Details for: KRCC1

Gene ID: 51315

Symbol: KRCC1

Ensembl ID: ENSG00000172086

Description: lysine rich coiled-coil 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 233.1155
    Cell Significance Index: -36.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 119.6562
    Cell Significance Index: -30.3500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 96.3958
    Cell Significance Index: -39.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.0078
    Cell Significance Index: -32.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.9747
    Cell Significance Index: -38.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 72.2221
    Cell Significance Index: -37.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 57.0771
    Cell Significance Index: -38.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.6585
    Cell Significance Index: -33.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.0579
    Cell Significance Index: -37.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.4559
    Cell Significance Index: -28.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0887
    Cell Significance Index: -22.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5843
    Cell Significance Index: -37.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.5660
    Cell Significance Index: -26.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7581
    Cell Significance Index: 105.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4624
    Cell Significance Index: 1320.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0628
    Cell Significance Index: 14.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8806
    Cell Significance Index: 174.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8605
    Cell Significance Index: 155.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8117
    Cell Significance Index: 132.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7520
    Cell Significance Index: 20.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7107
    Cell Significance Index: 97.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6758
    Cell Significance Index: 83.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6046
    Cell Significance Index: 71.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5902
    Cell Significance Index: 118.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5523
    Cell Significance Index: 42.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5290
    Cell Significance Index: 11.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4953
    Cell Significance Index: 31.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4948
    Cell Significance Index: 14.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4871
    Cell Significance Index: 266.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4796
    Cell Significance Index: 9.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4671
    Cell Significance Index: 21.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4411
    Cell Significance Index: 20.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4357
    Cell Significance Index: 55.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3780
    Cell Significance Index: 167.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3665
    Cell Significance Index: 20.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3565
    Cell Significance Index: 24.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3222
    Cell Significance Index: 11.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3214
    Cell Significance Index: 7.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2984
    Cell Significance Index: 15.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2644
    Cell Significance Index: 94.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2523
    Cell Significance Index: 8.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2162
    Cell Significance Index: 15.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1611
    Cell Significance Index: 15.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1414
    Cell Significance Index: 97.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1376
    Cell Significance Index: 23.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1255
    Cell Significance Index: 5.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1103
    Cell Significance Index: 21.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0739
    Cell Significance Index: 139.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0712
    Cell Significance Index: 2.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0541
    Cell Significance Index: 1.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0475
    Cell Significance Index: 73.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0448
    Cell Significance Index: 82.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0430
    Cell Significance Index: 0.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0276
    Cell Significance Index: 17.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0215
    Cell Significance Index: 9.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0190
    Cell Significance Index: 0.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0079
    Cell Significance Index: 0.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0032
    Cell Significance Index: 4.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0021
    Cell Significance Index: -1.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0045
    Cell Significance Index: -0.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0054
    Cell Significance Index: -4.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0193
    Cell Significance Index: -0.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0232
    Cell Significance Index: -14.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0339
    Cell Significance Index: -3.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0471
    Cell Significance Index: -26.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0750
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0879
    Cell Significance Index: -18.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1135
    Cell Significance Index: -32.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1156
    Cell Significance Index: -13.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1233
    Cell Significance Index: -6.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1280
    Cell Significance Index: -18.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1303
    Cell Significance Index: -14.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1621
    Cell Significance Index: -4.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1667
    Cell Significance Index: -4.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1988
    Cell Significance Index: -5.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2460
    Cell Significance Index: -28.0800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2696
    Cell Significance Index: -4.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3108
    Cell Significance Index: -32.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3175
    Cell Significance Index: -21.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3219
    Cell Significance Index: -19.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3293
    Cell Significance Index: -17.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3424
    Cell Significance Index: -8.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3660
    Cell Significance Index: -28.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3746
    Cell Significance Index: -16.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3843
    Cell Significance Index: -24.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4525
    Cell Significance Index: -6.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4678
    Cell Significance Index: -12.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4714
    Cell Significance Index: -28.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4832
    Cell Significance Index: -10.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4892
    Cell Significance Index: -18.5300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6051
    Cell Significance Index: -8.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6135
    Cell Significance Index: -11.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6695
    Cell Significance Index: -6.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6912
    Cell Significance Index: -18.4900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7946
    Cell Significance Index: -13.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7948
    Cell Significance Index: -13.6200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8163
    Cell Significance Index: -8.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8509
    Cell Significance Index: -27.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics:** 1. **Coiled-coil structure**: KRCC1 contains a coiled-coil domain, which is a characteristic feature of many protein-protein interaction domains. This domain allows for dimerization and oligomerization of the protein, potentially facilitating interactions with other proteins and influencing cellular processes. 2. **Lysine-rich domain**: The protein is rich in lysine residues, which are known to play a role in protein-protein interactions, protein stability, and post-translational modifications. 3. **Expression in various cell types**: KRCC1 is expressed in multiple cell types, including hematopoietic cells, epithelial cells, stem cells, and immune cells. This suggests that KRCC1 may play a role in regulating cellular differentiation, proliferation, and survival. **Pathways and functions:** 1. **Protein binding**: KRCC1 interacts with other proteins, including histones, transcription factors, and signaling molecules, to regulate gene expression and cellular processes. 2. **Cellular differentiation**: KRCC1 may influence the differentiation of hematopoietic cells, epithelial cells, and stem cells by regulating gene expression and protein interactions. 3. **Immune response**: KRCC1 may play a role in regulating immune responses by interacting with immune cells, such as T cells and mast cells, and influencing their function and differentiation. 4. **Tissue homeostasis**: KRCC1 may contribute to maintaining tissue homeostasis by regulating the expression of genes involved in cell growth, differentiation, and survival. **Clinical significance:** 1. **Autoimmune diseases**: Alterations in KRCC1 expression or function may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus, by disrupting immune homeostasis and promoting inflammation. 2. **Cancer**: KRCC1 may play a role in cancer development and progression by influencing cellular differentiation, proliferation, and survival. 3. **Immunodeficiency disorders**: KRCC1 may contribute to immunodeficiency disorders, such as severe combined immunodeficiency (SCID), by disrupting immune cell function and development. 4. **Stem cell research**: KRCC1 may be useful as a marker for stem cells, as it is highly expressed in embryonic stem cells and other stem cell types. In conclusion, KRCC1 is a multifunctional protein that plays a significant role in regulating immune responses, cellular differentiation, and tissue homeostasis. Further research is needed to fully understand the mechanisms by which KRCC1 influences cellular processes and to explore its potential therapeutic applications in autoimmune diseases, cancer, and immunodeficiency disorders.

Genular Protein ID: 38572104

Symbol: KRCC1_HUMAN

Name: Lysine-rich coiled-coil protein 1

UniProtKB Accession Codes:

Q9NPI7 Q3B7J7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 259
  • Mass: 30980
  • Checksum: 1FD963D642683F01
  • Sequence:
    • MKHSKKTYDS FQDELEDYIK VQKARGLEPK TCFRKMKGDY LETCGYKGEV NSRPTYRMFD 
QRLPSETIQT YPRSCNIPQT VENRLPQWLP AHDSRLRLDS LSYCQFTRDC FSEKPVPLNF 
NQQEYICGSH GVEHRVYKHF SSDNSTSTHQ ASHKQIHQKR KRHPEEGREK SEEERSKHKR 
KKSCEEIDLD KHKSIQRKKT EVEIETVHVS TEKLKNRKEK KSRDVVSKKE ERKRTKKKKE 
QGQERTEEEM LWDQSILGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.