Details for: ZBTB7B

Gene ID: 51043

Symbol: ZBTB7B

Ensembl ID: ENSG00000160685

Description: zinc finger and BTB domain containing 7B

Associated with

  • Adaptive thermogenesis
    (GO:1990845)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity
    (GO:0001217)
  • Ectoderm development
    (GO:0007398)
  • Histone deacetylase binding
    (GO:0042826)
  • Lactation
    (GO:0007595)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of cd8-positive, alpha-beta t cell differentiation
    (GO:0043377)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of nk t cell proliferation
    (GO:0051141)
  • Negative regulation of t-helper 17 cell differentiation
    (GO:2000320)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nk t cell differentiation
    (GO:0001865)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of brown fat cell differentiation
    (GO:0090336)
  • Positive regulation of cd4-positive, alpha-beta t cell differentiation
    (GO:0043372)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of interleukin-17 production
    (GO:0032740)
  • Positive regulation of srebp signaling pathway
    (GO:2000640)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to insulin
    (GO:0032868)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription by rna polymerase ii
    (GO:0006366)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.3479
    Cell Significance Index: -11.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.5220
    Cell Significance Index: -11.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.0180
    Cell Significance Index: -10.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 23.9898
    Cell Significance Index: -12.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.2596
    Cell Significance Index: -10.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.5948
    Cell Significance Index: -11.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 4.9004
    Cell Significance Index: 66.8600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 4.4933
    Cell Significance Index: 10.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0540
    Cell Significance Index: -10.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.2314
    Cell Significance Index: -9.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0195
    Cell Significance Index: -11.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.8911
    Cell Significance Index: 550.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.4719
    Cell Significance Index: -5.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.3300
    Cell Significance Index: 378.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8551
    Cell Significance Index: 40.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.6291
    Cell Significance Index: 24.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5709
    Cell Significance Index: 170.8700
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.5149
    Cell Significance Index: 1.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4723
    Cell Significance Index: 42.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3694
    Cell Significance Index: 62.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1826
    Cell Significance Index: 1067.8100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.1464
    Cell Significance Index: 7.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0000
    Cell Significance Index: 51.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9156
    Cell Significance Index: 90.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8905
    Cell Significance Index: 8.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8169
    Cell Significance Index: 22.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7576
    Cell Significance Index: 20.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6397
    Cell Significance Index: 45.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5654
    Cell Significance Index: 10.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5203
    Cell Significance Index: 24.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4451
    Cell Significance Index: 196.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4326
    Cell Significance Index: 20.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3597
    Cell Significance Index: 7.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3310
    Cell Significance Index: 59.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3283
    Cell Significance Index: 8.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3264
    Cell Significance Index: 24.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2778
    Cell Significance Index: 8.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2394
    Cell Significance Index: 47.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2194
    Cell Significance Index: 7.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2148
    Cell Significance Index: 13.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1888
    Cell Significance Index: 23.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1819
    Cell Significance Index: 2.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1712
    Cell Significance Index: 4.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1584
    Cell Significance Index: 86.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0977
    Cell Significance Index: 12.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0523
    Cell Significance Index: 7.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0421
    Cell Significance Index: 0.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0387
    Cell Significance Index: 1.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0315
    Cell Significance Index: 1.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0213
    Cell Significance Index: 3.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0068
    Cell Significance Index: 12.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0025
    Cell Significance Index: 1.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0024
    Cell Significance Index: 0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0014
    Cell Significance Index: -1.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -3.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0048
    Cell Significance Index: -3.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0058
    Cell Significance Index: -0.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0071
    Cell Significance Index: -4.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0110
    Cell Significance Index: -0.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0118
    Cell Significance Index: -1.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0129
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0138
    Cell Significance Index: -6.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0184
    Cell Significance Index: -10.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0195
    Cell Significance Index: -7.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0229
    Cell Significance Index: -14.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0230
    Cell Significance Index: -2.7100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0247
    Cell Significance Index: -0.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0256
    Cell Significance Index: -7.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0379
    Cell Significance Index: -4.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0482
    Cell Significance Index: -7.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0605
    Cell Significance Index: -12.7500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0725
    Cell Significance Index: -0.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0984
    Cell Significance Index: -6.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1035
    Cell Significance Index: -10.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1047
    Cell Significance Index: -1.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1050
    Cell Significance Index: -8.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1052
    Cell Significance Index: -2.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1054
    Cell Significance Index: -1.5600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1149
    Cell Significance Index: -1.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1275
    Cell Significance Index: -1.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1455
    Cell Significance Index: -8.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1541
    Cell Significance Index: -1.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1615
    Cell Significance Index: -3.3500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1675
    Cell Significance Index: -1.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1859
    Cell Significance Index: -12.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1878
    Cell Significance Index: -9.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2004
    Cell Significance Index: -12.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2079
    Cell Significance Index: -5.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2131
    Cell Significance Index: -11.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2308
    Cell Significance Index: -9.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2358
    Cell Significance Index: -8.6600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2387
    Cell Significance Index: -3.4200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2553
    Cell Significance Index: -6.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2634
    Cell Significance Index: -4.4300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2636
    Cell Significance Index: -1.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2692
    Cell Significance Index: -6.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ZBTB7B gene belongs to the Kruppel-like zinc finger family of transcription factors, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. The ZBTB7B protein exhibits a unique structure, consisting of a BTB domain and a zinc finger domain, which enables it to interact with other proteins and DNA sequences. Its expression is tightly regulated, and its function is often context-dependent, depending on the cellular environment and the presence of specific transcription factors. **Pathways and Functions:** The ZBTB7B gene is involved in several key pathways, including: 1. **Adaptive Thermogenesis:** ZBTB7B regulates the differentiation and function of brown fat cells, which are responsible for thermogenesis, a process that generates heat in response to cold exposure. 2. **Immune Regulation:** ZBTB7B modulates the differentiation and function of T cells, including CD8+ and CD4+ T cells, which play critical roles in immune responses. 3. **Gene Expression:** ZBTB7B regulates the expression of genes involved in various cellular processes, including cell differentiation, proliferation, and survival. 4. **Metabolism:** ZBTB7B is also implicated in the regulation of insulin signaling pathway and the production of interleukin-17, a cytokine involved in inflammation. **Clinical Significance:** The ZBTB7B gene has been implicated in various diseases, including: 1. **Metabolic Disorders:** ZBTB7B has been linked to metabolic disorders, such as obesity and diabetes, due to its role in regulating thermogenesis and glucose metabolism. 2. **Immune-Related Disorders:** ZBTB7B has been implicated in immune-related disorders, such as autoimmune diseases and cancer, due to its role in regulating T cell function and immune responses. 3. **Neurological Disorders:** ZBTB7B has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, due to its role in regulating gene expression and cellular function. In conclusion, the ZBTB7B gene is a critical regulator of immune responses and thermogenesis, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of ZBTB7B in human health and disease.

Genular Protein ID: 3675885455

Symbol: ZBT7B_HUMAN

Name: Krueppel-related zinc finger protein cKrox

UniProtKB Accession Codes:

O15156 B4E3K5 D3DV83 J3KQQ3 Q68DR2 Q96EP2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 11 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9370309

Title: Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression.

PubMed ID: 9370309

DOI: 10.1016/s0378-1119(97)00360-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20810990

Title: p300-mediated acetylation stabilizes the Th-inducing POK factor.

PubMed ID: 20810990

DOI: 10.4049/jimmunol.1001462

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 539
  • Mass: 58027
  • Checksum: 86B3616504B05B7E
  • Sequence:
    • MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA VLAACSHYFK 
KLFTEGGGGA VMGAGGSGTA TGGAGAGVCE LDFVGPEALG ALLEFAYTAT LTTSSANMPA 
VLQAARLLEI PCVIAACMEI LQGSGLEAPS PDEDDCERAR QYLEAFATAT ASGVPNGEDS 
PPQVPLPPPP PPPPRPVARR SRKPRKAFLQ TKGARANHLV PEVPTVPAHP LTYEEEEVAG 
RVGSSGGSGP GDSYSPPTGT ASPPEGPQSY EPYEGEEEEE ELVYPPAYGL AQGGGPPLSP 
EELGSDEDAI DPDLMAYLSS LHQDNLAPGL DSQDKLVRKR RSQMPQECPV CHKIIHGAGK 
LPRHMRTHTG EKPFACEVCG VRFTRNDKLK IHMRKHTGER PYSCPHCPAR FLHSYDLKNH 
MHLHTGDRPY ECHLCHKAFA KEDHLQRHLK GQNCLEVRTR RRRKDDAPPH YPPPSTAAAS 
PAGLDLSNGH LDTFRLSLAR FWEQSAPTGP PVSTPGPPDD DEEEGAPTTP QAEGAMESS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.