Details for: CRIM1

Gene ID: 51232

Symbol: CRIM1

Ensembl ID: ENSG00000150938

Description: cysteine rich transmembrane BMP regulator 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 402.5839
    Cell Significance Index: -62.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 245.4627
    Cell Significance Index: -62.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 164.1835
    Cell Significance Index: -67.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 135.3038
    Cell Significance Index: -63.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 132.3054
    Cell Significance Index: -53.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.3084
    Cell Significance Index: -53.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.8372
    Cell Significance Index: -62.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.5361
    Cell Significance Index: -63.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.9078
    Cell Significance Index: -43.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.3050
    Cell Significance Index: -50.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.8690
    Cell Significance Index: -62.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 10.3049
    Cell Significance Index: 275.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 6.2366
    Cell Significance Index: 160.3100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 4.0473
    Cell Significance Index: 58.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.2985
    Cell Significance Index: 5077.9000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 3.0551
    Cell Significance Index: 38.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.7958
    Cell Significance Index: 5156.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0814
    Cell Significance Index: 417.5200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.8644
    Cell Significance Index: 45.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7106
    Cell Significance Index: 120.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6758
    Cell Significance Index: 332.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1.6386
    Cell Significance Index: 9.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6275
    Cell Significance Index: 71.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5587
    Cell Significance Index: 87.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4693
    Cell Significance Index: 55.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4612
    Cell Significance Index: 179.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4501
    Cell Significance Index: 641.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4233
    Cell Significance Index: 109.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3311
    Cell Significance Index: 477.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1828
    Cell Significance Index: 137.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.0404
    Cell Significance Index: 1414.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0363
    Cell Significance Index: 112.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7605
    Cell Significance Index: 20.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7411
    Cell Significance Index: 133.5900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.6816
    Cell Significance Index: 6.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6486
    Cell Significance Index: 105.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5059
    Cell Significance Index: 14.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4987
    Cell Significance Index: 344.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4912
    Cell Significance Index: 5.5800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.4910
    Cell Significance Index: 7.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4706
    Cell Significance Index: 886.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4682
    Cell Significance Index: 21.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4648
    Cell Significance Index: 12.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4332
    Cell Significance Index: 10.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4086
    Cell Significance Index: 28.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3808
    Cell Significance Index: 48.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3372
    Cell Significance Index: 153.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2946
    Cell Significance Index: 29.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2870
    Cell Significance Index: 182.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2689
    Cell Significance Index: 146.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2686
    Cell Significance Index: 36.8800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2483
    Cell Significance Index: 2.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1774
    Cell Significance Index: 11.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1668
    Cell Significance Index: 7.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1523
    Cell Significance Index: 5.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1424
    Cell Significance Index: 14.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1239
    Cell Significance Index: 14.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0913
    Cell Significance Index: 17.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0248
    Cell Significance Index: 1.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0347
    Cell Significance Index: -21.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0374
    Cell Significance Index: -27.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0599
    Cell Significance Index: -45.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0828
    Cell Significance Index: -4.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0916
    Cell Significance Index: -51.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1750
    Cell Significance Index: -25.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1792
    Cell Significance Index: -37.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2037
    Cell Significance Index: -26.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2111
    Cell Significance Index: -36.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2197
    Cell Significance Index: -63.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2224
    Cell Significance Index: -4.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2232
    Cell Significance Index: -22.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2420
    Cell Significance Index: -27.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2650
    Cell Significance Index: -2.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3028
    Cell Significance Index: -22.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4108
    Cell Significance Index: -26.5000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4536
    Cell Significance Index: -3.8100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4789
    Cell Significance Index: -3.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5146
    Cell Significance Index: -11.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5206
    Cell Significance Index: -61.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5455
    Cell Significance Index: -11.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5794
    Cell Significance Index: -12.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6106
    Cell Significance Index: -13.3700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6487
    Cell Significance Index: -8.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7158
    Cell Significance Index: -56.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7503
    Cell Significance Index: -10.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7990
    Cell Significance Index: -41.6200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.8454
    Cell Significance Index: -10.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8534
    Cell Significance Index: -52.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8805
    Cell Significance Index: -15.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9665
    Cell Significance Index: -20.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9907
    Cell Significance Index: -21.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1217
    Cell Significance Index: -22.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1220
    Cell Significance Index: -16.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1338
    Cell Significance Index: -32.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1390
    Cell Significance Index: -59.8000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.1417
    Cell Significance Index: -19.7400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -1.1497
    Cell Significance Index: -18.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.1546
    Cell Significance Index: -30.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1562
    Cell Significance Index: -37.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CRIM1 is a transmembrane protein with a cysteine-rich motif, which is essential for its function as a BMP regulator. The protein's PDZ domain is crucial for interacting with other proteins and modulating BMP signaling pathways. CRIM1 is also characterized by its expression in various cell types, including hematopoietic progenitor cells, smooth muscle fibers, and epithelial cells. The gene's expression is significantly upregulated in certain cell types, such as polychromatophilic erythroblasts and orthochromatic erythroblasts. **Pathways and Functions** CRIM1 is involved in the regulation of BMP signaling pathways, which play a critical role in various cellular processes, including osteoblast differentiation, nervous system development, and cell proliferation. The protein's PDZ domain is essential for interacting with other proteins and modulating BMP signaling pathways. CRIM1 is also involved in the regulation of insulin-like growth factor receptor (IGF-R) signaling pathways, which are critical for cell growth and differentiation. In addition to its role in BMP signaling, CRIM1 is also involved in the regulation of other cellular processes, including: * Negative regulation of osteoblast differentiation * Negative regulation of nervous system development * Nervous system development * Serine-type endopeptidase inhibitor activity * Negative regulation of BMP signaling pathway **Clinical Significance** CRIM1 has been implicated in various diseases, including: * Osteoporosis: CRIM1's role in regulating osteoblast differentiation and BMP signaling pathways makes it a potential therapeutic target for osteoporosis. * Cancer: CRIM1's involvement in BMP signaling pathways and cell proliferation makes it a potential therapeutic target for cancer. * Neurological disorders: CRIM1's role in nervous system development and BMP signaling pathways makes it a potential therapeutic target for neurological disorders. In conclusion, CRIM1 is a complex protein with diverse roles in various cellular processes. Its involvement in BMP signaling pathways and other cellular processes makes it a potential therapeutic target for various diseases. Further research is needed to fully understand the complexities of CRIM1 and its role in human disease. **References** * (Insert references to relevant studies and publications on CRIM1) Note: This article is a summary of the key characteristics, pathways, and functions of the CRIM1 gene, and its clinical significance. The references provided are for illustrative purposes only and should be updated to reflect the most recent research on CRIM1.

Genular Protein ID: 3999340965

Symbol: CRIM1_HUMAN

Name: Cysteine-rich motor neuron 1 protein

UniProtKB Accession Codes:

Q9NZV1 Q2M2G4 Q59GH0 Q7LCQ5 Q9H318

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10642437

Title: CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis.

PubMed ID: 10642437

DOI: 10.1016/s0925-4773(99)00248-8

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12805376

Title: CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface.

PubMed ID: 12805376

DOI: 10.1074/jbc.m301247200

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 12464430

Title: CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo.

PubMed ID: 12464430

DOI: 10.1016/s0925-4773(02)00355-6

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1036
  • Mass: 113738
  • Checksum: 10CBF02A5C579C27
  • Sequence:
    • MYLVAGDRGL AGCGHLLVSL LGLLLLLARS GTRALVCLPC DESKCEEPRN CPGSIVQGVC 
GCCYTCASQR NESCGGTFGI YGTCDRGLRC VIRPPLNGDS LTEYEAGVCE DENWTDDQLL 
GFKPCNENLI AGCNIINGKC ECNTIRTCSN PFEFPSQDMC LSALKRIEEE KPDCSKARCE 
VQFSPRCPED SVLIEGYAPP GECCPLPSRC VCNPAGCLRK VCQPGNLNIL VSKASGKPGE 
CCDLYECKPV FGVDCRTVEC PPVQQTACPP DSYETQVRLT ADGCCTLPTR CECLSGLCGF 
PVCEVGSTPR IVSRGDGTPG KCCDVFECVN DTKPACVFNN VEYYDGDMFR MDNCRFCRCQ 
GGVAICFTAQ CGEINCERYY VPEGECCPVC EDPVYPFNNP AGCYANGLIL AHGDRWREDD 
CTFCQCVNGE RHCVATVCGQ TCTNPVKVPG ECCPVCEEPT IITVDPPACG ELSNCTLTGK 
DCINGFKRDH NGCRTCQCIN TEELCSERKQ GCTLNCPFGF LTDAQNCEIC ECRPRPKKCR 
PIICDKYCPL GLLKNKHGCD ICRCKKCPEL SCSKICPLGF QQDSHGCLIC KCREASASAG 
PPILSGTCLT VDGHHHKNEE SWHDGCRECY CLNGREMCAL ITCPVPACGN PTIHPGQCCP 
SCADDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ CTCHSGRVLC ETEVCPPLLC 
QNPSRTQDSC CPQCTDQPFR PSLSRNNSVP NYCKNDEGDI FLAAESWKPD VCTSCICIDS 
VISCFSESCP SVSCERPVLR KGQCCPYCIE DTIPKKVVCH FSGKAYADEE RWDLDSCTHC 
YCLQGQTLCS TVSCPPLPCV EPINVEGSCC PMCPEMYVPE PTNIPIEKTN HRGEVDLEVP 
LWPTPSENDI VHLPRDMGHL QVDYRDNRLH PSEDSSLDSI ASVVVPIIIC LSIIIAFLFI 
NQKKQWIPLL CWYRTPTKPS SLNNQLVSVD CKKGTRVQVD SSQRMLRIAE PDARFSGFYS 
MQKQNHLQAD NFYQTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.