Details for: CRLF3

Gene ID: 51379

Symbol: CRLF3

Ensembl ID: ENSG00000176390

Description: cytokine receptor like factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 184.4480
    Cell Significance Index: -28.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 125.0969
    Cell Significance Index: -31.7300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 80.4228
    Cell Significance Index: -33.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.8958
    Cell Significance Index: -35.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 72.2449
    Cell Significance Index: -29.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 66.8565
    Cell Significance Index: -34.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.2833
    Cell Significance Index: -29.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.9515
    Cell Significance Index: -33.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.5097
    Cell Significance Index: -25.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.6575
    Cell Significance Index: -28.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.4874
    Cell Significance Index: -29.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 5.8592
    Cell Significance Index: 100.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.5915
    Cell Significance Index: 62.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.2447
    Cell Significance Index: 137.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0564
    Cell Significance Index: 412.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6614
    Cell Significance Index: 329.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.3077
    Cell Significance Index: 49.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3018
    Cell Significance Index: 247.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1982
    Cell Significance Index: 53.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1963
    Cell Significance Index: 80.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1760
    Cell Significance Index: 31.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1152
    Cell Significance Index: 399.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1059
    Cell Significance Index: 62.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9855
    Cell Significance Index: 27.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8148
    Cell Significance Index: 62.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8044
    Cell Significance Index: 15.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8035
    Cell Significance Index: 79.4800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.8021
    Cell Significance Index: 7.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.7741
    Cell Significance Index: 112.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7031
    Cell Significance Index: 114.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4717
    Cell Significance Index: 55.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3939
    Cell Significance Index: 11.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3189
    Cell Significance Index: 34.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2775
    Cell Significance Index: 32.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2388
    Cell Significance Index: 367.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2254
    Cell Significance Index: 155.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1857
    Cell Significance Index: 342.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1675
    Cell Significance Index: 30.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1610
    Cell Significance Index: 19.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1485
    Cell Significance Index: 279.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1305
    Cell Significance Index: 1.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1140
    Cell Significance Index: 3.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1111
    Cell Significance Index: 5.7900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1107
    Cell Significance Index: 1.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0984
    Cell Significance Index: 6.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0957
    Cell Significance Index: 5.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0940
    Cell Significance Index: 127.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0581
    Cell Significance Index: 4.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0493
    Cell Significance Index: 26.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0466
    Cell Significance Index: 1.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0400
    Cell Significance Index: 25.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0368
    Cell Significance Index: 16.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0280
    Cell Significance Index: 12.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0157
    Cell Significance Index: 0.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0132
    Cell Significance Index: 0.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0040
    Cell Significance Index: 0.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0391
    Cell Significance Index: -28.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0409
    Cell Significance Index: -30.9600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0418
    Cell Significance Index: -0.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0424
    Cell Significance Index: -31.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0441
    Cell Significance Index: -1.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0604
    Cell Significance Index: -34.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0607
    Cell Significance Index: -8.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0621
    Cell Significance Index: -38.8100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0799
    Cell Significance Index: -1.1800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0802
    Cell Significance Index: -1.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0892
    Cell Significance Index: -4.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0982
    Cell Significance Index: -28.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1280
    Cell Significance Index: -21.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1524
    Cell Significance Index: -2.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1573
    Cell Significance Index: -20.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1607
    Cell Significance Index: -16.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1616
    Cell Significance Index: -20.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1705
    Cell Significance Index: -35.9200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2109
    Cell Significance Index: -2.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2280
    Cell Significance Index: -23.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2364
    Cell Significance Index: -27.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2698
    Cell Significance Index: -19.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2713
    Cell Significance Index: -5.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2874
    Cell Significance Index: -21.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3256
    Cell Significance Index: -19.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3565
    Cell Significance Index: -18.5200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3691
    Cell Significance Index: -2.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3737
    Cell Significance Index: -19.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3850
    Cell Significance Index: -12.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3919
    Cell Significance Index: -12.4800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3959
    Cell Significance Index: -9.6600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3969
    Cell Significance Index: -5.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4139
    Cell Significance Index: -32.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4259
    Cell Significance Index: -8.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4329
    Cell Significance Index: -8.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4510
    Cell Significance Index: -21.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4834
    Cell Significance Index: -10.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4843
    Cell Significance Index: -12.4500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5062
    Cell Significance Index: -3.4300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5837
    Cell Significance Index: -4.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6008
    Cell Significance Index: -16.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6243
    Cell Significance Index: -20.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6339
    Cell Significance Index: -13.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6420
    Cell Significance Index: -13.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CRLF3 is a cytokine receptor-like gene that belongs to the family of receptor tyrosine kinases (RTKs). This gene is characterized by its ability to bind to specific ligands, such as interleukin-7 (IL-7) and IL-15, which are essential for the development and maintenance of immune cells. The CRLF3 protein is structurally similar to other RTKs and possesses intrinsic tyrosine kinase activity, allowing it to phosphorylate and activate downstream signaling pathways. This gene is primarily expressed in hematopoietic cells, epithelial cells, and immune cells, including mast cells, T cells, and dendritic cells. **Pathways and Functions:** CRLF3 plays a critical role in regulating various cellular processes, including: 1. **Immune cell development and differentiation**: CRLF3 is essential for the development and differentiation of hematopoietic cells, including T cells, B cells, and dendritic cells. 2. **Cell growth and proliferation**: The CRLF3 protein regulates cell growth and proliferation by activating downstream signaling pathways, including the JAK-STAT pathway. 3. **Apoptosis**: CRLF3 has been shown to regulate apoptosis (programmed cell death) in various cell types, including immune cells. 4. **Inflammation**: The CRLF3 protein is involved in the regulation of inflammatory responses, including the production of cytokines and chemokines. **Clinical Significance:** Dysregulation of CRLF3 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: Mutations in the CRLF3 gene have been associated with autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: CRLF3 has been shown to be overexpressed in certain types of cancer, including acute lymphoblastic leukemia and multiple myeloma. 3. **Immunodeficiency disorders**: Defects in the CRLF3 gene have been linked to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 4. **Infectious diseases**: CRLF3 plays a crucial role in the regulation of immune responses to infections, including viral and bacterial infections. In conclusion, the CRLF3 gene is a critical component of the immune system that regulates various cellular processes, including immune cell development, cell growth, and inflammation. Understanding the role of CRLF3 in immune regulation has significant implications for the treatment and management of immune-related disorders and diseases.

Genular Protein ID: 2110906536

Symbol: CRLF3_HUMAN

Name: Cytokine receptor-like factor 3

UniProtKB Accession Codes:

Q8IUI8 A6NJF3 B2R8C3 Q2MLY7 Q9UNI3 Q9Y6M8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 19427400

Title: Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression.

PubMed ID: 19427400

DOI: 10.1016/j.biocel.2009.04.022

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16865251

Title: Identification of dysregulated genes in cutaneous squamous cell carcinoma.

PubMed ID: 16865251

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 442
  • Mass: 49766
  • Checksum: 89F6CACD76397AF8
  • Sequence:
    • MRGAMELEPE LLLQEARENV EAAQSYRREL GHRLEGLREA RRQIKESASQ TRDVLKQHFN 
DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE HGVNTAEDLV REGEIAMLGG 
VGEENEKLWS FTKKASHIQL DSLPEVPLLV DVPCLSAQLD DSILNIVKDH IFKHGTVASR 
PPVQIEELIE KPGGIIVRWC KVDDDFTAQD YRLQFRKCTS NHFEDVYVGS ETEFIVLHID 
PNVDYQFRVC ARGDGRQEWS PWSVPQIGHS TLVPHEWTAG FEGYSLSSRR NIALRNDSES 
SGVLYSRAPT YFCGQTLTFR VETVGQPDRR DSIGVCAEKQ DGYDSLQRDQ AVCISTNGAV 
FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TTSNNEGGHF KLRVTISSNN REVVFDWLLD 
QSCGSLYFGC SFFYPGWKVL VF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.