Details for: UCHL5

Gene ID: 51377

Symbol: UCHL5

Ensembl ID: ENSG00000116750

Description: ubiquitin C-terminal hydrolase L5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 168.9541
    Cell Significance Index: -26.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 112.7962
    Cell Significance Index: -28.6100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 79.8888
    Cell Significance Index: -32.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.6673
    Cell Significance Index: -34.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 72.9095
    Cell Significance Index: -29.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.4082
    Cell Significance Index: -33.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.2650
    Cell Significance Index: -29.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.8971
    Cell Significance Index: -31.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.2735
    Cell Significance Index: -30.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.2660
    Cell Significance Index: -28.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3989
    Cell Significance Index: -33.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0127
    Cell Significance Index: 199.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5754
    Cell Significance Index: 183.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2706
    Cell Significance Index: 138.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1875
    Cell Significance Index: 238.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1471
    Cell Significance Index: 186.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0076
    Cell Significance Index: 909.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9586
    Cell Significance Index: 190.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8985
    Cell Significance Index: 56.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6120
    Cell Significance Index: 42.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5210
    Cell Significance Index: 186.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4690
    Cell Significance Index: 84.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4477
    Cell Significance Index: 52.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4210
    Cell Significance Index: 19.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4199
    Cell Significance Index: 32.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4027
    Cell Significance Index: 219.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3961
    Cell Significance Index: 273.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3869
    Cell Significance Index: 47.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3511
    Cell Significance Index: 155.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3464
    Cell Significance Index: 15.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3379
    Cell Significance Index: 9.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3263
    Cell Significance Index: 7.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3000
    Cell Significance Index: 8.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2985
    Cell Significance Index: 16.7500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2768
    Cell Significance Index: 3.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2573
    Cell Significance Index: 13.5100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2395
    Cell Significance Index: 2.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2307
    Cell Significance Index: 14.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2300
    Cell Significance Index: 10.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2018
    Cell Significance Index: 7.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1919
    Cell Significance Index: 8.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1901
    Cell Significance Index: 26.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1845
    Cell Significance Index: 35.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1496
    Cell Significance Index: 25.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1304
    Cell Significance Index: 8.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1100
    Cell Significance Index: 7.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0632
    Cell Significance Index: 3.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0535
    Cell Significance Index: 3.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0399
    Cell Significance Index: 75.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0279
    Cell Significance Index: 0.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0272
    Cell Significance Index: 0.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0261
    Cell Significance Index: 3.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0239
    Cell Significance Index: 0.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0192
    Cell Significance Index: 0.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0180
    Cell Significance Index: 8.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0161
    Cell Significance Index: 0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0140
    Cell Significance Index: 8.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0104
    Cell Significance Index: 19.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0055
    Cell Significance Index: 8.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0054
    Cell Significance Index: 0.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0023
    Cell Significance Index: 0.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0073
    Cell Significance Index: -5.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0091
    Cell Significance Index: -5.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0100
    Cell Significance Index: -7.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0165
    Cell Significance Index: -22.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0188
    Cell Significance Index: -14.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0189
    Cell Significance Index: -2.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0272
    Cell Significance Index: -15.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0410
    Cell Significance Index: -5.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0456
    Cell Significance Index: -1.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0566
    Cell Significance Index: -5.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0726
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0857
    Cell Significance Index: -18.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0904
    Cell Significance Index: -4.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0942
    Cell Significance Index: -27.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1075
    Cell Significance Index: -8.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1141
    Cell Significance Index: -16.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1295
    Cell Significance Index: -3.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2026
    Cell Significance Index: -23.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2302
    Cell Significance Index: -6.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2555
    Cell Significance Index: -6.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2608
    Cell Significance Index: -5.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2677
    Cell Significance Index: -6.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2784
    Cell Significance Index: -28.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2895
    Cell Significance Index: -3.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3148
    Cell Significance Index: -24.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3441
    Cell Significance Index: -11.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3533
    Cell Significance Index: -9.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3833
    Cell Significance Index: -10.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4049
    Cell Significance Index: -14.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4221
    Cell Significance Index: -2.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4318
    Cell Significance Index: -26.4800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4476
    Cell Significance Index: -3.6500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.4765
    Cell Significance Index: -4.0500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4975
    Cell Significance Index: -10.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5193
    Cell Significance Index: -11.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5329
    Cell Significance Index: -11.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5629
    Cell Significance Index: -8.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6033
    Cell Significance Index: -17.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6069
    Cell Significance Index: -19.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UCHL5 is a cytosolic enzyme that belongs to the peptidyl-prolyl cis-trans isomerase family. It is characterized by its ability to remove ubiquitin from protein substrates, thereby regulating protein degradation and cellular homeostasis. UCHL5 is predominantly expressed in hematopoietic cells, including erythroblasts, oligopotent progenitor cells, and regulatory T cells. Its expression is also detected in embryonic stem cells, smooth muscle fibers, and ciliated cells of the bronchus. **Pathways and Functions:** UCHL5 is involved in various signaling pathways, including: 1. **Chromatin remodeling**: UCHL5 regulates chromatin structure and transcriptional activity by deubiquitinating histone-modifying enzymes. 2. **DNA repair**: UCHL5 participates in the repair of DNA double-strand breaks by deubiquitinating Ku70 and Ku80. 3. **Cell cycle regulation**: UCHL5 regulates cell cycle progression by deubiquitinating proteins involved in the G1/S transition. 4. **Signaling by TGF-β receptor complex**: UCHL5 negatively regulates TGF-β signaling by deubiquitinating Smad proteins. 5. **Telomere maintenance**: UCHL5 maintains telomeres by deubiquitinating telomerase and telomere-binding proteins. **Clinical Significance:** UCHL5 has been implicated in various diseases, including: 1. **Cancer**: UCHL5 is overexpressed in several types of cancer, including leukemia, lymphoma, and breast cancer. 2. **Autoimmune disorders**: UCHL5 is involved in the regulation of TGF-β signaling, which is dysregulated in autoimmune diseases such as rheumatoid arthritis and lupus. 3. **Neurological disorders**: UCHL5 is expressed in neurons and astrocytes, and its dysregulation has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. In conclusion, UCHL5 is a multifunctional enzyme that plays a crucial role in regulating protein degradation, DNA repair, and cell cycle progression. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its molecular mechanisms and clinical significance. Further research is needed to elucidate the precise role of UCHL5 in immunological processes and its potential as a therapeutic target.

Genular Protein ID: 2782427007

Symbol: UCHL5_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase isozyme L5

UniProtKB Accession Codes:

Q9Y5K5 Q5LJA6 Q5LJA7 Q8TBS4 Q96BJ9 Q9H1W5 Q9P0I3 Q9UQN2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16906146

Title: Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.

PubMed ID: 16906146

DOI: 10.1038/ncb1460

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16990800

Title: A novel proteasome-interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.

PubMed ID: 16990800

DOI: 10.1038/sj.emboj.7601338

PubMed ID: 17139257

Title: hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.

PubMed ID: 17139257

DOI: 10.1038/sj.emboj.7601450

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18922472

Title: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex.

PubMed ID: 18922472

DOI: 10.1016/j.molcel.2008.08.027

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21303910

Title: Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.

PubMed ID: 21303910

DOI: 10.1074/jbc.m111.222505

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19836345

Title: Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain.

PubMed ID: 19836345

DOI: 10.1016/j.bbrc.2009.10.062

Sequence Information:

  • Length: 329
  • Mass: 37607
  • Checksum: DF307347D48C9D0F
  • Sequence:
    • MTGNAGEWCL MESDPGVFTE LIKGFGCRGA QVEEIWSLEP ENFEKLKPVH GLIFLFKWQP 
GEEPAGSVVQ DSRLDTIFFA KQVINNACAT QAIVSVLLNC THQDVHLGET LSEFKEFSQS 
FDAAMKGLAL SNSDVIRQVH NSFARQQMFE FDTKTSAKEE DAFHFVSYVP VNGRLYELDG 
LREGPIDLGA CNQDDWISAV RPVIEKRIQK YSEGEIRFNL MAIVSDRKMI YEQKIAELQR 
QLAEEEPMDT DQGNSMLSAI QSEVAKNQML IEEEVQKLKR YKIENIRRKH NYLPFIMELL 
KTLAEHQQLI PLVEKAKEKQ NAKKAQETK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.