Details for: NRN1

Gene ID: 51299

Symbol: NRN1

Ensembl ID: ENSG00000124785

Description: neuritin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6664
    Cell Significance Index: -22.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.1001
    Cell Significance Index: 90.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.2772
    Cell Significance Index: 25.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.8060
    Cell Significance Index: 121.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7829
    Cell Significance Index: 37.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.4372
    Cell Significance Index: 24.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3756
    Cell Significance Index: 275.9500
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.3614
    Cell Significance Index: 11.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2160
    Cell Significance Index: 63.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.0069
    Cell Significance Index: 28.7400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.5338
    Cell Significance Index: 5.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1464
    Cell Significance Index: 18.0000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1139
    Cell Significance Index: 1.5200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0730
    Cell Significance Index: 0.9100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0509
    Cell Significance Index: 0.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0100
    Cell Significance Index: -6.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0118
    Cell Significance Index: -22.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0153
    Cell Significance Index: -6.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0164
    Cell Significance Index: -30.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0194
    Cell Significance Index: -29.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0217
    Cell Significance Index: -7.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0221
    Cell Significance Index: -30.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0270
    Cell Significance Index: -17.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0288
    Cell Significance Index: -21.8300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0336
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0337
    Cell Significance Index: -24.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0343
    Cell Significance Index: -21.4300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0386
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0397
    Cell Significance Index: -22.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0444
    Cell Significance Index: -20.1600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0497
    Cell Significance Index: -0.3000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0523
    Cell Significance Index: -0.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0574
    Cell Significance Index: -16.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0593
    Cell Significance Index: -1.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0711
    Cell Significance Index: -12.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0825
    Cell Significance Index: -10.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0963
    Cell Significance Index: -19.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1102
    Cell Significance Index: -23.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1152
    Cell Significance Index: -16.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1336
    Cell Significance Index: -13.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1346
    Cell Significance Index: -17.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1432
    Cell Significance Index: -16.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1449
    Cell Significance Index: -24.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1680
    Cell Significance Index: -11.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1689
    Cell Significance Index: -19.9200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1711
    Cell Significance Index: -2.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1807
    Cell Significance Index: -24.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2176
    Cell Significance Index: -24.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2206
    Cell Significance Index: -13.5600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2336
    Cell Significance Index: -2.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2367
    Cell Significance Index: -17.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2587
    Cell Significance Index: -16.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2659
    Cell Significance Index: -8.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2949
    Cell Significance Index: -13.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2987
    Cell Significance Index: -9.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3095
    Cell Significance Index: -17.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3163
    Cell Significance Index: -8.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3249
    Cell Significance Index: -24.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3375
    Cell Significance Index: -21.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3580
    Cell Significance Index: -12.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3880
    Cell Significance Index: -10.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4049
    Cell Significance Index: -10.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4159
    Cell Significance Index: -14.5700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4341
    Cell Significance Index: -4.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4390
    Cell Significance Index: -19.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4524
    Cell Significance Index: -20.0100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4557
    Cell Significance Index: -9.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4794
    Cell Significance Index: -22.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4853
    Cell Significance Index: -25.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4949
    Cell Significance Index: -12.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5115
    Cell Significance Index: -25.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5385
    Cell Significance Index: -14.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5400
    Cell Significance Index: -20.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6053
    Cell Significance Index: -17.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6374
    Cell Significance Index: -13.9600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6435
    Cell Significance Index: -6.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6574
    Cell Significance Index: -26.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6653
    Cell Significance Index: -19.5400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6733
    Cell Significance Index: -16.7900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.6735
    Cell Significance Index: -9.5700
  • Cell Name: vein endothelial cell of respiratory system (CL4033008)
    Fold Change: -0.6987
    Cell Significance Index: -4.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7006
    Cell Significance Index: -25.7200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.7155
    Cell Significance Index: -10.8900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.7544
    Cell Significance Index: -15.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7606
    Cell Significance Index: -20.3800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7662
    Cell Significance Index: -11.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7692
    Cell Significance Index: -27.0300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7860
    Cell Significance Index: -15.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7880
    Cell Significance Index: -20.7200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.7921
    Cell Significance Index: -8.6300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7944
    Cell Significance Index: -19.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8083
    Cell Significance Index: -20.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8285
    Cell Significance Index: -19.8700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.8405
    Cell Significance Index: -20.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8521
    Cell Significance Index: -21.7100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8989
    Cell Significance Index: -19.4200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.9047
    Cell Significance Index: -12.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9056
    Cell Significance Index: -19.2200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9106
    Cell Significance Index: -19.0100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.9191
    Cell Significance Index: -15.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** NRN1 is expressed in a diverse range of cell types, including neurons, stromal cells, and endothelial cells. This widespread expression suggests that NRN1 plays a crucial role in regulating cellular processes across different tissues. 2. **Post-Translational Modifications:** NRN1 undergoes various post-translational modifications, including glycosylation and phosphorylation, which are essential for its function in regulating axon extension and synaptic plasticity. 3. **Association with Neuronal Development:** NRN1 is involved in the regulation of neuronal growth and development, particularly during the extension of axons and dendrites. 4. **Clinical Significance:** NRN1 has been implicated in various neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). **Pathways and Functions:** 1. **Neuronal Projection Extension:** NRN1 plays a crucial role in regulating axon extension and dendrite formation during neuronal development. This process involves the activation of signaling pathways, including the MAPK/ERK and PI3K/AKT pathways. 2. **Synaptic Plasticity:** NRN1 is involved in regulating synaptic plasticity, particularly long-term potentiation (LTP) and long-term depression (LTD). These processes are essential for learning and memory. 3. **Cell Signaling:** NRN1 interacts with various signaling molecules, including growth factors, receptors, and ion channels, to regulate cellular processes. 4. **Endocytic Pathway:** NRN1 is involved in the regulation of the endocytic pathway, particularly in the postsynaptic endocytic zone. **Clinical Significance:** 1. **Diagnosis and Treatment of Neurodegenerative Disorders:** NRN1 has been implicated in various neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and ALS. Understanding the molecular mechanisms of NRN1 may lead to the development of novel diagnostic tools and therapeutic strategies. 2. **Regulation of Axon Extension and Dendrite Formation:** NRN1's role in regulating axon extension and dendrite formation makes it an attractive target for the treatment of neurological disorders, such as cerebral palsy and spinal cord injuries. 3. **Implications for Neuroregenerative Medicine:** The study of NRN1 has implications for neuroregenerative medicine, particularly in the development of novel therapies for neurological disorders. In conclusion, Neuritin 1 (NRN1) is a multifaceted gene that plays a critical role in regulating neuronal growth, development, and synaptic plasticity. Understanding the molecular mechanisms of NRN1 has significant implications for the diagnosis and treatment of neurodegenerative disorders, as well as the development of novel therapeutic strategies for neurological diseases.

Genular Protein ID: 263669442

Symbol: NRN1_HUMAN

Name: Neuritin

UniProtKB Accession Codes:

Q9NPD7 B2RA93 Q7Z4Y1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9122250

Title: Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis.

PubMed ID: 9122250

DOI: 10.1073/pnas.94.6.2648

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 142
  • Mass: 15333
  • Checksum: 6C3C3DAC8D6392E6
  • Sequence:
    • MGLKLNGRYI SLILAVQIAY LVQAVRAAGK CDAVFKGFSD CLLKLGDSMA NYPQGLDDKT 
NIKTVCTYWE DFHSCTVTAL TDCQEGAKDM WDKLRKESKN LNIQGSLFEL CGSGNGAAGS 
LLPAFPVLLV SLSAALATWL SF

Genular Protein ID: 47120356

Symbol: A0A087WWT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WWT2

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 HGNC 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 168
  • Mass: 18107
  • Checksum: 67DD81FA72A13F78
  • Sequence:
    • MATAARPQPD HSSSAPGLRT SRLPSFQRGG RGCIRGSHSE YRVHAYLVQA VRAAGKCDAV 
FKGFSDCLLK LGDSMANYPQ GLDDKTNIKT VCTYWEDFHS CTVTALTDCQ EGAKDMWDKL 
RKESKNLNIQ GSLFELCGSG NGAAGSLLPA FPVLLVSLSA ALATWLSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.