Details for: CDK17

Gene ID: 5128

Symbol: CDK17

Ensembl ID: ENSG00000059758

Description: cyclin dependent kinase 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 282.1044
    Cell Significance Index: -43.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 177.2173
    Cell Significance Index: -44.9500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 114.4563
    Cell Significance Index: -47.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 100.9695
    Cell Significance Index: -47.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.5244
    Cell Significance Index: -39.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 87.7650
    Cell Significance Index: -45.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.6866
    Cell Significance Index: -39.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.7653
    Cell Significance Index: -45.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.5705
    Cell Significance Index: -44.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.8902
    Cell Significance Index: -30.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.8180
    Cell Significance Index: -39.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.6243
    Cell Significance Index: -45.8700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 5.1361
    Cell Significance Index: 73.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3075
    Cell Significance Index: 462.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.1487
    Cell Significance Index: 95.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.0199
    Cell Significance Index: 76.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.9896
    Cell Significance Index: 133.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.9448
    Cell Significance Index: 109.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6338
    Cell Significance Index: 100.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4683
    Cell Significance Index: 291.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.3698
    Cell Significance Index: 39.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1.3688
    Cell Significance Index: 8.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3454
    Cell Significance Index: 930.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3197
    Cell Significance Index: 473.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1087
    Cell Significance Index: 26.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9181
    Cell Significance Index: 828.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8536
    Cell Significance Index: 65.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6548
    Cell Significance Index: 12.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5799
    Cell Significance Index: 1091.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4451
    Cell Significance Index: 11.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3937
    Cell Significance Index: 45.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3897
    Cell Significance Index: 42.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3753
    Cell Significance Index: 37.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3527
    Cell Significance Index: 57.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1815
    Cell Significance Index: 3.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1475
    Cell Significance Index: 4.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1380
    Cell Significance Index: 26.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1365
    Cell Significance Index: 16.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1344
    Cell Significance Index: 61.0000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.1342
    Cell Significance Index: 1.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1287
    Cell Significance Index: 15.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1160
    Cell Significance Index: 6.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1011
    Cell Significance Index: 55.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0974
    Cell Significance Index: 61.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0973
    Cell Significance Index: 2.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0806
    Cell Significance Index: 124.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0723
    Cell Significance Index: 13.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0675
    Cell Significance Index: 42.1700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0504
    Cell Significance Index: 0.8300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0482
    Cell Significance Index: 1.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0448
    Cell Significance Index: 3.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0386
    Cell Significance Index: 71.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0288
    Cell Significance Index: 12.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0235
    Cell Significance Index: 0.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0035
    Cell Significance Index: 4.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0154
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0316
    Cell Significance Index: -23.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0335
    Cell Significance Index: -4.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0549
    Cell Significance Index: -40.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0607
    Cell Significance Index: -45.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0716
    Cell Significance Index: -40.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0921
    Cell Significance Index: -4.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1010
    Cell Significance Index: -17.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1040
    Cell Significance Index: -2.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1212
    Cell Significance Index: -16.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1383
    Cell Significance Index: -39.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1392
    Cell Significance Index: -29.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1496
    Cell Significance Index: -19.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1969
    Cell Significance Index: -20.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2296
    Cell Significance Index: -23.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2397
    Cell Significance Index: -11.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2486
    Cell Significance Index: -32.1200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.3171
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3315
    Cell Significance Index: -37.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3320
    Cell Significance Index: -38.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4525
    Cell Significance Index: -29.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4689
    Cell Significance Index: -24.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4755
    Cell Significance Index: -35.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4847
    Cell Significance Index: -34.2800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4899
    Cell Significance Index: -7.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5048
    Cell Significance Index: -14.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5241
    Cell Significance Index: -33.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5420
    Cell Significance Index: -42.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5471
    Cell Significance Index: -11.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5498
    Cell Significance Index: -18.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5526
    Cell Significance Index: -33.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5637
    Cell Significance Index: -14.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5882
    Cell Significance Index: -27.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5950
    Cell Significance Index: -18.9500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6076
    Cell Significance Index: -8.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6251
    Cell Significance Index: -20.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6947
    Cell Significance Index: -36.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8192
    Cell Significance Index: -21.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8608
    Cell Significance Index: -17.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8623
    Cell Significance Index: -23.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8766
    Cell Significance Index: -30.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9172
    Cell Significance Index: -32.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9609
    Cell Significance Index: -11.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9711
    Cell Significance Index: -20.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cyclin-dependent kinase activity:** CDK17 is a member of the cyclin-dependent kinase family, which is characterized by its ability to phosphorylate and activate downstream targets. 2. **Cell cycle regulation:** CDK17 is involved in regulating the cell cycle, particularly in the G2/M phase, where it phosphorylates and activates key proteins involved in cell cycle progression. 3. **Tissue specificity:** CDK17 is highly expressed in specific tissues, including endothelial cells, pigmented epithelial cells, and neurons, suggesting a role in tissue-specific developmental processes. 4. **Phosphorylation motifs:** CDK17 contains specific phosphorylation motifs that allow it to interact with and phosphorylate downstream targets. **Pathways and Functions:** 1. **Cell cycle regulation:** CDK17 regulates the cell cycle by phosphorylating and activating key proteins involved in cell cycle progression, such as cyclin B1 and CDC2. 2. **Developmental processes:** CDK17 is involved in developmental processes, including neuronal development and differentiation, where it regulates the expression of key genes involved in neuronal function. 3. **Apoptosis:** CDK17 has been shown to regulate apoptosis (programmed cell death) by phosphorylating and activating pro-apoptotic proteins. 4. **DNA repair:** CDK17 is also involved in DNA repair processes, where it regulates the expression of key genes involved in DNA repair and maintenance. **Clinical Significance:** 1. **Cancer:** CDK17 has been implicated in various cancers, including breast, lung, and colon cancer, where it is often overexpressed and associated with poor prognosis. 2. **Neurological disorders:** CDK17 has been linked to neurological disorders, including Alzheimer's disease, Parkinson's disease, and stroke, where it is involved in neuronal differentiation and survival. 3. **Vascular diseases:** CDK17 has been implicated in vascular diseases, including atherosclerosis and hypertension, where it regulates endothelial cell function and vascular tone. 4. **Neurodevelopmental disorders:** CDK17 has been linked to neurodevelopmental disorders, including autism and schizophrenia, where it regulates neuronal development and function. In conclusion, CDK17 is a key regulator of cell cycle and developmental processes, with implications for various diseases, including cancer, neurological disorders, vascular diseases, and neurodevelopmental disorders. Further research is needed to fully understand the mechanisms of CDK17 and its role in human disease.

Genular Protein ID: 1286955808

Symbol: CDK17_HUMAN

Name: Cyclin-dependent kinase 17

UniProtKB Accession Codes:

Q00537 A8K1U6 B2RCQ2 Q8NEB8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 4 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 Rhea 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1639063

Title: A family of human cdc2-related protein kinases.

PubMed ID: 1639063

DOI: 10.1002/j.1460-2075.1992.tb05360.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

  • Length: 523
  • Mass: 59582
  • Checksum: 429ABD1DCBB5A082
  • Sequence:
    • MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEENSSKDNE PIVKNGRPPT SHSMHSFLHQ 
YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN LKMGSDGESD QASGTSSDEV 
QSPTGVCLRN RIHRRISMED LNKRLSLPAD IRIPDGYLEK LQINSPPFDQ PMSRRSRRAS 
LSEIGFGKME TYIKLEKLGE GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS 
LLKDLKHANI VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGNIMSMHNV KLFLYQILRG 
LAYCHRRKVL HRDLKPQNLL INEKGELKLA DFGLARAKSV PTKTYSNEVV TLWYRPPDVL 
LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL IFRLLGTPSQ ETWPGISSNE 
EFKNYNFPKY KPQPLINHAP RLDSEGIELI TKFLQYESKK RVSAEEAMKH VYFRSLGPRI 
HALPESVSIF SLKEIQLQKD PGFRNSSYPE TGHGKNRRQS MLF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.