Details for: YBX2

Gene ID: 51087

Symbol: YBX2

Ensembl ID: ENSG00000006047

Description: Y-box binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 21.2800
    Cell Significance Index: -3.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.8301
    Cell Significance Index: 81.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.8063
    Cell Significance Index: -3.4600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.3038
    Cell Significance Index: 17.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.4332
    Cell Significance Index: 29.7300
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 1.1911
    Cell Significance Index: 6.6300
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.0480
    Cell Significance Index: 0.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6896
    Cell Significance Index: 14.9400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.6041
    Cell Significance Index: -1.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5697
    Cell Significance Index: 56.3600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5656
    Cell Significance Index: 9.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5367
    Cell Significance Index: 11.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5344
    Cell Significance Index: 12.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4571
    Cell Significance Index: 27.4400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.4271
    Cell Significance Index: 3.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4090
    Cell Significance Index: 44.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3726
    Cell Significance Index: 70.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3564
    Cell Significance Index: 57.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3439
    Cell Significance Index: 7.5300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3245
    Cell Significance Index: 2.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2411
    Cell Significance Index: 3.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2282
    Cell Significance Index: 3.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2220
    Cell Significance Index: 7.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2126
    Cell Significance Index: 6.8100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.1912
    Cell Significance Index: 2.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1766
    Cell Significance Index: 159.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1697
    Cell Significance Index: 7.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1693
    Cell Significance Index: 11.7100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1183
    Cell Significance Index: 1.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1057
    Cell Significance Index: 2.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0768
    Cell Significance Index: 15.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0724
    Cell Significance Index: 1.8100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0705
    Cell Significance Index: 1.0100
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.0686
    Cell Significance Index: 0.6000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0398
    Cell Significance Index: 0.6700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0317
    Cell Significance Index: 0.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0233
    Cell Significance Index: 0.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0165
    Cell Significance Index: 3.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0084
    Cell Significance Index: 0.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0061
    Cell Significance Index: 0.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0061
    Cell Significance Index: 0.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0032
    Cell Significance Index: 1.4200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0028
    Cell Significance Index: 0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0008
    Cell Significance Index: 0.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0009
    Cell Significance Index: -0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0017
    Cell Significance Index: -2.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0033
    Cell Significance Index: -1.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0038
    Cell Significance Index: -0.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0038
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0045
    Cell Significance Index: -3.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0045
    Cell Significance Index: -0.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0046
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0055
    Cell Significance Index: -2.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0057
    Cell Significance Index: -0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0058
    Cell Significance Index: -3.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0067
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0072
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0094
    Cell Significance Index: -1.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0096
    Cell Significance Index: -1.3900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0130
    Cell Significance Index: -0.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0155
    Cell Significance Index: -0.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0164
    Cell Significance Index: -2.9600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0165
    Cell Significance Index: -0.2500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0202
    Cell Significance Index: -0.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0230
    Cell Significance Index: -2.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0237
    Cell Significance Index: -3.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0243
    Cell Significance Index: -2.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0254
    Cell Significance Index: -1.3200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0258
    Cell Significance Index: -0.1600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0265
    Cell Significance Index: -0.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0279
    Cell Significance Index: -0.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0300
    Cell Significance Index: -3.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0313
    Cell Significance Index: -2.3300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0378
    Cell Significance Index: -0.2800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0392
    Cell Significance Index: -0.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0397
    Cell Significance Index: -1.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0402
    Cell Significance Index: -2.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0440
    Cell Significance Index: -0.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0491
    Cell Significance Index: -2.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0492
    Cell Significance Index: -1.6100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0497
    Cell Significance Index: -1.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0506
    Cell Significance Index: -4.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0601
    Cell Significance Index: -1.5800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0619
    Cell Significance Index: -0.5200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0625
    Cell Significance Index: -0.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0634
    Cell Significance Index: -3.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0664
    Cell Significance Index: -1.3900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0700
    Cell Significance Index: -1.0200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0730
    Cell Significance Index: -1.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0761
    Cell Significance Index: -2.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0772
    Cell Significance Index: -2.1000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0805
    Cell Significance Index: -1.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0820
    Cell Significance Index: -3.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0846
    Cell Significance Index: -3.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** YBX2 is a small, acidic protein that belongs to the Y-box family of transcription factors. It is characterized by its ability to bind to specific DNA sequences, particularly those involved in the regulation of gene expression. The protein is highly conserved across species, suggesting its importance in various biological processes. YBX2 is also known to interact with other proteins and RNA molecules, modulating its activity and specificity. Its expression is tightly regulated, with specific patterns of expression observed in different cell types and tissues. **Pathways and Functions** YBX2 is involved in a wide range of biological pathways, including: 1. **Regulation of Gene Expression**: YBX2 acts as a transcriptional regulator, controlling the expression of genes involved in cell differentiation, proliferation, and survival. It binds to specific DNA sequences, such as the Y-box binding site, to modulate the activity of target genes. 2. **DNA Binding**: YBX2 is a DNA-binding protein that recognizes specific DNA sequences, including the Y-box binding site. It interacts with other proteins and RNA molecules to modulate its activity and specificity. 3. **Nucleic Acid Binding**: YBX2 binds to specific nucleic acid sequences, including RNA and DNA, to regulate gene expression and cellular processes. 4. **Transcriptional Control**: YBX2 regulates the activity of RNA polymerase II, a key enzyme involved in transcriptional control. It modulates the recruitment of transcriptional machinery to specific gene promoters. 5. **Cell Differentiation**: YBX2 is involved in the regulation of cell differentiation, particularly in hematopoietic and epithelial cells. It modulates the expression of genes involved in cell fate determination. **Clinical Significance** YBX2 has been implicated in various diseases, including: 1. **Immune Response**: YBX2 is involved in the regulation of immune responses, particularly in the context of inflammation and autoimmune diseases. It modulates the expression of genes involved in immune cell function and cytokine production. 2. **Cancer**: YBX2 has been implicated in the development and progression of various cancers, including leukemia, lymphoma, and solid tumors. It modulates the expression of genes involved in cell proliferation, survival, and metastasis. 3. **Neurological Disorders**: YBX2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. It modulates the expression of genes involved in neuronal function and survival. In conclusion, YBX2 is a multifunctional protein that plays a critical role in various biological processes, including gene regulation, cell differentiation, and immune response. Its expression is observed in a wide range of cell types, and its involvement in various diseases highlights its importance in human health and disease. Further research is needed to fully elucidate the mechanisms of YBX2 and its clinical significance in the context of immune response and disease.

Genular Protein ID: 4096073794

Symbol: YBOX2_HUMAN

Name: Y-box-binding protein 2

UniProtKB Accession Codes:

Q9Y2T7 D3DTP1 Q8N4P0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10100484

Title: Contrin, the human homologue of a germ-cell Y-box-binding protein: cloning, expression, and chromosomal localization.

PubMed ID: 10100484

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16479255

Title: Expression of Y-box-binding protein dbpC/contrin, a potentially new cancer/testis antigen.

PubMed ID: 16479255

DOI: 10.1038/sj.bjc.6602987

Sequence Information:

  • Length: 364
  • Mass: 38518
  • Checksum: 0B16DEF46F4634FA
  • Sequence:
    • MSEVEAAAGA TAVPAATVPA TAAGVVAVVV PVPAGEPQKG GGAGGGGGAA SGPAAGTPSA 
PGSRTPGNPA TAVSGTPAPP ARSQADKPVL AIQVLGTVKW FNVRNGYGFI NRNDTKEDVF 
VHQTAIKRNN PRKFLRSVGD GETVEFDVVE GEKGAEATNV TGPGGVPVKG SRYAPNRRKS 
RRFIPRPPSV APPPMVAEIP SAGTGPGSKG ERAEDSGQRP RRWCPPPFFY RRRFVRGPRP 
PNQQQPIEGT DRVEPKETAP LEGHQQQGDE RVPPPRFRPR YRRPFRPRPR QQPTTEGGDG 
ETKPSQGPAD GSRPEPQRPR NRPYFQRRRQ QAPGPQQAPG PRQPAAPETS APVNSGDPTT 
TILE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.