Details for: ISOC1

Gene ID: 51015

Symbol: ISOC1

Ensembl ID: ENSG00000066583

Description: isochorismatase domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 104.3426
    Cell Significance Index: -16.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 66.6881
    Cell Significance Index: -16.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.6071
    Cell Significance Index: -21.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.5862
    Cell Significance Index: -20.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3446
    Cell Significance Index: -21.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2896
    Cell Significance Index: -14.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.4735
    Cell Significance Index: -13.7400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.2604
    Cell Significance Index: 25.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1881
    Cell Significance Index: 220.4800
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.2024
    Cell Significance Index: 6.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1654
    Cell Significance Index: 352.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0653
    Cell Significance Index: -4.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7376
    Cell Significance Index: 40.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4858
    Cell Significance Index: 39.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2970
    Cell Significance Index: 16.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2460
    Cell Significance Index: 88.1200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.0409
    Cell Significance Index: 6.4400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.9540
    Cell Significance Index: 4.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9171
    Cell Significance Index: 47.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7769
    Cell Significance Index: 95.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7722
    Cell Significance Index: 21.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7175
    Cell Significance Index: 98.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6540
    Cell Significance Index: 17.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6538
    Cell Significance Index: 22.7200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6500
    Cell Significance Index: 5.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6469
    Cell Significance Index: 30.1600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.5806
    Cell Significance Index: 8.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5369
    Cell Significance Index: 237.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5149
    Cell Significance Index: 92.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5045
    Cell Significance Index: 275.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4163
    Cell Significance Index: 5.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4085
    Cell Significance Index: 8.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3944
    Cell Significance Index: 10.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3845
    Cell Significance Index: 38.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3829
    Cell Significance Index: 28.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3499
    Cell Significance Index: 7.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2953
    Cell Significance Index: 58.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2811
    Cell Significance Index: 13.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2634
    Cell Significance Index: 7.3600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2622
    Cell Significance Index: 2.8500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.2509
    Cell Significance Index: 1.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2434
    Cell Significance Index: 18.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2064
    Cell Significance Index: 39.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1795
    Cell Significance Index: 23.1900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1534
    Cell Significance Index: 2.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1521
    Cell Significance Index: 17.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1469
    Cell Significance Index: 25.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1155
    Cell Significance Index: 14.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0557
    Cell Significance Index: 11.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0490
    Cell Significance Index: 0.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0443
    Cell Significance Index: 30.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0337
    Cell Significance Index: 3.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0320
    Cell Significance Index: 11.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0164
    Cell Significance Index: 0.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0141
    Cell Significance Index: 0.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0134
    Cell Significance Index: 9.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0106
    Cell Significance Index: 0.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0095
    Cell Significance Index: 0.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0027
    Cell Significance Index: 2.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0047
    Cell Significance Index: -2.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0101
    Cell Significance Index: -6.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0125
    Cell Significance Index: -19.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0128
    Cell Significance Index: -23.5600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0135
    Cell Significance Index: -0.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0182
    Cell Significance Index: -24.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0195
    Cell Significance Index: -11.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0273
    Cell Significance Index: -2.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0424
    Cell Significance Index: -19.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0466
    Cell Significance Index: -13.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0469
    Cell Significance Index: -9.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0496
    Cell Significance Index: -0.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0527
    Cell Significance Index: -1.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0621
    Cell Significance Index: -7.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0782
    Cell Significance Index: -0.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0800
    Cell Significance Index: -4.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0825
    Cell Significance Index: -11.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0837
    Cell Significance Index: -2.9400
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: -0.1073
    Cell Significance Index: -0.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1163
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1189
    Cell Significance Index: -13.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1284
    Cell Significance Index: -10.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1320
    Cell Significance Index: -6.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1624
    Cell Significance Index: -4.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1750
    Cell Significance Index: -11.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1756
    Cell Significance Index: -7.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2022
    Cell Significance Index: -5.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2039
    Cell Significance Index: -21.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2082
    Cell Significance Index: -2.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2118
    Cell Significance Index: -14.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2158
    Cell Significance Index: -8.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2286
    Cell Significance Index: -14.0500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2460
    Cell Significance Index: -1.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2960
    Cell Significance Index: -18.1500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3035
    Cell Significance Index: -5.1100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3120
    Cell Significance Index: -1.9200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3161
    Cell Significance Index: -3.3000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3821
    Cell Significance Index: -5.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3912
    Cell Significance Index: -14.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ISOC1 gene is characterized by its unique isochorismatase domain, which is a conserved structural motif found in several proteins involved in cellular metabolism and homeostasis. The ISOC1 protein is predicted to be a cytoplasmic protein, with a molecular weight of approximately 30 kDa. Its expression is restricted to specific cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells. The ISOC1 gene has been mapped to the human genome on chromosome 17q21.3. **Pathways and Functions** The ISOC1 gene is involved in several biological pathways, including: 1. **Peroxisome function**: ISOC1 is predicted to play a role in the regulation of peroxisome function, which is critical for the breakdown of fatty acids and the synthesis of bile acids. 2. **Cellular metabolism**: ISOC1 is involved in the regulation of cellular metabolism, including glycolysis, gluconeogenesis, and fatty acid synthesis. 3. **Protein binding**: ISOC1 has been shown to interact with other proteins, including those involved in immune regulation and response. 4. **Cellular homeostasis**: ISOC1 is involved in the maintenance of cellular homeostasis, including the regulation of cellular stress responses and the modulation of cellular signaling pathways. **Clinical Significance** The ISOC1 gene has been found to be significantly expressed in various immune cells, including CD8-alpha-beta-positive T cells, CD8-positive T cells, and regulatory T cells. This suggests that ISOC1 may play a role in immune regulation and response, particularly in the context of autoimmune diseases and cancer. Furthermore, ISOC1 has been associated with several diseases, including: 1. **Autoimmune diseases**: ISOC1 has been found to be overexpressed in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: ISOC1 has been found to be overexpressed in several types of cancer, including breast cancer and colon cancer. 3. **Inflammatory diseases**: ISOC1 has been found to be overexpressed in inflammatory diseases, such as atherosclerosis and inflammatory bowel disease. In conclusion, the ISOC1 gene is a complex gene that plays a critical role in various biological processes, including cellular metabolism, protein binding, and cellular homeostasis. Its significant expression in immune cells suggests its potential role in immune regulation and response, particularly in the context of autoimmune diseases and cancer. Further research is needed to fully elucidate the functional significance of the ISOC1 gene and its implications for human health and disease.

Genular Protein ID: 690954995

Symbol: ISOC1_HUMAN

Name: Isochorismatase domain-containing protein 1

UniProtKB Accession Codes:

Q96CN7 Q7Z770

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 298
  • Mass: 32237
  • Checksum: 9843DA1A40E1BDA0
  • Sequence:
    • MAAAEPAVLA LPNSGAGGAG APSGTVPVLF CFSVFARPSS VPHGAGYELL IQKFLSLYGD 
QIDMHRKFVV QLFAEEWGQY VDLPKGFAVS ERCKVRLVPL QIQLTTLGNL TPSSTVFFCC 
DMQERFRPAI KYFGDIISVG QRLLQGARIL GIPVIVTEQY PKGLGSTVQE IDLTGVKLVL 
PKTKFSMVLP EVEAALAEIP GVRSVVLFGV ETHVCIQQTA LELVGRGVEV HIVADATSSR 
SMMDRMFALE RLARTGIIVT TSEAVLLQLV ADKDHPKFKE IQNLIKASAP ESGLLSKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.