Details for: CRIM1
Gene ID: 51232
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CRIM1
Ensembl ID: ENSG00000150938
Description: cysteine rich transmembrane BMP regulator 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 35.91rCSI 62.11%PRS 58.98
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CSI 34.2rCSI 48.48%PRS 64.85
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CSI 32.87rCSI 87.84%PRS 59.59
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CSI 25.63rCSI 70.63%PRS 63.65
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CSI 23.15rCSI 38.86%PRS 49.82
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CSI 21.97rCSI 21.15%PRS 68.42
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CSI 20.75rCSI 92.23%PRS 68.75
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CSI 16.49rCSI 22.91%PRS 67.15
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CSI 15.96rCSI 38.79%PRS 48.26
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CSI 15.85rCSI 78.12%PRS 78.97
-
CSI 15.85rCSI 25.28%PRS 60.49
-
CSI 15.74rCSI 45.56%PRS 69.26
-
CSI 14.96rCSI 23.12%PRS 67.2
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CSI 14.77rCSI 17.05%PRS 61.26
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CSI 14.43rCSI 49.41%PRS 56.7
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CSI 14.16rCSI 16.91%PRS 49.62
-
CSI 14.05rCSI 20.17%PRS 58.15
-
CSI 13.89rCSI 31.15%PRS 50.52
-
CSI 13.67rCSI 14.97%PRS 71.94
-
CSI 13.63rCSI 10.31%PRS 81.94
-
CSI 13.5rCSI 10.67%PRS 55.76
-
CSI 12.98rCSI 25.77%PRS 65.3
-
CSI 12.93rCSI 41.95%PRS 67.98
-
CSI 12.58rCSI 17.2%PRS 74.34
-
CSI 12.09rCSI 19.31%PRS 72.84
-
CSI 11.36rCSI 25.93%PRS 60.11
-
CSI 11.01rCSI 31.31%PRS 66.04
-
CSI 10.99rCSI 22.07%PRS 57.84
-
CSI 10.84rCSI 15.88%PRS 82.09
-
CSI 10.7rCSI 27.67%PRS 63.54
-
CSI 10.47rCSI 42.25%PRS 67.81
-
CSI 10.28rCSI 14.05%PRS 69.61
-
CSI 9.91rCSI 11.45%PRS 59.47
-
CSI 9.54rCSI 14.6%PRS 80.65
-
CSI 9.39rCSI 14.93%PRS 61.21
-
CSI 9.28rCSI 8.16%PRS 56.58
-
CSI 8.88rCSI 15.69%PRS 48.95
-
CSI 8.8rCSI 22.32%PRS 58.16
-
CSI 8.79rCSI 8.18%PRS 69.31
-
CSI 8.73rCSI 27.94%PRS 65.84
-
CSI 8.71rCSI 11.18%PRS 60.27
-
CSI 8.58rCSI 32.44%PRS 50.42
-
CSI 8.45rCSI 14.9%PRS 64.96
-
CSI 8.41rCSI 8.77%PRS 68.56
-
CSI 8.02rCSI 11.11%PRS 68.38
-
CSI 7.89rCSI 37.82%PRS 68.56
-
CSI 7.88rCSI 22.55%PRS 78.67
-
CSI 7.84rCSI 14.95%PRS 81.82
-
CSI 7.68rCSI 6.36%PRS 71.07
-
CSI 7.67rCSI 31.26%PRS 79.82
-
CSI 7.65rCSI 36.61%PRS 66.59
-
CSI 7.51rCSI 17.91%PRS 69.63
-
CSI 7.38rCSI 5.47%PRS 61.47
-
CSI 7.3rCSI 11.16%PRS 69.33
-
CSI 7.09rCSI 16.37%PRS 56.95
-
CSI 6.85rCSI 12.55%PRS 77.58
-
CSI 6.74rCSI 25.25%PRS 60.51
-
CSI 6.72rCSI 11.77%PRS 61.12
-
CSI 6.53rCSI 6.17%PRS 67.81
-
CSI 6.46rCSI 13.39%PRS 65.63
-
CSI 6.35rCSI 6.81%PRS 68.91
-
CSI 6.22rCSI 7.98%PRS 65.22
-
CSI 6.03rCSI 17.48%PRS 57.93
-
CSI 5.9rCSI 5.69%PRS 60.1
-
CSI 5.74rCSI 7.8%PRS 79.29
-
CSI 5.7rCSI 23.22%PRS 61.88
-
CSI 5.64rCSI 7.72%PRS 61.11
-
CSI 5.64rCSI 13.78%PRS 61.72
-
CSI 5.59rCSI 39.56%PRS 61.07
-
CSI 5.51rCSI 30.11%PRS 66.35
-
CSI 5.46rCSI 4.85%PRS 66.45
-
CSI 5.32rCSI 13.87%PRS 68.79
-
CSI 5.24rCSI 13.25%PRS 75.81
-
CSI 5.23rCSI 11.96%PRS 69.11
-
CSI 5.22rCSI 29.48%PRS 54.01
-
CSI 5.2rCSI 35.7%PRS 79.57
-
CSI 5.17rCSI 4.2%PRS 68.9
-
CSI 5.16rCSI 27.45%PRS 59.58
-
CSI 5.15rCSI 37.85%PRS 55.16
-
CSI 5.07rCSI 13.5%PRS 57.36
-
CSI 4.85rCSI 15.95%PRS 55.26
-
CSI 4.85rCSI 7.8%PRS 51.77
-
CSI 4.83rCSI 5.97%PRS 65.52
-
CSI 4.79rCSI 29.93%PRS 60.15
-
CSI 4.65rCSI 4.64%PRS 62.08
-
CSI 4.6rCSI 19.35%PRS 78.61
-
CSI 4.6rCSI 4.81%PRS 66.45
-
CSI 4.59rCSI 9.43%PRS 57.77
-
CSI 4.58rCSI 23.44%PRS 73.12
-
CSI 4.44rCSI 11.73%PRS 77.08
-
CSI 4.25rCSI 5.41%PRS 74.64
-
CSI 4.19rCSI 37.19%PRS 82.29
-
CSI 4.12rCSI 5.51%PRS 76.96
-
CSI 4.09rCSI 12.61%PRS 75.75
-
CSI 4.03rCSI 21.18%PRS 76.76
-
CSI 4.03rCSI 11.59%PRS 79.66
-
CSI 3.93rCSI 28.73%PRS 82.41
-
CSI 3.9rCSI 4.08%PRS 86.94
-
CSI 3.9rCSI 11.57%PRS 78.38
-
CSI 3.82rCSI 3.17%PRS 68.45
-
CSI 0.3rCSI 1.5%PRS 76.2%
-
CSI 0.3rCSI 5.3%PRS 85.7%
-
CSI 0.4rCSI 6.0%PRS 78.1%
-
CSI 0.6rCSI 8.6%PRS 82.2%
-
CSI 0.7rCSI 0.9%PRS 71.6%
-
CSI 0.7rCSI 6.3%PRS 55.8%
-
CSI 0.8rCSI 2.2%PRS 78.4%
-
CSI 0.9rCSI 20.5%PRS 84.8%
-
CSI 0.9rCSI 17.2%PRS 81.2%
-
CSI 1.0rCSI 3.4%PRS 75.6%
-
CSI 1.0rCSI 3.9%PRS 86.9%
-
CSI 1.1rCSI 4.2%PRS 79.2%
-
CSI 1.1rCSI 11.4%PRS 66.1%
-
CSI 1.1rCSI 2.1%PRS 84.3%
-
CSI 1.1rCSI 2.6%PRS 77.9%
-
CSI 1.2rCSI 7.4%PRS 77.5%
-
CSI 1.2rCSI 2.1%PRS 68.0%
-
CSI 1.2rCSI 3.0%PRS 67.0%
-
CSI 1.2rCSI 2.2%PRS 82.3%
-
CSI 1.3rCSI 2.9%PRS 75.6%
-
CSI 1.3rCSI 2.1%PRS 70.9%
-
CSI 1.3rCSI 2.9%PRS 54.5%
-
CSI 1.4rCSI 1.0%PRS 74.4%
-
CSI 1.4rCSI 3.4%PRS 67.4%
-
CSI 1.4rCSI 5.0%PRS 48.0%
-
CSI 1.4rCSI 3.1%PRS 56.3%
-
CSI 1.4rCSI 1.5%PRS 76.9%
-
CSI 1.5rCSI 2.7%PRS 80.9%
-
CSI 1.5rCSI 3.2%PRS 84.0%
-
CSI 1.5rCSI 2.3%PRS 73.5%
-
CSI 1.6rCSI 6.3%PRS 45.9%
-
CSI 1.6rCSI 2.6%PRS 79.0%
-
CSI 1.6rCSI 1.7%PRS 74.4%
-
CSI 1.6rCSI 7.2%PRS 81.1%
-
CSI 1.7rCSI 2.2%PRS 51.2%
-
CSI 1.7rCSI 3.5%PRS 68.5%
-
CSI 1.7rCSI 3.2%PRS 60.0%
-
CSI 1.8rCSI 11.2%PRS 68.7%
-
CSI 1.8rCSI 15.1%PRS 64.6%
-
CSI 1.8rCSI 4.2%PRS 76.4%
-
CSI 1.8rCSI 8.0%PRS 81.9%
-
CSI 1.8rCSI 6.8%PRS 59.0%
-
CSI 1.8rCSI 13.9%PRS 73.4%
-
CSI 1.8rCSI 4.4%PRS 76.8%
-
CSI 1.9rCSI 3.5%PRS 78.7%
-
CSI 1.9rCSI 3.7%PRS 71.8%
-
CSI 2.0rCSI 2.3%PRS 66.8%
-
CSI 2.1rCSI 4.7%PRS 64.1%
-
CSI 2.1rCSI 6.5%PRS 54.1%
-
CSI 2.1rCSI 23.0%PRS 78.6%
-
CSI 2.1rCSI 5.5%PRS 80.7%
-
CSI 2.1rCSI 11.4%PRS 78.9%
-
CSI 2.2rCSI 3.8%PRS 76.0%
-
CSI 2.2rCSI 17.7%PRS 62.1%
-
CSI 2.3rCSI 6.2%PRS 79.4%
-
CSI 2.3rCSI 2.9%PRS 73.1%
-
CSI 2.3rCSI 2.9%PRS 70.4%
-
CSI 2.3rCSI 10.7%PRS 77.0%
-
CSI 2.4rCSI 24.5%PRS 62.8%
-
CSI 2.4rCSI 4.0%PRS 57.7%
-
CSI 2.6rCSI 2.0%PRS 71.6%
-
CSI 2.6rCSI 19.7%PRS 82.6%
-
CSI 2.6rCSI 4.4%PRS 74.0%
-
CSI 2.7rCSI 4.0%PRS 61.8%
-
CSI 2.8rCSI 6.6%PRS 69.0%
-
CSI 2.8rCSI 4.3%PRS 75.1%
-
CSI 2.8rCSI 5.9%PRS 84.1%
-
CSI 2.8rCSI 9.4%PRS 53.2%
-
CSI 2.9rCSI 16.9%PRS 51.0%
-
CSI 2.9rCSI 20.6%PRS 68.1%
-
CSI 2.9rCSI 70.4%PRS 49.6%
-
CSI 2.9rCSI 70.5%PRS 49.0%
-
CSI 3.0rCSI 8.0%PRS 74.9%
-
CSI 3.0rCSI 5.9%PRS 79.6%
-
CSI 3.0rCSI 8.0%PRS 84.5%
-
CSI 3.0rCSI 7.1%PRS 84.4%
-
CSI 3.1rCSI 3.8%PRS 47.9%
-
CSI 3.1rCSI 10.0%PRS 67.9%
-
CSI 3.2rCSI 13.7%PRS 61.3%
-
CSI 3.3rCSI 8.5%PRS 71.5%
-
CSI 3.3rCSI 7.9%PRS 74.8%
-
CSI 3.3rCSI 7.3%PRS 79.6%
-
CSI 3.4rCSI 7.9%PRS 71.3%
-
CSI 3.4rCSI 7.5%PRS 72.8%
-
CSI 3.4rCSI 4.9%PRS 70.5%
-
CSI 3.5rCSI 3.7%PRS 65.5%
-
CSI 3.6rCSI 11.1%PRS 51.6%
-
CSI 3.6rCSI 10.3%PRS 78.6%
-
CSI 3.7rCSI 8.8%PRS 55.4%
-
CSI 3.7rCSI 10.8%PRS 67.4%
-
CSI 3.7rCSI 5.6%PRS 73.0%
-
CSI 3.7rCSI 10.1%PRS 82.7%
-
CSI 3.8rCSI 5.1%PRS 68.5%
-
CSI 3.8rCSI 3.2%PRS 68.5%
-
CSI 3.9rCSI 11.6%PRS 78.4%
-
CSI 3.9rCSI 4.1%PRS 86.9%
-
CSI 3.9rCSI 28.7%PRS 82.4%
-
CSI 4.0rCSI 11.6%PRS 79.7%
-
CSI 4.0rCSI 21.2%PRS 76.8%
-
CSI 4.1rCSI 12.6%PRS 75.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3999340965
Symbol: CRIM1_HUMAN
Name: Cysteine-rich motor neuron 1 protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10642437
Title: CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis.
PubMed ID: 10642437
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12805376
Title: CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface.
PubMed ID: 12805376
PubMed ID: 15340161
Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.
PubMed ID: 15340161
DOI: 10.1110/ps.04682504
PubMed ID: 12464430
Title: CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo.
PubMed ID: 12464430
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
Sequence Information:
- Length: 1036
- Mass: 113738
- Checksum: 10CBF02A5C579C27
- Sequence:
MYLVAGDRGL AGCGHLLVSL LGLLLLLARS GTRALVCLPC DESKCEEPRN CPGSIVQGVC GCCYTCASQR NESCGGTFGI YGTCDRGLRC VIRPPLNGDS LTEYEAGVCE DENWTDDQLL GFKPCNENLI AGCNIINGKC ECNTIRTCSN PFEFPSQDMC LSALKRIEEE KPDCSKARCE VQFSPRCPED SVLIEGYAPP GECCPLPSRC VCNPAGCLRK VCQPGNLNIL VSKASGKPGE CCDLYECKPV FGVDCRTVEC PPVQQTACPP DSYETQVRLT ADGCCTLPTR CECLSGLCGF PVCEVGSTPR IVSRGDGTPG KCCDVFECVN DTKPACVFNN VEYYDGDMFR MDNCRFCRCQ GGVAICFTAQ CGEINCERYY VPEGECCPVC EDPVYPFNNP AGCYANGLIL AHGDRWREDD CTFCQCVNGE RHCVATVCGQ TCTNPVKVPG ECCPVCEEPT IITVDPPACG ELSNCTLTGK DCINGFKRDH NGCRTCQCIN TEELCSERKQ GCTLNCPFGF LTDAQNCEIC ECRPRPKKCR PIICDKYCPL GLLKNKHGCD ICRCKKCPEL SCSKICPLGF QQDSHGCLIC KCREASASAG PPILSGTCLT VDGHHHKNEE SWHDGCRECY CLNGREMCAL ITCPVPACGN PTIHPGQCCP SCADDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ CTCHSGRVLC ETEVCPPLLC QNPSRTQDSC CPQCTDQPFR PSLSRNNSVP NYCKNDEGDI FLAAESWKPD VCTSCICIDS VISCFSESCP SVSCERPVLR KGQCCPYCIE DTIPKKVVCH FSGKAYADEE RWDLDSCTHC YCLQGQTLCS TVSCPPLPCV EPINVEGSCC PMCPEMYVPE PTNIPIEKTN HRGEVDLEVP LWPTPSENDI VHLPRDMGHL QVDYRDNRLH PSEDSSLDSI ASVVVPIIIC LSIIIAFLFI NQKKQWIPLL CWYRTPTKPS SLNNQLVSVD CKKGTRVQVD SSQRMLRIAE PDARFSGFYS MQKQNHLQAD NFYQTV