Details for: DCXR
Gene ID: 51181
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DCXR
Ensembl ID: ENSG00000169738
Description: dicarbonyl and L-xylulose reductase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 47.66rCSI 58.96%PRS 14.75
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CSI 36.3rCSI 85.18%PRS 24.6
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CSI 31.41rCSI 28.36%PRS 15.11
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CSI 29.49rCSI 42.5%PRS 26.71
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CSI 29.29rCSI 41.52%PRS 15.69
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CSI 28.95rCSI 51.82%PRS 15.64
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CSI 28.8rCSI 33.82%PRS 19.7
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CSI 23.09rCSI 56.39%PRS 16.61
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CSI 21.88rCSI 14.74%PRS 20.45
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CSI 20.5rCSI 16.99%PRS 15.92
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CSI 20.37rCSI 32.35%PRS 21.74
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CSI 19.94rCSI 25.03%PRS 21.76
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CSI 19.84rCSI 43.83%PRS 12.05
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CSI 18.37rCSI 31.46%PRS 22.86
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CSI 18.01rCSI 15.6%PRS 18.93
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CSI 16.92rCSI 33.72%PRS 28.41
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CSI 16.33rCSI 35.65%PRS 33.1
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CSI 16.06rCSI 16.83%PRS 18.02
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CSI 15.36rCSI 12.42%PRS 16.83
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CSI 15.02rCSI 42.89%PRS 29.01
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CSI 14.03rCSI 13.53%PRS 12.04
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CSI 13.39rCSI 20.77%PRS 25.42
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CSI 12.89rCSI 35.43%PRS 27.75
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CSI 12.87rCSI 23.38%PRS 25.69
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CSI 11.68rCSI 27.77%PRS 25.23
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CSI 11.4rCSI 29.76%PRS 26.09
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CSI 11.3rCSI 16.55%PRS 19.46
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CSI 11.23rCSI 60.62%PRS 30.39
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CSI 11.05rCSI 15.94%PRS 23.59
-
CSI 10.53rCSI 10.14%PRS 17.43
-
CSI 10.23rCSI 10.07%PRS 18.31
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CSI 9.58rCSI 51.54%PRS 29.96
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CSI 9.23rCSI 35.89%PRS 23.05
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CSI 9.18rCSI 10.33%PRS 27.06
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CSI 9.05rCSI 17.27%PRS 37.73
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CSI 8.76rCSI 37.84%PRS 31.28
-
CSI 8.02rCSI 10.29%PRS 19.45
-
CSI 8rCSI 25.67%PRS 24.38
-
CSI 7.89rCSI 27.68%PRS 29.84
-
CSI 7.86rCSI 77.34%PRS 45.65
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CSI 7.59rCSI 16.16%PRS 26.91
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CSI 7.46rCSI 10.91%PRS 17.83
-
CSI 7.4rCSI 10.11%PRS 19.12
-
CSI 7.11rCSI 7.45%PRS 15.68
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CSI 6.52rCSI 4.35%PRS 41.89
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CSI 6.35rCSI 12.36%PRS 17.24
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CSI 6.04rCSI 26.83%PRS 16.58
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CSI 5.84rCSI 23.34%PRS 35.86
-
CSI 5.65rCSI 5.01%PRS 16.88
-
CSI 5.6rCSI 8.57%PRS 27.33
-
CSI 5.37rCSI 6.83%PRS 19.59
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CSI 5.19rCSI 36.64%PRS 48.05
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CSI 5.05rCSI 7.4%PRS 22.1
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CSI 4.9rCSI 5.37%PRS 19.13
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CSI 4.89rCSI 7.02%PRS 13.06
-
CSI 4.82rCSI 39.23%PRS 17.14
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CSI 4.81rCSI 9.55%PRS 17.93
-
CSI 4.6rCSI 50.07%PRS 32.11
-
CSI 4.39rCSI 33%PRS 30.58
-
CSI 4.37rCSI 22.57%PRS 32.83
-
CSI 4.29rCSI 45.4%PRS 22.52
-
CSI 4.28rCSI 2.53%PRS 23.36
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CSI 4.23rCSI 2.94%PRS 20.02
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CSI 4.14rCSI 6.64%PRS 48.16
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CSI 4.1rCSI 5.68%PRS 23.96
-
CSI 4.09rCSI 4.27%PRS 17.27
-
CSI 4.05rCSI 34.96%PRS 27.67
-
CSI 3.96rCSI 5.06%PRS 59.8
-
CSI 3.93rCSI 2.94%PRS 27.1
-
CSI 3.85rCSI 3.56%PRS 30.52
-
CSI 3.85rCSI 37.99%PRS 52.83
-
CSI 3.74rCSI 11.04%PRS 20.36
-
CSI 3.69rCSI 3.63%PRS 26.43
-
CSI 3.62rCSI 42.04%PRS 58.43
-
CSI 3.5rCSI 5.98%PRS 33.99
-
CSI 3.5rCSI 3.07%PRS 19.25
-
CSI 3.5rCSI 3.56%PRS 24.15
-
CSI 3.49rCSI 7.96%PRS 14.51
-
CSI 3.48rCSI 2.75%PRS 11.58
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CSI 3.47rCSI 2.41%PRS 23.9
-
CSI 3.46rCSI 4.26%PRS 49.67
-
CSI 3.43rCSI 21.2%PRS 51.45
-
CSI 3.41rCSI 10.97%PRS 17.71
-
CSI 3.36rCSI 4.5%PRS 18.45
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CSI 3.34rCSI 2.81%PRS 26.99
-
CSI 3.21rCSI 5.18%PRS 26.35
-
CSI 3.14rCSI 3.68%PRS 22.67
-
CSI 3.1rCSI 41.03%PRS 51.02
-
CSI 3.05rCSI 2.55%PRS 45.61
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CSI 3.05rCSI 8.74%PRS 24.83
-
CSI 3.04rCSI 2.39%PRS 20.34
-
CSI 3.01rCSI 3.99%PRS 18.42
-
CSI 3rCSI 2.64%PRS 12.23
-
CSI 2.98rCSI 4.58%PRS 23.38
-
CSI 2.91rCSI 67.78%PRS 31.15
-
CSI 2.9rCSI 3.98%PRS 34.02
-
CSI 2.84rCSI 3.28%PRS 14.77
-
CSI 2.84rCSI 2.13%PRS 46.35
-
CSI 2.81rCSI 6.38%PRS 23.28
-
CSI 2.81rCSI 4.24%PRS 16.91
-
CSI -6.0rCSI -7.9%PRS 23.9%
-
CSI -4.7rCSI -7.0%PRS 19.3%
-
CSI -3.7rCSI -7.9%PRS 33.7%
-
CSI -2.8rCSI -6.6%PRS 20.9%
-
CSI -1.6rCSI -10.0%PRS 13.2%
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CSI -1.1rCSI -3.6%PRS 20.5%
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CSI -0.8rCSI -1.2%PRS 18.5%
-
CSI -0.8rCSI -6.7%PRS 81.3%
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CSI 0.0rCSI 0.2%PRS 30.2%
-
CSI 0.0rCSI 0.1%PRS 10.4%
-
CSI 0.1rCSI 1.2%PRS 59.5%
-
CSI 0.1rCSI 0.3%PRS 55.3%
-
CSI 0.1rCSI 2.4%PRS 48.8%
-
CSI 0.1rCSI 2.8%PRS 70.7%
-
CSI 0.1rCSI 0.3%PRS 17.4%
-
CSI 0.2rCSI 0.6%PRS 27.4%
-
CSI 0.2rCSI 0.4%PRS 22.5%
-
CSI 0.2rCSI 0.5%PRS 12.8%
-
CSI 0.2rCSI 1.3%PRS 25.2%
-
CSI 0.3rCSI 0.9%PRS 10.6%
-
CSI 0.3rCSI 0.7%PRS 14.0%
-
CSI 0.3rCSI 0.3%PRS 29.3%
-
CSI 0.3rCSI 1.9%PRS 50.6%
-
CSI 0.3rCSI 7.9%PRS 64.5%
-
CSI 0.3rCSI 0.6%PRS 41.7%
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CSI 0.3rCSI 0.4%PRS 16.8%
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CSI 0.3rCSI 1.9%PRS 25.7%
-
CSI 0.3rCSI 3.2%PRS 61.8%
-
CSI 0.4rCSI 1.9%PRS 40.1%
-
CSI 0.4rCSI 1.7%PRS 31.2%
-
CSI 0.4rCSI 1.4%PRS 28.9%
-
CSI 0.4rCSI 1.1%PRS 32.7%
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CSI 0.4rCSI 0.9%PRS 18.9%
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CSI 0.4rCSI 3.4%PRS 34.8%
-
CSI 0.4rCSI 2.5%PRS 24.7%
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CSI 0.5rCSI 6.9%PRS 40.8%
-
CSI 0.5rCSI 1.8%PRS 33.6%
-
CSI 0.5rCSI 2.1%PRS 42.6%
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CSI 0.5rCSI 2.1%PRS 16.1%
-
CSI 0.5rCSI 0.9%PRS 9.9%
-
CSI 0.5rCSI 2.3%PRS 38.5%
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CSI 0.5rCSI 9.0%PRS 48.1%
-
CSI 0.5rCSI 3.0%PRS 27.4%
-
CSI 0.5rCSI 0.8%PRS 23.3%
-
CSI 0.6rCSI 11.8%PRS 77.1%
-
CSI 0.6rCSI 2.6%PRS 54.6%
-
CSI 0.6rCSI 1.3%PRS 10.4%
-
CSI 0.6rCSI 1.7%PRS 31.9%
-
CSI 0.6rCSI 0.7%PRS 21.4%
-
CSI 0.6rCSI 0.9%PRS 14.3%
-
CSI 0.6rCSI 1.1%PRS 42.4%
-
CSI 0.6rCSI 1.6%PRS 21.8%
-
CSI 0.6rCSI 2.3%PRS 14.3%
-
CSI 0.6rCSI 1.2%PRS 37.7%
-
CSI 0.6rCSI 1.0%PRS 13.0%
-
CSI 0.6rCSI 0.7%PRS 12.4%
-
CSI 0.6rCSI 1.2%PRS 32.9%
-
CSI 0.7rCSI 0.6%PRS 21.0%
-
CSI 0.7rCSI 2.9%PRS 29.7%
-
CSI 0.7rCSI 1.7%PRS 25.1%
-
CSI 0.7rCSI 2.0%PRS 59.9%
-
CSI 0.7rCSI 2.1%PRS 26.1%
-
CSI 0.8rCSI 2.5%PRS 44.9%
-
CSI 0.8rCSI 1.7%PRS 15.6%
-
CSI 0.8rCSI 0.9%PRS 17.8%
-
CSI 0.8rCSI 2.2%PRS 19.1%
-
CSI 0.8rCSI 0.9%PRS 29.4%
-
CSI 0.8rCSI 1.0%PRS 9.2%
-
CSI 0.8rCSI 1.2%PRS 19.4%
-
CSI 0.8rCSI 2.7%PRS 50.6%
-
CSI 0.8rCSI 2.1%PRS 27.3%
-
CSI 0.8rCSI 1.3%PRS 12.9%
-
CSI 0.8rCSI 1.5%PRS 45.0%
-
CSI 0.8rCSI 1.0%PRS 29.3%
-
CSI 0.8rCSI 0.8%PRS 31.2%
-
CSI 0.8rCSI 1.0%PRS 16.6%
-
CSI 0.8rCSI 2.2%PRS 20.2%
-
CSI 0.8rCSI 1.1%PRS 15.0%
-
CSI 0.8rCSI 1.0%PRS 9.7%
-
CSI 0.9rCSI 1.4%PRS 19.9%
-
CSI 0.9rCSI 1.3%PRS 15.8%
-
CSI 0.9rCSI 1.6%PRS 28.2%
-
CSI 0.9rCSI 1.3%PRS 20.0%
-
CSI 0.9rCSI 9.4%PRS 56.3%
-
CSI 0.9rCSI 1.2%PRS 32.1%
-
CSI 0.9rCSI 0.7%PRS 29.9%
-
CSI 1.0rCSI 0.7%PRS 25.0%
-
CSI 1.0rCSI 2.9%PRS 36.4%
-
CSI 1.0rCSI 2.6%PRS 15.7%
-
CSI 1.0rCSI 1.8%PRS 12.8%
-
CSI 1.0rCSI 1.3%PRS 23.9%
-
CSI 1.1rCSI 2.6%PRS 46.6%
-
CSI 1.1rCSI 4.9%PRS 34.9%
-
CSI 1.1rCSI 4.1%PRS 16.6%
-
CSI 1.1rCSI 0.8%PRS 16.1%
-
CSI 1.1rCSI 4.3%PRS 27.7%
-
CSI 1.1rCSI 5.9%PRS 57.3%
-
CSI 1.1rCSI 0.8%PRS 23.1%
-
CSI 1.1rCSI 10.8%PRS 44.8%
-
CSI 1.1rCSI 1.8%PRS 16.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2218007120
Symbol: DCXR_HUMAN
Name: L-xylulose reductase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10385429
Title: P34H sperm protein is preferentially expressed by the human corpus epididymidis.
PubMed ID: 10385429
PubMed ID: 11882650
Title: Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney.
PubMed ID: 11882650
PubMed ID: 12680326
Title: Molecular cloning of human sperm surface protein P34H gene and semi-quantitative analysis of its expression in testis and epididymidis.
PubMed ID: 12680326
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 4392213
Title: The enzymatic defect in essential pentosuria.
PubMed ID: 4392213
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22042873
Title: Garrod's fourth inborn error of metabolism solved by the identification of mutations causing pentosuria.
PubMed ID: 22042873
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 12136162
Title: Crystallization and preliminary crystallographic analysis of human L-xylulose reductase.
PubMed ID: 12136162
PubMed ID: 15103634
Title: Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis.
PubMed ID: 15103634
DOI: 10.1002/prot.20047
Sequence Information:
- Length: 244
- Mass: 25913
- Checksum: F82B7A178D46EAA5
- Sequence:
MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG FWAC