Details for: CALHM2

Gene ID: 51063

Symbol: CALHM2

Ensembl ID: ENSG00000138172

Description: calcium homeostasis modulator family member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 70.4618
    Cell Significance Index: -10.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.7051
    Cell Significance Index: -9.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.3134
    Cell Significance Index: -10.6900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 24.2522
    Cell Significance Index: -11.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 22.9789
    Cell Significance Index: -11.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.3434
    Cell Significance Index: -10.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.8730
    Cell Significance Index: -10.9400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.5382
    Cell Significance Index: 29.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7901
    Cell Significance Index: -11.0100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.1091
    Cell Significance Index: -5.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4737
    Cell Significance Index: 43.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2495
    Cell Significance Index: 40.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1000
    Cell Significance Index: 49.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8215
    Cell Significance Index: 156.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6936
    Cell Significance Index: 7.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5499
    Cell Significance Index: 75.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5007
    Cell Significance Index: 452.0500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4879
    Cell Significance Index: 7.7400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3311
    Cell Significance Index: 4.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2876
    Cell Significance Index: 46.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2823
    Cell Significance Index: 5.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2490
    Cell Significance Index: 6.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2280
    Cell Significance Index: 22.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2147
    Cell Significance Index: 23.3600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1690
    Cell Significance Index: 1.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1675
    Cell Significance Index: 2.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1519
    Cell Significance Index: 3.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1369
    Cell Significance Index: 2.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1334
    Cell Significance Index: 6.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1263
    Cell Significance Index: 8.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1202
    Cell Significance Index: 15.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1011
    Cell Significance Index: 7.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0844
    Cell Significance Index: 16.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0632
    Cell Significance Index: 1.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0400
    Cell Significance Index: 27.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0400
    Cell Significance Index: 17.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0377
    Cell Significance Index: 1.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0352
    Cell Significance Index: 5.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0122
    Cell Significance Index: 0.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0089
    Cell Significance Index: 0.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0060
    Cell Significance Index: 0.2100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0051
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0022
    Cell Significance Index: 4.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0036
    Cell Significance Index: -0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0059
    Cell Significance Index: -0.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0063
    Cell Significance Index: -0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0091
    Cell Significance Index: -12.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0109
    Cell Significance Index: -3.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0115
    Cell Significance Index: -2.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0139
    Cell Significance Index: -10.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0159
    Cell Significance Index: -10.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0162
    Cell Significance Index: -11.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0191
    Cell Significance Index: -10.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0198
    Cell Significance Index: -0.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0213
    Cell Significance Index: -12.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0225
    Cell Significance Index: -14.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0231
    Cell Significance Index: -10.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0274
    Cell Significance Index: -0.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0347
    Cell Significance Index: -9.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0360
    Cell Significance Index: -0.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0384
    Cell Significance Index: -7.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0453
    Cell Significance Index: -4.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0489
    Cell Significance Index: -3.0000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0499
    Cell Significance Index: -0.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0550
    Cell Significance Index: -6.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0598
    Cell Significance Index: -7.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0664
    Cell Significance Index: -13.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0688
    Cell Significance Index: -11.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0734
    Cell Significance Index: -8.4100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0757
    Cell Significance Index: -0.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0777
    Cell Significance Index: -10.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0857
    Cell Significance Index: -9.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1010
    Cell Significance Index: -2.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1037
    Cell Significance Index: -10.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1095
    Cell Significance Index: -8.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1159
    Cell Significance Index: -5.4500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1246
    Cell Significance Index: -0.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1299
    Cell Significance Index: -9.9700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1433
    Cell Significance Index: -2.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1526
    Cell Significance Index: -7.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1590
    Cell Significance Index: -4.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1610
    Cell Significance Index: -6.6000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1638
    Cell Significance Index: -1.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1672
    Cell Significance Index: -11.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1733
    Cell Significance Index: -8.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1794
    Cell Significance Index: -11.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1834
    Cell Significance Index: -11.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1881
    Cell Significance Index: -9.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1935
    Cell Significance Index: -10.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2022
    Cell Significance Index: -5.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2207
    Cell Significance Index: -7.6700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2231
    Cell Significance Index: -9.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2267
    Cell Significance Index: -7.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2282
    Cell Significance Index: -11.9800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2316
    Cell Significance Index: -3.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2408
    Cell Significance Index: -10.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2428
    Cell Significance Index: -7.9500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2476
    Cell Significance Index: -3.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium Homeostasis Regulation:** CALHM2 is involved in regulating calcium ion import and export, which is essential for maintaining cellular homeostasis and proper cellular function. 2. **Monoatomic Cation Channel Activity:** CALHM2 has been shown to exhibit monoatomic cation channel activity, allowing it to transport monoatomic cations, such as calcium, across cell membranes. 3. **Regulation of Synaptic Plasticity:** CALHM2 has been implicated in regulating synaptic plasticity, a process critical for learning and memory. 4. **Microglial Cell Activation:** CALHM2 has been shown to regulate microglial cell activation, a key process in the immune response and neuroinflammation. **Pathways and Functions:** CALHM2 is involved in various cellular pathways, including: 1. **ATP Export:** CALHM2 has been shown to regulate ATP export, which is essential for maintaining cellular energy homeostasis. 2. **Calcium Ion Import:** CALHM2 plays a critical role in regulating calcium ion import, which is essential for maintaining cellular homeostasis. 3. **Monoatomic Cation Transmembrane Transport:** CALHM2 has been shown to exhibit monoatomic cation transmembrane transport activity, allowing it to transport monoatomic cations across cell membranes. 4. **Plasma Membrane:** CALHM2 is localized to the plasma membrane, where it regulates calcium ion import and export. 5. **Positive Regulation of Apoptotic Process:** CALHM2 has been shown to regulate the apoptotic process, a critical process in cell death and survival. 6. **Regulation of Microglial Cell Activation:** CALHM2 regulates microglial cell activation, a key process in the immune response and neuroinflammation. 7. **Regulation of Synaptic Plasticity:** CALHM2 regulates synaptic plasticity, a process critical for learning and memory. **Clinical Significance:** CALHM2 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** CALHM2 has been shown to play a critical role in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Inflammatory Disorders:** CALHM2 has been implicated in inflammatory disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** CALHM2 has been shown to regulate cancer cell growth and survival, highlighting its potential as a therapeutic target. In conclusion, CALHM2 is a critical gene involved in regulating calcium homeostasis, synaptic plasticity, and microglial cell activation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 2501820922

Symbol: CAHM2_HUMAN

Name: Protein FAM26B

UniProtKB Accession Codes:

Q9HA72 D3DR94 O95893 Q6ZUV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 6 Ensembl 2 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 9 Rhea 2 SMR 1 STRING 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18585350

Title: A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.

PubMed ID: 18585350

DOI: 10.1016/j.cell.2008.05.048

PubMed ID: 32374262

Title: Cryo-EM structures and functional properties of CALHM channels of the human placenta.

PubMed ID: 32374262

DOI: 10.7554/elife.55853

PubMed ID: 31776515

Title: The structures and gating mechanism of human calcium homeostasis modulator2.

PubMed ID: 31776515

DOI: 10.1038/s41586-019-1781-3

PubMed ID: 31988524

Title: Structure and assembly of calcium homeostasis modulator proteins.

PubMed ID: 31988524

DOI: 10.1038/s41594-019-0369-9

PubMed ID: 32832629

Title: Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies.

PubMed ID: 32832629

DOI: 10.1126/sciadv.aba8105

Sequence Information:

  • Length: 323
  • Mass: 36175
  • Checksum: 20A4BC58F6763926
  • Sequence:
    • MAALIAENFR FLSLFFKSKD VMIFNGLVAL GTVGSQELFS VVAFHCPCSP ARNYLYGLAA 
IGVPALVLFI IGIILNNHTW NLVAECQHRR TKNCSAAPTF LLLSSILGRA AVAPVTWSVI 
SLLRGEAYVC ALSEFVDPSS LTAREEHFPS AHATEILARF PCKENPDNLS DFREEVSRRL 
RYESQLFGWL LIGVVAILVF LTKCLKHYCS PLSYRQEAYW AQYRANEDQL FQRTAEVHSR 
VLAANNVRRF FGFVALNKDD EELIANFPVE GTQPRPQWNA ITGVYLYREN QGLPLYSRLH 
KWAQGLAGNG AAPDNVEMAL LPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.