Details for: ABI3

Gene ID: 51225

Symbol: ABI3

Ensembl ID: ENSG00000108798

Description: ABI family member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 73.6120
    Cell Significance Index: -11.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.4181
    Cell Significance Index: -11.5200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.7840
    Cell Significance Index: -15.3500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 33.4266
    Cell Significance Index: -13.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.6968
    Cell Significance Index: -15.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.2785
    Cell Significance Index: -11.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.2942
    Cell Significance Index: 81.9100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 4.5019
    Cell Significance Index: 12.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9498
    Cell Significance Index: -11.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8649
    Cell Significance Index: -6.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1487
    Cell Significance Index: 13.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1415
    Cell Significance Index: 24.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0796
    Cell Significance Index: 127.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8808
    Cell Significance Index: 167.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8525
    Cell Significance Index: 15.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6279
    Cell Significance Index: 18.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6208
    Cell Significance Index: 560.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4404
    Cell Significance Index: 22.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3879
    Cell Significance Index: 7.1700
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.3150
    Cell Significance Index: 0.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2241
    Cell Significance Index: 22.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2174
    Cell Significance Index: 35.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2170
    Cell Significance Index: 23.6000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.1142
    Cell Significance Index: 0.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0824
    Cell Significance Index: 1.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0622
    Cell Significance Index: 4.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0545
    Cell Significance Index: 34.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0227
    Cell Significance Index: 16.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0054
    Cell Significance Index: -10.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0068
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0074
    Cell Significance Index: -5.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0080
    Cell Significance Index: -0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0086
    Cell Significance Index: -15.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0102
    Cell Significance Index: -15.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0104
    Cell Significance Index: -0.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0110
    Cell Significance Index: -6.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0112
    Cell Significance Index: -15.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0125
    Cell Significance Index: -9.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0131
    Cell Significance Index: -2.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0228
    Cell Significance Index: -14.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0258
    Cell Significance Index: -1.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0300
    Cell Significance Index: -10.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0310
    Cell Significance Index: -1.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0321
    Cell Significance Index: -14.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0367
    Cell Significance Index: -10.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0376
    Cell Significance Index: -3.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0384
    Cell Significance Index: -6.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0429
    Cell Significance Index: -8.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0452
    Cell Significance Index: -9.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0455
    Cell Significance Index: -2.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0631
    Cell Significance Index: -2.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0687
    Cell Significance Index: -2.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0698
    Cell Significance Index: -4.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0701
    Cell Significance Index: -9.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0730
    Cell Significance Index: -8.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0734
    Cell Significance Index: -13.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0735
    Cell Significance Index: -5.8200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0892
    Cell Significance Index: -3.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0907
    Cell Significance Index: -11.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0912
    Cell Significance Index: -2.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0959
    Cell Significance Index: -13.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1049
    Cell Significance Index: -2.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1100
    Cell Significance Index: -14.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1105
    Cell Significance Index: -11.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1134
    Cell Significance Index: -13.9400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1156
    Cell Significance Index: -1.6900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1177
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1197
    Cell Significance Index: -13.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1263
    Cell Significance Index: -2.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1485
    Cell Significance Index: -6.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1647
    Cell Significance Index: -9.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1697
    Cell Significance Index: -13.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1771
    Cell Significance Index: -11.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1856
    Cell Significance Index: -11.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1888
    Cell Significance Index: -14.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2154
    Cell Significance Index: -6.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2287
    Cell Significance Index: -14.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2359
    Cell Significance Index: -13.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2468
    Cell Significance Index: -3.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2550
    Cell Significance Index: -11.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2587
    Cell Significance Index: -12.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2596
    Cell Significance Index: -13.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2630
    Cell Significance Index: -13.6600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2797
    Cell Significance Index: -4.7500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2847
    Cell Significance Index: -1.7200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2883
    Cell Significance Index: -4.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2991
    Cell Significance Index: -11.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3012
    Cell Significance Index: -10.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3027
    Cell Significance Index: -8.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3178
    Cell Significance Index: -8.1700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.3196
    Cell Significance Index: -1.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3534
    Cell Significance Index: -11.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3601
    Cell Significance Index: -11.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3669
    Cell Significance Index: -6.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3713
    Cell Significance Index: -9.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3776
    Cell Significance Index: -5.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3814
    Cell Significance Index: -14.0000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4126
    Cell Significance Index: -5.9900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4143
    Cell Significance Index: -8.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin-binding protein:** ABI3 is a member of the ABI gene family, which is known to bind to actin filaments and regulate their dynamics. 2. **Cytoplasmic localization:** ABI3 is primarily localized to the cytoplasm, where it interacts with actin filaments and regulates their assembly and disassembly. 3. **Regulation of cellular senescence:** ABI3 has been shown to induce cellular senescence by regulating the expression of senescence-associated genes and inhibiting cell proliferation. 4. **Negative regulation of lamellipodium assembly:** ABI3 negatively regulates lamellipodium assembly, a process critical for cell migration and adhesion. 5. **Positive regulation of cellular senescence:** ABI3 has been shown to regulate cellular senescence by promoting the expression of senescence-associated genes and inhibiting cell proliferation. **Pathways and Functions:** 1. **Actin-based cell projection:** ABI3 regulates the assembly and disassembly of actin filaments, which are essential for the formation of actin-based cell projections. 2. **Cytoplasmic organization:** ABI3 regulates the organization of cytoplasmic structures, including lamellipodia and actin filaments. 3. **Cell migration:** ABI3 negatively regulates lamellipodium assembly, which is critical for cell migration and adhesion. 4. **Cellular senescence:** ABI3 regulates cellular senescence by promoting the expression of senescence-associated genes and inhibiting cell proliferation. 5. **Neurotransmission:** ABI3 is also implicated in the regulation of postsynaptic density assembly and neuronal migration. **Clinical Significance:** 1. **Neurological disorders:** ABI3 has been implicated in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 2. **Cancer:** ABI3 has been shown to regulate cellular senescence, which can have implications for cancer development and progression. 3. **Immune system:** ABI3 is expressed in immune cells, including monocytes and intraepithelial lymphocytes, and has been implicated in immune regulation. 4. **Neurodevelopmental disorders:** ABI3 has been implicated in the regulation of neuronal migration and development, which can have implications for neurodevelopmental disorders, such as autism spectrum disorder. In conclusion, the ABI3 gene plays a critical role in regulating actin-based cell projections, cytoskeleton organization, and cellular senescence. Its dysregulation has been implicated in various diseases, including neurological disorders, cancer, and immune system dysregulation. Further research is needed to fully elucidate the mechanisms of ABI3 and its role in human disease.

Genular Protein ID: 625768860

Symbol: ABI3_HUMAN

Name: ABI gene family member 3

UniProtKB Accession Codes:

Q9P2A4 C9IZN8 Q9H0P6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10978530

Title: Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein.

PubMed ID: 10978530

DOI: 10.1016/s0167-4781(00)00158-5

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11956071

Title: Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells.

PubMed ID: 11956071

PubMed ID: 11501947

Title: Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3.

PubMed ID: 11501947

DOI: 10.1007/s100380170049

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 366
  • Mass: 39035
  • Checksum: 23EC3838E41D8ECD
  • Sequence:
    • MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET MAFTTQALAS 
VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH MEKVARREIG TLATVQRLPP 
GQKVIAPENL PPLTPYCRRP LNFGCLDDIG HGIKDLSTQL SRTGTLSRKS IKAPATPASA 
TLGRPPRIPE PVHLPVVPDG RLSAASSAFS LASAGSAEGV GGAPTPKGQA APPAPPLPSS 
LDPPPPPAAV EVFQRPPTLE ELSPPPPDEE LPLPLDLPPP PPLDGDELGL PPPPPGFGPD 
EPSWVPASYL EKVVTLYPYT SQKDNELSFS EGTVICVTRR YSDGWCEGVS SEGTGFFPGN 
YVEPSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.