Details for: ZNF589

Gene ID: 51385

Symbol: ZNF589

Ensembl ID: ENSG00000164048

Description: zinc finger protein 589

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.8558
    Cell Significance Index: -13.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.0416
    Cell Significance Index: -13.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.1749
    Cell Significance Index: -11.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.5738
    Cell Significance Index: -11.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.0142
    Cell Significance Index: -13.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5542
    Cell Significance Index: -12.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3401
    Cell Significance Index: -7.3100
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.5845
    Cell Significance Index: 2.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9932
    Cell Significance Index: 66.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7946
    Cell Significance Index: 285.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7315
    Cell Significance Index: 20.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7147
    Cell Significance Index: 8.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6450
    Cell Significance Index: 63.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6375
    Cell Significance Index: 15.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6151
    Cell Significance Index: 37.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5877
    Cell Significance Index: 117.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4782
    Cell Significance Index: 431.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4610
    Cell Significance Index: 7.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4494
    Cell Significance Index: 12.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4033
    Cell Significance Index: 25.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3929
    Cell Significance Index: 74.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3595
    Cell Significance Index: 15.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3568
    Cell Significance Index: 13.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3437
    Cell Significance Index: 55.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3057
    Cell Significance Index: 8.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2974
    Cell Significance Index: 16.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2872
    Cell Significance Index: 31.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2856
    Cell Significance Index: 56.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2475
    Cell Significance Index: 4.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1902
    Cell Significance Index: 8.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1708
    Cell Significance Index: 3.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1549
    Cell Significance Index: 9.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1459
    Cell Significance Index: 3.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1350
    Cell Significance Index: 3.8900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1334
    Cell Significance Index: 1.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1175
    Cell Significance Index: 221.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1149
    Cell Significance Index: 7.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1064
    Cell Significance Index: 2.6600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0952
    Cell Significance Index: 1.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0804
    Cell Significance Index: 43.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0632
    Cell Significance Index: 116.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0556
    Cell Significance Index: 85.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0482
    Cell Significance Index: 21.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0408
    Cell Significance Index: 25.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0406
    Cell Significance Index: 7.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0394
    Cell Significance Index: 3.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0268
    Cell Significance Index: 36.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0208
    Cell Significance Index: 9.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0200
    Cell Significance Index: 1.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0181
    Cell Significance Index: 2.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0142
    Cell Significance Index: 0.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0040
    Cell Significance Index: 0.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0052
    Cell Significance Index: -0.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0070
    Cell Significance Index: -0.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0127
    Cell Significance Index: -9.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0150
    Cell Significance Index: -11.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0158
    Cell Significance Index: -11.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0219
    Cell Significance Index: -13.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0220
    Cell Significance Index: -12.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0316
    Cell Significance Index: -5.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0405
    Cell Significance Index: -2.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0406
    Cell Significance Index: -11.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0527
    Cell Significance Index: -6.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0568
    Cell Significance Index: -6.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0568
    Cell Significance Index: -1.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0577
    Cell Significance Index: -2.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0632
    Cell Significance Index: -13.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0648
    Cell Significance Index: -1.3800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0665
    Cell Significance Index: -1.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0693
    Cell Significance Index: -7.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0765
    Cell Significance Index: -8.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0765
    Cell Significance Index: -7.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0771
    Cell Significance Index: -9.9600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1047
    Cell Significance Index: -1.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1047
    Cell Significance Index: -5.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1123
    Cell Significance Index: -2.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1131
    Cell Significance Index: -2.4000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1146
    Cell Significance Index: -1.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1170
    Cell Significance Index: -7.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1205
    Cell Significance Index: -2.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1254
    Cell Significance Index: -4.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1402
    Cell Significance Index: -6.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1406
    Cell Significance Index: -10.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1432
    Cell Significance Index: -11.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1456
    Cell Significance Index: -10.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1535
    Cell Significance Index: -8.0000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1556
    Cell Significance Index: -1.4800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1667
    Cell Significance Index: -2.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1762
    Cell Significance Index: -5.7700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.1949
    Cell Significance Index: -1.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1951
    Cell Significance Index: -6.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1961
    Cell Significance Index: -5.7600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2004
    Cell Significance Index: -3.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2105
    Cell Significance Index: -5.6200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2136
    Cell Significance Index: -6.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2257
    Cell Significance Index: -7.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2305
    Cell Significance Index: -5.7500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2425
    Cell Significance Index: -5.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2498
    Cell Significance Index: -8.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2539
    Cell Significance Index: -4.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ZNF589 is a member of the zinc finger protein family, characterized by its unique DNA-binding domain that enables it to interact with RNA polymerase II-specific sequences. This specific binding affinity allows ZNF589 to repress transcription in a sequence-specific manner, thereby regulating the expression of target genes. The protein's ability to bind to zinc ions further underscores its structural and functional significance. **Pathways and Functions** ZNF589 is involved in several key signaling pathways that regulate gene expression, including: 1. **DNA-binding transcription repressor activity**: ZNF589's ability to bind to RNA polymerase II-specific sequences enables it to repress transcription, thereby regulating the expression of target genes. 2. **Negative regulation of transcription by RNA polymerase II**: ZNF589's repressive activity on transcription is mediated through its interaction with RNA polymerase II, thus influencing the overall gene expression landscape. 3. **Generic transcription pathway**: ZNF589's involvement in the generic transcription pathway highlights its role in regulating the expression of housekeeping genes, which are essential for maintaining cellular homeostasis. 4. **Zinc ion binding**: ZNF589's ability to bind to zinc ions highlights its structural significance and underscores the importance of zinc in protein function. **Clinical Significance** ZNF589's involvement in various cellular processes and its expression in multiple cell types make it an attractive candidate for studying human diseases. Some potential clinical applications of ZNF589 include: 1. **Hematological disorders**: ZNF589's expression in hematopoietic cells suggests its potential involvement in hematological disorders, such as leukemia and lymphoma. 2. **Cancer**: ZNF589's role in regulating gene expression and its involvement in cancer cell development make it a potential therapeutic target for cancer treatment. 3. **Neurological disorders**: ZNF589's expression in neuronal cells highlights its potential involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ZNF589 is a complex zinc finger protein that plays a multifaceted role in regulating gene expression through its ability to bind to RNA polymerase II-specific sequences. Its diverse cellular expression patterns and involvement in various signaling pathways underscore its clinical significance and potential applications in human diseases. Further research is needed to fully elucidate the mechanisms underlying ZNF589's functions and to explore its therapeutic potential in various disease contexts.

Genular Protein ID: 4257668138

Symbol: ZN589_HUMAN

Name: Zinc finger protein 589

UniProtKB Accession Codes:

Q86UQ0 Q86UC9 Q9BRI6 Q9BRY3 Q9Y611 Q9Y612

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10029171

Title: SZF1: a novel KRAB-zinc finger gene expressed in CD34+ stem/progenitor cells.

PubMed ID: 10029171

DOI: 10.1016/s0301-472x(98)00035-6

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12097288

Title: A common DNA-binding site for SZF1 and the BRCA1-associated zinc finger protein, ZBRK1.

PubMed ID: 12097288

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 23665872

Title: Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.

PubMed ID: 23665872

DOI: 10.1007/s00018-013-1359-4

Sequence Information:

  • Length: 364
  • Mass: 41189
  • Checksum: EC335916B88993E3
  • Sequence:
    • MWAPREQLLG WTAEALPAKD SAWPWEEKPR YLGPVTFEDV AVLFTEAEWK RLSLEQRNLY 
KEVMLENLRN LVSLAESKPE VHTCPSCPLA FGSQQFLSQD ELHNHPIPGF HAGNQLHPGN 
PCPEDQPQSQ HPSDKNHRGA EAEDQRVEGG VRPLFWSTNE RGALVGFSSL FQRPPISSWG 
GNRILEIQLS PAQNASSEEV DRISKRAETP GFGAVTFGEC ALAFNQKSNL FRQKAVTAEK 
SSDKRQSQVC RECGRGFSRK SQLIIHQRTH TGEKPYVCGE CGRGFIVESV LRNHLSTHSG 
EKPYVCSHCG RGFSCKPYLI RHQRTHTREK SFMCTVCGRG FREKSELIKH QRIHTGDKPY 
VCRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.