Details for: PLLP

Gene ID: 51090

Symbol: PLLP

Ensembl ID: ENSG00000102934

Description: plasmolipin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 123.5653
    Cell Significance Index: -19.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 77.4710
    Cell Significance Index: -19.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.4732
    Cell Significance Index: -14.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 36.3253
    Cell Significance Index: -17.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.8724
    Cell Significance Index: -19.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.5696
    Cell Significance Index: -14.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2030
    Cell Significance Index: -7.0100
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 2.6887
    Cell Significance Index: 10.3000
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.5161
    Cell Significance Index: 19.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8237
    Cell Significance Index: 39.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4208
    Cell Significance Index: 154.5400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.3795
    Cell Significance Index: 3.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2687
    Cell Significance Index: 17.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1891
    Cell Significance Index: 10.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9196
    Cell Significance Index: 26.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8322
    Cell Significance Index: 12.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8110
    Cell Significance Index: 56.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7937
    Cell Significance Index: 41.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6973
    Cell Significance Index: 629.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6286
    Cell Significance Index: 113.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5453
    Cell Significance Index: 15.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5342
    Cell Significance Index: 291.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4922
    Cell Significance Index: 60.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4545
    Cell Significance Index: 20.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4164
    Cell Significance Index: 9.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3164
    Cell Significance Index: 3.2800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2508
    Cell Significance Index: 3.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2477
    Cell Significance Index: 24.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2179
    Cell Significance Index: 4.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2169
    Cell Significance Index: 43.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1276
    Cell Significance Index: 3.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1256
    Cell Significance Index: 16.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0940
    Cell Significance Index: 17.8900
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.0773
    Cell Significance Index: 0.4300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0740
    Cell Significance Index: 0.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0634
    Cell Significance Index: 10.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0519
    Cell Significance Index: 6.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0492
    Cell Significance Index: 1.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0463
    Cell Significance Index: 5.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0395
    Cell Significance Index: 2.0600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0316
    Cell Significance Index: 0.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0305
    Cell Significance Index: 1.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0212
    Cell Significance Index: 9.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0204
    Cell Significance Index: 15.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0112
    Cell Significance Index: 7.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0073
    Cell Significance Index: -13.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0140
    Cell Significance Index: -25.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0165
    Cell Significance Index: -5.9400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0170
    Cell Significance Index: -26.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0171
    Cell Significance Index: -12.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0209
    Cell Significance Index: -28.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0215
    Cell Significance Index: -13.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0298
    Cell Significance Index: -22.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0345
    Cell Significance Index: -21.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0350
    Cell Significance Index: -2.6100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0364
    Cell Significance Index: -0.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0385
    Cell Significance Index: -4.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0401
    Cell Significance Index: -22.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0419
    Cell Significance Index: -19.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0425
    Cell Significance Index: -8.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0553
    Cell Significance Index: -15.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0593
    Cell Significance Index: -1.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0637
    Cell Significance Index: -1.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0676
    Cell Significance Index: -6.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0685
    Cell Significance Index: -9.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0795
    Cell Significance Index: -3.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1081
    Cell Significance Index: -15.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1101
    Cell Significance Index: -23.1900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1208
    Cell Significance Index: -0.4600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1219
    Cell Significance Index: -1.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1329
    Cell Significance Index: -8.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1487
    Cell Significance Index: -9.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1568
    Cell Significance Index: -18.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1879
    Cell Significance Index: -19.5600
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.1893
    Cell Significance Index: -1.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2072
    Cell Significance Index: -16.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2232
    Cell Significance Index: -17.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2247
    Cell Significance Index: -15.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2259
    Cell Significance Index: -15.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2313
    Cell Significance Index: -9.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2340
    Cell Significance Index: -14.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2579
    Cell Significance Index: -16.6400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2986
    Cell Significance Index: -3.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2989
    Cell Significance Index: -15.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3509
    Cell Significance Index: -19.6900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.3571
    Cell Significance Index: -2.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3995
    Cell Significance Index: -17.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4053
    Cell Significance Index: -10.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4128
    Cell Significance Index: -14.3500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4297
    Cell Significance Index: -3.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4325
    Cell Significance Index: -9.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4335
    Cell Significance Index: -22.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4401
    Cell Significance Index: -16.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4471
    Cell Significance Index: -13.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4666
    Cell Significance Index: -17.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4700
    Cell Significance Index: -11.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4896
    Cell Significance Index: -17.1500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.4966
    Cell Significance Index: -6.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5096
    Cell Significance Index: -13.4000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.5150
    Cell Significance Index: -10.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLLP is a type of plasmalipid protein, characterized by its unique structure and function. It is a transmembrane protein that interacts with other lipids and proteins to form compact myelin, a complex structure composed of lipids and protein subunits. PLLP exhibits distinct binding properties, including identical protein binding and membrane raft interactions, which facilitate its association with other myelin components. Its expression is highly specific, with significant expression in cells involved in hematopoiesis, immune responses, and epithelial functions. **Pathways and Functions:** The functions of PLLP are deeply intertwined with the formation and maintenance of compact myelin. It plays a critical role in the structural integrity of the myelin sheath, which is essential for efficient neuronal transmission and axonal function. PLLP's interactions with other myelin components, such as lipids and protein subunits, facilitate the formation of compact myelin, a process that involves the organization of lipids and proteins into a highly ordered, crystalline structure. Additionally, PLLP's involvement in plasma membrane dynamics underscores its role in regulating cellular processes, including cell signaling, differentiation, and migration. **Clinical Significance:** Dysregulation of PLLP expression and function has been implicated in various neurological and immunological disorders, including multiple sclerosis, Guillain-Barré syndrome, and autoimmune diseases. The disruption of compact myelin structure and function can lead to impaired neuronal transmission, axonal degeneration, and inflammatory responses. Further research on PLLP's role in disease pathogenesis and its potential as a therapeutic target is necessary to elucidate the complex mechanisms underlying these disorders. In conclusion, PLLP is a critical component of the myelin sheath, and its dysregulation has significant implications for neurological and immunological health. Further investigation into the structure, function, and regulation of PLLP is essential to understand its role in maintaining the integrity of compact myelin and to develop novel therapeutic strategies for the treatment of related disorders.

Genular Protein ID: 1669745007

Symbol: PLLP_HUMAN

Name: Plasmolipin

UniProtKB Accession Codes:

Q9Y342 B2R9T6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 182
  • Mass: 19987
  • Checksum: 6F09AA080E2F67E8
  • Sequence:
    • MAEFPSKVST RTSSPAQGAE ASVSALRPDL GFVRSRLGAL MLLQLVLGLL VWALIADTPY 
HLYPAYGWVM FVAVFLWLVT IVLFNLYLFQ LHMKLYMVPW PLVLMIFNIS ATVLYITAFI 
ACSAAVDLTS LRGTRPYNQR AAASFFACLV MIAYGVSAFF SYQAWRGVGS NAATSQMAGG 
YA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.