Details for: KLHL5

Gene ID: 51088

Symbol: KLHL5

Ensembl ID: ENSG00000109790

Description: kelch like family member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 225.7864
    Cell Significance Index: -35.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 133.2580
    Cell Significance Index: -33.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.7430
    Cell Significance Index: -35.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.5310
    Cell Significance Index: -30.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.0618
    Cell Significance Index: -35.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.1605
    Cell Significance Index: -30.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.6709
    Cell Significance Index: -35.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.0279
    Cell Significance Index: -34.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.7501
    Cell Significance Index: -36.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.1579
    Cell Significance Index: -24.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9938
    Cell Significance Index: -35.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.9640
    Cell Significance Index: 130.5900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 5.1620
    Cell Significance Index: 64.0300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.9272
    Cell Significance Index: 42.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.9128
    Cell Significance Index: 195.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5130
    Cell Significance Index: 287.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4709
    Cell Significance Index: 66.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3788
    Cell Significance Index: 273.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3011
    Cell Significance Index: 79.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.1455
    Cell Significance Index: 32.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1034
    Cell Significance Index: 29.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8442
    Cell Significance Index: 169.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7925
    Cell Significance Index: 548.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6766
    Cell Significance Index: 66.9400
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.6539
    Cell Significance Index: 5.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6526
    Cell Significance Index: 589.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5394
    Cell Significance Index: 28.1000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.5214
    Cell Significance Index: 5.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4109
    Cell Significance Index: 147.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4040
    Cell Significance Index: 9.6900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3758
    Cell Significance Index: 6.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3369
    Cell Significance Index: 54.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2795
    Cell Significance Index: 7.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2598
    Cell Significance Index: 141.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2462
    Cell Significance Index: 29.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2176
    Cell Significance Index: 26.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1948
    Cell Significance Index: 21.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1603
    Cell Significance Index: 11.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1228
    Cell Significance Index: 16.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1207
    Cell Significance Index: 227.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1192
    Cell Significance Index: 0.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0819
    Cell Significance Index: 4.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0703
    Cell Significance Index: 108.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0688
    Cell Significance Index: 126.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0600
    Cell Significance Index: 10.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0461
    Cell Significance Index: 0.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0287
    Cell Significance Index: 13.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0163
    Cell Significance Index: 22.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0135
    Cell Significance Index: 0.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0121
    Cell Significance Index: 0.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0036
    Cell Significance Index: 1.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0044
    Cell Significance Index: -2.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0097
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0149
    Cell Significance Index: -9.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0183
    Cell Significance Index: -13.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0293
    Cell Significance Index: -21.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0360
    Cell Significance Index: -5.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0366
    Cell Significance Index: -20.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0385
    Cell Significance Index: -6.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0460
    Cell Significance Index: -34.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0602
    Cell Significance Index: -7.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0784
    Cell Significance Index: -2.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0833
    Cell Significance Index: -17.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0884
    Cell Significance Index: -5.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1061
    Cell Significance Index: -30.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1105
    Cell Significance Index: -11.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1227
    Cell Significance Index: -9.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1246
    Cell Significance Index: -2.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1413
    Cell Significance Index: -16.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1483
    Cell Significance Index: -19.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1599
    Cell Significance Index: -18.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1729
    Cell Significance Index: -3.6700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2131
    Cell Significance Index: -4.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2250
    Cell Significance Index: -15.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2280
    Cell Significance Index: -3.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2444
    Cell Significance Index: -10.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2465
    Cell Significance Index: -4.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2515
    Cell Significance Index: -11.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2603
    Cell Significance Index: -27.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2632
    Cell Significance Index: -30.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2723
    Cell Significance Index: -10.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2819
    Cell Significance Index: -9.2300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2945
    Cell Significance Index: -4.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3057
    Cell Significance Index: -19.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3429
    Cell Significance Index: -21.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3528
    Cell Significance Index: -16.4500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3587
    Cell Significance Index: -5.3000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3609
    Cell Significance Index: -4.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3947
    Cell Significance Index: -31.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4017
    Cell Significance Index: -10.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4376
    Cell Significance Index: -30.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4385
    Cell Significance Index: -22.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4395
    Cell Significance Index: -9.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4500
    Cell Significance Index: -14.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4571
    Cell Significance Index: -7.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5285
    Cell Significance Index: -10.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5667
    Cell Significance Index: -35.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5907
    Cell Significance Index: -18.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6074
    Cell Significance Index: -12.6000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6142
    Cell Significance Index: -15.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLHL5 is characterized by its unique RING finger domain, which confers its E3 ubiquitin ligase activity. This domain enables KLHL5 to recognize and target specific substrates for ubiquitination, thereby modulating protein degradation and immune responses. The gene's expression in diverse cell types, including hematopoietic cells, epithelial cells, and immune cells, underscores its broad functional scope. KLHL5's involvement in actin binding, cytoskeleton organization, and protein binding further highlights its role in maintaining cellular homeostasis. **Pathways and Functions:** KLHL5's ubiquitin ligase activity enables it to regulate protein degradation through the proteasome-mediated ubiquitin-dependent protein catabolic process. This process is critical for maintaining immune homeostasis, as KLHL5 can modulate the degradation of key immune-related proteins. Additionally, KLHL5's involvement in antigen processing and presentation, particularly through Class I MHC-mediated pathways, underscores its role in regulating immune responses. The gene's interactions with Cul3 and Neddylation pathways further highlight its complex role in protein modification and degradation. **Clinical Significance:** KLHL5's involvement in immune regulation and cellular homeostasis has significant implications for the development of novel therapeutic strategies for immune-related disorders. For instance, dysregulation of KLHL5 has been implicated in various diseases, including autoimmune disorders, cancer, and inflammatory diseases. Further studies on KLHL5's role in disease pathogenesis and its potential as a therapeutic target are warranted. Additionally, the gene's expression in various cell types highlights its potential as a biomarker for disease diagnosis and monitoring. In conclusion, KLHL5's complex interactions with various signaling pathways and its broad expression in diverse cell types underscore its pivotal role in maintaining immune homeostasis and cellular balance. Further research on KLHL5's function and potential therapeutic applications will provide valuable insights into the regulation of immune responses and the development of novel therapeutic strategies for immune-related disorders.

Genular Protein ID: 1960528727

Symbol: KLHL5_HUMAN

Name: Kelch-like protein 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11590829

Title: Cloning and characterization of KLHL5, a novel human gene encoding a kelch-related protein with a BTB domain.

PubMed ID: 11590829

DOI: 10.1023/a:1010203114697

PubMed ID: 14672410

Title: Characterization of a novel splicing variant of KLHL5, a member of the kelch protein family.

PubMed ID: 14672410

DOI: 10.1023/a:1026372901766

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 755
  • Mass: 84457
  • Checksum: 2AB1BFB98F387F6C
  • Sequence:
  • MNVIYFPLHI FVVYSRAYTS LVLVGCTNLC AVLFARCLDD HLVSLRMSGS RKEFDVKQIL 
    KIRWRWFGHQ ASSPNSTVDS QQGEFWNRGQ TGANGGRKFL DPCSLQLPLA SIGYRRSSQL 
    DFQNSPSWPM ASTSEVPAFE FTAEDCGGAH WLDRPEVDDG TSEEENESDS SSCRTSNSSQ 
    TLSSCHTMEP CTSDEFFQAL NHAEQTFKKM ENYLRHKQLC DVILVAGDRR IPAHRLVLSS 
    VSDYFAAMFT NDVREARQEE IKMEGVEPNS LWSLIQYAYT GRLELKEDNI ECLLSTACLL 
    QLSQVVEACC KFLMKQLHPS NCLGIRSFAD AQGCTDLHKV AHNYTMEHFM EVIRNQEFVL 
    LPASEIAKLL ASDDMNIPNE ETILNALLTW VRHDLEQRRK DLSKLLAYIR LPLLAPQFLA 
    DMENNVLFRD DIECQKLIME AMKYHLLPER RPMLQSPRTK PRKSTVGTLF AVGGMDSTKG 
    ATSIEKYDLR TNMWTPVANM NGRRLQFGVA VLDDKLYVVG GRDGLKTLNT VECYNPKTKT 
    WSVMPPMSTH RHGLGVAVLE GPMYAVGGHD GWSYLNTVER WDPQARQWNF VATMSTPRST 
    VGVAVLSGKL YAVGGRDGSS CLKSVECFDP HTNKWTLCAQ MSKRRGGVGV TTWNGLLYAI 
    GGHDAPASNL TSRLSDCVER YDPKTDMWTA VASMSISRDA VGVCLLGDKL YAVGGYDGQA 
    YLNTVEAYDP QTNEWTQVAP LCLGRAGACV VTVKL

Genular Protein ID: 1823711082

Symbol: Q59HD9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 593
  • Mass: 66256
  • Checksum: E5C4CEAD99436207
  • Sequence:
  • AVTHGRLRSP TRTSNSSQTL SSCHTMEPCT SDEFFQALNH AEQTFKKMEN YLRHKQLCDV 
    ILVAGDRRIP AHRLVLSSVS DYFAAMFTND VREARQEEIK MEGVEPNSLW SLIQYAYTGR 
    LELKEDNIEC LLSTACLLQL SQVVEACCKF LMKQLHPSNC LGIRSFADAQ GCTDLHKVAH 
    NYTMEHFMEV IRNQEFVLLP ASEIAKLLAS DDMNIPNEET ILNALLTWVR HDLEQRRKDL 
    SKLLAYIRLP LLAPQFLADM ENNVLFRDDI ECQKLIMEAM KYHLLPERRP MLQSPRTKPR 
    KSTVGTLFAV GGMDSTKGAT SIEKYDLRTN MWTPVANMNG RRLQFGVAVL DDKLYVVGGR 
    DGLKTLNTVE CYNPKTKTWS VMPPMSTHRH GLGVAVLEGP MYAVGGHDGW SYLNTVERWD 
    PQARQWNFVA TMSTPRSTVG VAVLSGKLYA VGGRDGSSCL KSVECFDPHT NKWTLCAQMS 
    KRRGGVGVTT WNGLLYAIGG HDAPASNLTS RLSDCVERYD PKTDMWTAVA SMSISRDAVG 
    VCLLGDKLYA VGGYDGQAYL NTVEAYDPQT NEWTQVAPLC LGRAGACVVT VKL

Genular Protein ID: 2830138671

Symbol: Q7Z6D5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 762
  • Mass: 85029
  • Checksum: B520081D12B6E0AB
  • Sequence:
  • CGTPAWPPRP AVTHGRLRSP TRRAYTSLVL VGCTNLCAVL FARCLDDHLV SLRMSGSRKE 
    FDVKQILKIR WRWFGHQASS PNSTVDSQQG EFWNRGQTGA NGGRKFLDPC SLQLPLASIG 
    YRRSSQLDFQ NSPSWPMAST SEVPAFEFTA EDCGGAHWLD RPEVDDGTSE EENESDSSSC 
    RTSNSSQTLS SCHTMEPCTS DEFFQALNHA EQTFKKMENY LRHKQLCDVI LVAGDRRIPA 
    HRLVLSSVSD YFAAMFTNDV REARQEEIKM EGVEPNSLWS LIQYAYTGRL ELKEDNIECL 
    LSTACLLQLS QVVEACCKFL MKQLHPSNCL GIRSFADAQG CTDLHKVAHN YTMEHFMEVI 
    RNQEFVLLPA SEIAKLLASD DMNIPNEETI LNALLTWVRH DLEQRRKDLS KLLAYIRLPL 
    LAPQFLADME NNVLFRDDIE CQKLIMEAMK YHLLPERRPM LQSPRTKPRK STVGTLFAVG 
    GMDSTKGATS IEKYDLRTNM WTPVANMNGR RLQFGVAVLD DKLYVVGGRD GLKTLNTVEC 
    YNPKTKTWSV MPPMSTHRHG LGVAVLEGPM YAVGGHDGWS YLNTVERWDP QARQWNFVAT 
    MSTPRSTVGV AVLSGKLYAV GGRDGSSCLK SVECFDPHTN KWTLCAQMSK RRGGVGVTTW 
    NGLLYAIGGH DAPASNLTSR LSDCVERYDP KTDMWTAVAS MSISRDAVGV CLLGDKLYAV 
    GGYDGQAYLN TVEAYDPQTN EWTQVAPLCL GRAGACVVTV KL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.