Details for: MS4A4A

Gene ID: 51338

Symbol: MS4A4A

Ensembl ID: ENSG00000110079

Description: membrane spanning 4-domains A4A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.6612
    Cell Significance Index: -17.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.7042
    Cell Significance Index: -17.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 28.5000
    Cell Significance Index: -14.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.4490
    Cell Significance Index: -17.8200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.2665
    Cell Significance Index: 66.0100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 3.4965
    Cell Significance Index: 43.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3851
    Cell Significance Index: -5.2200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.4041
    Cell Significance Index: 11.4500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.3815
    Cell Significance Index: 3.0900
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.2643
    Cell Significance Index: 1.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0711
    Cell Significance Index: 1.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0606
    Cell Significance Index: 1.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0463
    Cell Significance Index: 28.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0237
    Cell Significance Index: 2.4300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0075
    Cell Significance Index: 0.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0005
    Cell Significance Index: 0.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0034
    Cell Significance Index: -6.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0076
    Cell Significance Index: -14.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0138
    Cell Significance Index: -21.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0152
    Cell Significance Index: -1.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0163
    Cell Significance Index: -4.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0174
    Cell Significance Index: -11.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0176
    Cell Significance Index: -12.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0200
    Cell Significance Index: -27.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0201
    Cell Significance Index: -15.1800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0237
    Cell Significance Index: -0.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0269
    Cell Significance Index: -1.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0343
    Cell Significance Index: -15.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0376
    Cell Significance Index: -7.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0407
    Cell Significance Index: -14.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0477
    Cell Significance Index: -8.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0693
    Cell Significance Index: -10.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0753
    Cell Significance Index: -15.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1077
    Cell Significance Index: -13.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1174
    Cell Significance Index: -13.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1179
    Cell Significance Index: -15.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1195
    Cell Significance Index: -14.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1214
    Cell Significance Index: -15.6900
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1304
    Cell Significance Index: -1.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1390
    Cell Significance Index: -19.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1512
    Cell Significance Index: -17.6200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1515
    Cell Significance Index: -3.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1621
    Cell Significance Index: -7.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1639
    Cell Significance Index: -12.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1718
    Cell Significance Index: -17.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1832
    Cell Significance Index: -5.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1874
    Cell Significance Index: -14.3800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1895
    Cell Significance Index: -1.6700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1930
    Cell Significance Index: -1.9700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2011
    Cell Significance Index: -1.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2096
    Cell Significance Index: -15.6300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2279
    Cell Significance Index: -3.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2356
    Cell Significance Index: -12.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2417
    Cell Significance Index: -12.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2564
    Cell Significance Index: -17.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2583
    Cell Significance Index: -16.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2584
    Cell Significance Index: -13.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2694
    Cell Significance Index: -16.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2754
    Cell Significance Index: -12.8400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2907
    Cell Significance Index: -12.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3106
    Cell Significance Index: -19.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3120
    Cell Significance Index: -8.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3726
    Cell Significance Index: -20.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3744
    Cell Significance Index: -13.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3838
    Cell Significance Index: -9.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3975
    Cell Significance Index: -20.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4182
    Cell Significance Index: -18.5000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.4229
    Cell Significance Index: -3.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4312
    Cell Significance Index: -12.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4583
    Cell Significance Index: -16.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4855
    Cell Significance Index: -11.7600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.4872
    Cell Significance Index: -4.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4897
    Cell Significance Index: -17.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4912
    Cell Significance Index: -18.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5087
    Cell Significance Index: -16.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5118
    Cell Significance Index: -7.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5124
    Cell Significance Index: -15.0500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.5350
    Cell Significance Index: -10.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5495
    Cell Significance Index: -17.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5497
    Cell Significance Index: -14.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5524
    Cell Significance Index: -15.8400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5811
    Cell Significance Index: -14.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6042
    Cell Significance Index: -21.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6159
    Cell Significance Index: -17.5800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6264
    Cell Significance Index: -15.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6543
    Cell Significance Index: -13.7000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.6559
    Cell Significance Index: -9.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6667
    Cell Significance Index: -17.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6845
    Cell Significance Index: -13.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6869
    Cell Significance Index: -17.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7015
    Cell Significance Index: -15.3600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.7045
    Cell Significance Index: -10.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7358
    Cell Significance Index: -21.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7467
    Cell Significance Index: -18.6500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.7490
    Cell Significance Index: -15.2400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7518
    Cell Significance Index: -18.0300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7526
    Cell Significance Index: -16.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane structure**: The MS4A4A protein is characterized by its membrane-spanning structure, consisting of four domains that provide structural support and facilitate protein-protein interactions. 2. **Cellular expression**: This gene is significantly expressed in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, peripheral blood mononuclear cells, and immune cells such as Langerhans cells and myeloid leukocytes. 3. **Protein-protein interactions**: The MS4A4A protein interacts with other proteins, including those involved in signaling pathways, to regulate cellular processes. 4. **Endoplasmic reticulum and Golgi apparatus association**: The gene is associated with the endoplasmic reticulum and Golgi apparatus, suggesting its involvement in protein modification and secretion. **Pathways and Functions:** 1. **Immune system regulation**: The MS4A4A protein plays a crucial role in regulating immune responses, including the activation and maturation of immune cells. 2. **Cell signaling**: The protein is involved in various signaling pathways, including those regulating cellular growth, differentiation, and survival. 3. **Protein binding**: MS4A4A interacts with other proteins, including those involved in immune responses, to regulate cellular processes. 4. **Endocytosis and exocytosis**: The gene is associated with the endoplasmic reticulum and Golgi apparatus, suggesting its involvement in protein modification and secretion. **Clinical Significance:** Dysregulation of the MS4A4A gene has been implicated in various diseases, including: 1. **Immune system disorders**: Mutations in the MS4A4A gene have been associated with immune system disorders, such as autoimmune diseases and immunodeficiency syndromes. 2. **Cancer**: The protein's involvement in cell signaling and protein-protein interactions suggests its potential role in cancer development and progression. 3. **Neurological disorders**: The gene's expression in the brain and its association with endocytosis and exocytosis suggest its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the MS4A4A gene is a multifaceted protein with significant roles in immune system regulation, cell signaling, and protein-protein interactions. Further research is necessary to fully understand the gene's functions and its implications in human disease.

Genular Protein ID: 3912689953

Symbol: M4A4A_HUMAN

Name: Membrane-spanning 4-domains subfamily A member 4A

UniProtKB Accession Codes:

Q96JQ5 Q8TEZ6 Q96PG7 Q9BY18 Q9H3V3 Q9P1S3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11245982

Title: Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor.

PubMed ID: 11245982

DOI: 10.1016/s0378-1119(00)00598-9

PubMed ID: 11401424

Title: Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse.

PubMed ID: 11401424

DOI: 10.1006/geno.2000.6472

PubMed ID: 11486273

Title: Structural organization of the human MS4A gene cluster on chromosome 11q12.

PubMed ID: 11486273

DOI: 10.1007/s002510100339

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 239
  • Mass: 25441
  • Checksum: F0617D94669CB447
  • Sequence:
    • MHQTYSRHCR PEESTFSAAM TTMQGMEQAM PGAGPGVPQL GNMAVIHSHL WKGLQEKFLK 
GEPKVLGVVQ ILTALMSLSM GITMMCMASN TYGSNPISVY IGYTIWGSVM FIISGSLSIA 
AGIRTTKGLV RGSLGMNITS SVLAASGILI NTFSLAFYSF HHPYCNYYGN SNNCHGTMSI 
LMGLDGMVLL LSVLEFCIAV SLSAFGCKVL CCTPGGVVLI LPSHSHMAET ASPTPLNEV

Genular Protein ID: 1090508247

Symbol: Q4JF27_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4JF27

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 220
  • Mass: 23170
  • Checksum: 620D5FD6435B48F1
  • Sequence:
    • MTTMQGMEQA MPGAGPGVPQ LGNMAVIHSH LWKGLQEKFL KGEPKVLGVV QILTALMSLS 
MGITMMCMAS NTYGSNPISA YIGYTIWGSV MFIISGSLPI AAGIRTTKGL VRGSLGMNIT 
SSVLAASGIL INTFSLAFYS FHHPYCNYYG NSNNCHGTVS ILMGLDGMVL LLSVLEFCIA 
VSLSAFGCKV LCCTPGGVVL ILPSHSHMAE TASPTPLNEV

Genular Protein ID: 1218743821

Symbol: A0A384MDW1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A384MDW1

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 GO 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 2 SAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 220
  • Mass: 23220
  • Checksum: 7648C762197C1179
  • Sequence:
    • MTTMQGMEQA MPGAGPGVPQ LGNMAVIHSH LWKGLQEKFL KGEPKVLGVV QILTALMSLS 
MGITMMCMAS NTYGSNPISV YIGYTIWGSV MFIISGSLSI AAGIRTTKGL VRGSLGMNIT 
SSVLAASGIL INTFSLAFYS FHHPYCNYYG NSNNCHGTMS ILMGLDGMVL LLSVLEFCIA 
VSLSAFGCKV LCCTPGGVVL ILPSHSHMAE TASPTPLNEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.