Details for: CYB5R4

Gene ID: 51167

Symbol: CYB5R4

Ensembl ID: ENSG00000065615

Description: cytochrome b5 reductase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 184.8980
    Cell Significance Index: -28.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 100.2589
    Cell Significance Index: -25.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.1648
    Cell Significance Index: -31.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.8050
    Cell Significance Index: -27.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 59.3330
    Cell Significance Index: -30.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.6884
    Cell Significance Index: -27.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.4291
    Cell Significance Index: -30.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.1872
    Cell Significance Index: -27.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.7592
    Cell Significance Index: -29.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7787
    Cell Significance Index: -30.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5437
    Cell Significance Index: -16.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4969
    Cell Significance Index: 300.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1227
    Cell Significance Index: 20.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9925
    Cell Significance Index: 43.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9914
    Cell Significance Index: 37.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9653
    Cell Significance Index: 346.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9133
    Cell Significance Index: 99.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8643
    Cell Significance Index: 100.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8324
    Cell Significance Index: 55.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8296
    Cell Significance Index: 573.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8281
    Cell Significance Index: 134.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6239
    Cell Significance Index: 35.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6109
    Cell Significance Index: 39.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5105
    Cell Significance Index: 92.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5083
    Cell Significance Index: 31.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4986
    Cell Significance Index: 98.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4665
    Cell Significance Index: 55.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4324
    Cell Significance Index: 29.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3665
    Cell Significance Index: 45.0700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3386
    Cell Significance Index: 4.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2710
    Cell Significance Index: 6.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2217
    Cell Significance Index: 42.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2211
    Cell Significance Index: 138.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1772
    Cell Significance Index: 17.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1599
    Cell Significance Index: 2.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1565
    Cell Significance Index: 3.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1309
    Cell Significance Index: 3.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1182
    Cell Significance Index: 106.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1045
    Cell Significance Index: 57.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1028
    Cell Significance Index: 2.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0905
    Cell Significance Index: 40.0000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0692
    Cell Significance Index: 1.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0656
    Cell Significance Index: 1.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0629
    Cell Significance Index: 2.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0555
    Cell Significance Index: 1.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0546
    Cell Significance Index: 4.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0343
    Cell Significance Index: 1.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0322
    Cell Significance Index: 14.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0210
    Cell Significance Index: 39.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0125
    Cell Significance Index: 0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0109
    Cell Significance Index: 20.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0060
    Cell Significance Index: 9.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0057
    Cell Significance Index: -3.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0066
    Cell Significance Index: -9.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0235
    Cell Significance Index: -1.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0285
    Cell Significance Index: -21.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0303
    Cell Significance Index: -4.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0327
    Cell Significance Index: -23.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0375
    Cell Significance Index: -21.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0398
    Cell Significance Index: -5.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0437
    Cell Significance Index: -7.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0523
    Cell Significance Index: -5.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0805
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0868
    Cell Significance Index: -18.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0924
    Cell Significance Index: -26.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1031
    Cell Significance Index: -11.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1170
    Cell Significance Index: -15.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1651
    Cell Significance Index: -7.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1654
    Cell Significance Index: -3.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1661
    Cell Significance Index: -21.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1986
    Cell Significance Index: -14.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2209
    Cell Significance Index: -15.6200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2225
    Cell Significance Index: -11.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2312
    Cell Significance Index: -6.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2413
    Cell Significance Index: -11.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2583
    Cell Significance Index: -26.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2736
    Cell Significance Index: -6.8400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2740
    Cell Significance Index: -31.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2843
    Cell Significance Index: -8.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3025
    Cell Significance Index: -15.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3556
    Cell Significance Index: -3.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3619
    Cell Significance Index: -28.6600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4282
    Cell Significance Index: -5.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4471
    Cell Significance Index: -14.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4602
    Cell Significance Index: -11.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4930
    Cell Significance Index: -16.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4941
    Cell Significance Index: -5.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5027
    Cell Significance Index: -16.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5162
    Cell Significance Index: -31.6500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5433
    Cell Significance Index: -11.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5508
    Cell Significance Index: -14.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5514
    Cell Significance Index: -11.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5654
    Cell Significance Index: -11.1800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6022
    Cell Significance Index: -7.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6344
    Cell Significance Index: -22.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7028
    Cell Significance Index: -19.1300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.7099
    Cell Significance Index: -9.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7171
    Cell Significance Index: -19.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Flavohemoprotein structure**: CYB5R4 is a flavohemoprotein, a type of protein that contains a non-heme iron center and a flavin group, which enables it to participate in redox reactions. 2. **Redox activity**: CYB5R4 exhibits redox activity, facilitating the transfer of electrons and the reduction of cytochrome b5. 3. **Cellular localization**: CYB5R4 is localized in the cytoplasm and endoplasmic reticulum, where it participates in various cellular processes. **Pathways and Functions** 1. **Oxidative metabolism**: CYB5R4 is involved in oxidative metabolism, particularly in the transfer of electrons and the reduction of cytochrome b5. 2. **Heme binding**: CYB5R4 binds heme, which is essential for the proper functioning of various cellular pathways. 3. **Antioxidant defense**: CYB5R4 participates in antioxidant defense mechanisms, helping to regulate reactive oxygen species (ROS) levels. 4. **Immune function**: CYB5R4 is expressed in immune cells, such as T cells and mast cells, where it plays a role in immune function and response to pathogens. **Clinical Significance** 1. **Hematological disorders**: Alterations in CYB5R4 expression have been linked to hematological disorders, such as anemia and leukemia. 2. **Neurological disorders**: CYB5R4 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: CYB5R4 has been found to be overexpressed in various types of cancer, including breast cancer and lung cancer. 4. **Infectious diseases**: CYB5R4 plays a role in the immune response to infectious diseases, such as tuberculosis and malaria. In conclusion, CYB5R4 is a multifunctional protein that plays a crucial role in cellular metabolism, immune function, and disease pathology. Further research is needed to fully elucidate the mechanisms by which CYB5R4 influences these processes, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2781792977

Symbol: NB5R4_HUMAN

Name: Flavohemoprotein b5/b5R

UniProtKB Accession Codes:

Q7L1T6 B1AEM2 Q5TGI9 Q9NUE4 Q9UHI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10611283

Title: Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells.

PubMed ID: 10611283

DOI: 10.1073/pnas.96.26.14742

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 20630863

Title: Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain.

PubMed ID: 20630863

DOI: 10.1074/jbc.m110.120329

PubMed ID: 15504981

Title: Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus.

PubMed ID: 15504981

DOI: 10.2337/diabetes.53.11.2992

PubMed ID: 15131110

Title: NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum.

PubMed ID: 15131110

DOI: 10.1074/jbc.m402664200

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 521
  • Mass: 59474
  • Checksum: 9D83BAB387E3B0F4
  • Sequence:
    • MLNVPSQSFP APRSQQRVAS GGRSKVPLKQ GRSLMDWIRL TKSGKDLTGL KGRLIEVTEE 
ELKKHNKKDD CWICIRGFVY NVSPYMEYHP GGEDELMRAA GSDGTELFDQ VHRWVNYESM 
LKECLVGRMA IKPAVLKDYR EEEKKVLNGM LPKSQVTDTL AKEGPSYPSY DWFQTDSLVT 
IAIYTKQKDI NLDSIIVDHQ NDSFRAETII KDCLYLIHIG LSHEVQEDFS VRVVESVGKI 
EIVLQKKENT SWDFLGHPLK NHNSLIPRKD TGLYYRKCQL ISKEDVTHDT RLFCLMLPPS 
THLQVPIGQH VYLKLPITGT EIVKPYTPVS GSLLSEFKEP VLPNNKYIYF LIKIYPTGLF 
TPELDRLQIG DFVSVSSPEG NFKISKFQEL EDLFLLAAGT GFTPMVKILN YALTDIPSLR 
KVKLMFFNKT EDDIIWRSQL EKLAFKDKRL DVEFVLSAPI SEWNGKQGHI SPALLSEFLK 
RNLDKSKVLV CICGPVPFTE QGVRLLHDLN FSKNEIHSFT A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.