Details for: ZDHHC2

Gene ID: 51201

Symbol: ZDHHC2

Ensembl ID: ENSG00000104219

Description: zinc finger DHHC-type palmitoyltransferase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 160.0821
    Cell Significance Index: -24.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.1657
    Cell Significance Index: -25.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.4206
    Cell Significance Index: -22.5200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 54.9099
    Cell Significance Index: -22.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.0792
    Cell Significance Index: -25.7600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 41.0419
    Cell Significance Index: -27.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.5742
    Cell Significance Index: -26.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7691
    Cell Significance Index: -26.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9614
    Cell Significance Index: -27.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1175
    Cell Significance Index: -11.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.1932
    Cell Significance Index: 38.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.8062
    Cell Significance Index: 21.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.7533
    Cell Significance Index: 173.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8142
    Cell Significance Index: 94.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.5192
    Cell Significance Index: 26.0400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.3346
    Cell Significance Index: 14.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2719
    Cell Significance Index: 76.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0881
    Cell Significance Index: 29.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0622
    Cell Significance Index: 213.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6987
    Cell Significance Index: 15.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6164
    Cell Significance Index: 28.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5580
    Cell Significance Index: 31.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5327
    Cell Significance Index: 96.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5191
    Cell Significance Index: 4.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5088
    Cell Significance Index: 50.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5026
    Cell Significance Index: 347.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4862
    Cell Significance Index: 174.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4776
    Cell Significance Index: 431.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4754
    Cell Significance Index: 32.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3731
    Cell Significance Index: 45.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3400
    Cell Significance Index: 8.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3369
    Cell Significance Index: 57.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3328
    Cell Significance Index: 21.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2704
    Cell Significance Index: 20.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2428
    Cell Significance Index: 132.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2274
    Cell Significance Index: 10.0600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2094
    Cell Significance Index: 1.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2021
    Cell Significance Index: 4.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1921
    Cell Significance Index: 5.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1650
    Cell Significance Index: 310.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1629
    Cell Significance Index: 32.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1601
    Cell Significance Index: 20.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1568
    Cell Significance Index: 9.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1519
    Cell Significance Index: 3.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1414
    Cell Significance Index: 26.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1070
    Cell Significance Index: 7.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1056
    Cell Significance Index: 67.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0925
    Cell Significance Index: 142.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0885
    Cell Significance Index: 2.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0671
    Cell Significance Index: 7.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0473
    Cell Significance Index: 6.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0394
    Cell Significance Index: 53.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0355
    Cell Significance Index: 65.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0288
    Cell Significance Index: 2.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0192
    Cell Significance Index: 0.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0111
    Cell Significance Index: 0.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0053
    Cell Significance Index: 2.4200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0045
    Cell Significance Index: 0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0002
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0080
    Cell Significance Index: -0.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0084
    Cell Significance Index: -6.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0151
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0173
    Cell Significance Index: -10.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0255
    Cell Significance Index: -14.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0289
    Cell Significance Index: -12.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0509
    Cell Significance Index: -7.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0619
    Cell Significance Index: -13.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0807
    Cell Significance Index: -23.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0824
    Cell Significance Index: -9.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0847
    Cell Significance Index: -3.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0867
    Cell Significance Index: -8.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1016
    Cell Significance Index: -11.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1226
    Cell Significance Index: -14.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1324
    Cell Significance Index: -17.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1594
    Cell Significance Index: -11.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1596
    Cell Significance Index: -3.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2290
    Cell Significance Index: -6.4000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2334
    Cell Significance Index: -2.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2337
    Cell Significance Index: -24.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2364
    Cell Significance Index: -5.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2525
    Cell Significance Index: -20.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3533
    Cell Significance Index: -9.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3678
    Cell Significance Index: -19.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3947
    Cell Significance Index: -12.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4084
    Cell Significance Index: -13.0800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4207
    Cell Significance Index: -5.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4243
    Cell Significance Index: -13.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4328
    Cell Significance Index: -15.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4387
    Cell Significance Index: -26.9000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4586
    Cell Significance Index: -6.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5024
    Cell Significance Index: -26.3800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.5181
    Cell Significance Index: -6.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5289
    Cell Significance Index: -15.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5645
    Cell Significance Index: -11.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5718
    Cell Significance Index: -20.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5854
    Cell Significance Index: -21.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6755
    Cell Significance Index: -16.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6831
    Cell Significance Index: -14.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6946
    Cell Significance Index: -20.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ZDHHC2 is a member of the DHHC (DHHC-type palmitoyltransferase) family of enzymes, which are involved in the post-translational modification of proteins. The enzyme is characterized by its ability to palmitoylate cysteine residues on target proteins, which allows them to interact with membranes and other cellular components. ZDHHC2 is specifically expressed in various cell types, including hematopoietic cells, epithelial cells, and neuronal cells. **Pathways and Functions** ZDHHC2 is involved in several cellular pathways, including: 1. **Glutamatergic Synapse**: ZDHHC2 regulates the clustering of AMPA glutamate receptors, which is essential for synaptic plasticity and learning. 2. **Infectious Disease**: ZDHHC2 is involved in the regulation of viral infections, including SARS-CoV-2, by palmitoylating proteins that interact with viral receptors. 3. **Metabolism of Proteins**: ZDHHC2 regulates the palmitoylation of proteins involved in protein degradation and recycling. 4. **Cell-Cell Adhesion**: ZDHHC2 regulates the palmitoylation of proteins involved in cell-cell adhesion, which is essential for maintaining tissue structure and function. **Clinical Significance** ZDHHC2 has been implicated in various diseases, including: 1. **Cancer**: Reduced expression of ZDHHC2 has been associated with metastasis, suggesting that this enzyme may play a role in regulating cancer cell migration and invasion. 2. **Neurological Disorders**: ZDHHC2 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where dysregulation of synaptic plasticity and protein palmitoylation may contribute to disease pathogenesis. 3. **Viral Infections**: ZDHHC2 may play a role in regulating viral infections, including SARS-CoV-2, by palmitoylating proteins that interact with viral receptors. In conclusion, ZDHHC2 is a critical enzyme involved in various cellular pathways, including glutamatergic synapse, infectious disease, and protein metabolism. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and viral infections, highlighting the importance of this enzyme in maintaining cellular homeostasis and regulating cellular processes.

Genular Protein ID: 3539452197

Symbol: ZDHC2_HUMAN

Name: Reduced expression associated with metastasis protein

UniProtKB Accession Codes:

Q9UIJ5 D3DSP5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 28 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 12 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10918388

Title: Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis.

PubMed ID: 10918388

DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1001>3.0.co;2-#

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18508921

Title: DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151.

PubMed ID: 18508921

DOI: 10.1091/mbc.e07-11-1164

PubMed ID: 18296695

Title: Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method.

PubMed ID: 18296695

DOI: 10.1074/mcp.m800069-mcp200

PubMed ID: 19144824

Title: Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling.

PubMed ID: 19144824

DOI: 10.1091/mbc.e08-08-0849

PubMed ID: 21343290

Title: Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.

PubMed ID: 21343290

DOI: 10.1074/jbc.m110.193763

PubMed ID: 21471008

Title: The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain.

PubMed ID: 21471008

DOI: 10.1091/mbc.e10-11-0924

PubMed ID: 22034844

Title: DHHC2 is a protein S-acyltransferase for Lck.

PubMed ID: 22034844

DOI: 10.3109/09687688.2011.630682

PubMed ID: 23793055

Title: Oligomerization of DHHC protein S-acyltransferases.

PubMed ID: 23793055

DOI: 10.1074/jbc.m113.458794

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30404808

Title: Fatty acid synthase promotes the palmitoylation of Chikungunya virus nsP1.

PubMed ID: 30404808

DOI: 10.1128/jvi.01747-18

Sequence Information:

  • Length: 367
  • Mass: 42022
  • Checksum: B7BFB82837B7EE98
  • Sequence:
    • MAPSGPGSSA RRRCRRVLYW IPVVFITLLL GWSYYAYAIQ LCIVSMENTG EQVVCLMAYH 
LLFAMFVWSY WKTIFTLPMN PSKEFHLSYA EKDLLEREPR GEAHQEVLRR AAKDLPIYTR 
TMSGAIRYCD RCQLIKPDRC HHCSVCDKCI LKMDHHCPWV NNCVGFSNYK FFLLFLAYSL 
LYCLFIAATD LQYFIKFWTN GLPDTQAKFH IMFLFFAAAM FSVSLSSLFG YHCWLVSKNK 
STLEAFRSPV FRHGTDKNGF SLGFSKNMRQ VFGDEKKYWL LPIFSSLGDG CSFPTCLVNQ 
DPEQASTPAG LNSTAKNLEN HQFPAKPLRE SQSHLLTDSQ SWTESSINPG KCKAGMSNPA 
LTMENET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.