Details for: KCTD3

Gene ID: 51133

Symbol: KCTD3

Ensembl ID: ENSG00000136636

Description: potassium channel tetramerization domain containing 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 314.1209
    Cell Significance Index: -48.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 192.2384
    Cell Significance Index: -48.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 102.3982
    Cell Significance Index: -41.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 43.5929
    Cell Significance Index: -41.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.4151
    Cell Significance Index: -49.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.6535
    Cell Significance Index: -49.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.6734
    Cell Significance Index: -50.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.1974
    Cell Significance Index: 221.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.9805
    Cell Significance Index: 569.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7572
    Cell Significance Index: 348.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6697
    Cell Significance Index: 181.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5466
    Cell Significance Index: 92.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4377
    Cell Significance Index: 288.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2938
    Cell Significance Index: 72.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2784
    Cell Significance Index: 24.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0229
    Cell Significance Index: 22.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9744
    Cell Significance Index: 349.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9442
    Cell Significance Index: 27.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7570
    Cell Significance Index: 58.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6160
    Cell Significance Index: 16.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5366
    Cell Significance Index: 36.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5086
    Cell Significance Index: 351.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4985
    Cell Significance Index: 13.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4401
    Cell Significance Index: 20.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4051
    Cell Significance Index: 49.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3976
    Cell Significance Index: 71.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3700
    Cell Significance Index: 22.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3604
    Cell Significance Index: 58.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3340
    Cell Significance Index: 301.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3166
    Cell Significance Index: 14.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2596
    Cell Significance Index: 35.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2211
    Cell Significance Index: 10.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1843
    Cell Significance Index: 18.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1659
    Cell Significance Index: 90.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1530
    Cell Significance Index: 29.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1481
    Cell Significance Index: 2.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1363
    Cell Significance Index: 6.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1337
    Cell Significance Index: 22.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1231
    Cell Significance Index: 2.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1168
    Cell Significance Index: 51.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1028
    Cell Significance Index: 5.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0805
    Cell Significance Index: 6.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0720
    Cell Significance Index: 2.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0714
    Cell Significance Index: 1.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0672
    Cell Significance Index: 8.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0660
    Cell Significance Index: 124.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0293
    Cell Significance Index: 13.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0244
    Cell Significance Index: 45.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0235
    Cell Significance Index: 0.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0190
    Cell Significance Index: 12.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0123
    Cell Significance Index: 18.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0171
    Cell Significance Index: -10.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0192
    Cell Significance Index: -14.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0246
    Cell Significance Index: -33.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0281
    Cell Significance Index: -0.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0295
    Cell Significance Index: -21.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0296
    Cell Significance Index: -3.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0606
    Cell Significance Index: -34.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0664
    Cell Significance Index: -50.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1341
    Cell Significance Index: -28.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1403
    Cell Significance Index: -8.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1477
    Cell Significance Index: -15.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1539
    Cell Significance Index: -17.9400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1541
    Cell Significance Index: -2.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1750
    Cell Significance Index: -25.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1875
    Cell Significance Index: -21.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2425
    Cell Significance Index: -17.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3245
    Cell Significance Index: -37.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3288
    Cell Significance Index: -8.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3642
    Cell Significance Index: -18.4100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3656
    Cell Significance Index: -2.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3697
    Cell Significance Index: -43.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3831
    Cell Significance Index: -39.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4065
    Cell Significance Index: -9.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4312
    Cell Significance Index: -13.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4335
    Cell Significance Index: -27.9700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.4520
    Cell Significance Index: -6.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4817
    Cell Significance Index: -25.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5026
    Cell Significance Index: -12.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5314
    Cell Significance Index: -42.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5495
    Cell Significance Index: -15.6800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5741
    Cell Significance Index: -3.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5901
    Cell Significance Index: -30.9900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6448
    Cell Significance Index: -9.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6787
    Cell Significance Index: -41.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7293
    Cell Significance Index: -15.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7460
    Cell Significance Index: -6.8700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7507
    Cell Significance Index: -11.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7833
    Cell Significance Index: -27.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7834
    Cell Significance Index: -20.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8040
    Cell Significance Index: -11.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8300
    Cell Significance Index: -13.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8463
    Cell Significance Index: -18.5300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.9304
    Cell Significance Index: -11.5400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9447
    Cell Significance Index: -11.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9501
    Cell Significance Index: -30.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9656
    Cell Significance Index: -11.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9861
    Cell Significance Index: -32.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0065
    Cell Significance Index: -29.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0233
    Cell Significance Index: -29.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** KCTD3 is expressed in a wide range of cell types, including hematopoietic cells, mast cells, epithelial cells, and immune cells such as CD8-alpha-beta-positive alpha-beta intraepithelial T cells. 2. **Protein structure:** KCTD3 contains a BTB/POZ domain, a tetramerization domain, and a C-terminal region. 3. **Function:** KCTD3 is involved in protein homooligomerization, signaling by Rho GTPases, and cell migration. 4. **Signaling pathways:** KCTD3 interacts with various signaling molecules, including Rho GTPases, Cdc42 GTPases, and Miro GTPases, to regulate cellular processes. **Pathways and Functions:** 1. **Rho GTPase cycle:** KCTD3 interacts with Rho GTPases to regulate cell migration, adhesion, and survival. This interaction is crucial for the proper functioning of immune cells, such as T cells and mast cells. 2. **Cdc42 GTPase cycle:** KCTD3 is involved in the regulation of the Cdc42 GTPase cycle, which is essential for cell migration, adhesion, and survival. 3. **Signaling by Rho GTPases and Miro GTPases:** KCTD3 interacts with Rho GTPases and Miro GTPases to regulate signaling pathways involved in cell migration, adhesion, and survival. 4. **Homooligomerization:** KCTD3 forms homooligomers, which are essential for its function in protein-protein interactions. **Clinical Significance:** 1. **Immune disorders:** KCTD3 has been implicated in various immune disorders, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** KCTD3 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma. 3. **Inflammatory diseases:** KCTD3 has been implicated in inflammatory diseases, such as asthma and inflammatory bowel disease. 4. **Neurological disorders:** KCTD3 has been found to be involved in neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, KCTD3 plays a crucial role in immune response and is involved in various cellular processes, including signaling pathways and protein-protein interactions. Further research is necessary to fully understand the functions and clinical significance of KCTD3 in the immune system.

Genular Protein ID: 1407760922

Symbol: KCTD3_HUMAN

Name: BTB/POZ domain-containing protein KCTD3

UniProtKB Accession Codes:

Q9Y597 A0AV15 D3DTA6 Q49AG7 Q504Q9 Q6PJN6 Q8ND58 Q8NDJ0 Q8WX16

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 815
  • Mass: 88984
  • Checksum: 65131F449069B5B9
  • Sequence:
    • MAGGHCGSFP AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG RISTLRDETG 
AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY GITPLVRRLL LCEELERSSC 
GSVLFHGYLP PPGIPSRKIN NTVRSADSRN GLNSTEGEAR GNGTQPVLSG TGEETVRLGF 
PVDPRKVLIV AGHHNWIVAA YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG 
GPHGDKDKMV AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV 
GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK DNDLLVTELY 
HDPSNDAITA LSVYLTPKTS VSGNWIEIAY GTSSGAVRVI VQHPETVGSG PQLFQTFTVH 
RSPVTKIMLS EKHLVSVCAD NNHVRTWTVT RFRGMISTQP GSTPLASFKI LSLEETESHG 
SYSSGNDIGP FGERDDQQVF IQKVVPITNK LFVRLSSTGK RICEIQAVDC TTISSFTVRE 
CEGSSRMGSR PRRYLFTGHT NGSIQMWDLT TAMDMVNKSE DKDVGGPTEE ELLKLLDQCD 
LSTSRCATPN ISPATSVVQH SHLRESNSSL QLQHHDTTHE AATYGSMRPY RESPLLARAR 
RTESFHSYRD FQTINLNRNV ERAVPENGNL GPIQAEVKGA TGECNISERK SPGVEIKSLR 
ELDSGLEVHK IAEGFSESKK RSSEDENENK IEFRKKGGFE GGGFLGRKKV PYLASSPSTS 
DGGTDSPGTA SPSPTKTTPS PRHKKSDSSG QEYSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.