Details for: IRAK4

Gene ID: 51135

Symbol: IRAK4

Ensembl ID: ENSG00000198001

Description: interleukin 1 receptor associated kinase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.3830
    Cell Significance Index: -18.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.5321
    Cell Significance Index: -17.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.4115
    Cell Significance Index: -18.8600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.5011
    Cell Significance Index: -21.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.1656
    Cell Significance Index: -21.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.9268
    Cell Significance Index: -19.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.1928
    Cell Significance Index: -19.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7338
    Cell Significance Index: -15.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.1507
    Cell Significance Index: -15.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1266
    Cell Significance Index: -20.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6834
    Cell Significance Index: -10.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4625
    Cell Significance Index: 237.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2387
    Cell Significance Index: 16.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8769
    Cell Significance Index: 95.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7672
    Cell Significance Index: 46.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5400
    Cell Significance Index: 34.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5226
    Cell Significance Index: 32.9400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4312
    Cell Significance Index: 5.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3822
    Cell Significance Index: 45.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3597
    Cell Significance Index: 10.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3492
    Cell Significance Index: 10.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3095
    Cell Significance Index: 61.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3038
    Cell Significance Index: 8.4900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3017
    Cell Significance Index: 4.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2786
    Cell Significance Index: 7.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2426
    Cell Significance Index: 11.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2305
    Cell Significance Index: 41.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2286
    Cell Significance Index: 10.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2156
    Cell Significance Index: 4.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2032
    Cell Significance Index: 20.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1917
    Cell Significance Index: 23.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1861
    Cell Significance Index: 9.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1671
    Cell Significance Index: 91.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1570
    Cell Significance Index: 21.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1570
    Cell Significance Index: 69.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1360
    Cell Significance Index: 3.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1086
    Cell Significance Index: 2.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1030
    Cell Significance Index: 5.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1018
    Cell Significance Index: 70.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0959
    Cell Significance Index: 19.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0952
    Cell Significance Index: 1.7600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0783
    Cell Significance Index: 1.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0731
    Cell Significance Index: 12.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0613
    Cell Significance Index: 11.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0585
    Cell Significance Index: 2.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0527
    Cell Significance Index: 3.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0230
    Cell Significance Index: 2.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0118
    Cell Significance Index: 22.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0105
    Cell Significance Index: 3.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0097
    Cell Significance Index: 0.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0087
    Cell Significance Index: 16.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0073
    Cell Significance Index: 4.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0020
    Cell Significance Index: 3.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0148
    Cell Significance Index: -20.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0153
    Cell Significance Index: -6.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0157
    Cell Significance Index: -0.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0157
    Cell Significance Index: -2.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0157
    Cell Significance Index: -1.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0166
    Cell Significance Index: -12.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0214
    Cell Significance Index: -15.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0318
    Cell Significance Index: -0.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0325
    Cell Significance Index: -18.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0364
    Cell Significance Index: -22.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0399
    Cell Significance Index: -3.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0493
    Cell Significance Index: -14.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0669
    Cell Significance Index: -7.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0729
    Cell Significance Index: -8.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0746
    Cell Significance Index: -2.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0761
    Cell Significance Index: -1.6200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0844
    Cell Significance Index: -1.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1009
    Cell Significance Index: -5.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1045
    Cell Significance Index: -13.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1052
    Cell Significance Index: -22.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1322
    Cell Significance Index: -9.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1764
    Cell Significance Index: -18.3700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1870
    Cell Significance Index: -2.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2019
    Cell Significance Index: -5.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2304
    Cell Significance Index: -18.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2535
    Cell Significance Index: -13.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2617
    Cell Significance Index: -4.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2627
    Cell Significance Index: -6.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2644
    Cell Significance Index: -17.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2771
    Cell Significance Index: -17.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2773
    Cell Significance Index: -8.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2933
    Cell Significance Index: -17.9800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2943
    Cell Significance Index: -6.2900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2973
    Cell Significance Index: -4.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3051
    Cell Significance Index: -7.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3084
    Cell Significance Index: -2.8400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3167
    Cell Significance Index: -2.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3380
    Cell Significance Index: -14.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3824
    Cell Significance Index: -14.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4004
    Cell Significance Index: -6.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4043
    Cell Significance Index: -10.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4085
    Cell Significance Index: -6.0300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4208
    Cell Significance Index: -5.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4478
    Cell Significance Index: -16.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4517
    Cell Significance Index: -11.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4634
    Cell Significance Index: -2.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IRAK4 is a serine/threonine kinase that belongs to the IRAK family of kinases. It is a crucial component in the signaling pathways of TLRs, which recognize pathogen-associated molecular patterns (PAMPs) and trigger innate immune responses. IRAK4 is characterized by its ability to phosphorylate and activate downstream kinases, including IRAK1, IRAK2, and TRAF6, which in turn regulate the activation of NF-κB and MAP kinases. IRAK4 is also involved in the regulation of cytokine-mediated signaling pathways, including the IL-1 family signaling pathway. **Pathways and Functions** IRAK4 is involved in several signaling pathways, including: 1. **MyD88-dependent cascade initiated on plasma membrane**: IRAK4 is a key component in this pathway, which regulates the activation of NF-κB and MAP kinases in response to TLR ligands. 2. **Cytokine-mediated signaling pathway**: IRAK4 is involved in the regulation of cytokine-mediated signaling pathways, including the IL-1 family signaling pathway. 3. **Toll-like receptor signaling pathway**: IRAK4 is a key component in this pathway, which regulates the activation of NF-κB and MAP kinases in response to TLR ligands. 4. **JNK cascade**: IRAK4 is involved in the regulation of the JNK cascade, which regulates the activation of NF-κB and MAP kinases. IRAK4 functions as a positive regulator in the signaling pathways of TLRs and cytokine-mediated signaling pathways. It phosphorylates and activates downstream kinases, which in turn regulate the activation of NF-κB and MAP kinases. **Clinical Significance** IRAK4 deficiency has been associated with several diseases, including: 1. **Autoimmune disorders**: IRAK4 deficiency has been linked to autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Inflammatory conditions**: IRAK4 deficiency has been associated with inflammatory conditions, such as inflammatory bowel disease and psoriasis. 3. **Infections**: IRAK4 deficiency has been linked to increased susceptibility to infections, such as sepsis and pneumonia. 4. **Cancer**: IRAK4 has been implicated in the development and progression of certain cancers, such as melanoma and lung cancer. In summary, IRAK4 is a crucial component in the innate immune response, particularly in the signaling pathways of TLRs and cytokine-mediated signaling pathways. Its deficiency has been associated with several diseases, including autoimmune disorders, inflammatory conditions, and infections. Further research is needed to fully understand the role of IRAK4 in the immune system and its clinical significance.

Genular Protein ID: 3748943029

Symbol: IRAK4_HUMAN

Name: Interleukin-1 receptor-associated kinase 4

UniProtKB Accession Codes:

Q9NWZ3 Q69FE1 Q8TDF7 Q9Y589

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 3 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 74 PDBsum 74 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 18 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11960013

Title: IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase.

PubMed ID: 11960013

DOI: 10.1073/pnas.082100399

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12496252

Title: Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.

PubMed ID: 12496252

DOI: 10.1074/jbc.m212112200

PubMed ID: 12538665

Title: Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4.

PubMed ID: 12538665

DOI: 10.1084/jem.20021790

PubMed ID: 12925671

Title: Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections.

PubMed ID: 12925671

DOI: 10.1084/jem.20030701

PubMed ID: 15084582

Title: IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness.

PubMed ID: 15084582

DOI: 10.1074/jbc.m400785200

PubMed ID: 12637671

Title: Pyogenic bacterial infections in humans with IRAK-4 deficiency.

PubMed ID: 12637671

DOI: 10.1126/science.1081902

PubMed ID: 16286016

Title: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines.

PubMed ID: 16286016

DOI: 10.1016/j.immuni.2005.09.015

PubMed ID: 16951688

Title: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1.

PubMed ID: 16951688

DOI: 10.1038/ni1383

PubMed ID: 17217339

Title: Cross-talk between IRAK-4 and the NADPH oxidase.

PubMed ID: 17217339

DOI: 10.1042/bj20061184

PubMed ID: 17337443

Title: IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression.

PubMed ID: 17337443

DOI: 10.1074/jbc.m700548200

PubMed ID: 16950813

Title: IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease.

PubMed ID: 16950813

DOI: 10.1136/jmg.2006.044446

PubMed ID: 17997719

Title: The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

PubMed ID: 17997719

DOI: 10.1042/bj20071365

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20400509

Title: IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

PubMed ID: 20400509

DOI: 10.1074/jbc.m109.098137

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21325272

Title: Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.

PubMed ID: 21325272

DOI: 10.1074/jbc.m110.199653

PubMed ID: 21269878

Title: What the Myddosome structure tells us about the initiation of innate immunity.

PubMed ID: 21269878

DOI: 10.1016/j.it.2010.12.005

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 33238146

Title: Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation.

PubMed ID: 33238146

DOI: 10.1016/j.str.2020.11.004

PubMed ID: 17161373

Title: Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.

PubMed ID: 17161373

DOI: 10.1016/j.str.2006.11.001

PubMed ID: 17312103

Title: Cutting Edge: IL-1 receptor-associated kinase 4 structures reveal novel features and multiple conformations.

PubMed ID: 17312103

DOI: 10.4049/jimmunol.178.5.2641

PubMed ID: 20485341

Title: Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.

PubMed ID: 20485341

DOI: 10.1038/nature09121

PubMed ID: 17878374

Title: TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway.

PubMed ID: 17878374

DOI: 10.4049/jimmunol.179.7.4754

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 19663824

Title: Impaired neutrophil migration and phagocytosis in IRAK-4 deficiency.

PubMed ID: 19663824

DOI: 10.1111/j.1365-2141.2009.07838.x

PubMed ID: 21057262

Title: Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.

PubMed ID: 21057262

DOI: 10.1097/md.0b013e3181fd8ec3

PubMed ID: 24316379

Title: Functional assessment of the mutational effects of human IRAK4 and MyD88 genes.

PubMed ID: 24316379

DOI: 10.1016/j.molimm.2013.11.008

Sequence Information:

  • Length: 460
  • Mass: 51530
  • Checksum: 6C8156ADF25FF81E
  • Sequence:
    • MNKPITPSTY VRCLNVGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ FHIRRFEALL 
QTGKSPTSEL LFDWGTTNCT VGDLVDLLIQ NEFFAPASLL LPDAVPKTAN TLPSKEAITV 
QQKQMPFCDK DRTLMTPVQN LEQSYMPPDS SSPENKSLEV SDTRFHSFSF YELKNVTNNF 
DERPISVGGN KMGEGGFGVV YKGYVNNTTV AVKKLAAMVD ITTEELKQQF DQEIKVMAKC 
QHENLVELLG FSSDGDDLCL VYVYMPNGSL LDRLSCLDGT PPLSWHMRCK IAQGAANGIN 
FLHENHHIHR DIKSANILLD EAFTAKISDF GLARASEKFA QTVMTSRIVG TTAYMAPEAL 
RGEITPKSDI YSFGVVLLEI ITGLPAVDEH REPQLLLDIK EEIEDEEKTI EDYIDKKMND 
ADSTSVEAMY SVASQCLHEK KNKRPDIKKV QQLLQEMTAS

Genular Protein ID: 3477458471

Symbol: B4E359_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E359

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 14 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 6 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 5 Rhea 6 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 336
  • Mass: 37674
  • Checksum: 2DCBEDE3B0C8C8EA
  • Sequence:
    • MPFCDKDRTL MTPVQNLEQS YMPPDSSSPE NQSLEVSDTR FHSFSFYELK NVTNNFDERP 
ISVGGNKMGE GGFGVVYKGY VNNTTVAVKK LAAMVDITTE ELKQQFDQEI KVMAKCQHEN 
LVELLGFSSD GDDLCLVYVY MPNGSLLDRL SCLDGTPPLS WHMRCKIAQG AANGINFLHE 
NHHIHRDIKS ANILLDEAFT AKISDFGLAR ASEKFAQTVM TSRIVGTTAY MAPEALRGEI 
TPKSDIYSFG VVLLEIITGL PAVDEHREPQ LLLDIKEEIE DEEKTIEDYI DKKMNDADST 
SVEAMYSVAS QCLHEKKNKR PDIKKVQQLL QEMTAS

Genular Protein ID: 3425082881

Symbol: B2RAP9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RAP9

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 14 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 8 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 6 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 460
  • Mass: 51507
  • Checksum: 697B0A97CD9F9E1E
  • Sequence:
    • MNKPITPSTY VRCLNVGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ FHIRRFEALL 
QTGKSPTSEL LFDWGTTNCT VGDLVDLLIQ NEFFAPASLL LPDAVPKTAN TLPSKEAITV 
QQKQMPFCDK DRTLMTPVQN LEQSYMPPDS SSPENKSLEV SDTRFHSFSF YELKNVTNNF 
DERPISVGGN KMGEGGFGVV YKGYVNNTTV AVKKLAAMVD ITTEELKQQF DQEIKVMAKC 
QHENLVELLG FSSDGDDLCL VYVYMPNGSL LDRLSCLDGT PPLSWHMRCK IAQGAANGIN 
FLHENNHIHR DIKSANILLD EAFTAKISDF GLARASEKFA QTVMTSRIVG TTAYMAPEAL 
RGEITPKSDI YSFGVVLLEI ITGLPAVDEH REPQLLLDIK EEIEDEEKTI EDYIDKKMND 
ADSTSVEAMY SVASQCLHEK KNKRPDIKKV QQLLQEMTAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.