Details for: CLEC4A

Gene ID: 50856

Symbol: CLEC4A

Ensembl ID: ENSG00000111729

Description: C-type lectin domain family 4 member A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 36.1310
    Cell Significance Index: -5.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.0245
    Cell Significance Index: -5.8400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 15.6692
    Cell Significance Index: -8.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.6068
    Cell Significance Index: -5.6800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.1659
    Cell Significance Index: 33.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.5744
    Cell Significance Index: 29.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.4952
    Cell Significance Index: -5.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.2765
    Cell Significance Index: 32.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5712
    Cell Significance Index: 25.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4807
    Cell Significance Index: 47.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3453
    Cell Significance Index: 65.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2383
    Cell Significance Index: 215.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1697
    Cell Significance Index: 4.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1418
    Cell Significance Index: 15.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1390
    Cell Significance Index: 22.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1297
    Cell Significance Index: 2.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1168
    Cell Significance Index: 7.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1042
    Cell Significance Index: 2.2200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0914
    Cell Significance Index: 0.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0814
    Cell Significance Index: 2.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0611
    Cell Significance Index: 12.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0600
    Cell Significance Index: 4.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0375
    Cell Significance Index: 1.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0355
    Cell Significance Index: 7.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0238
    Cell Significance Index: 16.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0230
    Cell Significance Index: 8.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0096
    Cell Significance Index: 0.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0013
    Cell Significance Index: -0.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0024
    Cell Significance Index: -1.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0035
    Cell Significance Index: -0.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0057
    Cell Significance Index: -0.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0068
    Cell Significance Index: -3.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0073
    Cell Significance Index: -1.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0078
    Cell Significance Index: -5.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0089
    Cell Significance Index: -2.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0100
    Cell Significance Index: -7.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0105
    Cell Significance Index: -7.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0138
    Cell Significance Index: -7.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0143
    Cell Significance Index: -0.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0166
    Cell Significance Index: -1.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0202
    Cell Significance Index: -2.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0211
    Cell Significance Index: -1.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0216
    Cell Significance Index: -2.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0303
    Cell Significance Index: -2.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0305
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0326
    Cell Significance Index: -4.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0383
    Cell Significance Index: -8.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0431
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0432
    Cell Significance Index: -7.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0433
    Cell Significance Index: -5.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0481
    Cell Significance Index: -1.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0518
    Cell Significance Index: -3.4800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0543
    Cell Significance Index: -0.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0546
    Cell Significance Index: -7.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0590
    Cell Significance Index: -1.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0595
    Cell Significance Index: -1.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0694
    Cell Significance Index: -3.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0711
    Cell Significance Index: -8.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0716
    Cell Significance Index: -4.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0730
    Cell Significance Index: -3.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0817
    Cell Significance Index: -4.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0831
    Cell Significance Index: -3.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0880
    Cell Significance Index: -4.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0911
    Cell Significance Index: -6.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0921
    Cell Significance Index: -1.8000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0944
    Cell Significance Index: -4.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0984
    Cell Significance Index: -7.7900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1258
    Cell Significance Index: -1.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1322
    Cell Significance Index: -6.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1332
    Cell Significance Index: -4.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1353
    Cell Significance Index: -4.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1396
    Cell Significance Index: -4.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1396
    Cell Significance Index: -3.9000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1455
    Cell Significance Index: -3.5300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1460
    Cell Significance Index: -1.9400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1496
    Cell Significance Index: -1.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1555
    Cell Significance Index: -7.2500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1619
    Cell Significance Index: -2.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1671
    Cell Significance Index: -3.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1681
    Cell Significance Index: -4.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1695
    Cell Significance Index: -4.8600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1698
    Cell Significance Index: -2.1000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1718
    Cell Significance Index: -2.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1773
    Cell Significance Index: -5.0600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1854
    Cell Significance Index: -1.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1862
    Cell Significance Index: -6.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1863
    Cell Significance Index: -4.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1868
    Cell Significance Index: -3.9100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1896
    Cell Significance Index: -2.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1948
    Cell Significance Index: -4.1400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1964
    Cell Significance Index: -4.1000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1988
    Cell Significance Index: -4.9600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1998
    Cell Significance Index: -1.8600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2002
    Cell Significance Index: -3.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2033
    Cell Significance Index: -8.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2060
    Cell Significance Index: -4.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2094
    Cell Significance Index: -7.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2109
    Cell Significance Index: -3.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2153
    Cell Significance Index: -6.8100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2168
    Cell Significance Index: -1.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLEC4A is a transmembrane glycoprotein with a single C-type lectin domain, which confers its ability to bind carbohydrates. The receptor is expressed on the surface of various cell types, including hematopoietic cells, dendritic cells, and epithelial cells. CLEC4A is characterized by its ability to recognize and bind to specific carbohydrate ligands, such as D-mannose and D-glucose, which are involved in various biological processes. **Pathways and Functions:** CLEC4A is involved in multiple signaling pathways, including: 1. **Adaptive Immune Response:** CLEC4A interacts with dendritic cells and T cells, modulating the adaptive immune response by regulating cytokine production and antigen presentation. 2. **Antifungal Innate Immune Response:** CLEC4A recognizes fungal pathogens and triggers an immune response by activating the NF-κB pathway and inducing the production of pro-inflammatory cytokines. 3. **Antigen Processing and Presentation:** CLEC4A interacts with MHC class I molecules, facilitating the presentation of exogenous peptide antigens to CD8+ T cells. 4. **Cell Adhesion:** CLEC4A mediates cell adhesion to the extracellular matrix, regulating cell migration and tissue repair. 5. **Calcium Ion Binding:** CLEC4A interacts with calcium ions, modulating signaling pathways and regulating cellular functions. **Clinical Significance:** CLEC4A has been implicated in various diseases, including: 1. **Autoimmune Disorders:** CLEC4A has been shown to regulate the immune response in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** CLEC4A has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential as a biomarker and therapeutic target. 3. **Infectious Diseases:** CLEC4A has been implicated in the recognition and elimination of fungal pathogens, making it a potential target for antifungal therapies. 4. **Neurological Disorders:** CLEC4A has been found to be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CLEC4A is a multifunctional C-type lectin receptor involved in various physiological processes, including immune response, cell adhesion, and antigen presentation. Its dysregulation has been implicated in various diseases, making it a promising target for therapeutic interventions. Further research is needed to fully elucidate the functions and clinical significance of CLEC4A.

Genular Protein ID: 2505366160

Symbol: CLC4A_HUMAN

Name: C-type lectin DDB27

UniProtKB Accession Codes:

Q9UMR7 Q17R69 Q8WXW9 Q9H2Z9 Q9NS33 Q9UI34

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10438934

Title: APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif.

PubMed ID: 10438934

PubMed ID: 11178971

Title: Cloning and characterization of a novel ITIM containing lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants.

PubMed ID: 11178971

DOI: 10.1006/bbrc.2001.4322

PubMed ID: 11994513

Title: The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation.

PubMed ID: 11994513

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18258799

Title: Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production.

PubMed ID: 18258799

DOI: 10.1182/blood-2007-03-081398

PubMed ID: 20530286

Title: Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR.

PubMed ID: 20530286

DOI: 10.1182/blood-2010-01-264960

PubMed ID: 21536857

Title: DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway.

PubMed ID: 21536857

DOI: 10.1182/blood-2011-01-331363

PubMed ID: 27015765

Title: Crystal structure of human dendritic cell inhibitory receptor C-type lectin domain reveals the binding mode with N-glycan.

PubMed ID: 27015765

DOI: 10.1002/1873-3468.12162

Sequence Information:

  • Length: 237
  • Mass: 27512
  • Checksum: 1D07003E4C9CF96E
  • Sequence:
    • MTSEITYAEV RFKNEFKSSG INTASSAASK ERTAPHKSNT GFPKLLCASL LIFFLLLAIS 
FFIAFVIFFQ KYSQLLEKKT TKELVHTTLE CVKKNMPVEE TAWSCCPKNW KSFSSNCYFI 
STESASWQDS EKDCARMEAH LLVINTQEEQ DFIFQNLQEE SAYFVGLSDP EGQRHWQWVD 
QTPYNESSTF WHPREPSDPN ERCVVLNFRK SPKRWGWNDV NCLGPQRSVC EMMKIHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.