Details for: PCBP1
Gene ID: 5093
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PCBP1
Ensembl ID: ENSG00000169564
Description: poly(rC) binding protein 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 69.83rCSI 67.22%PRS 4.87
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CSI 65.52rCSI 68.48%PRS 5
-
CSI 63.86rCSI 49.2%PRS 4.25
-
CSI 62.79rCSI 56.7%PRS 4.15
-
CSI 58.29rCSI 61.06%PRS 4.39
-
CSI 56.12rCSI 69.42%PRS 4.13
-
CSI 56.08rCSI 51.49%PRS 5.38
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CSI 52.96rCSI 43.9%PRS 4.44
-
CSI 52.67rCSI 50.78%PRS 2.54
-
CSI 48.73rCSI 42.2%PRS 5.24
-
CSI 47.41rCSI 73.26%PRS 4.41
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CSI 46.52rCSI 46.43%PRS 4.02
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CSI 45.06rCSI 56.55%PRS 5.98
-
CSI 43.47rCSI 38.58%PRS 4.71
-
CSI 42.63rCSI 28.41%PRS 13.26
-
CSI 41rCSI 33.15%PRS 4.63
-
CSI 39.68rCSI 67.98%PRS 6.3
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CSI 38.64rCSI 45.38%PRS 5.71
-
CSI 37.54rCSI 31.34%PRS 15.41
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CSI 37.18rCSI 32.69%PRS 3.4
-
CSI 35.92rCSI 24.2%PRS 5.72
-
CSI 35.42rCSI 30.79%PRS 5.8
-
CSI 34.25rCSI 22.76%PRS 5.61
-
CSI 33.61rCSI 28.18%PRS 5.66
-
CSI 32.4rCSI 44.15%PRS 4.26
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CSI 31.63rCSI 38.2%PRS 5.51
-
CSI 31.58rCSI 25.07%PRS 8.4
-
CSI 31.52rCSI 41.9%PRS 5.15
-
CSI 30.8rCSI 58.14%PRS 5.87
-
CSI 30.72rCSI 45.55%PRS 47.24
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CSI 30.11rCSI 34.46%PRS 9.81
-
CSI 29.43rCSI 22.26%PRS 6.62
-
CSI 28.69rCSI 22.57%PRS 5.61
-
CSI 28.6rCSI 46.12%PRS 7.66
-
CSI 28.59rCSI 28.12%PRS 5.15
-
CSI 27.78rCSI 24.4%PRS 5.27
-
CSI 27.69rCSI 53.85%PRS 4.81
-
CSI 27.09rCSI 38.66%PRS 5.36
-
CSI 26.88rCSI 40.56%PRS 4.63
-
CSI 26.18rCSI 27.34%PRS 15.2
-
CSI 25.41rCSI 38.87%PRS 7.71
-
CSI 25.08rCSI 36.17%PRS 6.55
-
CSI 24.32rCSI 37.37%PRS 6.8
-
CSI 24.05rCSI 34.51%PRS 3.93
-
CSI 23.22rCSI 16.14%PRS 5.53
-
CSI 23.03rCSI 35.38%PRS 5.47
-
CSI 22.91rCSI 41.63%PRS 7.21
-
CSI 22.49rCSI 27.25%PRS 7.09
-
CSI 22.28rCSI 64.49%PRS 5.33
-
CSI 21.9rCSI 51.98%PRS 6.32
-
CSI 21.77rCSI 26.13%PRS 4.7
-
CSI 21.65rCSI 51.47%PRS 7.18
-
CSI 21.28rCSI 24.68%PRS 7.06
-
CSI 20.65rCSI 19.05%PRS 4.76
-
CSI 20.64rCSI 26.47%PRS 5.44
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CSI 20.56rCSI 29.47%PRS 6.59
-
CSI 20.11rCSI 15.08%PRS 14.3
-
CSI 20.05rCSI 18.54%PRS 8.69
-
CSI 19.98rCSI 22.49%PRS 7.87
-
CSI 19.96rCSI 39.8%PRS 8.06
-
CSI 19.95rCSI 43.55%PRS 9.66
-
CSI 19.94rCSI 17.1%PRS 12.66
-
CSI 19.71rCSI 19.46%PRS 20.59
-
CSI 19.47rCSI 28.06%PRS 7.64
-
CSI 19.16rCSI 40.78%PRS 7.65
-
CSI 19.14rCSI 55.12%PRS 9.62
-
CSI 18.91rCSI 25.27%PRS 9.04
-
CSI 18.78rCSI 27.51%PRS 5.59
-
CSI 18.64rCSI 29.88%PRS 15.63
-
CSI 18.45rCSI 17.43%PRS 4.91
-
CSI 17.93rCSI 60.63%PRS 8.12
-
CSI 17.84rCSI 24.37%PRS 5.21
-
CSI 17.69rCSI 20.45%PRS 3.42
-
CSI 17.67rCSI 18.77%PRS 8.44
-
CSI 17.28rCSI 31.2%PRS 14.28
-
CSI 17.25rCSI 14.28%PRS 4.7
-
CSI 17.08rCSI 12.75%PRS 7.99
-
CSI 16.73rCSI 12.97%PRS 4.48
-
CSI 16.7rCSI 17.42%PRS 4.81
-
CSI 16.25rCSI 24.82%PRS 8.28
-
CSI 16.01rCSI 12.94%PRS 11
-
CSI 15.89rCSI 19.58%PRS 15.9
-
CSI 15.15rCSI 28.92%PRS 11.58
-
CSI 15.1rCSI 24.87%PRS 5.5
-
CSI 15.08rCSI 28.52%PRS 10.64
-
CSI 14.65rCSI 88.65%PRS 11.11
-
CSI 14.58rCSI 51.16%PRS 8.57
-
CSI 14.52rCSI 57.78%PRS 8.44
-
CSI 14.14rCSI 42.16%PRS 12.81
-
CSI 13.91rCSI 16.93%PRS 5.96
-
CSI 13.88rCSI 28.5%PRS 11.45
-
CSI 13.74rCSI 44.07%PRS 7.1
-
CSI 13.73rCSI 29.2%PRS 9.05
-
CSI 13.72rCSI 13.48%PRS 14.19
-
CSI 13.67rCSI 73.78%PRS 9.34
-
CSI 13.54rCSI 14.52%PRS 4.34
-
CSI 13.51rCSI 15.87%PRS 43.17
-
CSI 13.18rCSI 10.42%PRS 3.25
-
CSI 13.01rCSI 10.57%PRS 4.99
-
CSI 12.96rCSI 17.65%PRS 11.9
-
CSI -14.9rCSI -16.3%PRS 5.5%
-
CSI -13.2rCSI -23.4%PRS 6.4%
-
CSI -11.4rCSI -20.2%PRS 6.3%
-
CSI -10.3rCSI -16.5%PRS 4.1%
-
CSI -6.3rCSI -7.5%PRS 8.3%
-
CSI -6.2rCSI -10.8%PRS 3.6%
-
CSI -6.2rCSI -13.9%PRS 3.0%
-
CSI -5.9rCSI -9.7%PRS 3.7%
-
CSI -5.4rCSI -7.2%PRS 6.4%
-
CSI -5.4rCSI -15.2%PRS 6.4%
-
CSI -5.4rCSI -23.6%PRS 4.8%
-
CSI -4.6rCSI -20.9%PRS 17.3%
-
CSI -4.1rCSI -68.7%PRS 24.2%
-
CSI -4.1rCSI -12.7%PRS 3.3%
-
CSI -3.8rCSI -7.1%PRS 3.6%
-
CSI -3.4rCSI -13.2%PRS 7.8%
-
CSI -3.0rCSI -6.0%PRS 13.7%
-
CSI -2.4rCSI -3.8%PRS 6.1%
-
CSI -2.3rCSI -8.7%PRS 4.1%
-
CSI -2.0rCSI -13.0%PRS 22.1%
-
CSI -1.8rCSI -2.9%PRS 3.2%
-
CSI -1.3rCSI -4.9%PRS 3.0%
-
CSI -1.3rCSI -24.0%PRS 38.6%
-
CSI -1.1rCSI -3.4%PRS 8.0%
-
CSI -1.0rCSI -3.1%PRS 5.8%
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CSI -0.9rCSI -5.2%PRS 26.2%
-
CSI -0.7rCSI -1.2%PRS 3.6%
-
CSI -0.7rCSI -1.2%PRS 4.6%
-
CSI -0.5rCSI -2.2%PRS 5.7%
-
CSI -0.5rCSI -3.0%PRS 3.1%
-
CSI -0.5rCSI -4.8%PRS 42.2%
-
CSI -0.4rCSI -8.2%PRS 68.9%
-
CSI -0.3rCSI -1.5%PRS 7.4%
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CSI 0.0rCSI 0.6%PRS 39.0%
-
CSI 0.1rCSI 0.2%PRS 3.0%
-
CSI 0.1rCSI 2.3%PRS 41.4%
-
CSI 0.1rCSI 2.6%PRS 27.1%
-
CSI 0.1rCSI 2.7%PRS 39.9%
-
CSI 0.1rCSI 0.5%PRS 21.4%
-
CSI 0.2rCSI 0.8%PRS 7.8%
-
CSI 0.2rCSI 0.2%PRS 5.2%
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CSI 0.2rCSI 0.4%PRS 3.7%
-
CSI 0.2rCSI 0.5%PRS 4.8%
-
CSI 0.2rCSI 3.5%PRS 31.2%
-
CSI 0.2rCSI 5.2%PRS 30.0%
-
CSI 0.3rCSI 0.5%PRS 2.8%
-
CSI 0.3rCSI 2.7%PRS 42.9%
-
CSI 0.4rCSI 2.0%PRS 17.7%
-
CSI 0.4rCSI 2.1%PRS 9.6%
-
CSI 0.5rCSI 4.1%PRS 32.4%
-
CSI 0.5rCSI 0.7%PRS 7.0%
-
CSI 0.5rCSI 7.5%PRS 61.7%
-
CSI 0.5rCSI 0.8%PRS 4.8%
-
CSI 0.5rCSI 1.2%PRS 6.5%
-
CSI 0.6rCSI 1.2%PRS 10.5%
-
CSI 0.6rCSI 1.5%PRS 5.6%
-
CSI 0.6rCSI 15.4%PRS 26.2%
-
CSI 0.6rCSI 1.6%PRS 6.9%
-
CSI 0.6rCSI 5.6%PRS 28.7%
-
CSI 0.6rCSI 2.7%PRS 13.9%
-
CSI 0.7rCSI 1.2%PRS 2.8%
-
CSI 0.7rCSI 1.2%PRS 4.5%
-
CSI 0.7rCSI 0.9%PRS 3.0%
-
CSI 0.8rCSI 4.0%PRS 11.2%
-
CSI 0.8rCSI 1.9%PRS 15.7%
-
CSI 0.8rCSI 1.9%PRS 2.8%
-
CSI 0.8rCSI 6.3%PRS 5.0%
-
CSI 0.8rCSI 1.9%PRS 33.2%
-
CSI 0.8rCSI 8.1%PRS 48.4%
-
CSI 0.9rCSI 2.1%PRS 2.6%
-
CSI 1.0rCSI 6.2%PRS 35.9%
-
CSI 1.0rCSI 2.2%PRS 7.3%
-
CSI 1.0rCSI 1.7%PRS 5.0%
-
CSI 1.0rCSI 3.7%PRS 23.5%
-
CSI 1.0rCSI 1.3%PRS 5.0%
-
CSI 1.0rCSI 2.9%PRS 5.4%
-
CSI 1.2rCSI 9.2%PRS 21.6%
-
CSI 1.2rCSI 1.6%PRS 4.5%
-
CSI 1.2rCSI 5.5%PRS 21.9%
-
CSI 1.2rCSI 1.2%PRS 10.3%
-
CSI 1.3rCSI 29.0%PRS 34.9%
-
CSI 1.3rCSI 11.9%PRS 18.2%
-
CSI 1.4rCSI 6.2%PRS 17.9%
-
CSI 1.4rCSI 8.7%PRS 23.8%
-
CSI 1.4rCSI 27.6%PRS 17.3%
-
CSI 1.5rCSI 2.4%PRS 3.7%
-
CSI 1.5rCSI 20.5%PRS 45.1%
-
CSI 1.6rCSI 17.8%PRS 8.7%
-
CSI 1.7rCSI 25.8%PRS 12.5%
-
CSI 1.7rCSI 7.9%PRS 13.1%
-
CSI 1.8rCSI 6.7%PRS 5.1%
-
CSI 1.8rCSI 30.9%PRS 20.1%
-
CSI 1.9rCSI 8.3%PRS 25.5%
-
CSI 1.9rCSI 8.3%PRS 18.7%
-
CSI 1.9rCSI 3.3%PRS 10.3%
-
CSI 2.0rCSI 46.4%PRS 6.8%
-
CSI 2.1rCSI 4.0%PRS 7.6%
-
CSI 2.1rCSI 5.4%PRS 8.4%
-
CSI 2.1rCSI 12.3%PRS 7.1%
-
CSI 2.2rCSI 3.4%PRS 12.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2521290461
Symbol: PCBP1_HUMAN
Name: Heterogeneous nuclear ribonucleoprotein E1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7607214
Title: Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains.
PubMed ID: 7607214
PubMed ID: 7556077
Title: Identification of two KH domain proteins in the alpha-globin mRNP stability complex.
PubMed ID: 7556077
PubMed ID: 8152927
Title: Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K.
PubMed ID: 8152927
DOI: 10.1093/nar/22.6.959
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12414943
Title: Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication.
PubMed ID: 12414943
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 15731341
Title: Structure and RNA binding of the third KH domain of poly(C)-binding protein 1.
PubMed ID: 15731341
DOI: 10.1093/nar/gki265
Sequence Information:
- Length: 356
- Mass: 37498
- Checksum: 6D1A261276CA206D
- Sequence:
MDAGVTESGL NVTLTIRLLM HGKEVGSIIG KKGESVKRIR EESGARINIS EGNCPERIIT LTGPTNAIFK AFAMIIDKLE EDINSSMTNS TAASRPPVTL RLVVPATQCG SLIGKGGCKI KEIRESTGAQ VQVAGDMLPN STERAITIAG VPQSVTECVK QICLVMLETL SQSPQGRVMT IPYQPMPASS PVICAGGQDR CSDAAGYPHA THDLEGPPLD AYSIQGQHTI SPLDLAKLNQ VARQQSHFAM MHGGTGFAGI DSSSPEVKGY WASLDASTQT THELTIPNNL IGCIIGRQGA NINEIRQMSG AQIKIANPVE GSSGRQVTIT GSAASISLAQ YLINARLSSE KGMGCS