Details for: ZNF639

Gene ID: 51193

Symbol: ZNF639

Ensembl ID: ENSG00000121864

Description: zinc finger protein 639

Associated with

  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation by host of viral transcription
    (GO:0043922)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation by host of viral transcription
    (GO:0043923)
  • Positive regulation of cell growth
    (GO:0030307)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Symbiont entry into host cell
    (GO:0046718)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 132.5659
    Cell Significance Index: -20.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.4817
    Cell Significance Index: -20.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.2835
    Cell Significance Index: -23.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.1284
    Cell Significance Index: -18.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.6443
    Cell Significance Index: -22.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.0217
    Cell Significance Index: -22.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4514
    Cell Significance Index: -22.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7057
    Cell Significance Index: -22.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3766
    Cell Significance Index: -7.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4844
    Cell Significance Index: 40.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0372
    Cell Significance Index: 65.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8745
    Cell Significance Index: 142.2400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5753
    Cell Significance Index: 9.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5644
    Cell Significance Index: 7.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5535
    Cell Significance Index: 38.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5465
    Cell Significance Index: 493.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4107
    Cell Significance Index: 82.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4067
    Cell Significance Index: 80.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3834
    Cell Significance Index: 52.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3249
    Cell Significance Index: 15.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2613
    Cell Significance Index: 142.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2586
    Cell Significance Index: 114.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2548
    Cell Significance Index: 7.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2324
    Cell Significance Index: 83.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2231
    Cell Significance Index: 2.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2204
    Cell Significance Index: 7.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2180
    Cell Significance Index: 2.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2145
    Cell Significance Index: 4.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2043
    Cell Significance Index: 141.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2035
    Cell Significance Index: 36.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2010
    Cell Significance Index: 24.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1959
    Cell Significance Index: 8.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1836
    Cell Significance Index: 11.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1751
    Cell Significance Index: 13.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1688
    Cell Significance Index: 21.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1546
    Cell Significance Index: 15.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1471
    Cell Significance Index: 11.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1468
    Cell Significance Index: 3.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1444
    Cell Significance Index: 10.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1376
    Cell Significance Index: 23.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1124
    Cell Significance Index: 14.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0882
    Cell Significance Index: 4.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0825
    Cell Significance Index: 1.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0800
    Cell Significance Index: 4.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0788
    Cell Significance Index: 9.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0711
    Cell Significance Index: 4.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0614
    Cell Significance Index: 1.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0603
    Cell Significance Index: 2.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0471
    Cell Significance Index: 1.6600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0265
    Cell Significance Index: 0.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0243
    Cell Significance Index: 4.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0133
    Cell Significance Index: 25.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0014
    Cell Significance Index: -1.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0074
    Cell Significance Index: -4.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0089
    Cell Significance Index: -12.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0091
    Cell Significance Index: -6.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0117
    Cell Significance Index: -5.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0124
    Cell Significance Index: -6.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0172
    Cell Significance Index: -13.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0333
    Cell Significance Index: -0.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0437
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0438
    Cell Significance Index: -9.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0454
    Cell Significance Index: -13.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0551
    Cell Significance Index: -0.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0621
    Cell Significance Index: -6.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0631
    Cell Significance Index: -7.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0641
    Cell Significance Index: -7.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0652
    Cell Significance Index: -7.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0824
    Cell Significance Index: -1.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0828
    Cell Significance Index: -12.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1009
    Cell Significance Index: -2.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1093
    Cell Significance Index: -5.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1112
    Cell Significance Index: -2.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1322
    Cell Significance Index: -3.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1340
    Cell Significance Index: -3.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1368
    Cell Significance Index: -4.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1672
    Cell Significance Index: -11.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1917
    Cell Significance Index: -4.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1947
    Cell Significance Index: -20.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2229
    Cell Significance Index: -5.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2248
    Cell Significance Index: -13.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2265
    Cell Significance Index: -17.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2321
    Cell Significance Index: -12.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2691
    Cell Significance Index: -5.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2729
    Cell Significance Index: -12.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2779
    Cell Significance Index: -7.1000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2990
    Cell Significance Index: -3.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3367
    Cell Significance Index: -12.7500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3396
    Cell Significance Index: -7.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3661
    Cell Significance Index: -8.7800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3790
    Cell Significance Index: -2.2900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4037
    Cell Significance Index: -5.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4184
    Cell Significance Index: -21.1400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4377
    Cell Significance Index: -3.7200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4736
    Cell Significance Index: -13.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4762
    Cell Significance Index: -17.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4835
    Cell Significance Index: -15.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZNF639 exhibits distinct characteristics that enable it to regulate gene expression. These include: 1. **DNA-binding activity**: ZNF639 possesses a zinc finger domain, which allows it to bind to specific DNA sequences, thereby regulating transcription. 2. **Transcriptional activation**: ZNF639 acts as a transcriptional activator, promoting the expression of target genes. 3. **Negative regulation**: ZNF639 also exhibits negative regulatory functions, repressing the expression of certain genes. 4. **Cell-type specificity**: ZNF639 is specifically expressed in various cell types, including hematopoietic cells, smooth muscle cells, and immune cells. **Pathways and Functions:** ZNF639 is involved in several cellular pathways, including: 1. **Transcriptional regulation**: ZNF639 regulates the expression of target genes by binding to specific DNA sequences. 2. **Cell growth and proliferation**: ZNF639 promotes cell growth and proliferation by activating the expression of genes involved in cell cycle progression. 3. **Immune response**: ZNF639 plays a role in regulating the immune response by modulating the expression of genes involved in immune cell activation and function. 4. **Viral regulation**: ZNF639 negatively regulates viral transcription, suggesting a potential role in antiviral defense. **Clinical Significance:** Dysregulation of ZNF639 has been implicated in several diseases, including: 1. **Cancer**: Aberrant expression of ZNF639 has been observed in various types of cancer, suggesting a potential role in tumorigenesis. 2. **Autoimmune diseases**: ZNF639 may play a role in regulating immune responses, and its dysregulation has been linked to autoimmune diseases such as rheumatoid arthritis. 3. **Infectious diseases**: ZNF639 negatively regulates viral transcription, suggesting a potential role in antiviral defense and the prevention of infectious diseases. In conclusion, ZNF639 is a multifunctional gene that plays a crucial role in regulating gene expression, cell growth, and immune response. Its dysregulation has been implicated in several diseases, highlighting the potential importance of this gene in human health and disease. Further research is needed to fully elucidate the molecular mechanisms and clinical implications of ZNF639.

Genular Protein ID: 2649942213

Symbol: ZN639_HUMAN

Name: Zinc finger protein 639

UniProtKB Accession Codes:

Q9UID6 A9X3Z9 D3DNR3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 7 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16182284

Title: Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1.

PubMed ID: 16182284

DOI: 10.1016/j.yexcr.2005.06.018

PubMed ID: 14522885

Title: Identification of ZASC1 encoding a Kruppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas.

PubMed ID: 14522885

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17623809

Title: Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs).

PubMed ID: 17623809

DOI: 10.1101/gr.6320607

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 485
  • Mass: 56054
  • Checksum: BDEB00B87BCC1C1C
  • Sequence:
    • MNEYPKKRKR KTLHPSRYSD SSGISRIADG FNGIFSDHCY SVCSMRQPDL KYFDNKDDDS 
DTETSNDLPK FADGIKARNR NQNYLVPSPV LRILDHTAFS TEKSADIVIC DEECDSPESV 
NQQTQEESPI EVHTAEDVPI AVEVHAISED YDIETENNSS ESLQDQTDEE PPAKLCKILD 
KSQALNVTAQ QKWPLLRANS SGLYKCELCE FNSKYFSDLK QHMILKHKRT DSNVCRVCKE 
SFSTNMLLIE HAKLHEEDPY ICKYCDYKTV IFENLSQHIA DTHFSDHLYW CEQCDVQFSS 
SSELYLHFQE HSCDEQYLCQ FCEHETNDPE DLHSHVVNEH ACKLIELSDK YNNGEHGQYS 
LLSKITFDKC KNFFVCQVCG FRSRLHTNVN RHVAIEHTKI FPHVCDDCGK GFSSMLEYCK 
HLNSHLSEGI YLCQYCEYST GQIEDLKIHL DFKHSADLPH KCSDCLMRFG NERELISHLP 
VHETT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.