Details for: UBAP1

Gene ID: 51271

Symbol: UBAP1

Ensembl ID: ENSG00000165006

Description: ubiquitin associated protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 304.5417
    Cell Significance Index: -47.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 186.9948
    Cell Significance Index: -47.4300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 123.9963
    Cell Significance Index: -51.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 106.3918
    Cell Significance Index: -50.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 101.8567
    Cell Significance Index: -41.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.9167
    Cell Significance Index: -47.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.2090
    Cell Significance Index: -47.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.1976
    Cell Significance Index: -46.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.0069
    Cell Significance Index: -39.9500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.7799
    Cell Significance Index: -27.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.6557
    Cell Significance Index: -49.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.3300
    Cell Significance Index: 31.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2111
    Cell Significance Index: 59.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7179
    Cell Significance Index: 340.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7067
    Cell Significance Index: 130.9700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.5017
    Cell Significance Index: 36.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.4892
    Cell Significance Index: 38.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4411
    Cell Significance Index: 289.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1732
    Cell Significance Index: 420.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.1533
    Cell Significance Index: 28.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1328
    Cell Significance Index: 1022.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0576
    Cell Significance Index: 28.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9976
    Cell Significance Index: 19.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8709
    Cell Significance Index: 24.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8201
    Cell Significance Index: 23.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8000
    Cell Significance Index: 44.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7025
    Cell Significance Index: 114.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6927
    Cell Significance Index: 124.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6582
    Cell Significance Index: 18.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6479
    Cell Significance Index: 64.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6023
    Cell Significance Index: 65.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5641
    Cell Significance Index: 42.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5230
    Cell Significance Index: 8.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5124
    Cell Significance Index: 66.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4871
    Cell Significance Index: 336.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3934
    Cell Significance Index: 24.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3847
    Cell Significance Index: 25.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3779
    Cell Significance Index: 22.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3488
    Cell Significance Index: 18.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3217
    Cell Significance Index: 39.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2803
    Cell Significance Index: 38.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2782
    Cell Significance Index: 13.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2651
    Cell Significance Index: 7.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2088
    Cell Significance Index: 114.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2074
    Cell Significance Index: 9.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2047
    Cell Significance Index: 38.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2029
    Cell Significance Index: 7.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1971
    Cell Significance Index: 371.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1845
    Cell Significance Index: 117.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1833
    Cell Significance Index: 21.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1727
    Cell Significance Index: 22.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1470
    Cell Significance Index: 65.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1386
    Cell Significance Index: 6.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1036
    Cell Significance Index: 47.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0742
    Cell Significance Index: 100.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0724
    Cell Significance Index: 12.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0639
    Cell Significance Index: 98.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0516
    Cell Significance Index: 95.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0217
    Cell Significance Index: 0.8200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0177
    Cell Significance Index: 0.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0070
    Cell Significance Index: 0.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0076
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0158
    Cell Significance Index: -11.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0183
    Cell Significance Index: -11.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0438
    Cell Significance Index: -33.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0473
    Cell Significance Index: -34.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0594
    Cell Significance Index: -33.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0821
    Cell Significance Index: -4.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1053
    Cell Significance Index: -10.7600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1089
    Cell Significance Index: -12.4300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1177
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1284
    Cell Significance Index: -27.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1394
    Cell Significance Index: -16.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1401
    Cell Significance Index: -20.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1432
    Cell Significance Index: -9.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1483
    Cell Significance Index: -42.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2479
    Cell Significance Index: -11.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2541
    Cell Significance Index: -6.0900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2711
    Cell Significance Index: -2.8800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2845
    Cell Significance Index: -4.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2885
    Cell Significance Index: -33.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2915
    Cell Significance Index: -18.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3119
    Cell Significance Index: -19.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3335
    Cell Significance Index: -7.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3350
    Cell Significance Index: -34.8800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3704
    Cell Significance Index: -3.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3951
    Cell Significance Index: -27.9400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4142
    Cell Significance Index: -6.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4243
    Cell Significance Index: -6.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4313
    Cell Significance Index: -11.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4449
    Cell Significance Index: -15.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4533
    Cell Significance Index: -14.5200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4646
    Cell Significance Index: -7.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4807
    Cell Significance Index: -5.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5330
    Cell Significance Index: -15.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5435
    Cell Significance Index: -43.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5919
    Cell Significance Index: -12.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5938
    Cell Significance Index: -17.4400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6233
    Cell Significance Index: -9.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7064
    Cell Significance Index: -43.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** UBAP1 is a ubiquitin-associated protein that belongs to the ubiquitin-binding protein family. It is characterized by its ability to bind to ubiquitin and other proteins, regulating their degradation and localization. UBAP1 has been shown to interact with various proteins, including ubiquitin ligases, ubiquitin-conjugating enzymes, and other ubiquitin-associated proteins. Its expression is widespread across different cell types, with significant levels detected in hematopoietic cells, epithelial cells, and immune cells. **Pathways and Functions** UBAP1 plays a crucial role in various cellular processes, including: 1. **Autophagy**: UBAP1 has been shown to regulate autophagy by interacting with autophagy-related proteins, such as LC3 and ATG5. 2. **Endosomal sorting**: UBAP1 participates in the endosomal sorting complex required for transport (ESCRT) pathway, which is essential for the regulation of endosomal membrane dynamics and the sorting of proteins. 3. **HIV infection**: UBAP1 has been shown to interact with HIV proteins, such as Gag and Gag-Pol, regulating their maturation and localization. 4. **Cellular regulation**: UBAP1 regulates cellular processes, including protein degradation, cell cycle progression, and apoptosis. **Clinical Significance** UBAP1 has significant implications in various diseases, including: 1. **HIV infection**: UBAP1's role in HIV infection highlights its potential as a therapeutic target for HIV treatment. 2. **Cancer**: UBAP1's involvement in autophagy and endosomal sorting pathways makes it a potential target for cancer therapy. 3. **Neurodegenerative diseases**: UBAP1's regulation of autophagy and endosomal sorting pathways suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, UBAP1 is a multifaceted protein that plays a crucial role in various cellular processes, including HIV infection, autophagy, and endosomal sorting. Its significant clinical implications highlight its potential as a therapeutic target for various diseases. Further research is needed to fully elucidate the functions of UBAP1 and its role in disease pathology.

Genular Protein ID: 3672923041

Symbol: UBAP1_HUMAN

Name: Nasopharyngeal carcinoma-associated gene 20 protein

UniProtKB Accession Codes:

Q9NZ09 B7Z348 B7Z8N9 D3DRL7 F5GXE2 F5H0J8 Q4V759 Q53FP7 Q5T7B3 Q6FI75 Q8NC52 Q8NCG6 Q8NCH9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 21 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 5 RefSeq 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11599797

Title: Isolation and characterization of a novel cDNA, UBAP1, derived from the tumor suppressor locus in human chromosome 9p21-22.

PubMed ID: 11599797

DOI: 10.1007/s004320100252

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21757351

Title: UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.

PubMed ID: 21757351

DOI: 10.1016/j.cub.2011.06.028

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24284069

Title: The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex.

PubMed ID: 24284069

DOI: 10.1242/jcs.140673

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 22405001

Title: The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.

PubMed ID: 22405001

DOI: 10.1016/j.str.2011.12.013

PubMed ID: 27839950

Title: Structural basis for selective interaction between the ESCRT regulator HD-PTP and UBAP1.

PubMed ID: 27839950

DOI: 10.1016/j.str.2016.10.006

PubMed ID: 30929741

Title: Truncating mutations in UBAP1 cause hereditary spastic paraplegia.

PubMed ID: 30929741

DOI: 10.1016/j.ajhg.2019.03.001

PubMed ID: 31203368

Title: Stop-gain mutations in UBAP1 cause pure autosomal-dominant spastic paraplegia.

PubMed ID: 31203368

DOI: 10.1093/brain/awz158

Sequence Information:

  • Length: 502
  • Mass: 55084
  • Checksum: 548457B0B2ABC0F4
  • Sequence:
    • MASKKLGADF HGTFSYLDDV PFKTGDKFKT PAKVGLPIGF SLPDCLQVVR EVQYDFSLEK 
KTIEWAEEIK KIEEAEREAE CKIAEAEAKV NSKSGPEGDS KMSFSKTHST ATMPPPINPI 
LASLQHNSIL TPTRVSSSAT KQKVLSPPHI KADFNLADFE CEEDPFDNLE LKTIDEKEEL 
RNILVGTTGP IMAQLLDNNL PRGGSGSVLQ DEEVLASLER ATLDFKPLHK PNGFITLPQL 
GNCEKMSLSS KVSLPPIPAV SNIKSLSFPK LDSDDSNQKT AKLASTFHST SCLRNGTFQN 
SLKPSTQSSA SELNGHHTLG LSALNLDSGT EMPALTSSQM PSLSVLSVCT EESSPPNTGP 
TVTPPNFSVS QVPNMPSCPQ AYSELQMLSP SERQCVETVV NMGYSYECVL RAMKKKGENI 
EQILDYLFAH GQLCEKGFDP LLVEEALEMH QCSEEKMMEF LQLMSKFKEM GFELKDIKEV 
LLLHNNDQDN ALEDLMARAG AS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.