Details for: PI15

Gene ID: 51050

Symbol: PI15

Ensembl ID: ENSG00000137558

Description: peptidase inhibitor 15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 10.1043
    Cell Significance Index: 62.3400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 7.7675
    Cell Significance Index: 68.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 6.4888
    Cell Significance Index: 134.6100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 5.0994
    Cell Significance Index: 58.7300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.6999
    Cell Significance Index: 22.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.2263
    Cell Significance Index: 197.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3625
    Cell Significance Index: 43.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1971
    Cell Significance Index: 25.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8577
    Cell Significance Index: 163.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8099
    Cell Significance Index: 12.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7468
    Cell Significance Index: 73.8800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6500
    Cell Significance Index: 7.2700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5778
    Cell Significance Index: 14.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5583
    Cell Significance Index: 504.1100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4944
    Cell Significance Index: 7.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4786
    Cell Significance Index: 4.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3631
    Cell Significance Index: 59.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2931
    Cell Significance Index: 31.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2560
    Cell Significance Index: 19.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1434
    Cell Significance Index: 3.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1287
    Cell Significance Index: 8.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1161
    Cell Significance Index: 23.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0952
    Cell Significance Index: 18.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0706
    Cell Significance Index: 44.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0593
    Cell Significance Index: 3.5600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0528
    Cell Significance Index: 0.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0510
    Cell Significance Index: 7.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0501
    Cell Significance Index: 1.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0482
    Cell Significance Index: 17.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0478
    Cell Significance Index: 1.3000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0445
    Cell Significance Index: 0.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0312
    Cell Significance Index: 1.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0275
    Cell Significance Index: 50.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0116
    Cell Significance Index: 1.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0071
    Cell Significance Index: 10.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0027
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0013
    Cell Significance Index: -0.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0022
    Cell Significance Index: -0.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0045
    Cell Significance Index: -2.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0064
    Cell Significance Index: -1.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0073
    Cell Significance Index: -0.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0093
    Cell Significance Index: -6.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0094
    Cell Significance Index: -5.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0104
    Cell Significance Index: -0.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0108
    Cell Significance Index: -0.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0110
    Cell Significance Index: -6.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0124
    Cell Significance Index: -1.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0132
    Cell Significance Index: -5.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0150
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0155
    Cell Significance Index: -2.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0230
    Cell Significance Index: -1.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0241
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0258
    Cell Significance Index: -2.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0277
    Cell Significance Index: -3.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0361
    Cell Significance Index: -2.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0409
    Cell Significance Index: -1.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0416
    Cell Significance Index: -6.0400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0459
    Cell Significance Index: -0.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0499
    Cell Significance Index: -5.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0506
    Cell Significance Index: -2.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0547
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0548
    Cell Significance Index: -6.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0568
    Cell Significance Index: -3.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0606
    Cell Significance Index: -6.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0668
    Cell Significance Index: -2.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0720
    Cell Significance Index: -5.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0774
    Cell Significance Index: -1.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0896
    Cell Significance Index: -1.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0926
    Cell Significance Index: -5.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0930
    Cell Significance Index: -2.3200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0950
    Cell Significance Index: -4.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1083
    Cell Significance Index: -5.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1110
    Cell Significance Index: -3.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1113
    Cell Significance Index: -3.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1146
    Cell Significance Index: -6.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1152
    Cell Significance Index: -3.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1164
    Cell Significance Index: -3.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1194
    Cell Significance Index: -1.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1244
    Cell Significance Index: -6.4600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1271
    Cell Significance Index: -4.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1338
    Cell Significance Index: -1.5200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1400
    Cell Significance Index: -1.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1503
    Cell Significance Index: -3.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1613
    Cell Significance Index: -5.9200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1776
    Cell Significance Index: -4.4300
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1797
    Cell Significance Index: -2.0800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1826
    Cell Significance Index: -1.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1836
    Cell Significance Index: -4.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1863
    Cell Significance Index: -3.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1865
    Cell Significance Index: -4.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2037
    Cell Significance Index: -7.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2118
    Cell Significance Index: -5.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2140
    Cell Significance Index: -5.7400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2176
    Cell Significance Index: -5.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2185
    Cell Significance Index: -4.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PI15 is a small, secreted protein (approximately 25 kDa) that belongs to the peptidase inhibitor family. It exhibits potent inhibitory activity against a range of peptidases, including serine proteases, aspartic proteases, and cysteine proteases. PI15's inhibitory activity is mediated through its ability to bind to the active site of peptidases, thereby preventing substrate access and enzymatic activity. This mechanism of action is crucial for regulating various cellular processes, including cell signaling, migration, and proliferation. **Pathways and Functions:** PI15's involvement in multiple cellular pathways underscores its multifaceted role in maintaining tissue homeostasis. Notably, PI15's peptidase inhibitory activity regulates: 1. **Cell proliferation and differentiation**: PI15's inhibition of serine proteases, such as urokinase-type plasminogen activator (uPA), regulates cell migration, invasion, and proliferation in various tissues, including cancer. 2. **Cell survival and apoptosis**: PI15's inhibition of cysteine proteases, such as granzyme B, regulates cell survival and apoptosis in immune cells and cancer cells. 3. **Inflammation and immune response**: PI15's inhibition of aspartic proteases, such as cathepsin L, regulates inflammation and immune response in various tissues, including the gut and mammary gland. 4. **Extracellular matrix remodeling**: PI15's inhibition of matrix metalloproteinases (MMPs) regulates extracellular matrix remodeling in various tissues, including the skin, lung, and cardiovascular system. **Clinical Significance:** Recent studies have highlighted PI15's clinical significance in various diseases, including: 1. **Cancer**: PI15's expression is altered in various types of cancer, including prostate, breast, and colon cancer, underscoring its potential as a biomarker and therapeutic target. 2. **Inflammatory disorders**: PI15's expression is altered in inflammatory disorders, such as rheumatoid arthritis and inflammatory bowel disease, underscoring its potential as a therapeutic target. 3. **Metabolic disorders**: PI15's expression is altered in metabolic disorders, such as obesity and diabetes, underscoring its potential as a therapeutic target. In conclusion, PI15 is a multifaceted peptidase inhibitor with widespread implications in cellular regulation and disease. Further studies are needed to fully elucidate PI15's role in various diseases and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 4110508831

Symbol: PI15_HUMAN

Name: Peptidase inhibitor 15

UniProtKB Accession Codes:

O43692 Q68CY1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9473672

Title: cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells.

PubMed ID: 9473672

DOI: 10.1016/s0167-4781(97)00149-8

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8882727

Title: Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells.

PubMed ID: 8882727

DOI: 10.1093/oxfordjournals.jbchem.a021244

PubMed ID: 11287197

Title: Cloning and expression of a novel cysteine-rich secreted protein family member expressed in thyroid and pancreatic mesoderm within the chicken embryo.

PubMed ID: 11287197

DOI: 10.1016/s0925-4773(01)00293-3

Sequence Information:

  • Length: 258
  • Mass: 29065
  • Checksum: 1915A5831637795F
  • Sequence:
    • MIAISAVSSA LLFSLLCEAS TVVLLNSTDS SPPTNNFTDI EAALKAQLDS ADIPKARRKR 
YISQNDMIAI LDYHNQVRGK VFPPAANMEY MVWDENLAKS AEAWAATCIW DHGPSYLLRF 
LGQNLSVRTG RYRSILQLVK PWYDEVKDYA FPYPQDCNPR CPMRCFGPMC THYTQMVWAT 
SNRIGCAIHT CQNMNVWGSV WRRAVYLVCN YAPKGNWIGE APYKVGVPCS SCPPSYGGSC 
TDNLCFPGVT SNYLYWFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.