0126
    Cell Significance Index: -0.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0145
    Cell Significance Index: -1.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0160
    Cell Significance Index: -0.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0160
    Cell Significance Index: -1.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0183
    Cell Significance Index: -0.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0203
    Cell Significance Index: -2.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0214
    Cell Significance Index: -2.5200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0236
    Cell Significance Index: -0.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0286
    Cell Significance Index: -2.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0304
    Cell Significance Index: -0.6300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0334
    Cell Significance Index: -0.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0365
    Cell Significance Index: -2.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0384
    Cell Significance Index: -2.9500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0393
    Cell Significance Index: -0.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0408
    Cell Significance Index: -1.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0422
    Cell Significance Index: -0.8800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0422
    Cell Significance Index: -0.8300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0486
    Cell Significance Index: -0.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0492
    Cell Significance Index: -3.1800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0514
    Cell Significance Index: -0.7300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0540
    Cell Significance Index: -0.7200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0584
    Cell Significance Index: -0.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0616
    Cell Significance Index: -0.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0619
    Cell Significance Index: -2.9100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0622
    Cell Significance Index: -0.5900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0622
    Cell Significance Index: -1.2400
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0649
    Cell Significance Index: -0.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0656
    Cell Significance Index: -1.2800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0690
    Cell Significance Index: -0.7200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0690
    Cell Significance Index: -0.6600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0726
    Cell Significance Index: -1.0400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0731
    Cell Significance Index: -0.7000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0732
    Cell Significance Index: -0.7100
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0733
    Cell Significance Index: -0.7200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0769
    Cell Significance Index: -0.7300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0776
    Cell Significance Index: -1.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0836
    Cell Significance Index: -1.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0849
    Cell Significance Index: -2.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0863
    Cell Significance Index: -2.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0891
    Cell Significance Index: -2.3800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0895
    Cell Significance Index: -1.1700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0895
    Cell Significance Index: -1.3600
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0919
    Cell Significance Index: -0.7300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0949
    Cell Significance Index: -2.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1025
    Cell Significance Index: -3.0200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1043
    Cell Significance Index: -1.5600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1043
    Cell Significance Index: -1.5200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1082
    Cell Significance Index: -1.7400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1096
    Cell Significance Index: -1.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1108
    Cell Significance Index: -2.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1113
    Cell Significance Index: -3.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1131
    Cell Significance Index: -2.8900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1141
    Cell Significance Index: -0.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1144
    Cell Significance Index: -3.3600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1150
    Cell Significance Index: -1.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1158
    Cell Significance Index: -2.9500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1163
    Cell Significance Index: -1.6300
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.1191
    Cell Significance Index: -1.4400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1192
    Cell Significance Index: -0.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Bitter taste receptor**: TAS2R10 is a G-protein-coupled receptor (GPCR) that specifically binds to bitter compounds, triggering a signaling cascade that ultimately leads to the perception of bitter taste. 2. **Expression in various tissues**: TAS2R10 is expressed in multiple tissues, including blood vessel endothelial cells, enterocytes, colon goblet cells, and granulocyte monocyte progenitor cells, suggesting its involvement in various physiological processes beyond taste perception. 3. **Signaling pathways**: TAS2R10 activates multiple signaling pathways, including G alpha (i) signaling events, GPCR downstream signaling, and GPCR ligand binding, which ultimately modulate cellular responses to bitter compounds. 4. **Variability in bitter taste perception**: TAS2R10 variants have been associated with differences in bitter taste perception, highlighting the complex genetic factors that influence individual differences in taste sensitivity. **Pathways and Functions:** 1. **G protein-coupled receptor activity**: TAS2R10 binds to bitter compounds, triggering the activation of G-proteins and the subsequent initiation of downstream signaling pathways. 2. **G alpha (i) signaling events**: TAS2R10 activates G alpha (i) proteins, which modulate the activity of downstream effectors, including adenylyl cyclase and phospholipase C. 3. **GPCR downstream signaling**: TAS2R10 activates GPCR downstream signaling pathways, including the regulation of ion channels and the modulation of cellular responses to bitter compounds. 4. **Sensory perception of bitter taste**: TAS2R10 plays a critical role in the perception of bitter taste, allowing individuals to detect and discriminate between different bitter compounds. **Clinical Significance:** 1. **Bitter taste disorders**: TAS2R10 variants have been associated with bitter taste disorders, including impaired bitter taste perception and altered taste preferences. 2. **Dietary implications**: Understanding the role of TAS2R10 in bitter taste perception has significant implications for dietary recommendations, particularly for individuals with impaired bitter taste. 3. **Pharmacological applications**: TAS2R10 has been explored as a potential target for the development of novel bitter taste modulators, which could have therapeutic applications in the treatment of bitter taste disorders. 4. **Evolutionary conservation**: TAS2R10 has been conserved across species, suggesting its evolutionary importance in maintaining the delicate balance of bitter taste perception. In conclusion, TAS2R10 plays a critical role in the perception of bitter taste, and its dysregulation has significant implications for our understanding of bitter taste disorders and dietary recommendations. Further research is needed to fully elucidate the molecular mechanisms underlying TAS2R10 function and its clinical significance.

Genular Protein ID: 842300427

Symbol: T2R10_HUMAN

Name: Taste receptor type 2 member 10

UniProtKB Accession Codes:

Q9NYW0 Q3MIM9 Q6NTD9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 6 Ensembl 3 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10761934

Title: A novel family of mammalian taste receptors.

PubMed ID: 10761934

DOI: 10.1016/s0092-8674(00)80705-9

PubMed ID: 15496549

Title: Evolution of bitter taste receptors in humans and apes.

PubMed ID: 15496549

DOI: 10.1093/molbev/msi027

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10761935

Title: T2Rs function as bitter taste receptors.

PubMed ID: 10761935

DOI: 10.1016/s0092-8674(00)80706-0

PubMed ID: 15759003

Title: The receptors and coding logic for bitter taste.

PubMed ID: 15759003

DOI: 10.1038/nature03352

PubMed ID: 12139982

Title: Receptors for bitter and sweet taste.

PubMed ID: 12139982

DOI: 10.1016/s0959-4388(02)00345-8

PubMed ID: 11696554

Title: Molecular mechanisms of bitter and sweet taste transduction.

PubMed ID: 11696554

DOI: 10.1074/jbc.r100054200

PubMed ID: 12581520

Title: Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

PubMed ID: 12581520

DOI: 10.1016/s0092-8674(03)00071-0

Sequence Information:

  • Length: 307
  • Mass: 35365
  • Checksum: 058DD69A55AE71C6
  • Sequence:
    • MLRVVEGIFI FVVVSESVFG VLGNGFIGLV NCIDCAKNKL STIGFILTGL AISRIFLIWI 
IITDGFIQIF SPNIYASGNL IEYISYFWVI GNQSSMWFAT SLSIFYFLKI ANFSNYIFLW 
LKSRTNMVLP FMIVFLLISS LLNFAYIAKI LNDYKTKNDT VWDLNMYKSE YFIKQILLNL 
GVIFFFTLSL ITCIFLIISL WRHNRQMQSN VTGLRDSNTE AHVKAMKVLI SFIILFILYF 
IGMAIEISCF TVRENKLLLM FGMTTTAIYP WGHSFILILG NSKLKQASLR VLQQLKCCEK 
RKNLRVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.