Details for: PCBP1

Gene ID: 5093

Symbol: PCBP1

Ensembl ID: ENSG00000169564

Description: poly(rC) binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 469.9276
    Cell Significance Index: -73.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 322.7366
    Cell Significance Index: -81.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 284.2594
    Cell Significance Index: -117.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 237.5589
    Cell Significance Index: -96.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 219.4133
    Cell Significance Index: -103.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 204.5743
    Cell Significance Index: -105.2300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 155.3302
    Cell Significance Index: -104.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 77.8292
    Cell Significance Index: -95.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 26.1680
    Cell Significance Index: -103.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.8384
    Cell Significance Index: -76.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.0438
    Cell Significance Index: -64.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.9536
    Cell Significance Index: -28.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.7845
    Cell Significance Index: 88.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.4491
    Cell Significance Index: 257.0600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.2409
    Cell Significance Index: 41.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.9345
    Cell Significance Index: 346.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.7054
    Cell Significance Index: 440.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.6112
    Cell Significance Index: 122.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.4881
    Cell Significance Index: 65.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4218
    Cell Significance Index: 332.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.3522
    Cell Significance Index: 151.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3281
    Cell Significance Index: 286.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2804
    Cell Significance Index: 62.0700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.2536
    Cell Significance Index: 18.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.2278
    Cell Significance Index: 63.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1118
    Cell Significance Index: 380.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0949
    Cell Significance Index: 1144.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.0517
    Cell Significance Index: 141.8900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.0344
    Cell Significance Index: 12.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.0181
    Cell Significance Index: 260.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.9934
    Cell Significance Index: 69.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8643
    Cell Significance Index: 824.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8121
    Cell Significance Index: 37.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.7540
    Cell Significance Index: 81.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6864
    Cell Significance Index: 119.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5440
    Cell Significance Index: 17.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.3380
    Cell Significance Index: 23.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2093
    Cell Significance Index: 32.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2006
    Cell Significance Index: 153.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1913
    Cell Significance Index: 71.5200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1875
    Cell Significance Index: 12.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9496
    Cell Significance Index: 188.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7702
    Cell Significance Index: 131.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7592
    Cell Significance Index: 39.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7370
    Cell Significance Index: 21.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3887
    Cell Significance Index: 77.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3449
    Cell Significance Index: 65.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2454
    Cell Significance Index: 2.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1140
    Cell Significance Index: 86.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0981
    Cell Significance Index: 35.1800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0748
    Cell Significance Index: 0.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0687
    Cell Significance Index: 6.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0092
    Cell Significance Index: 6.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0114
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0173
    Cell Significance Index: -12.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0296
    Cell Significance Index: -55.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0339
    Cell Significance Index: -1.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0408
    Cell Significance Index: -36.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0559
    Cell Significance Index: -34.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0607
    Cell Significance Index: -82.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0680
    Cell Significance Index: -125.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0753
    Cell Significance Index: -7.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0795
    Cell Significance Index: -122.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1177
    Cell Significance Index: -2.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1341
    Cell Significance Index: -85.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1342
    Cell Significance Index: -75.6900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2082
    Cell Significance Index: -2.9200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2123
    Cell Significance Index: -24.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2126
    Cell Significance Index: -96.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2206
    Cell Significance Index: -46.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2905
    Cell Significance Index: -31.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2948
    Cell Significance Index: -84.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4011
    Cell Significance Index: -25.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4549
    Cell Significance Index: -52.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5362
    Cell Significance Index: -62.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5564
    Cell Significance Index: -11.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6309
    Cell Significance Index: -22.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6593
    Cell Significance Index: -95.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7054
    Cell Significance Index: -18.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7131
    Cell Significance Index: -15.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8172
    Cell Significance Index: -11.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8591
    Cell Significance Index: -24.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9102
    Cell Significance Index: -72.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9616
    Cell Significance Index: -5.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9749
    Cell Significance Index: -65.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9811
    Cell Significance Index: -102.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1330
    Cell Significance Index: -69.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.2317
    Cell Significance Index: -36.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.2346
    Cell Significance Index: -55.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2963
    Cell Significance Index: -99.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3784
    Cell Significance Index: -77.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.4540
    Cell Significance Index: -38.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5202
    Cell Significance Index: -48.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.5825
    Cell Significance Index: -82.4300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.6358
    Cell Significance Index: -28.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.6703
    Cell Significance Index: -42.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.6951
    Cell Significance Index: -25.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7076
    Cell Significance Index: -104.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.8518
    Cell Significance Index: -19.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCBP1 is a member of the poly(rC) binding protein family, which consists of four proteins (PCBP1-4). These proteins share a common binding motif for poly(rC) tracts and are involved in various RNA-related processes. PCBP1 is a 43-kDa protein that is predominantly expressed in cells of the immune system, including monocytes, T cells, and macrophages. Its expression is also observed in other cell types, such as fibroblasts, skeletal muscle satellite cells, and progenitor cells. **Pathways and Functions:** PCBP1 is involved in several RNA-binding pathways, including: 1. **RNA splicing**: PCBP1 regulates the splicing of pre-mRNAs by interacting with the spliceosome and modulating the activity of splicing factors. 2. **RNA metabolism**: PCBP1 is involved in the processing of capped intron-containing pre-mRNAs and the regulation of mRNA stability. 3. **Transcriptional control**: PCBP1 modulates the activity of RNA polymerase II and regulates the expression of genes involved in immune responses. 4. **Exosome-mediated RNA degradation**: PCBP1 is involved in the regulation of exosome-mediated RNA degradation, which is essential for the removal of aberrant or toxic RNAs. **Clinical Significance:** PCBP1's involvement in immune regulation and RNA metabolism makes it a potential target for immunotherapy and disease treatment. Dysregulation of PCBP1 has been implicated in various diseases, including: 1. **Autoimmune disorders**: PCBP1's role in regulating immune responses makes it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: PCBP1's involvement in RNA metabolism and transcriptional control suggests that it may play a role in the development and progression of cancer. 3. **Neurological disorders**: PCBP1's expression in neurons and its involvement in RNA metabolism suggest that it may be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. **Conclusion:** In conclusion, PCBP1 is a multifaceted protein that plays a crucial role in immune regulation, RNA metabolism, and transcriptional control. Its dysregulation has been implicated in various diseases, making it a potential target for immunotherapy and disease treatment. Further research is needed to fully elucidate the mechanisms by which PCBP1 regulates immune responses and to explore its therapeutic potential. **Future Directions:** 1. **Investigating PCBP1's role in immune regulation**: Further studies are needed to elucidate the mechanisms by which PCBP1 regulates immune responses and to identify its key interacting partners. 2. **Exploring PCBP1's therapeutic potential**: PCBP1's involvement in various diseases suggests that it may be a potential target for immunotherapy and disease treatment. Further studies are needed to investigate its therapeutic potential. 3. **Developing novel therapeutic strategies**: The development of novel therapeutic strategies that target PCBP1's RNA-binding and transcriptional control activities may provide new avenues for treating diseases associated with PCBP1 dysregulation. **References:** * [Insert references to relevant studies and reviews on PCBP1] **Limitations:** * This review is limited by the availability of data on PCBP1's function and regulation in the immune system. * Further studies are needed to fully elucidate the mechanisms by which PCBP1 regulates immune responses and to explore its therapeutic potential. **Future Research Directions:** * Investigating PCBP1's role in immune regulation and its interaction with other RNA-binding proteins. * Exploring PCBP1's therapeutic potential in autoimmune and cancer diseases. * Developing novel therapeutic strategies that target PCBP1's RNA-binding and transcriptional control activities.

Genular Protein ID: 2521290461

Symbol: PCBP1_HUMAN

Name: Heterogeneous nuclear ribonucleoprotein E1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7607214

Title: Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains.

PubMed ID: 7607214

DOI: 10.1111/j.1432-1033.1995.tb20581.x

PubMed ID: 7556077

Title: Identification of two KH domain proteins in the alpha-globin mRNP stability complex.

PubMed ID: 7556077

DOI: 10.1002/j.1460-2075.1995.tb00110.x

PubMed ID: 8152927

Title: Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K.

PubMed ID: 8152927

DOI: 10.1093/nar/22.6.959

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12414943

Title: Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication.

PubMed ID: 12414943

DOI: 10.1128/jvi.76.23.12008-12022.2002

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15731341

Title: Structure and RNA binding of the third KH domain of poly(C)-binding protein 1.

PubMed ID: 15731341

DOI: 10.1093/nar/gki265

Sequence Information:

  • Length: 356
  • Mass: 37498
  • Checksum: 6D1A261276CA206D
  • Sequence:
  • MDAGVTESGL NVTLTIRLLM HGKEVGSIIG KKGESVKRIR EESGARINIS EGNCPERIIT 
    LTGPTNAIFK AFAMIIDKLE EDINSSMTNS TAASRPPVTL RLVVPATQCG SLIGKGGCKI 
    KEIRESTGAQ VQVAGDMLPN STERAITIAG VPQSVTECVK QICLVMLETL SQSPQGRVMT 
    IPYQPMPASS PVICAGGQDR CSDAAGYPHA THDLEGPPLD AYSIQGQHTI SPLDLAKLNQ 
    VARQQSHFAM MHGGTGFAGI DSSSPEVKGY WASLDASTQT THELTIPNNL IGCIIGRQGA 
    NINEIRQMSG AQIKIANPVE GSSGRQVTIT GSAASISLAQ YLINARLSSE KGMGCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.