Details for: SCCPDH

Gene ID: 51097

Symbol: SCCPDH

Ensembl ID: ENSG00000143653

Description: saccharopine dehydrogenase (putative)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 201.8705
    Cell Significance Index: -31.4000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 102.5494
    Cell Significance Index: -42.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 90.5208
    Cell Significance Index: -22.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 86.0264
    Cell Significance Index: -40.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.6262
    Cell Significance Index: -34.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.6826
    Cell Significance Index: -38.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.7059
    Cell Significance Index: -40.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.1878
    Cell Significance Index: -34.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.8365
    Cell Significance Index: -38.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.8562
    Cell Significance Index: -34.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.9859
    Cell Significance Index: -39.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 7.3219
    Cell Significance Index: 380.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.6099
    Cell Significance Index: 51.6600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6400
    Cell Significance Index: -10.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.2279
    Cell Significance Index: 223.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.3690
    Cell Significance Index: 63.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2799
    Cell Significance Index: 411.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0474
    Cell Significance Index: 122.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.5378
    Cell Significance Index: 41.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5177
    Cell Significance Index: 186.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3530
    Cell Significance Index: 268.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2125
    Cell Significance Index: 90.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1888
    Cell Significance Index: 41.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1238
    Cell Significance Index: 72.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0311
    Cell Significance Index: 206.8300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.9961
    Cell Significance Index: 6.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8985
    Cell Significance Index: 490.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7021
    Cell Significance Index: 15.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6741
    Cell Significance Index: 11.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6172
    Cell Significance Index: 16.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6051
    Cell Significance Index: 38.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5784
    Cell Significance Index: 79.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5326
    Cell Significance Index: 480.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4928
    Cell Significance Index: 63.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3965
    Cell Significance Index: 142.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3016
    Cell Significance Index: 8.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2639
    Cell Significance Index: 45.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2515
    Cell Significance Index: 173.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2509
    Cell Significance Index: 47.7500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2342
    Cell Significance Index: 1.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2204
    Cell Significance Index: 12.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1853
    Cell Significance Index: 115.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1431
    Cell Significance Index: 16.8700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1153
    Cell Significance Index: 0.9400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0981
    Cell Significance Index: 1.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0775
    Cell Significance Index: 1.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0771
    Cell Significance Index: 4.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0470
    Cell Significance Index: 4.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0429
    Cell Significance Index: 5.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0329
    Cell Significance Index: 14.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0251
    Cell Significance Index: 1.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0217
    Cell Significance Index: 0.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0082
    Cell Significance Index: 15.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0039
    Cell Significance Index: 6.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0083
    Cell Significance Index: -15.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0091
    Cell Significance Index: -12.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0124
    Cell Significance Index: -0.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0208
    Cell Significance Index: -13.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0247
    Cell Significance Index: -0.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0260
    Cell Significance Index: -19.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0310
    Cell Significance Index: -23.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0325
    Cell Significance Index: -0.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0356
    Cell Significance Index: -3.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0398
    Cell Significance Index: -3.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0446
    Cell Significance Index: -25.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0532
    Cell Significance Index: -0.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0536
    Cell Significance Index: -8.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0549
    Cell Significance Index: -24.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0709
    Cell Significance Index: -3.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0779
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0783
    Cell Significance Index: -16.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1013
    Cell Significance Index: -11.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1071
    Cell Significance Index: -12.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1189
    Cell Significance Index: -34.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1220
    Cell Significance Index: -2.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1666
    Cell Significance Index: -7.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1766
    Cell Significance Index: -1.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1841
    Cell Significance Index: -26.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1904
    Cell Significance Index: -8.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2060
    Cell Significance Index: -7.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2216
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2227
    Cell Significance Index: -25.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2293
    Cell Significance Index: -15.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3005
    Cell Significance Index: -4.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3610
    Cell Significance Index: -10.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3663
    Cell Significance Index: -38.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3668
    Cell Significance Index: -25.9400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3753
    Cell Significance Index: -5.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4314
    Cell Significance Index: -34.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4935
    Cell Significance Index: -22.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5034
    Cell Significance Index: -12.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5134
    Cell Significance Index: -10.0200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5506
    Cell Significance Index: -5.8500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5646
    Cell Significance Index: -7.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6369
    Cell Significance Index: -18.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6485
    Cell Significance Index: -39.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6900
    Cell Significance Index: -11.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7343
    Cell Significance Index: -17.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cellular expression**: SCCPD is significantly expressed in hematopoietic oligopotent progenitor cells, polychromatophilic erythroblasts, and embryonic stem cells, indicating its role in the development and maintenance of blood cells. 2. **Gene ontology**: The gene is associated with various biological processes, including glycolipid biosynthesis, platelet activation, and response to calcium levels, highlighting its involvement in cellular signaling and regulation. 3. **Protein similarity**: The SCCPD gene shares similarity with saccharopine dehydrogenase, a known enzyme involved in amino acid metabolism, suggesting potential functional overlap between the two. 4. **Cell type specificity**: The expression of SCCPD is observed in a range of cell types, including smooth muscle cells, epithelial cells, and immune cells, indicating its role in maintaining tissue homeostasis and responding to environmental stimuli. **Pathways and Functions** 1. **Glycolipid biosynthesis**: SCCPD may play a role in the synthesis of glycolipids, which are essential components of cellular membranes and play a crucial role in cell signaling and recognition. 2. **Platelet activation**: The SCCPD gene is involved in platelet activation, which is a critical process in blood coagulation and hemostasis. The protein encoded by SCCPD may regulate platelet function and response to calcium levels. 3. **Response to elevated platelet cytosolic Ca2+**: SCCPD may respond to changes in calcium levels within platelets, regulating platelet activation and function. 4. **Oxidoreductase activity**: The SCCPD gene is associated with oxidoreductase activity, which is a critical process in cellular metabolism and signaling. **Clinical Significance** 1. **Blood disorders**: The SCCPD gene is expressed in hematopoietic cells, suggesting its potential role in the development of blood disorders, such as anemia or leukemia. 2. **Cardiovascular disease**: The involvement of SCCPD in platelet activation and response to calcium levels may contribute to the development of cardiovascular disease, including thrombosis and atherosclerosis. 3. **Cancer**: The expression of SCCPD in epithelial cells and immune cells may contribute to cancer development and progression, particularly in cases where cell signaling and regulation are disrupted. 4. **Neurological disorders**: The involvement of SCCPD in cellular signaling and regulation may contribute to the development of neurological disorders, such as Alzheimer's disease or Parkinson's disease. In conclusion, the SCCPD gene is a putative gene that is involved in multiple cellular processes, including glycolipid biosynthesis, platelet activation, and response to calcium levels. Its expression in various cell types suggests its widespread role in the body, and its potential involvement in disease states such as blood disorders, cardiovascular disease, cancer, and neurological disorders. Further research is necessary to fully elucidate the function and clinical significance of the SCCPD gene.

Genular Protein ID: 2135516507

Symbol: SCPDL_HUMAN

Name: Saccharopine dehydrogenase-like oxidoreductase

UniProtKB Accession Codes:

Q8NBX0 Q8TAR0 Q9Y363

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 429
  • Mass: 47151
  • Checksum: A93EBEDDF128A548
  • Sequence:
    • MATEQRPFHL VVFGASGFTG QFVTEEVARE QVDPERSSRL PWAVAGRSRE KLQRVLEKAA 
LKLGRPTLSS EVGIIICDIA NPASLDEMAK QATVVLNCVG PYRFYGEPVI KACIENGASC 
IDISGEPQFL ELMQLKYHEK AADKGVYIIG SSGFDSIPAD LGVIYTRNKM NGTLTAVESF 
LTIHSGPEGL SIHDGTWKSA IYGFGDQSNL RKLRNVSNLK PVPLIGPKLK RRWPISYCRE 
LKGYSIPFMG SDVSVVRRTQ RYLYENLEES PVQYAAYVTV GGITSVIKLM FAGLFFLFFV 
RFGIGRQLLI KFPWFFSFGY FSKQGPTQKQ IDAASFTLTF FGQGYSQGTG TDKNKPNIKI 
CTQVKGPEAG YVATPIAMVQ AAMTLLSDAS HLPKAGGVFT PGAAFSKTKL IDRLNKHGIE 
FSVISSSEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.