Details for: GASK1B

Gene ID: 51313

Symbol: GASK1B

Ensembl ID: ENSG00000164125

Description: golgi associated kinase 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 152.8173
    Cell Significance Index: -23.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.9114
    Cell Significance Index: -23.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.8978
    Cell Significance Index: -24.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.7378
    Cell Significance Index: -25.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.3882
    Cell Significance Index: -21.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.2768
    Cell Significance Index: -23.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3753
    Cell Significance Index: -18.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0288
    Cell Significance Index: -23.7900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.9659
    Cell Significance Index: 76.8300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.3345
    Cell Significance Index: 19.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.0501
    Cell Significance Index: 23.2900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.6539
    Cell Significance Index: 23.7500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.5611
    Cell Significance Index: 19.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4567
    Cell Significance Index: 200.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1443
    Cell Significance Index: 30.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1244
    Cell Significance Index: 213.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7159
    Cell Significance Index: 646.4200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.6690
    Cell Significance Index: 4.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5712
    Cell Significance Index: 113.3600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.4366
    Cell Significance Index: 3.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3935
    Cell Significance Index: 11.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3134
    Cell Significance Index: 31.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2956
    Cell Significance Index: 48.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2419
    Cell Significance Index: 26.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1634
    Cell Significance Index: 3.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1421
    Cell Significance Index: 10.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1413
    Cell Significance Index: 28.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0891
    Cell Significance Index: 16.0700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0876
    Cell Significance Index: 1.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0543
    Cell Significance Index: 29.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0420
    Cell Significance Index: 1.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0385
    Cell Significance Index: 2.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0355
    Cell Significance Index: 0.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0136
    Cell Significance Index: 0.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0108
    Cell Significance Index: 1.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0102
    Cell Significance Index: 0.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0022
    Cell Significance Index: 0.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0122
    Cell Significance Index: -23.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0149
    Cell Significance Index: -27.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0179
    Cell Significance Index: -27.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0206
    Cell Significance Index: -27.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0210
    Cell Significance Index: -0.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0222
    Cell Significance Index: -15.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0276
    Cell Significance Index: -20.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0284
    Cell Significance Index: -1.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0327
    Cell Significance Index: -23.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0333
    Cell Significance Index: -24.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0361
    Cell Significance Index: -22.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0413
    Cell Significance Index: -25.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0452
    Cell Significance Index: -25.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0454
    Cell Significance Index: -4.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0505
    Cell Significance Index: -18.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0512
    Cell Significance Index: -6.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0527
    Cell Significance Index: -23.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0570
    Cell Significance Index: -4.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0745
    Cell Significance Index: -21.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1035
    Cell Significance Index: -4.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1043
    Cell Significance Index: -2.6800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1051
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1203
    Cell Significance Index: -20.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1243
    Cell Significance Index: -26.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1464
    Cell Significance Index: -2.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1486
    Cell Significance Index: -17.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1548
    Cell Significance Index: -17.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1645
    Cell Significance Index: -23.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1792
    Cell Significance Index: -10.7600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1862
    Cell Significance Index: -2.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1881
    Cell Significance Index: -24.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2027
    Cell Significance Index: -15.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2282
    Cell Significance Index: -23.7600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2570
    Cell Significance Index: -2.6600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2686
    Cell Significance Index: -1.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2693
    Cell Significance Index: -14.0300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2758
    Cell Significance Index: -4.0200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2896
    Cell Significance Index: -1.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2935
    Cell Significance Index: -9.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2944
    Cell Significance Index: -7.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2955
    Cell Significance Index: -9.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2963
    Cell Significance Index: -15.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3020
    Cell Significance Index: -23.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3061
    Cell Significance Index: -5.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3368
    Cell Significance Index: -15.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3446
    Cell Significance Index: -21.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3647
    Cell Significance Index: -24.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3905
    Cell Significance Index: -24.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3922
    Cell Significance Index: -25.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4207
    Cell Significance Index: -13.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4295
    Cell Significance Index: -11.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4395
    Cell Significance Index: -24.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4545
    Cell Significance Index: -6.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4643
    Cell Significance Index: -21.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4779
    Cell Significance Index: -25.0900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.4839
    Cell Significance Index: -3.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5035
    Cell Significance Index: -13.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5127
    Cell Significance Index: -10.9200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5169
    Cell Significance Index: -12.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5283
    Cell Significance Index: -23.3700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5497
    Cell Significance Index: -9.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5541
    Cell Significance Index: -19.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5654
    Cell Significance Index: -28.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular expression:** GASK1B is expressed in a wide range of cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, smooth muscle fibers of the ileum, peripheral blood mononuclear cells, ciliated cells of the bronchus, orthochromatic erythroblasts, epidermal Langerhans cells, stromal cells of the bone marrow, and fallopian tube secretory epithelial cells. 2. **Golgi apparatus localization:** GASK1B is specifically localized to the Golgi apparatus, suggesting its involvement in Golgi-mediated processes. 3. **Serine/threonine kinase activity:** GASK1B exhibits serine/threonine kinase activity, which is crucial for its regulatory functions. **Pathways and Functions:** 1. **Golgi apparatus signaling:** GASK1B is involved in Golgi-mediated signaling pathways, which regulate various cellular processes, including cell growth, differentiation, and survival. 2. **Cell growth and proliferation:** GASK1B has been shown to regulate cell growth and proliferation in hematopoietic cells, suggesting its potential role in hematopoiesis. 3. **Differentiation and survival:** GASK1B may also regulate differentiation and survival in various cell types, including hematopoietic cells and epithelial cells. 4. **Apoptosis regulation:** GASK1B has been implicated in the regulation of apoptosis, particularly in hematopoietic cells. **Clinical Significance:** 1. **Hematological disorders:** GASK1B may play a role in hematological disorders, such as leukemia and lymphoma, where its dysregulation can contribute to disease progression. 2. **Cancer:** GASK1B's involvement in cell growth, differentiation, and survival suggests its potential role in cancer development and progression. 3. **Inflammatory diseases:** GASK1B's expression in peripheral blood mononuclear cells and its involvement in Golgi-mediated signaling pathways may also contribute to the pathogenesis of inflammatory diseases, such as atherosclerosis and rheumatoid arthritis. 4. **Neurological disorders:** GASK1B's expression in ciliated cells of the bronchus and its potential role in Golgi-mediated signaling pathways may also be relevant to neurological disorders, such as neurodegenerative diseases. In conclusion, GASK1B is a unique enzyme with multifaceted functions in various cell types. Further studies are needed to fully elucidate its roles in different cellular processes and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 486658871

Symbol: GAK1B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6UWH4 Q498Z3 Q6IAF9 Q6ZMF2 Q86XL0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 4 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 3 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11256614

Title: Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.

PubMed ID: 11256614

DOI: 10.1093/embo-reports/kvd058

Sequence Information:

  • Length: 519
  • Mass: 57552
  • Checksum: 94F6EE648E4CB0BD
  • Sequence:
    • MTCPDKPGQL INWFICSLCV PRVRKLWSSR RPRTRRNLLL GTACAIYLGF LVSQVGRASL 
QHGQAAEKGP HRSRDTAEPS FPEIPLDGTL APPESQGNGS TLQPNVVYIT LRSKRSKPAN 
IRGTVKPKRR KKHAVASAAP GQEALVGPSL QPQEAAREAD AVAPGYAQGA NLVKIGERPW 
RLVRGPGVRA GGPDFLQPSS RESNIRIYSE SAPSWLSKDD IRRMRLLADS AVAGLRPVSS 
RSGARLLVLE GGAPGAVLRC GPSPCGLLKQ PLDMSEVFAF HLDRILGLNR TLPSVSRKAE 
FIQDGRPCPI ILWDASLSSA SNDTHSSVKL TWGTYQQLLK QKCWQNGRVP KPESGCTEIH 
HHEWSKMALF DFLLQIYNRL DTNCCGFRPR KEDACVQNGL RPKCDDQGSA ALAHIIQRKH 
DPRHLVFIDN KGFFDRSEDN LNFKLLEGIK EFPASAVSVL KSQHLRQKLL QSLFLDKVYW 
ESQGGRQGIE KLIDVIEHRA KILITYINAH GVKVLPMNE

Genular Protein ID: 2838542520

Symbol: Q9NYZ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NYZ0

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 GO 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 246
  • Mass: 28233
  • Checksum: 90BF8959053E896D
  • Sequence:
    • MSEVFAFHLD RILGLNRTLP SVSRKAEFIQ DGRPCPIILW DASLSSASND THSSVKLTWG 
TYQQLLKQKC WQNGRVPKPE SGCTEIHHHE WSKMALFDFL LQIYNRLDTN CCGFRPRKED 
ACVQNGLRPK CDDQGSAALA HIIQRKHDPR HLVFIDNKGF FDRSEDNLNF KLLEGIKEFP 
ASAVSVLKSQ HLRQKLLQSL FLDKVYWESQ GGRQGIEKLI DVIEHRAKIL ITYINAHGVK 
VLPMNE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.